MX2007013203A - Nuevas aminas ciclicas. - Google Patents
Nuevas aminas ciclicas.Info
- Publication number
- MX2007013203A MX2007013203A MX2007013203A MX2007013203A MX2007013203A MX 2007013203 A MX2007013203 A MX 2007013203A MX 2007013203 A MX2007013203 A MX 2007013203A MX 2007013203 A MX2007013203 A MX 2007013203A MX 2007013203 A MX2007013203 A MX 2007013203A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- cyclic amines
- novel cyclic
- novel
- medicaments
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
La invencion esta relacionada con nuevas aminas ciclicas de la formula (I) (ver formula (I)) en las que de X1 a X3, de Y1 a Y3, R1??, R1?? y n son los definidos en la descripcion y en las reivindicaciones, ademas de sales fisiologicamente aceptables de las mismas. Estos compuestos inhiben el factor de coagulacion Xa y se pueden utilizar como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05103452 | 2005-04-27 | ||
PCT/EP2006/061776 WO2006114401A2 (en) | 2005-04-27 | 2006-04-24 | Novel cyclic amines |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007013203A true MX2007013203A (es) | 2007-12-11 |
Family
ID=37215107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007013203A MX2007013203A (es) | 2005-04-27 | 2006-04-24 | Nuevas aminas ciclicas. |
Country Status (15)
Country | Link |
---|---|
US (1) | US7820699B2 (es) |
EP (1) | EP1877404A2 (es) |
JP (1) | JP4843025B2 (es) |
KR (1) | KR100933231B1 (es) |
CN (1) | CN101208334B (es) |
AR (1) | AR054188A1 (es) |
AU (1) | AU2006239329B2 (es) |
BR (1) | BRPI0609917A2 (es) |
CA (1) | CA2604603C (es) |
IL (1) | IL186487A (es) |
MX (1) | MX2007013203A (es) |
NO (1) | NO20075158L (es) |
TW (1) | TW200720270A (es) |
WO (1) | WO2006114401A2 (es) |
ZA (1) | ZA200709267B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7550487B2 (en) * | 2004-03-26 | 2009-06-23 | Hoffmann-La Roche Inc. | Pyrrolidine-3,4-dicarboxamide derivatives |
PL1882684T3 (pl) * | 2005-05-19 | 2015-08-31 | Astellas Pharma Inc | Pochodna pirolidyny albo jej sól |
EP1951717A1 (en) * | 2005-11-16 | 2008-08-06 | F.Hoffmann-La Roche Ag | Novel pyrrolidine derivatives as inhibitors of coagulation factor xa |
JP5473334B2 (ja) | 2005-12-23 | 2014-04-16 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
EP2468724B1 (en) | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
EP2205583A2 (en) | 2007-10-01 | 2010-07-14 | F. Hoffmann-Roche AG | N-heterocyclic biaryl carboxamides as ccr receptor antagonists |
EP2060564A1 (en) * | 2007-11-19 | 2009-05-20 | Ludwig-Maximilians-Universität München | Non-peptidic promoters of apoptosis |
KR101979036B1 (ko) | 2010-12-23 | 2019-05-15 | 알렉토스 테라퓨틱스 인크. | 선택적인 글리코시다아제 저해제 및 이의 용도 |
EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
EP2726492B1 (en) | 2011-06-27 | 2017-11-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
WO2014032188A1 (en) | 2012-08-31 | 2014-03-06 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
CA2890115A1 (en) | 2012-10-31 | 2014-05-08 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
US9808445B2 (en) | 2014-04-16 | 2017-11-07 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
WO2015160636A1 (en) * | 2014-04-16 | 2015-10-22 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
CN104892593B (zh) * | 2015-06-19 | 2018-02-06 | 汕头经济特区鮀滨制药厂 | 一种利伐沙班的有关物质f、g的合成方法 |
CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
WO2022232161A1 (en) * | 2021-04-26 | 2022-11-03 | Sypherion, Llc | Inhibitors of nsp1 for treatment of sars-cov-2 |
CN114573501A (zh) * | 2022-03-02 | 2022-06-03 | 河南阿尔法医药科技有限公司 | 一种可规模化生产2,2′:6′,2″-三联吡啶-4′-甲醛的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR030676A1 (es) * | 1999-07-28 | 2003-09-03 | Ortho Mcneil Pharm Inc | Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden |
EP1720844B1 (de) | 2003-04-03 | 2009-04-29 | MERCK PATENT GmbH | Pyrrolidin-1,2-dicarbonsäure-1-(phenylamid)-2-(4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen |
US20050119266A1 (en) | 2003-10-01 | 2005-06-02 | Yan Shi | Pyrrolidine and piperidine derivatives as factor Xa inhibitors |
BRPI0512535A (pt) | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
-
2006
- 2006-04-13 US US11/403,973 patent/US7820699B2/en not_active Expired - Fee Related
- 2006-04-24 BR BRPI0609917-3A patent/BRPI0609917A2/pt not_active IP Right Cessation
- 2006-04-24 CA CA2604603A patent/CA2604603C/en active Active
- 2006-04-24 MX MX2007013203A patent/MX2007013203A/es active IP Right Grant
- 2006-04-24 TW TW095114487A patent/TW200720270A/zh unknown
- 2006-04-24 CN CN2006800230613A patent/CN101208334B/zh not_active Expired - Fee Related
- 2006-04-24 AU AU2006239329A patent/AU2006239329B2/en not_active Ceased
- 2006-04-24 WO PCT/EP2006/061776 patent/WO2006114401A2/en active Application Filing
- 2006-04-24 KR KR1020077024610A patent/KR100933231B1/ko not_active IP Right Cessation
- 2006-04-24 JP JP2008508202A patent/JP4843025B2/ja not_active Expired - Fee Related
- 2006-04-24 EP EP06777206A patent/EP1877404A2/en not_active Withdrawn
- 2006-04-25 AR ARP060101638A patent/AR054188A1/es unknown
-
2007
- 2007-10-08 IL IL186487A patent/IL186487A/en not_active IP Right Cessation
- 2007-10-10 NO NO20075158A patent/NO20075158L/no not_active Application Discontinuation
- 2007-10-26 ZA ZA200709267A patent/ZA200709267B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AR054188A1 (es) | 2007-06-06 |
TW200720270A (en) | 2007-06-01 |
CN101208334B (zh) | 2012-06-13 |
KR100933231B1 (ko) | 2009-12-22 |
US20060247238A1 (en) | 2006-11-02 |
WO2006114401A2 (en) | 2006-11-02 |
KR20070114836A (ko) | 2007-12-04 |
JP4843025B2 (ja) | 2011-12-21 |
EP1877404A2 (en) | 2008-01-16 |
AU2006239329B2 (en) | 2012-11-08 |
WO2006114401A3 (en) | 2007-04-12 |
JP2008539196A (ja) | 2008-11-13 |
ZA200709267B (en) | 2008-12-31 |
IL186487A (en) | 2012-01-31 |
CA2604603C (en) | 2014-12-09 |
US7820699B2 (en) | 2010-10-26 |
NO20075158L (no) | 2007-11-23 |
BRPI0609917A2 (pt) | 2010-05-11 |
CA2604603A1 (en) | 2006-11-02 |
IL186487A0 (en) | 2008-01-20 |
AU2006239329A1 (en) | 2006-11-02 |
CN101208334A (zh) | 2008-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |