MX2007006679A - Piperidinasulfonilureas y-tioureas, su preparacion, su uso y composiciones farmaceuticas que las comprenden. - Google Patents

Piperidinasulfonilureas y-tioureas, su preparacion, su uso y composiciones farmaceuticas que las comprenden.

Info

Publication number
MX2007006679A
MX2007006679A MX2007006679A MX2007006679A MX2007006679A MX 2007006679 A MX2007006679 A MX 2007006679A MX 2007006679 A MX2007006679 A MX 2007006679A MX 2007006679 A MX2007006679 A MX 2007006679A MX 2007006679 A MX2007006679 A MX 2007006679A
Authority
MX
Mexico
Prior art keywords
formula
piperidinesulfonylureas
pharmaceutical compositions
thioureas
preparation
Prior art date
Application number
MX2007006679A
Other languages
English (en)
Inventor
Heinrich Christian Englert
Holger Heitsch
Uwe Gerlach
Heinz Goegelein
Stephanie Knieps
Karl-Heinz Lehr
Stefania Pfeiffer-Marek
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of MX2007006679A publication Critical patent/MX2007006679A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invencion se refiere a piperidinasulfonilureas y piperidinasulfoniltioureas de formula I, (ver formula l) en la que A, X, R(1), R(2) y R(3) tienen los significados indicados en las reivindicaciones; los compuestos de la formula I son principios activos farmaceuticos valiosos que muestran en particular un efecto inhibidor en los canales de potasio sensibles al ATP del musculo cardiaco, y son adecuados, por ejemplo, para el tratamiento de trastornos del sistema cardiovascular tales como enfermedad cardiaca coronaria, arritmias, insuficiencia cardiaca, cardiomiopatias o contractilidad del corazon reducida, o para prevenir la muerte cardiaca repentina; la invencion se refiere ademas a procedimientos para preparar los compuestos de formula I, a su uso y a composiciones farmaceuticas que los comprenden.
MX2007006679A 2004-12-18 2005-12-07 Piperidinasulfonilureas y-tioureas, su preparacion, su uso y composiciones farmaceuticas que las comprenden. MX2007006679A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004061017A DE102004061017A1 (de) 2004-12-18 2004-12-18 Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2005/013087 WO2006063722A1 (en) 2004-12-18 2005-12-07 Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them

Publications (1)

Publication Number Publication Date
MX2007006679A true MX2007006679A (es) 2007-08-14

Family

ID=35811666

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006679A MX2007006679A (es) 2004-12-18 2005-12-07 Piperidinasulfonilureas y-tioureas, su preparacion, su uso y composiciones farmaceuticas que las comprenden.

Country Status (17)

Country Link
US (1) US8586612B2 (es)
EP (1) EP1828131B1 (es)
JP (1) JP5231807B2 (es)
KR (1) KR101261251B1 (es)
CN (1) CN101080388B (es)
AT (1) ATE397588T1 (es)
AU (1) AU2005315927B2 (es)
BR (1) BRPI0515770A (es)
CA (1) CA2590405C (es)
DE (2) DE102004061017A1 (es)
DK (1) DK1828131T3 (es)
ES (1) ES2306252T3 (es)
HK (1) HK1113353A1 (es)
IL (1) IL183807A (es)
MX (1) MX2007006679A (es)
PT (1) PT1828131E (es)
WO (1) WO2006063722A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR084019A1 (es) * 2010-11-30 2013-04-17 Astrazeneca Ab DERIVADOS DE BENZAMIDA COMO BLOQUEADORES DE IKACh
CN104788425A (zh) * 2015-03-12 2015-07-22 佛山市赛维斯医药科技有限公司 一类含烟酸酰胺和哌啶结构ptp1b抑制剂、制备方法及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914416A (en) 1966-12-23 1975-10-21 Exsymol Sa Certain monomethyl trisilanol mannuronate complexes for treating cellulitis
US3829434A (en) * 1972-11-10 1974-08-13 Pfizer Piperidinesulfonylurea derivatives
US3914426A (en) * 1972-11-10 1975-10-21 Pfizer Piperidinesulfonylurea derivatives for lowering blood sugar levels
US3887561A (en) 1972-11-10 1975-06-03 Pfizer Piperidinesulfonylurea derivatives
US3944524A (en) 1974-04-26 1976-03-16 Pfizer Inc. 4-Substituted-1-piperidinesulfonamides
US3987172A (en) 1974-04-26 1976-10-19 Pfizer Inc. Piperidinesulfonylurea derivatives
US3936455A (en) 1975-01-31 1976-02-03 Pfizer Inc. Piperidinesulfonylurea derivatives
DE2948434A1 (de) * 1979-12-01 1981-06-11 Hoechst Ag, 6000 Frankfurt 1-piperidinsulfonylharnstoffe und verfahren zu ihrer herstellung
DE4032766A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
US5574843A (en) 1991-04-26 1996-11-12 Escom Ag Methods and apparatus providing for a presentation system for multimedia applications
ES2098069T3 (es) 1993-02-23 1997-04-16 Hoechst Ag Bencenosulfonil-ureas y -tioureas sustituidas, procedimiento para su preparacion y su utilizacion como agentes farmaceuticos.
DE4341655A1 (de) 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19503136A1 (de) * 1995-02-01 1996-08-08 Hoechst Ag Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19505397A1 (de) 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
CN1195524C (zh) * 1998-09-10 2005-04-06 阿文蒂斯药物德国有限公司 苯磺酰(硫)脲与β－受体阻滞剂联合在制备用于心脏迷走神经机能障碍治疗和预防的药物中的用途
US6414036B1 (en) * 1999-09-01 2002-07-02 Van Beek Global/Ninkov Llc Composition for treatment of infections of humans and animals

Also Published As

Publication number Publication date
KR101261251B1 (ko) 2013-05-07
IL183807A0 (en) 2007-09-20
CA2590405A1 (en) 2006-06-22
AU2005315927A1 (en) 2006-06-22
KR20070086366A (ko) 2007-08-27
BRPI0515770A (pt) 2008-07-29
IL183807A (en) 2011-10-31
DE602005007381D1 (de) 2008-07-17
HK1113353A1 (en) 2008-10-03
US20080033016A1 (en) 2008-02-07
EP1828131A1 (en) 2007-09-05
JP5231807B2 (ja) 2013-07-10
ES2306252T3 (es) 2008-11-01
CN101080388B (zh) 2010-12-22
JP2008524132A (ja) 2008-07-10
EP1828131B1 (en) 2008-06-04
US8586612B2 (en) 2013-11-19
ATE397588T1 (de) 2008-06-15
WO2006063722A1 (en) 2006-06-22
DE102004061017A1 (de) 2006-06-22
AU2005315927B2 (en) 2012-02-09
CA2590405C (en) 2013-03-12
PT1828131E (pt) 2008-07-24
DK1828131T3 (da) 2008-09-29
CN101080388A (zh) 2007-11-28

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