MX2007005317A - Modalidades de formacion de imagen para seleccionar agentes terapeuticos para la enfermedad de alzheimer. - Google Patents

Modalidades de formacion de imagen para seleccionar agentes terapeuticos para la enfermedad de alzheimer.

Info

Publication number
MX2007005317A
MX2007005317A MX2007005317A MX2007005317A MX2007005317A MX 2007005317 A MX2007005317 A MX 2007005317A MX 2007005317 A MX2007005317 A MX 2007005317A MX 2007005317 A MX2007005317 A MX 2007005317A MX 2007005317 A MX2007005317 A MX 2007005317A
Authority
MX
Mexico
Prior art keywords
imaging modalities
disease therapeutics
screening alzheimer
screening
alzheimer
Prior art date
Application number
MX2007005317A
Other languages
English (en)
Inventor
Julia L Rutkowski
Jack Steven Jacobsen
Orest Hurko
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2007005317A publication Critical patent/MX2007005317A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease

Abstract

El uso de modelos animales de trastornos neurodegenerativos para el establecimiento de indices de diagnostico y terapeuticos preclinicos, y para los metodos de evaluacion, para identificar las terapias preclinicas efectivas.
MX2007005317A 2004-11-05 2005-11-03 Modalidades de formacion de imagen para seleccionar agentes terapeuticos para la enfermedad de alzheimer. MX2007005317A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62516204P 2004-11-05 2004-11-05
PCT/US2005/039865 WO2006052691A2 (en) 2004-11-05 2005-11-03 Pet and magnetic resonance for screening alzheimer's disease therapeutics

Publications (1)

Publication Number Publication Date
MX2007005317A true MX2007005317A (es) 2007-06-11

Family

ID=36129750

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007005317A MX2007005317A (es) 2004-11-05 2005-11-03 Modalidades de formacion de imagen para seleccionar agentes terapeuticos para la enfermedad de alzheimer.

Country Status (9)

Country Link
US (1) US20060117397A1 (es)
EP (1) EP1807119A2 (es)
JP (1) JP2008519282A (es)
CN (1) CN101072591A (es)
AU (1) AU2005304931A1 (es)
BR (1) BRPI0517672A (es)
CA (1) CA2586220A1 (es)
MX (1) MX2007005317A (es)
WO (1) WO2006052691A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
WO2006124956A1 (en) * 2005-05-17 2006-11-23 Satori Pharmaceuticals, Inc. Compounds useful for treating neurodegenerative disorders
EP1955190B1 (en) * 2005-11-10 2018-08-29 In Silico Biosciences, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
JP5153114B2 (ja) * 2006-10-12 2013-02-27 知宏 千葉 新規のアルツハイマー病検出方法
JP5319121B2 (ja) * 2007-01-30 2013-10-16 株式会社東芝 診療支援システム及び診療支援装置
CA2680762A1 (en) * 2007-03-12 2008-09-25 National Institute Of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
EP2155259A2 (en) * 2007-05-10 2010-02-24 The Trustees of Columbia University in the City of New York Methods for diagnosing diseases and evaluating treatments therefor using pet
WO2008154415A1 (en) * 2007-06-08 2008-12-18 New York University Stage specific prognostic in vivo markers of brain aging and dementia
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
EP2268647B1 (en) 2008-03-21 2017-01-25 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
ES2685464T3 (es) * 2008-04-04 2018-10-09 The Regents Of The University Of California Nanopartículas magnéticas funcionalizadas y métodos de uso de las mismas
US8593141B1 (en) 2009-11-24 2013-11-26 Hypres, Inc. Magnetic resonance system and method employing a digital squid
MX2012011924A (es) * 2010-04-13 2013-03-05 Baxter Healthcare Sa Uso de tasa de aumento de tamaño ventricular en el tratamiento intravenoso con inmunoglobulina de la enfermedad de alzheimer.
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
DE102012209059B4 (de) 2012-05-30 2024-05-02 Siemens Healthineers Ag Verfahren und Vorrichtung zur Bestimmung einer zeitlichen Änderung eines Biomarkers in einem Untersuchungsgebiet
US10203388B2 (en) 2016-01-04 2019-02-12 Toshiba Medical Systems Corporation Magnetic resonance imaging apparatus and magnetic resonance imaging method

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233774D1 (de) * 1991-01-21 2009-12-10 Elan Pharm Inc Prüfung und Modell für Alzheimers-Krankheit
ATE198622T1 (de) * 1993-10-27 2001-01-15 Elan Pharm Inc Transgene tiere, die app allele mit der schwedischen mutation beherbergen
JPH07132033A (ja) * 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US6717031B2 (en) * 1995-06-07 2004-04-06 Kate Dora Games Method for selecting a transgenic mouse model of alzheimer's disease
US5894078A (en) * 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
US5849999A (en) * 1996-10-16 1998-12-15 The Mclean Hospital Corporation Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
US6284944B1 (en) * 1997-08-29 2001-09-04 Cephalon, Inc, Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
US6175057B1 (en) * 1997-10-08 2001-01-16 The Regents Of The University Of California Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
US5846197A (en) * 1998-03-16 1998-12-08 Beth Israel Deaconess Medical Center Compensating for magnetization transfer effects in multislice and three-dimensional MRI blood flow mapping studies
US6664443B1 (en) * 1998-05-01 2003-12-16 Mayo Foundation For Medical Education And Research Pathogenic Tau mutations in transgenic mice
EP1105163A4 (en) * 1998-08-20 2003-05-02 Univ California METHOD FOR MARKING AMYLOID PLAQUES AND NEUROFIBRILLIC GIFTS
US6374130B1 (en) * 1999-04-06 2002-04-16 Eric M. Reiman Methods for tracking the progression of Alzheimer's disease identifying treatment using transgenic mice
US7371920B2 (en) * 2000-06-20 2008-05-13 The Governing Council Of The University Of Toronto Transgenic mouse model of neurodegenerative disorders
US6593516B1 (en) * 2002-10-03 2003-07-15 Rico Corp. Holder for a musical instrument reed
US20050102708A1 (en) * 2003-03-12 2005-05-12 Laurent Lecanu Animal model simulating neurologic disease

Also Published As

Publication number Publication date
BRPI0517672A (pt) 2008-10-14
CN101072591A (zh) 2007-11-14
WO2006052691A2 (en) 2006-05-18
CA2586220A1 (en) 2006-05-18
EP1807119A2 (en) 2007-07-18
US20060117397A1 (en) 2006-06-01
JP2008519282A (ja) 2008-06-05
AU2005304931A1 (en) 2006-05-18
WO2006052691A3 (en) 2007-05-10

Similar Documents

Publication Publication Date Title
MX2007005317A (es) Modalidades de formacion de imagen para seleccionar agentes terapeuticos para la enfermedad de alzheimer.
WO2011045415A3 (en) Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
WO2008048410A3 (en) Diagnostic methods and genetic markers for alzheimer disease
EA016193B9 (ru) Антитела, направленные против бета-амилоидного пептида, и способы их использования
Kukolja et al. Noradrenergic-glucocorticoid modulation of emotional memory encoding in the human hippocampus
MY164376A (en) Phosphospecific antibodies recognizing tau
WO2006102370A3 (en) Functional brain mri mapping as a marker in cns diseases and disorders
EA201590833A1 (ru) Антитела для лечения и профилактики болезни альцгеймера и их применение
MX354662B (es) Anticuerpos fosfoespecificos que reconocen la tau.
IL208926A0 (en) Use of epothelone d in treating tau-associated diseases including alzheimer's disease
NO20090156L (no) Humanisert antistoff
MY171300A (en) Pharmaceutical composition
EA200700427A1 (ru) Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний
EP1951892A4 (en) ANTIBODY TREATMENT OF MORBUS ALZHEIMER AND RELATED DISEASES
WO2007149293A3 (en) Transgenic flies expressing tau and amyloid precursor fragment
EP2001503A4 (en) DIAGNOSIS AND TREATMENT OF MORBUS ALZHEIMER
Hagiwara et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors
WO2018060766A3 (en) Genetic susceptibility diagnosis and treatment of mental disorders
WO2006091964A8 (en) Regulators of protein misfolding and aggregation and methods of using the same
PH12012501882B1 (en) Humanized antibody against amyloid beta
GB0701177D0 (en) Agents and methods for early diagnosis and monitoring of alzheimer's disease and other neurological disorders
EP1769089A4 (en) METHODS AND COMPOSITIONS FOR PRE-SYMPTOMATIC OR POST-SYMPTOMATIC DIAGNOSIS OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS
Kim The effects of home visit healthcare using a complex program on community-dwelling frail elders' strength, frailty, and depression
EP2147117A4 (en) METHOD FOR DIAGNOSIS OF MORBUS ALZHEIMER AND MARKERS IDENTIFIED BY SET ASSOCIATION
Olympics Healthy athletes

Legal Events

Date Code Title Description
FA Abandonment or withdrawal