MX2007001539A - Compuestos heterociclicos como agentes farmaceuticos. - Google Patents

Info

Publication number

MX2007001539A

MX2007001539A MX2007001539A MX2007001539A MX2007001539A MX 2007001539 A MX2007001539 A MX 2007001539A MX 2007001539 A MX2007001539 A MX 2007001539A MX 2007001539 A MX2007001539 A MX 2007001539A MX 2007001539 A MX2007001539 A MX 2007001539A

Authority

MX

Mexico

Prior art keywords

optionally substituted

substituted

heterocyclyl

heteroaryl

aryl

Prior art date

2004-08-10

Links

• Espacenet
• Global Dossier
• Discuss

• 150000002391 heterocyclic compounds Chemical class 0.000 title description 2
• 239000008177 pharmaceutical agent Substances 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 175
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 97
• 239000000203 mixture Substances 0.000 claims abstract description 97
• 238000000034 method Methods 0.000 claims abstract description 67
• 230000000694 effects Effects 0.000 claims abstract description 56
• 201000010099 disease Diseases 0.000 claims abstract description 51
• 208000035475 disorder Diseases 0.000 claims abstract description 46
• 208000024891 symptom Diseases 0.000 claims abstract description 25
• 125000001072 heteroaryl group Chemical group 0.000 claims description 266
• 125000000623 heterocyclic group Chemical group 0.000 claims description 262
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 232
• 125000004475 heteroaralkyl group Chemical group 0.000 claims description 227
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 212
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 209
• 125000005843 halogen group Chemical group 0.000 claims description 190
• 125000000217 alkyl group Chemical group 0.000 claims description 187
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 184
• 125000003118 aryl group Chemical group 0.000 claims description 175
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 174
• 125000002577 pseudohalo group Chemical group 0.000 claims description 174
• 125000001424 substituent group Chemical group 0.000 claims description 162
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 161
• 125000001188 haloalkyl group Chemical group 0.000 claims description 146
• -1 3-acetylphenylimino Chemical group 0.000 claims description 110
• 229910052739 hydrogen Inorganic materials 0.000 claims description 96
• 239000001257 hydrogen Substances 0.000 claims description 96
• 125000003107 substituted aryl group Chemical group 0.000 claims description 88
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 79
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 68
• 125000003342 alkenyl group Chemical group 0.000 claims description 63
• 125000005017 substituted alkenyl group Chemical group 0.000 claims description 63
• 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 59
• 125000000304 alkynyl group Chemical group 0.000 claims description 59
• 108020004017 nuclear receptors Proteins 0.000 claims description 58
• 150000002431 hydrogen Chemical class 0.000 claims description 57
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 57
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 42
• 102100038495 Bile acid receptor Human genes 0.000 claims description 40
• 101000603876 Homo sapiens Bile acid receptor Proteins 0.000 claims description 40
• 229910052757 nitrogen Inorganic materials 0.000 claims description 35
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 29
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
• 125000002947 alkylene group Chemical group 0.000 claims description 21
• 229940107161 cholesterol Drugs 0.000 claims description 21
• 239000003795 chemical substances by application Substances 0.000 claims description 20
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 19
• 239000000556 agonist Substances 0.000 claims description 15
• 239000005557 antagonist Substances 0.000 claims description 15
• 235000012000 cholesterol Nutrition 0.000 claims description 15
• 206010012601 diabetes mellitus Diseases 0.000 claims description 15
• 239000008194 pharmaceutical composition Substances 0.000 claims description 14
• 208000031226 Hyperlipidaemia Diseases 0.000 claims description 13
• 239000003937 drug carrier Substances 0.000 claims description 13
• 229910052760 oxygen Inorganic materials 0.000 claims description 13
• 125000004449 heterocyclylalkenyl group Chemical group 0.000 claims description 12
• 201000001320 Atherosclerosis Diseases 0.000 claims description 11
• 230000015572 biosynthetic process Effects 0.000 claims description 11
• 229910052717 sulfur Inorganic materials 0.000 claims description 11
• 230000004060 metabolic process Effects 0.000 claims description 10
• 208000035150 Hypercholesterolemia Diseases 0.000 claims description 9
• 208000006575 hypertriglyceridemia Diseases 0.000 claims description 9
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 9
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
• 206010008635 Cholestasis Diseases 0.000 claims description 8
• 238000010521 absorption reaction Methods 0.000 claims description 8
• 150000001413 amino acids Chemical class 0.000 claims description 8
• 239000003613 bile acid Substances 0.000 claims description 8
• 230000007870 cholestasis Effects 0.000 claims description 8
• 231100000359 cholestasis Toxicity 0.000 claims description 8
• 201000001421 hyperglycemia Diseases 0.000 claims description 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
• 208000032928 Dyslipidaemia Diseases 0.000 claims description 7
• 208000017170 Lipid metabolism disease Diseases 0.000 claims description 7
• 206010049287 Lipodystrophy acquired Diseases 0.000 claims description 7
• 208000008589 Obesity Diseases 0.000 claims description 7
• 208000006132 lipodystrophy Diseases 0.000 claims description 7
• 235000020824 obesity Nutrition 0.000 claims description 7
• 238000003786 synthesis reaction Methods 0.000 claims description 7
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
• 230000015556 catabolic process Effects 0.000 claims description 6
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 5
• 230000009102 absorption Effects 0.000 claims description 5
• 239000003963 antioxidant agent Substances 0.000 claims description 5
• 235000006708 antioxidants Nutrition 0.000 claims description 5
• 239000012190 activator Substances 0.000 claims description 4
• 230000029142 excretion Effects 0.000 claims description 4
• 229940088597 hormone Drugs 0.000 claims description 4
• 239000005556 hormone Substances 0.000 claims description 4
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 4
• UEKDOPPDCYNGHM-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3,5-dibenzyl-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C1N(CC=2C=CC=CC=2)C(=O)C(CC=2C=CC=CC=2)S1 UEKDOPPDCYNGHM-UHFFFAOYSA-N 0.000 claims description 3
• HLSDYWFUKOZJTE-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-(2,3-dihydroindol-1-ylmethylidene)-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN1C2=CC=CC=C2CC1 HLSDYWFUKOZJTE-UHFFFAOYSA-N 0.000 claims description 3
• UYOKDJNIHORDNT-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-(2-phenylethyl)-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C1N(CC=2C=CC=CC=2)C(=O)C(CCC=2C=CC=CC=2)S1 UYOKDJNIHORDNT-UHFFFAOYSA-N 0.000 claims description 3
• PZCIROBDGVLEIL-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-(furan-2-ylmethylidene)-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CC1=CC=CO1 PZCIROBDGVLEIL-UHFFFAOYSA-N 0.000 claims description 3
• ZWQHCOQRXKFJGB-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-[(4-methylpiperazin-1-yl)methylidene]-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN1CCN(C)CC1 ZWQHCOQRXKFJGB-UHFFFAOYSA-N 0.000 claims description 3
• KYXHFHACYVKHAB-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-benzylidene-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CC1=CC=CC=C1 KYXHFHACYVKHAB-UHFFFAOYSA-N 0.000 claims description 3
• FTTCNMOCBHYESC-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-phenacyl-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C1N(CC=2C=CC=CC=2)C(=O)C(CC(=O)C=2C=CC=CC=2)S1 FTTCNMOCBHYESC-UHFFFAOYSA-N 0.000 claims description 3
• 229930003427 Vitamin E Natural products 0.000 claims description 3
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
• 102000006255 nuclear receptors Human genes 0.000 claims description 3
• 229940088594 vitamin Drugs 0.000 claims description 3
• 229930003231 vitamin Natural products 0.000 claims description 3
• 235000013343 vitamin Nutrition 0.000 claims description 3
• 239000011782 vitamin Substances 0.000 claims description 3
• 235000019165 vitamin E Nutrition 0.000 claims description 3
• 239000011709 vitamin E Substances 0.000 claims description 3
• 229940046009 vitamin E Drugs 0.000 claims description 3
• VZGIJCXVUUINRV-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-[(n-methylanilino)methylidene]-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN(C)C1=CC=CC=C1 VZGIJCXVUUINRV-UHFFFAOYSA-N 0.000 claims description 2
• BZXKLXUWHZDDTA-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-[[benzyl(methyl)amino]methylidene]-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN(C)CC1=CC=CC=C1 BZXKLXUWHZDDTA-UHFFFAOYSA-N 0.000 claims description 2
• GMUCPXKPCHHGMW-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-[[methyl(2-phenylethyl)amino]methylidene]-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN(C)CCC1=CC=CC=C1 GMUCPXKPCHHGMW-UHFFFAOYSA-N 0.000 claims description 2
• HKFQHSDEEUNRTI-UHFFFAOYSA-N 3-[[3-benzyl-5-(2,3-dihydroindol-1-ylmethylidene)-4-oxo-1,3-thiazolidin-2-ylidene]amino]-4-(ethylamino)benzonitrile Chemical compound CCNC1=CC=C(C#N)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN1C2=CC=CC=C2CC1 HKFQHSDEEUNRTI-UHFFFAOYSA-N 0.000 claims description 2
• ZQWBBJKQQQLRBO-UHFFFAOYSA-N 3-[[3-benzyl-5-(dimethylaminomethylidene)-4-oxo-1,3-thiazolidin-2-ylidene]amino]-4-(ethylamino)benzonitrile Chemical compound CCNC1=CC=C(C#N)C=C1N=C1N(CC=2C=CC=CC=2)C(=O)C(=CN(C)C)S1 ZQWBBJKQQQLRBO-UHFFFAOYSA-N 0.000 claims description 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
• 239000003112 inhibitor Substances 0.000 claims 17
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 14
• 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 12
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 10
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 10
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
• 239000004031 partial agonist Substances 0.000 claims 9
• 102000004877 Insulin Human genes 0.000 claims 7
• 108090001061 Insulin Proteins 0.000 claims 7
• 125000001841 imino group Chemical group [H]N=* 0.000 claims 7
• 229940125396 insulin Drugs 0.000 claims 7
• 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 6
• 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 6
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 6
• 230000003143 atherosclerotic effect Effects 0.000 claims 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
• DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 claims 6
• OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 5
• 239000013543 active substance Substances 0.000 claims 5
• 229960003692 gamma aminobutyric acid Drugs 0.000 claims 5
• 229940125388 beta agonist Drugs 0.000 claims 4
• LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 4
• 239000002464 receptor antagonist Substances 0.000 claims 4
• 230000028327 secretion Effects 0.000 claims 4
• DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 claims 3
• DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 claims 3
• ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 claims 3
• 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 3
• 206010003210 Arteriosclerosis Diseases 0.000 claims 3
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 3
• 229940123208 Biguanide Drugs 0.000 claims 3
• 102000013585 Bombesin Human genes 0.000 claims 3
• 108010051479 Bombesin Proteins 0.000 claims 3
• 101800000414 Corticotropin Proteins 0.000 claims 3
• FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 claims 3
• 239000004131 EU approved raising agent Substances 0.000 claims 3
• 102000019432 Galanin Human genes 0.000 claims 3
• 101800002068 Galanin Proteins 0.000 claims 3
• 102000000853 LDL receptors Human genes 0.000 claims 3
• 108010001831 LDL receptors Proteins 0.000 claims 3
• 229940127470 Lipase Inhibitors Drugs 0.000 claims 3
• ZPXSCAKFGYXMGA-UHFFFAOYSA-N Mazindol Chemical compound N12CCN=C2C2=CC=CC=C2C1(O)C1=CC=C(Cl)C=C1 ZPXSCAKFGYXMGA-UHFFFAOYSA-N 0.000 claims 3
• 101710151321 Melanostatin Proteins 0.000 claims 3
• 102400000064 Neuropeptide Y Human genes 0.000 claims 3
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 3
• 108010044210 PPAR-beta Proteins 0.000 claims 3
• 101150014691 PPARA gene Proteins 0.000 claims 3
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 3
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 3
• 229940100389 Sulfonylurea Drugs 0.000 claims 3
• 229940123464 Thiazolidinedione Drugs 0.000 claims 3
• 229960001138 acetylsalicylic acid Drugs 0.000 claims 3
• 239000000048 adrenergic agonist Substances 0.000 claims 3
• 239000003529 anticholesteremic agent Substances 0.000 claims 3
• 239000003524 antilipemic agent Substances 0.000 claims 3
• 229940127218 antiplatelet drug Drugs 0.000 claims 3
• 239000002876 beta blocker Substances 0.000 claims 3
• 229940097320 beta blocking agent Drugs 0.000 claims 3
• 108040005346 beta3-adrenergic receptor activity proteins Proteins 0.000 claims 3
• 229960000516 bezafibrate Drugs 0.000 claims 3
• IIBYAHWJQTYFKB-UHFFFAOYSA-N bezafibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1CCNC(=O)C1=CC=C(Cl)C=C1 IIBYAHWJQTYFKB-UHFFFAOYSA-N 0.000 claims 3
• 150000004283 biguanides Chemical class 0.000 claims 3
• 229920000080 bile acid sequestrant Polymers 0.000 claims 3
• 229940096699 bile acid sequestrants Drugs 0.000 claims 3
• DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims 3
• 230000001906 cholesterol absorption Effects 0.000 claims 3
• 229960001214 clofibrate Drugs 0.000 claims 3
• KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims 3
• 229960000258 corticotropin Drugs 0.000 claims 3
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 3
• FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 claims 3
• 229960004597 dexfenfluramine Drugs 0.000 claims 3
• 229960004890 diethylpropion Drugs 0.000 claims 3
• XXEPPPIWZFICOJ-UHFFFAOYSA-N diethylpropion Chemical compound CCN(CC)C(C)C(=O)C1=CC=CC=C1 XXEPPPIWZFICOJ-UHFFFAOYSA-N 0.000 claims 3
• DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims 3
• 229960001582 fenfluramine Drugs 0.000 claims 3
• 229960002297 fenofibrate Drugs 0.000 claims 3
• YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims 3
• 229940125753 fibrate Drugs 0.000 claims 3
• 235000010855 food raising agent Nutrition 0.000 claims 3
• 230000002496 gastric effect Effects 0.000 claims 3
• 239000000411 inducer Substances 0.000 claims 3
• 229960000299 mazindol Drugs 0.000 claims 3
• SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 claims 3
• 229960003966 nicotinamide Drugs 0.000 claims 3
• 235000005152 nicotinamide Nutrition 0.000 claims 3
• 239000011570 nicotinamide Substances 0.000 claims 3
• 229960003512 nicotinic acid Drugs 0.000 claims 3
• 235000001968 nicotinic acid Nutrition 0.000 claims 3
• 239000011664 nicotinic acid Substances 0.000 claims 3
• URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 claims 3
• 229960003562 phentermine Drugs 0.000 claims 3
• 229960000395 phenylpropanolamine Drugs 0.000 claims 3
• DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims 3
• 239000000106 platelet aggregation inhibitor Substances 0.000 claims 3
• 229960003611 pramlintide Drugs 0.000 claims 3
• 108010029667 pramlintide Proteins 0.000 claims 3
• NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 claims 3
• 229960002847 prasterone Drugs 0.000 claims 3
• FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 claims 3
• 229960003912 probucol Drugs 0.000 claims 3
• GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 3
• 229960004622 raloxifene Drugs 0.000 claims 3
• 229940044551 receptor antagonist Drugs 0.000 claims 3
• 229960004425 sibutramine Drugs 0.000 claims 3
• UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 3
• 208000011580 syndromic disease Diseases 0.000 claims 3
• 150000001467 thiazolidinediones Chemical class 0.000 claims 3
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
• QRMFPGOYLMAMMW-UHFFFAOYSA-N 2-[5-acetyl-2-(ethylamino)phenyl]imino-3-benzyl-5-(dimethylaminomethylidene)-1,3-thiazolidin-4-one Chemical compound CCNC1=CC=C(C(C)=O)C=C1N=C1N(CC=2C=CC=CC=2)C(=O)C(=CN(C)C)S1 QRMFPGOYLMAMMW-UHFFFAOYSA-N 0.000 claims 2
• 239000005541 ACE inhibitor Substances 0.000 claims 2
• 229940123413 Angiotensin II antagonist Drugs 0.000 claims 2
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
• 102000016267 Leptin Human genes 0.000 claims 2
• 108010092277 Leptin Proteins 0.000 claims 2
• 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 claims 2
• 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 claims 2
• 108700012920 TNF Proteins 0.000 claims 2
• 229930003270 Vitamin B Natural products 0.000 claims 2
• 229930003268 Vitamin C Natural products 0.000 claims 2
• 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 2
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
• 239000005516 coenzyme A Substances 0.000 claims 2
• 229940093530 coenzyme a Drugs 0.000 claims 2
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
• 239000003382 histamine H3 receptor agonist Substances 0.000 claims 2
• 239000003395 histamine H3 receptor antagonist Substances 0.000 claims 2
• 229940039781 leptin Drugs 0.000 claims 2
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 2
• GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 2
• RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
• 229940044601 receptor agonist Drugs 0.000 claims 2
• 239000000018 receptor agonist Substances 0.000 claims 2
• 239000003488 releasing hormone Substances 0.000 claims 2
• 235000019156 vitamin B Nutrition 0.000 claims 2
• 239000011720 vitamin B Substances 0.000 claims 2
• 235000019158 vitamin B6 Nutrition 0.000 claims 2
• 239000011726 vitamin B6 Substances 0.000 claims 2
• 235000019154 vitamin C Nutrition 0.000 claims 2
• 239000011718 vitamin C Substances 0.000 claims 2
• 229940011671 vitamin b6 Drugs 0.000 claims 2
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
• VGMAZNQMJZEYGA-UHFFFAOYSA-N 3-(furan-2-ylmethyl)-1,3-thiazolidin-4-one Chemical compound O=C1CSCN1Cc1ccco1 VGMAZNQMJZEYGA-UHFFFAOYSA-N 0.000 claims 1
• FDKVVPGVZUSTGF-UHFFFAOYSA-N 3-[[3-benzyl-5-[(4-methoxy-n-methylanilino)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]-4-(ethylamino)benzonitrile Chemical compound CCNC1=CC=C(C#N)C=C1N=C(S1)N(CC=2C=CC=CC=2)C(=O)C1=CN(C)C1=CC=C(OC)C=C1 FDKVVPGVZUSTGF-UHFFFAOYSA-N 0.000 claims 1
• 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
• 229940123471 Angiotensin II agonist Drugs 0.000 claims 1
• 102100034159 Beta-3 adrenergic receptor Human genes 0.000 claims 1
• GCVLCLFIEOVLMG-JTUXUYRKSA-N CC(=O)C1=CC=CC(\N=C/2N(C(=O)C(=C/N3C4=CC=CC=C4CC3)/S\2)CC=2OC=CC=2)=C1 Chemical compound CC(=O)C1=CC=CC(\N=C/2N(C(=O)C(=C/N3C4=CC=CC=C4CC3)/S\2)CC=2OC=CC=2)=C1 GCVLCLFIEOVLMG-JTUXUYRKSA-N 0.000 claims 1
• 102000004980 Dopamine D2 Receptors Human genes 0.000 claims 1
• 108090001111 Dopamine D2 Receptors Proteins 0.000 claims 1
• 229940096895 Dopamine D2 receptor agonist Drugs 0.000 claims 1
• 229940123603 Dopamine D2 receptor antagonist Drugs 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• 108010012088 Fibrinogen Receptors Proteins 0.000 claims 1
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
• 102000004384 Histamine H3 receptors Human genes 0.000 claims 1
• 108090000981 Histamine H3 receptors Proteins 0.000 claims 1
• 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims 1
• 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims 1
• 108090000854 Oxidoreductases Proteins 0.000 claims 1
• 102000004316 Oxidoreductases Human genes 0.000 claims 1
• 229930003779 Vitamin B12 Natural products 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
• 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 230000003078 antioxidant effect Effects 0.000 claims 1
• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims 1
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
• 239000005515 coenzyme Substances 0.000 claims 1
• 229960003638 dopamine Drugs 0.000 claims 1
• 239000000442 dopamine 2 receptor blocking agent Substances 0.000 claims 1
• 239000002288 dopamine 2 receptor stimulating agent Substances 0.000 claims 1
• 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 239000002319 fibrinogen receptor antagonist Substances 0.000 claims 1
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
• 210000002752 melanocyte Anatomy 0.000 claims 1
• 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
• 235000019163 vitamin B12 Nutrition 0.000 claims 1
• 239000011715 vitamin B12 Substances 0.000 claims 1
• 102000005962 receptors Human genes 0.000 abstract description 25
• 108020003175 receptors Proteins 0.000 abstract description 24
• 238000011282 treatment Methods 0.000 abstract description 20
• 230000002265 prevention Effects 0.000 abstract description 11
• 102000007399 Nuclear hormone receptor Human genes 0.000 description 57
• 102000004311 liver X receptors Human genes 0.000 description 35
• 108090000865 liver X receptors Proteins 0.000 description 35
• 239000000243 solution Substances 0.000 description 31
• 235000002639 sodium chloride Nutrition 0.000 description 28
• 238000009472 formulation Methods 0.000 description 26
• 102000004164 orphan nuclear receptors Human genes 0.000 description 26
• 108090000629 orphan nuclear receptors Proteins 0.000 description 26
• 239000000725 suspension Substances 0.000 description 21
• 238000006243 chemical reaction Methods 0.000 description 20
• 239000002552 dosage form Substances 0.000 description 18
• 108090000623 proteins and genes Proteins 0.000 description 18
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
• 150000003839 salts Chemical class 0.000 description 16
• 239000007788 liquid Substances 0.000 description 15
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
• 239000004480 active ingredient Substances 0.000 description 13
• 239000002775 capsule Substances 0.000 description 13
• 239000000839 emulsion Substances 0.000 description 13
• 238000002360 preparation method Methods 0.000 description 13
• 239000000126 substance Substances 0.000 description 13
• 239000003826 tablet Substances 0.000 description 13
• 108010038912 Retinoid X Receptors Proteins 0.000 description 12
• 239000002904 solvent Substances 0.000 description 12
• 102000034527 Retinoid X Receptors Human genes 0.000 description 11
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 10
• 229930006000 Sucrose Natural products 0.000 description 10
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 10
• 239000000796 flavoring agent Substances 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• 239000000843 powder Substances 0.000 description 10
• 239000000651 prodrug Substances 0.000 description 10
• 229940002612 prodrug Drugs 0.000 description 10
• 239000005720 sucrose Substances 0.000 description 10
• 238000012360 testing method Methods 0.000 description 9
• 239000003981 vehicle Substances 0.000 description 9
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
• 239000002253 acid Substances 0.000 description 8
• 150000001718 carbodiimides Chemical class 0.000 description 8
• 125000004432 carbon atom Chemical group C* 0.000 description 8
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 8
• 150000002148 esters Chemical class 0.000 description 8
• 235000019441 ethanol Nutrition 0.000 description 8
• 235000013355 food flavoring agent Nutrition 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 239000007924 injection Substances 0.000 description 8
• 238000002347 injection Methods 0.000 description 8
• 239000002502 liposome Substances 0.000 description 8
• 239000002953 phosphate buffered saline Substances 0.000 description 8
• 230000000699 topical effect Effects 0.000 description 8
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 7
• 239000005977 Ethylene Substances 0.000 description 7
• 101000603962 Homo sapiens Oxysterols receptor LXR-alpha Proteins 0.000 description 7
• 206010028980 Neoplasm Diseases 0.000 description 7
• 102100038476 Oxysterols receptor LXR-alpha Human genes 0.000 description 7
• 239000002585 base Substances 0.000 description 7
• 210000004027 cell Anatomy 0.000 description 7
• 239000007891 compressed tablet Substances 0.000 description 7
• 229920001577 copolymer Polymers 0.000 description 7
• 239000003085 diluting agent Substances 0.000 description 7
• 235000003599 food sweetener Nutrition 0.000 description 7
• 230000006870 function Effects 0.000 description 7
• 235000011187 glycerol Nutrition 0.000 description 7
• 239000008187 granular material Substances 0.000 description 7
• 239000007787 solid Substances 0.000 description 7
• 239000003765 sweetening agent Substances 0.000 description 7
• 235000020357 syrup Nutrition 0.000 description 7
• 239000006188 syrup Substances 0.000 description 7
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 6
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
• 239000004698 Polyethylene Substances 0.000 description 6
• 150000001412 amines Chemical class 0.000 description 6
• 125000004122 cyclic group Chemical group 0.000 description 6
• 239000003995 emulsifying agent Substances 0.000 description 6
• 239000008101 lactose Substances 0.000 description 6
• 239000003446 ligand Substances 0.000 description 6
• 150000002632 lipids Chemical class 0.000 description 6
• 239000008176 lyophilized powder Substances 0.000 description 6
• 230000001404 mediated effect Effects 0.000 description 6
• 238000007911 parenteral administration Methods 0.000 description 6
• 239000000546 pharmaceutical excipient Substances 0.000 description 6
• 229920000573 polyethylene Polymers 0.000 description 6
• 239000000047 product Substances 0.000 description 6
• 230000004044 response Effects 0.000 description 6
• 210000001519 tissue Anatomy 0.000 description 6
• PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 description 6
• XHNJAEUCAPAPFV-UHFFFAOYSA-N 3,4-dihydropyrrol-2-imine Chemical class N=1C(CCC=1)=N XHNJAEUCAPAPFV-UHFFFAOYSA-N 0.000 description 5
• 208000002874 Acne Vulgaris Diseases 0.000 description 5
• 208000024827 Alzheimer disease Diseases 0.000 description 5
• 208000032382 Ischaemic stroke Diseases 0.000 description 5
• 208000018737 Parkinson disease Diseases 0.000 description 5
• 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 5
• 239000002202 Polyethylene glycol Substances 0.000 description 5
• 229920002472 Starch Polymers 0.000 description 5
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 5
• 150000007513 acids Chemical class 0.000 description 5
• 206010000496 acne Diseases 0.000 description 5
• 239000007864 aqueous solution Substances 0.000 description 5
• 201000011510 cancer Diseases 0.000 description 5
• 229910052799 carbon Inorganic materials 0.000 description 5
• 239000001768 carboxy methyl cellulose Substances 0.000 description 5
• 201000001883 cholelithiasis Diseases 0.000 description 5
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
• 238000000576 coating method Methods 0.000 description 5
• 239000003086 colorant Substances 0.000 description 5
• 239000008121 dextrose Substances 0.000 description 5
• 230000014509 gene expression Effects 0.000 description 5
• 150000004677 hydrates Chemical class 0.000 description 5
• 150000002466 imines Chemical group 0.000 description 5
• 150000002540 isothiocyanates Chemical class 0.000 description 5
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 5
• 229920001223 polyethylene glycol Polymers 0.000 description 5
• 102000004169 proteins and genes Human genes 0.000 description 5
• 239000006215 rectal suppository Substances 0.000 description 5
• 210000003491 skin Anatomy 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 239000012453 solvate Substances 0.000 description 5
• 239000008107 starch Substances 0.000 description 5
• 235000019698 starch Nutrition 0.000 description 5
• 229940032147 starch Drugs 0.000 description 5
• 239000000080 wetting agent Substances 0.000 description 5
• GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
• OLAXGXSXHZEQFM-UHFFFAOYSA-N 5-(aminomethylidene)-3,4-dihydropyrrol-2-amine Chemical class NC=C1CCC(=N)N1 OLAXGXSXHZEQFM-UHFFFAOYSA-N 0.000 description 4
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 4
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
• 208000024172 Cardiovascular disease Diseases 0.000 description 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
• 206010061218 Inflammation Diseases 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 4
• 108091027981 Response element Proteins 0.000 description 4
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
• DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 4
• 150000001241 acetals Chemical class 0.000 description 4
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
• 235000010323 ascorbic acid Nutrition 0.000 description 4
• 230000037365 barrier function of the epidermis Effects 0.000 description 4
• 230000027455 binding Effects 0.000 description 4
• 239000011230 binding agent Substances 0.000 description 4
• 239000007853 buffer solution Substances 0.000 description 4
• 239000000969 carrier Substances 0.000 description 4
• 238000006482 condensation reaction Methods 0.000 description 4
• 125000000392 cycloalkenyl group Chemical group 0.000 description 4
• 235000014113 dietary fatty acids Nutrition 0.000 description 4
• 230000004069 differentiation Effects 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 210000002615 epidermis Anatomy 0.000 description 4
• 239000000194 fatty acid Substances 0.000 description 4
• 229930195729 fatty acid Natural products 0.000 description 4
• 150000004665 fatty acids Chemical class 0.000 description 4
• 239000000499 gel Substances 0.000 description 4
• 239000008273 gelatin Substances 0.000 description 4
• 229920000159 gelatin Polymers 0.000 description 4
• 239000008103 glucose Substances 0.000 description 4
• 208000020346 hyperlipoproteinemia Diseases 0.000 description 4
• 208000026278 immune system disease Diseases 0.000 description 4
• 230000004054 inflammatory process Effects 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 210000000936 intestine Anatomy 0.000 description 4
• 239000000314 lubricant Substances 0.000 description 4
• 238000004519 manufacturing process Methods 0.000 description 4
• 239000012528 membrane Substances 0.000 description 4
• 210000004379 membrane Anatomy 0.000 description 4
• 210000004400 mucous membrane Anatomy 0.000 description 4
• 231100000252 nontoxic Toxicity 0.000 description 4
• 230000003000 nontoxic effect Effects 0.000 description 4
• 239000000049 pigment Substances 0.000 description 4
• 239000006187 pill Substances 0.000 description 4
• 238000013268 sustained release Methods 0.000 description 4
• 239000012730 sustained-release form Substances 0.000 description 4
• 229940036555 thyroid hormone Drugs 0.000 description 4
• 239000005495 thyroid hormone Substances 0.000 description 4
• 229940117958 vinyl acetate Drugs 0.000 description 4
• 239000001993 wax Substances 0.000 description 4
• HYMJHROUVPWYNQ-UHFFFAOYSA-N 2-amino-1,3-thiazol-4-one Chemical compound NC1=NC(=O)CS1 HYMJHROUVPWYNQ-UHFFFAOYSA-N 0.000 description 3
• UJBDWOYYHFGTGA-UHFFFAOYSA-N 3,4-dihydropyrrole-2-thione Chemical class S=C1CCC=N1 UJBDWOYYHFGTGA-UHFFFAOYSA-N 0.000 description 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
• 229920000623 Cellulose acetate phthalate Polymers 0.000 description 3
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
• 108010010803 Gelatin Proteins 0.000 description 3
• 241000282412 Homo Species 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 3
• 240000007472 Leucaena leucocephala Species 0.000 description 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
• 229930195725 Mannitol Natural products 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 229920001615 Tragacanth Polymers 0.000 description 3
• 229930003316 Vitamin D Natural products 0.000 description 3
• 150000001242 acetic acid derivatives Chemical class 0.000 description 3
• 230000009471 action Effects 0.000 description 3
• 239000011149 active material Substances 0.000 description 3
• 239000000443 aerosol Substances 0.000 description 3
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 239000004599 antimicrobial Substances 0.000 description 3
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 3
• 150000001860 citric acid derivatives Chemical class 0.000 description 3
• 150000002084 enol ethers Chemical class 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 3
• 239000007903 gelatin capsule Substances 0.000 description 3
• 235000019322 gelatine Nutrition 0.000 description 3
• 235000011852 gelatine desserts Nutrition 0.000 description 3
• 102000034356 gene-regulatory proteins Human genes 0.000 description 3
• 108091006104 gene-regulatory proteins Proteins 0.000 description 3
• 239000011521 glass Substances 0.000 description 3
• 229940093915 gynecological organic acid Drugs 0.000 description 3
• 150000004820 halides Chemical class 0.000 description 3
• 229910052736 halogen Inorganic materials 0.000 description 3
• 150000002367 halogens Chemical class 0.000 description 3
• 238000000338 in vitro Methods 0.000 description 3
• 238000001990 intravenous administration Methods 0.000 description 3
• 210000004185 liver Anatomy 0.000 description 3
• 229910052749 magnesium Chemical class 0.000 description 3
• 235000019359 magnesium stearate Nutrition 0.000 description 3
• 239000000594 mannitol Substances 0.000 description 3
• 235000010355 mannitol Nutrition 0.000 description 3
• 210000004877 mucosa Anatomy 0.000 description 3
• 230000007935 neutral effect Effects 0.000 description 3
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
• 239000003921 oil Substances 0.000 description 3
• 235000019198 oils Nutrition 0.000 description 3
• 150000007524 organic acids Chemical class 0.000 description 3
• 235000005985 organic acids Nutrition 0.000 description 3
• KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
• 229920001296 polysiloxane Polymers 0.000 description 3
• 239000003755 preservative agent Substances 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 238000001403 relative X-ray reflectometry Methods 0.000 description 3
• KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical compound O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 description 3
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
• 235000015424 sodium Nutrition 0.000 description 3
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
• 239000001488 sodium phosphate Substances 0.000 description 3
• 239000007909 solid dosage form Substances 0.000 description 3
• 150000003431 steroids Chemical class 0.000 description 3
• 210000002784 stomach Anatomy 0.000 description 3
• 239000000375 suspending agent Substances 0.000 description 3
• 230000009885 systemic effect Effects 0.000 description 3
• 239000000454 talc Substances 0.000 description 3
• 235000012222 talc Nutrition 0.000 description 3
• 229910052623 talc Inorganic materials 0.000 description 3
• 238000011200 topical administration Methods 0.000 description 3
• 150000003626 triacylglycerols Chemical class 0.000 description 3
• 235000019166 vitamin D Nutrition 0.000 description 3
• 239000011710 vitamin D Substances 0.000 description 3
• 150000003710 vitamin D derivatives Chemical class 0.000 description 3
• 229940046008 vitamin d Drugs 0.000 description 3
• SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 2
• WGIMXKDCVCTHGW-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCCO WGIMXKDCVCTHGW-UHFFFAOYSA-N 0.000 description 2
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
• FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 2
• JXPFJBJQNHEHKD-UHFFFAOYSA-N 2-amino-5-(aminomethylidene)-1,3-thiazol-4-one Chemical class NC=C1SC(=N)NC1=O JXPFJBJQNHEHKD-UHFFFAOYSA-N 0.000 description 2
• NJBMZYSKLWQXLJ-UHFFFAOYSA-N 3,4-dihydro-2h-pyrrol-5-amine Chemical class NC1=NCCC1 NJBMZYSKLWQXLJ-UHFFFAOYSA-N 0.000 description 2
• XYIWBFQEHFJEMF-UHFFFAOYSA-N 5-(aminomethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound NC=C1SC(=S)NC1=O XYIWBFQEHFJEMF-UHFFFAOYSA-N 0.000 description 2
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 2
• 241000416162 Astragalus gummifer Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical class [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• 102000008186 Collagen Human genes 0.000 description 2
• 108010035532 Collagen Proteins 0.000 description 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
• 108020004414 DNA Proteins 0.000 description 2
• 230000004568 DNA-binding Effects 0.000 description 2
• 101100202237 Danio rerio rxrab gene Proteins 0.000 description 2
• 101100309320 Danio rerio rxrga gene Proteins 0.000 description 2
• 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
• UPEZCKBFRMILAV-JNEQICEOSA-N Ecdysone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@H]([C@@H](O)CCC(O)(C)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 UPEZCKBFRMILAV-JNEQICEOSA-N 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
• QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
• 150000000994 L-ascorbates Chemical class 0.000 description 2
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical class [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
• 208000034493 Mucous membrane disease Diseases 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
• ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
• 101150050070 RXRA gene Proteins 0.000 description 2
• 239000008156 Ringer's lactate solution Substances 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 2
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
• XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 150000001299 aldehydes Chemical class 0.000 description 2
• 229910052783 alkali metal Inorganic materials 0.000 description 2
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
• 150000003973 alkyl amines Chemical class 0.000 description 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
• UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 239000003708 ampul Substances 0.000 description 2
• 239000003098 androgen Substances 0.000 description 2
• 229940069428 antacid Drugs 0.000 description 2
• 239000003159 antacid agent Substances 0.000 description 2
• 239000008365 aqueous carrier Substances 0.000 description 2
• 239000008122 artificial sweetener Substances 0.000 description 2
• 239000011668 ascorbic acid Substances 0.000 description 2
• 229960005070 ascorbic acid Drugs 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• 229910052788 barium Inorganic materials 0.000 description 2
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical class [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 2
• UPABQMWFWCMOFV-UHFFFAOYSA-N benethamine Chemical compound C=1C=CC=CC=1CNCCC1=CC=CC=C1 UPABQMWFWCMOFV-UHFFFAOYSA-N 0.000 description 2
• 239000000440 bentonite Substances 0.000 description 2
• 229910000278 bentonite Inorganic materials 0.000 description 2
• 235000012216 bentonite Nutrition 0.000 description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• 229960004217 benzyl alcohol Drugs 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 150000004648 butanoic acid derivatives Chemical class 0.000 description 2
• 239000011575 calcium Chemical class 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
• 235000013539 calcium stearate Nutrition 0.000 description 2
• 239000008116 calcium stearate Substances 0.000 description 2
• 239000001569 carbon dioxide Substances 0.000 description 2
• 229910002092 carbon dioxide Inorganic materials 0.000 description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
• 150000001768 cations Chemical class 0.000 description 2
• 235000010980 cellulose Nutrition 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 229940081734 cellulose acetate phthalate Drugs 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 239000002738 chelating agent Substances 0.000 description 2
• 239000007910 chewable tablet Substances 0.000 description 2
• 229940112822 chewing gum Drugs 0.000 description 2
• 235000015218 chewing gum Nutrition 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 2
• 229960002023 chloroprocaine Drugs 0.000 description 2
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
• 229960001231 choline Drugs 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 229920001436 collagen Polymers 0.000 description 2
• 238000007906 compression Methods 0.000 description 2
• 230000006835 compression Effects 0.000 description 2
• 235000012343 cottonseed oil Nutrition 0.000 description 2
• 239000002385 cottonseed oil Substances 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 2
• 239000008355 dextrose injection Substances 0.000 description 2
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
• 229940038472 dicalcium phosphate Drugs 0.000 description 2
• 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 2
• 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
• 229910000397 disodium phosphate Inorganic materials 0.000 description 2
• 235000019800 disodium phosphate Nutrition 0.000 description 2
• 239000002270 dispersing agent Substances 0.000 description 2
• 238000001035 drying Methods 0.000 description 2
• 239000000975 dye Substances 0.000 description 2
• UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 description 2
• 235000013399 edible fruits Nutrition 0.000 description 2
• 238000009505 enteric coating Methods 0.000 description 2
• 239000002702 enteric coating Substances 0.000 description 2
• 238000006345 epimerization reaction Methods 0.000 description 2
• 239000000262 estrogen Substances 0.000 description 2
• 229940011871 estrogen Drugs 0.000 description 2
• 150000002170 ethers Chemical class 0.000 description 2
• 238000013213 extrapolation Methods 0.000 description 2
• 238000009501 film coating Methods 0.000 description 2
• 239000007888 film coating Substances 0.000 description 2
• 235000019634 flavors Nutrition 0.000 description 2
• 238000004108 freeze drying Methods 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 2
• 125000002541 furyl group Chemical group 0.000 description 2
• 239000003862 glucocorticoid Substances 0.000 description 2
• 235000001727 glucose Nutrition 0.000 description 2
• 150000002334 glycols Chemical class 0.000 description 2
• 125000000262 haloalkenyl group Chemical group 0.000 description 2
• 125000005842 heteroatom Chemical group 0.000 description 2
• 239000000833 heterodimer Substances 0.000 description 2
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
• 230000002779 inactivation Effects 0.000 description 2
• 229910052500 inorganic mineral Inorganic materials 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 2
• 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 239000004922 lacquer Substances 0.000 description 2
• 150000003893 lactate salts Chemical class 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 229910052744 lithium Inorganic materials 0.000 description 2
• 239000003589 local anesthetic agent Substances 0.000 description 2
• 229960005015 local anesthetics Drugs 0.000 description 2
• 239000006210 lotion Substances 0.000 description 2
• 239000011777 magnesium Chemical class 0.000 description 2
• 150000002688 maleic acid derivatives Chemical class 0.000 description 2
• 238000004949 mass spectrometry Methods 0.000 description 2
• 238000001819 mass spectrum Methods 0.000 description 2
• 238000002844 melting Methods 0.000 description 2
• 230000008018 melting Effects 0.000 description 2
• 229910052751 metal Chemical class 0.000 description 2
• 239000002184 metal Chemical class 0.000 description 2
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
• 235000010755 mineral Nutrition 0.000 description 2
• 239000011707 mineral Substances 0.000 description 2
• 239000002395 mineralocorticoid Substances 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 125000002950 monocyclic group Chemical group 0.000 description 2
• 125000001624 naphthyl group Chemical group 0.000 description 2
• 239000000346 nonvolatile oil Substances 0.000 description 2
• 239000006186 oral dosage form Substances 0.000 description 2
• 239000005022 packaging material Substances 0.000 description 2
• 210000002824 peroxisome Anatomy 0.000 description 2
• 239000000825 pharmaceutical preparation Substances 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
• 235000021317 phosphate Nutrition 0.000 description 2
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
• 235000011007 phosphoric acid Nutrition 0.000 description 2
• 230000035790 physiological processes and functions Effects 0.000 description 2
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
• 229920000136 polysorbate Polymers 0.000 description 2
• 229920000053 polysorbate 80 Polymers 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 239000011591 potassium Chemical class 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 2
• 229960004919 procaine Drugs 0.000 description 2
• 230000008569 process Effects 0.000 description 2
• 239000000583 progesterone congener Substances 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
• RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 2
• 229940093625 propylene glycol monostearate Drugs 0.000 description 2
• 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
• 125000004076 pyridyl group Chemical group 0.000 description 2
• 125000000168 pyrrolyl group Chemical group 0.000 description 2
• 150000003254 radicals Chemical group 0.000 description 2
• 229930002330 retinoic acid Natural products 0.000 description 2
• 229940081974 saccharin Drugs 0.000 description 2
• 235000019204 saccharin Nutrition 0.000 description 2
• 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 235000019980 sodium acid phosphate Nutrition 0.000 description 2
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
• 235000017557 sodium bicarbonate Nutrition 0.000 description 2
• CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
• 229940035044 sorbitan monolaurate Drugs 0.000 description 2
• 235000011069 sorbitan monooleate Nutrition 0.000 description 2
• 239000000600 sorbitol Substances 0.000 description 2
• 235000010356 sorbitol Nutrition 0.000 description 2
• 239000007921 spray Substances 0.000 description 2
• 239000008174 sterile solution Substances 0.000 description 2
• 239000008223 sterile water Substances 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• 150000003890 succinate salts Chemical class 0.000 description 2
• 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 2
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
• 239000000829 suppository Substances 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 238000007910 systemic administration Methods 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 125000001544 thienyl group Chemical group 0.000 description 2
• ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 2
• UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
• 150000003585 thioureas Chemical class 0.000 description 2
• 235000010487 tragacanth Nutrition 0.000 description 2
• 239000000196 tragacanth Substances 0.000 description 2
• 229940116362 tragacanth Drugs 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• 229910052723 transition metal Inorganic materials 0.000 description 2
• 229960001727 tretinoin Drugs 0.000 description 2
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
• 229940070710 valerate Drugs 0.000 description 2
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 235000005282 vitamin D3 Nutrition 0.000 description 2
• 239000011647 vitamin D3 Substances 0.000 description 2
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
• 229940021056 vitamin d3 Drugs 0.000 description 2
• 229910052725 zinc Inorganic materials 0.000 description 2
• 239000011701 zinc Chemical class 0.000 description 2
• KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 description 1
• ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• GCVLCLFIEOVLMG-UHFFFAOYSA-N 2-(3-acetylphenyl)imino-5-(2,3-dihydroindol-1-ylmethylidene)-3-(furan-2-ylmethyl)-1,3-thiazolidin-4-one Chemical compound CC(=O)C1=CC=CC(N=C2N(C(=O)C(=CN3C4=CC=CC=C4CC3)S2)CC=2OC=CC=2)=C1 GCVLCLFIEOVLMG-UHFFFAOYSA-N 0.000 description 1
• OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
• UNNGUFMVYQJGTD-UHFFFAOYSA-N 2-Ethylbutanal Chemical compound CCC(CC)C=O UNNGUFMVYQJGTD-UHFFFAOYSA-N 0.000 description 1
• KVUPQEKUVSNRCD-UHFFFAOYSA-N 2-amino-1,3-oxazol-4-one Chemical compound NC1=NC(=O)CO1 KVUPQEKUVSNRCD-UHFFFAOYSA-N 0.000 description 1
• LRIYFYUQOIQGQV-UHFFFAOYSA-N 2-amino-1,3-thiazolidin-4-one Chemical compound NC1NC(=O)CS1 LRIYFYUQOIQGQV-UHFFFAOYSA-N 0.000 description 1
• TYKJILJOXAHUFO-UHFFFAOYSA-N 2-amino-1,4-dihydroimidazol-5-one Chemical compound NC1=NC(=O)CN1 TYKJILJOXAHUFO-UHFFFAOYSA-N 0.000 description 1
• CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 1
• 125000006088 2-oxoazepinyl group Chemical group 0.000 description 1
• 125000004638 2-oxopiperazinyl group Chemical group O=C1N(CCNC1)* 0.000 description 1
• 125000004637 2-oxopiperidinyl group Chemical group O=C1N(CCCC1)* 0.000 description 1
• ODJQKYXPKWQWNK-UHFFFAOYSA-N 3,3'-Thiobispropanoic acid Chemical compound OC(=O)CCSCCC(O)=O ODJQKYXPKWQWNK-UHFFFAOYSA-N 0.000 description 1
• MJKVTPMWOKAVMS-UHFFFAOYSA-N 3-hydroxy-1-benzopyran-2-one Chemical class C1=CC=C2OC(=O)C(O)=CC2=C1 MJKVTPMWOKAVMS-UHFFFAOYSA-N 0.000 description 1
• ASNHGEVAWNWCRQ-UHFFFAOYSA-N 4-(hydroxymethyl)oxolane-2,3,4-triol Chemical compound OCC1(O)COC(O)C1O ASNHGEVAWNWCRQ-UHFFFAOYSA-N 0.000 description 1
• ALEVUYMOJKJJSA-UHFFFAOYSA-N 4-hydroxy-2-propylbenzoic acid Chemical class CCCC1=CC(O)=CC=C1C(O)=O ALEVUYMOJKJJSA-UHFFFAOYSA-N 0.000 description 1
• 125000005986 4-piperidonyl group Chemical group 0.000 description 1
• PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 239000005995 Aluminium silicate Substances 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
• 102000014914 Carrier Proteins Human genes 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
• 239000004709 Chlorinated polyethylene Substances 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 102000008169 Co-Repressor Proteins Human genes 0.000 description 1
• 108010060434 Co-Repressor Proteins Proteins 0.000 description 1
• ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• 229920002785 Croscarmellose sodium Polymers 0.000 description 1
• XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
• 229920000858 Cyclodextrin Polymers 0.000 description 1
• 102100038637 Cytochrome P450 7A1 Human genes 0.000 description 1
• KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
• IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 108010010234 HDL Lipoproteins Proteins 0.000 description 1
• 102000015779 HDL Lipoproteins Human genes 0.000 description 1
• 244000043261 Hevea brasiliensis Species 0.000 description 1
• 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 1
• 101000957672 Homo sapiens Cytochrome P450 7A1 Proteins 0.000 description 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
• 241000218194 Laurales Species 0.000 description 1
• 241000195947 Lycopodium Species 0.000 description 1
• 235000006679 Mentha X verticillata Nutrition 0.000 description 1
• 235000002899 Mentha suaveolens Nutrition 0.000 description 1
• 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 244000294411 Mirabilis expansa Species 0.000 description 1
• 235000015429 Mirabilis expansa Nutrition 0.000 description 1
• 229920000715 Mucilage Polymers 0.000 description 1
• HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
• ZSXGLVDWWRXATF-UHFFFAOYSA-N N,N-dimethylformamide dimethyl acetal Chemical compound COC(OC)N(C)C ZSXGLVDWWRXATF-UHFFFAOYSA-N 0.000 description 1
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
• 239000004677 Nylon Substances 0.000 description 1
• 102000016978 Orphan receptors Human genes 0.000 description 1
• 108070000031 Orphan receptors Proteins 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
• 229920002732 Polyanhydride Polymers 0.000 description 1
• 239000005062 Polybutadiene Substances 0.000 description 1
• 229920000954 Polyglycolide Polymers 0.000 description 1
• 229920002367 Polyisobutene Polymers 0.000 description 1
• 229920001710 Polyorthoester Polymers 0.000 description 1
• 239000004372 Polyvinyl alcohol Substances 0.000 description 1
• HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 229920001800 Shellac Polymers 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 240000006474 Theobroma bicolor Species 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
• 239000003490 Thiodipropionic acid Substances 0.000 description 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
• 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 description 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001919 adrenal effect Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 235000010419 agar Nutrition 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
• 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 1
• 150000001350 alkyl halides Chemical class 0.000 description 1
• 125000004414 alkyl thio group Chemical group 0.000 description 1
• 230000029936 alkylation Effects 0.000 description 1
• 238000005804 alkylation reaction Methods 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 230000001458 anti-acid effect Effects 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• 150000004982 aromatic amines Chemical class 0.000 description 1
• 125000005125 aryl alkyl amino carbonyl group Chemical group 0.000 description 1
• 125000005100 aryl amino carbonyl group Chemical group 0.000 description 1
• 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 1
• 125000005110 aryl thio group Chemical group 0.000 description 1
• 125000004104 aryloxy group Chemical group 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 239000000305 astragalus gummifer gum Substances 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 125000002785 azepinyl group Chemical group 0.000 description 1
• 150000001540 azides Chemical class 0.000 description 1
• 150000007981 azolines Chemical class 0.000 description 1
• 230000003385 bacteriostatic effect Effects 0.000 description 1
• LFYJSSARVMHQJB-QIXNEVBVSA-N bakuchiol Chemical compound CC(C)=CCC[C@@](C)(C=C)\C=C\C1=CC=C(O)C=C1 LFYJSSARVMHQJB-QIXNEVBVSA-N 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
• 125000005870 benzindolyl group Chemical group 0.000 description 1
• 125000005605 benzo group Chemical group 0.000 description 1
• 125000000928 benzodioxinyl group Chemical group O1C(=COC2=C1C=CC=C2)* 0.000 description 1
• 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 229960004365 benzoic acid Drugs 0.000 description 1
• 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 description 1
• 125000005874 benzothiadiazolyl group Chemical group 0.000 description 1
• 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 1
• 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• 125000002619 bicyclic group Chemical group 0.000 description 1
• 238000002306 biochemical method Methods 0.000 description 1
• 229920000249 biocompatible polymer Polymers 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
• 210000001124 body fluid Anatomy 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 125000005620 boronic acid group Chemical class 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• MKUWVMRNQOOSAT-UHFFFAOYSA-N but-3-en-2-ol Chemical compound CC(O)C=C MKUWVMRNQOOSAT-UHFFFAOYSA-N 0.000 description 1
• DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
• 229920005549 butyl rubber Polymers 0.000 description 1
• 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
• 239000007963 capsule composition Substances 0.000 description 1
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
• 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 150000003857 carboxamides Chemical class 0.000 description 1
• 150000001735 carboxylic acids Chemical class 0.000 description 1
• 235000021466 carotenoid Nutrition 0.000 description 1
• 150000001747 carotenoids Chemical class 0.000 description 1
• 239000001913 cellulose Chemical class 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
• GGCLNOIGPMGLDB-GYKMGIIDSA-N cholest-5-en-3-one Chemical class C1C=C2CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 GGCLNOIGPMGLDB-GYKMGIIDSA-N 0.000 description 1
• 230000031154 cholesterol homeostasis Effects 0.000 description 1
• 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
• 235000017471 coenzyme Q10 Nutrition 0.000 description 1
• 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 238000002648 combination therapy Methods 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 235000008504 concentrate Nutrition 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 238000009833 condensation Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 239000008120 corn starch Substances 0.000 description 1
• 239000006184 cosolvent Substances 0.000 description 1
• 150000001896 cresols Chemical class 0.000 description 1
• 229960001681 croscarmellose sodium Drugs 0.000 description 1
• XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
• 229940097362 cyclodextrins Drugs 0.000 description 1
• UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
• DEZRYPDIMOWBDS-UHFFFAOYSA-N dcm dichloromethane Chemical compound ClCCl.ClCCl DEZRYPDIMOWBDS-UHFFFAOYSA-N 0.000 description 1
• 125000005507 decahydroisoquinolyl group Chemical group 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• RAFNCPHFRHZCPS-UHFFFAOYSA-N di(imidazol-1-yl)methanethione Chemical compound C1=CN=CN1C(=S)N1C=CN=C1 RAFNCPHFRHZCPS-UHFFFAOYSA-N 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 125000004473 dialkylaminocarbonyl group Chemical group 0.000 description 1
• 230000001079 digestive effect Effects 0.000 description 1
• SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
• UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
• 208000037765 diseases and disorders Diseases 0.000 description 1
• 239000007919 dispersible tablet Substances 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 239000012990 dithiocarbamate Substances 0.000 description 1
• 150000004659 dithiocarbamates Chemical class 0.000 description 1
• 239000002934 diuretic Substances 0.000 description 1
• 229940030606 diuretics Drugs 0.000 description 1
• UZZWBUYVTBPQIV-UHFFFAOYSA-N dme dimethoxyethane Chemical compound COCCOC.COCCOC UZZWBUYVTBPQIV-UHFFFAOYSA-N 0.000 description 1
• CETRZFQIITUQQL-UHFFFAOYSA-N dmso dimethylsulfoxide Chemical compound CS(C)=O.CS(C)=O CETRZFQIITUQQL-UHFFFAOYSA-N 0.000 description 1
• 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 150000002031 dolichols Chemical class 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 239000008298 dragée Substances 0.000 description 1
• 230000036267 drug metabolism Effects 0.000 description 1
• 230000002500 effect on skin Effects 0.000 description 1
• 239000012039 electrophile Substances 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 239000002895 emetic Substances 0.000 description 1
• 239000008393 encapsulating agent Substances 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 150000002085 enols Chemical class 0.000 description 1
• 239000002662 enteric coated tablet Substances 0.000 description 1
• 230000002255 enzymatic effect Effects 0.000 description 1
• OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
• HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
• VKLGEXLJDNOHKX-UHFFFAOYSA-N ethoxyethane hexane Chemical class CCOCC.CCCCCC.CCCCCC.CCCCCC.CCCCCC.CCCCCC.CCCCCC VKLGEXLJDNOHKX-UHFFFAOYSA-N 0.000 description 1
• 229920001038 ethylene copolymer Polymers 0.000 description 1
• 239000005038 ethylene vinyl acetate Substances 0.000 description 1
• OJCSPXHYDFONPU-UHFFFAOYSA-N etoac etoac Chemical compound CCOC(C)=O.CCOC(C)=O OJCSPXHYDFONPU-UHFFFAOYSA-N 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 108091005640 farnesylated proteins Proteins 0.000 description 1
• 239000003925 fat Substances 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 239000010685 fatty oil Substances 0.000 description 1
• 238000003818 flash chromatography Methods 0.000 description 1
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 239000006260 foam Substances 0.000 description 1
• 230000001408 fungistatic effect Effects 0.000 description 1
• 125000003844 furanonyl group Chemical group 0.000 description 1
• 208000001130 gallstones Diseases 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 230000023266 generation of precursor metabolites and energy Effects 0.000 description 1
• 229960005150 glycerol Drugs 0.000 description 1
• 125000006456 halo alkyl cycloalkyl group Chemical group 0.000 description 1
• 125000004438 haloalkoxy group Chemical group 0.000 description 1
• 150000002373 hemiacetals Chemical class 0.000 description 1
• 230000002440 hepatic effect Effects 0.000 description 1
• 125000005241 heteroarylamino group Chemical group 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 239000000710 homodimer Substances 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
• 229920001477 hydrophilic polymer Polymers 0.000 description 1
• 229960004337 hydroquinone Drugs 0.000 description 1
• ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• 239000007946 hypodermic tablet Substances 0.000 description 1
• 125000002632 imidazolidinyl group Chemical group 0.000 description 1
• 125000002883 imidazolyl group Chemical group 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 239000012535 impurity Substances 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 1
• 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 description 1
• 125000001041 indolyl group Chemical group 0.000 description 1
• 208000027866 inflammatory disease Diseases 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 238000002664 inhalation therapy Methods 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 229910052740 iodine Inorganic materials 0.000 description 1
• 229920000554 ionomer Polymers 0.000 description 1
• 230000002262 irrigation Effects 0.000 description 1
• 238000003973 irrigation Methods 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
• 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 1
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
• 125000004628 isothiazolidinyl group Chemical group S1N(CCC1)* 0.000 description 1
• 125000001786 isothiazolyl group Chemical group 0.000 description 1
• 239000000644 isotonic solution Substances 0.000 description 1
• 125000003965 isoxazolidinyl group Chemical group 0.000 description 1
• 125000000842 isoxazolyl group Chemical group 0.000 description 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 239000010410 layer Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 108020001756 ligand binding domains Proteins 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 125000005647 linker group Chemical group 0.000 description 1
• 239000008297 liquid dosage form Substances 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 230000003908 liver function Effects 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• BCVXHSPFUWZLGQ-UHFFFAOYSA-N mecn acetonitrile Chemical compound CC#N.CC#N BCVXHSPFUWZLGQ-UHFFFAOYSA-N 0.000 description 1
• COTNUBDHGSIOTA-UHFFFAOYSA-N meoh methanol Chemical compound OC.OC COTNUBDHGSIOTA-UHFFFAOYSA-N 0.000 description 1
• 229960003151 mercaptamine Drugs 0.000 description 1
• QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
• 229910052753 mercury Inorganic materials 0.000 description 1
• 229940041669 mercury Drugs 0.000 description 1
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 229960001047 methyl salicylate Drugs 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 235000010981 methylcellulose Nutrition 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 235000013536 miso Nutrition 0.000 description 1
• 235000013379 molasses Nutrition 0.000 description 1
• 125000002757 morpholinyl group Chemical group 0.000 description 1
• 238000000465 moulding Methods 0.000 description 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
• 229920003052 natural elastomer Polymers 0.000 description 1
• 229920001206 natural gum Polymers 0.000 description 1
• 229920001194 natural rubber Polymers 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 102000027419 nuclear receptor subfamilies Human genes 0.000 description 1
• 108091008607 nuclear receptor subfamilies Proteins 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• 229920001778 nylon Polymers 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 125000005060 octahydroindolyl group Chemical group N1(CCC2CCCCC12)* 0.000 description 1
• 125000005061 octahydroisoindolyl group Chemical group C1(NCC2CCCCC12)* 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 229940049964 oleate Drugs 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
• 239000007935 oral tablet Substances 0.000 description 1
• 150000002905 orthoesters Chemical class 0.000 description 1
• 125000001715 oxadiazolyl group Chemical group 0.000 description 1
• 125000000160 oxazolidinyl group Chemical group 0.000 description 1
• 125000002971 oxazolyl group Chemical group 0.000 description 1
• 125000000466 oxiranyl group Chemical group 0.000 description 1
• 125000005476 oxopyrrolidinyl group Chemical group 0.000 description 1
• 239000001301 oxygen Chemical group 0.000 description 1
• LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
• 239000006174 pH buffer Substances 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 229910052763 palladium Inorganic materials 0.000 description 1
• 239000003182 parenteral nutrition solution Substances 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000006072 paste Substances 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 239000001814 pectin Substances 0.000 description 1
• 235000010987 pectin Nutrition 0.000 description 1
• 229920001277 pectin Polymers 0.000 description 1
• 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
• 239000003614 peroxisome proliferator Substances 0.000 description 1
• 239000008024 pharmaceutical diluent Substances 0.000 description 1
• 229940127557 pharmaceutical product Drugs 0.000 description 1
• 230000003285 pharmacodynamic effect Effects 0.000 description 1
• 239000002831 pharmacologic agent Substances 0.000 description 1
• 125000001791 phenazinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 description 1
• 150000002989 phenols Chemical class 0.000 description 1
• 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 description 1
• 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 description 1
• 229960000969 phenyl salicylate Drugs 0.000 description 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 150000003016 phosphoric acids Chemical class 0.000 description 1
• XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
• 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 125000004193 piperazinyl group Chemical group 0.000 description 1
• 125000003386 piperidinyl group Chemical group 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
• 229920001084 poly(chloroprene) Polymers 0.000 description 1
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
• 229920002857 polybutadiene Polymers 0.000 description 1
• 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
• 229920000139 polyethylene terephthalate Polymers 0.000 description 1
• 239000005020 polyethylene terephthalate Substances 0.000 description 1
• 239000004633 polyglycolic acid Substances 0.000 description 1
• 229920001195 polyisoprene Polymers 0.000 description 1
• 239000004626 polylactic acid Substances 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000004926 polymethyl methacrylate Substances 0.000 description 1
• 229940051841 polyoxyethylene ether Drugs 0.000 description 1
• 229920000056 polyoxyethylene ether Polymers 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 239000011118 polyvinyl acetate Substances 0.000 description 1
• 229920002689 polyvinyl acetate Polymers 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 229920000915 polyvinyl chloride Polymers 0.000 description 1
• 239000004800 polyvinyl chloride Substances 0.000 description 1
• 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
• 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
• 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 150000004032 porphyrins Chemical class 0.000 description 1
• 229910000160 potassium phosphate Inorganic materials 0.000 description 1
• 235000011009 potassium phosphates Nutrition 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 229940069328 povidone Drugs 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 150000003141 primary amines Chemical class 0.000 description 1
• 229960001309 procaine hydrochloride Drugs 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 235000010388 propyl gallate Nutrition 0.000 description 1
• 239000000473 propyl gallate Substances 0.000 description 1
• 229940075579 propyl gallate Drugs 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
• 229960003415 propylparaben Drugs 0.000 description 1
• 125000006239 protecting group Chemical group 0.000 description 1
• 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
• 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
• 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
• 125000003373 pyrazinyl group Chemical group 0.000 description 1
• 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
• 125000003226 pyrazolyl group Chemical group 0.000 description 1
• 125000002098 pyridazinyl group Chemical group 0.000 description 1
• 125000000714 pyrimidinyl group Chemical group 0.000 description 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
• 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
• 229940100618 rectal suppository Drugs 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
• 230000009467 reduction Effects 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• CRDYSYOERSZTHZ-UHFFFAOYSA-M selenocyanate Chemical compound [Se-]C#N CRDYSYOERSZTHZ-UHFFFAOYSA-M 0.000 description 1
• 230000035807 sensation Effects 0.000 description 1
• 235000019615 sensations Nutrition 0.000 description 1
• 230000008786 sensory perception of smell Effects 0.000 description 1
• 235000019613 sensory perceptions of taste Nutrition 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
• 239000004208 shellac Substances 0.000 description 1
• 229940113147 shellac Drugs 0.000 description 1
• 235000013874 shellac Nutrition 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 239000000741 silica gel Substances 0.000 description 1
• 229910002027 silica gel Inorganic materials 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 229960004249 sodium acetate Drugs 0.000 description 1
• WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
• 239000004299 sodium benzoate Substances 0.000 description 1
• 235000010234 sodium benzoate Nutrition 0.000 description 1
• 229960003885 sodium benzoate Drugs 0.000 description 1
• WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
• 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• 239000008354 sodium chloride injection Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• DCQXTYAFFMSNNH-UHFFFAOYSA-M sodium;2-[bis(2-hydroxyethyl)amino]ethanol;acetate Chemical compound [Na+].CC([O-])=O.OCCN(CCO)CCO DCQXTYAFFMSNNH-UHFFFAOYSA-M 0.000 description 1
• 239000008137 solubility enhancer Substances 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 239000001593 sorbitan monooleate Substances 0.000 description 1
• 229940035049 sorbitan monooleate Drugs 0.000 description 1
• 229940084106 spermaceti Drugs 0.000 description 1
• 239000012177 spermaceti Substances 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 238000011146 sterile filtration Methods 0.000 description 1
• 239000003270 steroid hormone Substances 0.000 description 1
• 239000007940 sugar coated tablet Substances 0.000 description 1
• 238000009495 sugar coating Methods 0.000 description 1
• 150000003455 sulfinic acids Chemical class 0.000 description 1
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
• 150000003457 sulfones Chemical class 0.000 description 1
• 150000003460 sulfonic acids Chemical class 0.000 description 1
• 239000011593 sulfur Chemical group 0.000 description 1
• 125000004434 sulfur atom Chemical group 0.000 description 1
• 239000007916 tablet composition Substances 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 230000035923 taste sensation Effects 0.000 description 1
• 229920001897 terpolymer Polymers 0.000 description 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
• CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
• 125000003831 tetrazolyl group Chemical group 0.000 description 1
• WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
• 125000001113 thiadiazolyl group Chemical group 0.000 description 1
• 125000006089 thiamorpholinyl sulfoxide group Chemical group 0.000 description 1
• 125000001984 thiazolidinyl group Chemical group 0.000 description 1
• 125000000335 thiazolyl group Chemical group 0.000 description 1
• 239000002562 thickening agent Substances 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 238000004809 thin layer chromatography Methods 0.000 description 1
• 235000019303 thiodipropionic acid Nutrition 0.000 description 1
• 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 108091008023 transcriptional regulators Proteins 0.000 description 1
• 230000037317 transdermal delivery Effects 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 125000004306 triazinyl group Chemical group 0.000 description 1
• 125000001425 triazolyl group Chemical group 0.000 description 1
• 229940117013 triethanolamine oleate Drugs 0.000 description 1
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
• YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
• 229940035936 ubiquinone Drugs 0.000 description 1
• 229920011532 unplasticized polyvinyl chloride Polymers 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1
• 239000008215 water for injection Substances 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 235000010447 xylitol Nutrition 0.000 description 1
• 239000000811 xylitol Substances 0.000 description 1
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
• 229960002675 xylitol Drugs 0.000 description 1