MX169411B - Emulsion acuosa estable de un compuesto perfluoroquimico y metodo para prepararla - Google Patents
Emulsion acuosa estable de un compuesto perfluoroquimico y metodo para prepararlaInfo
- Publication number
- MX169411B MX169411B MX010828A MX1082888A MX169411B MX 169411 B MX169411 B MX 169411B MX 010828 A MX010828 A MX 010828A MX 1082888 A MX1082888 A MX 1082888A MX 169411 B MX169411 B MX 169411B
- Authority
- MX
- Mexico
- Prior art keywords
- perfluorochemical
- weight
- compound
- emulsion
- perflurochemical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Colloid Chemistry (AREA)
Abstract
La presente invención se refiere a una emulsión acuosa estable de un compuesto perfluoroquímico, que comprende aproximadamente 60 por ciento en peso/volumen o más de un compuesto perfluoroquímico, aproximadamente 0.5 a 7 por ciento en peso de fun fosfolípido, que emulsiona con el compuesto perfluoroquímico, aproximadamente 5-30 por ciento en peso de un triglicérido de ácidos grasos y el resto de un medio acuoso. Metodo para preparar una emulsión acuosa estable de un compuesto perfluoroquímico en un margen de concentración de dicho compuesto perfluoroquímico de aproximadamente 60 por ciento en peso/volumen o más, en que el emulsionante acuoso se mezcla con una primera porción del volumen del perfluoroquímico, manteniendo una temperatura debajo de 35 grados, para producir una emulsión perfluroquímica inicial y en seguida mezclar la porción restante del volumen del perfluroquímico con la emulsión perfluroquímica inicial, en tanto se mantiene la temperatura debajo de 35 grados C, para suministrar una emulsión perfluroquímica final que tiene una concentración del compuesto perfluoroquímico e el margen de 60 por ciento en peso/volumen o mayor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/028,521 US4895876A (en) | 1987-03-20 | 1987-03-20 | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX169411B true MX169411B (es) | 1993-07-02 |
Family
ID=21843917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX010828A MX169411B (es) | 1987-03-20 | 1988-03-18 | Emulsion acuosa estable de un compuesto perfluoroquimico y metodo para prepararla |
Country Status (10)
Country | Link |
---|---|
US (1) | US4895876A (es) |
EP (1) | EP0282949B1 (es) |
JP (1) | JPS63264521A (es) |
KR (1) | KR900006830B1 (es) |
BR (1) | BR8801157A (es) |
CA (1) | CA1312011C (es) |
DE (1) | DE3871195D1 (es) |
ES (1) | ES2032887T3 (es) |
MX (1) | MX169411B (es) |
ZA (1) | ZA881953B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
US5514720A (en) * | 1986-07-09 | 1996-05-07 | Hemagen/Pfc | Stable emulsions of highly fluorinated organic compounds |
US5684050A (en) * | 1986-01-24 | 1997-11-04 | Hemagen/Pfc | Stable emulsions of highly fluorinated organic compounds |
US4781676A (en) * | 1987-02-20 | 1988-11-01 | Air Products And Chemicals, Inc. | Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
JPH0372423A (ja) * | 1989-05-26 | 1991-03-27 | Green Cross Corp:The | パーフルオロカーボン化合物含有乳化製剤 |
EP0440925A1 (en) * | 1989-12-13 | 1991-08-14 | The Green Cross Corporation | Internal organ-preserving liquid and method for preserving internal organs |
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
CA2050212C (en) * | 1990-09-03 | 1997-09-30 | Andrew M. Murray | Hair treatment composition |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5146014A (en) * | 1991-07-02 | 1992-09-08 | Air Products And Chemicals, Inc. | Perfluoroethyldimethyl cyclohexane |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
WO1993002653A1 (en) * | 1991-08-08 | 1993-02-18 | Segel Leigh D | Fluorocarbon blood substitute |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
EP0605477B2 (en) * | 1991-09-17 | 2007-06-20 | GE Healthcare AS | Gaseous ultrasound contrast media |
US5304325A (en) * | 1991-11-13 | 1994-04-19 | Hemagen/Pfc | Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use |
AU667847B2 (en) * | 1991-11-14 | 1996-04-18 | Alliance Pharmaceutical Corporation | Method and apparatus for partial liquid ventilation using fluorocarbons |
US5403575A (en) * | 1991-12-12 | 1995-04-04 | Hemagen/Pfc | Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them |
GB9204509D0 (en) * | 1992-03-02 | 1992-04-15 | Unilever Plc | Hair care composition |
US5628930A (en) * | 1992-10-27 | 1997-05-13 | Alliance Pharmaceutical Corp. | Stabilization of fluorocarbon emulsions |
US5595687A (en) | 1992-10-30 | 1997-01-21 | Thomas Jefferson University | Emulsion stability |
US5420359A (en) * | 1992-12-11 | 1995-05-30 | Minnesota Mining And Manufacturing Company | Chlorofluoroether compositions and preparation thereof |
CA2154590C (en) * | 1993-01-25 | 2001-06-12 | Steven C. Quay | Phase shift colloids as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
US5635538A (en) * | 1993-03-16 | 1997-06-03 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions with reduced pulmonary gas-trapping properties |
US5969004A (en) * | 1993-10-15 | 1999-10-19 | The Gillette Company | Aqueous inks |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
US6521211B1 (en) * | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5726209A (en) * | 1995-06-07 | 1998-03-10 | Alliance Pharmaceutical Corp. | Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir |
US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
US20050019266A1 (en) * | 1997-05-06 | 2005-01-27 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
ES2305368T3 (es) * | 2002-05-10 | 2008-11-01 | THE PROCTER & GAMBLE COMPANY | Tisu estampado en relieve que tiene fibras superficiales sueltas y metodo para su produccion. |
GB0319500D0 (en) * | 2003-08-19 | 2003-09-17 | Resolution Chemicals Ltd | Particle-size reduction apparatus,and use thereof |
US8012457B2 (en) * | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
WO2007059431A1 (en) | 2005-11-14 | 2007-05-24 | The Trustees Of Columbia University In The City Of New York | Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs |
WO2014160989A2 (en) * | 2013-03-28 | 2014-10-02 | The Trustees Of Columbia University In The City Of New York | Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation |
CN101443272A (zh) * | 2006-05-15 | 2009-05-27 | 弗吉尼亚联邦大学 | 用于受控和持续产生并输送过氧化物的方法和组合物 |
US8410181B2 (en) | 2006-09-19 | 2013-04-02 | The Trustees Of Columbia University In The City Of New York | Omega-3 diglyceride emulsions |
US8618056B2 (en) | 2007-12-22 | 2013-12-31 | Cuthbert O. Simpkins | Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries |
WO2010008594A1 (en) * | 2008-07-18 | 2010-01-21 | Oxygen Biotherapeutics, Inc. | Method of treating traumatic brain injury |
US20100144597A1 (en) * | 2008-12-10 | 2010-06-10 | Ward Kevin R | Novel combinatorial approaches to enhancing oxygen transport to tissues |
CA2756685C (en) * | 2009-04-15 | 2019-12-24 | Oxygen Biotherapeutics, Inc. | Emulsions of perfluorocarbons |
MX2012010769A (es) * | 2010-03-19 | 2013-02-27 | Oxygen Biotherapeutics Inc | Formulaciones perfluorocarbonadas oftalmicas en forma de crema. |
CN103491976B (zh) * | 2011-01-14 | 2015-04-01 | 卡思伯特·O·辛普金斯 | 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物 |
US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
WO2024046999A1 (de) | 2022-08-31 | 2024-03-07 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Lecithin-modifizierte nanoskalierte sauerstoffträger (lenox) |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5331209B2 (es) * | 1973-10-05 | 1978-09-01 | ||
US4105798A (en) * | 1976-07-19 | 1978-08-08 | Sun Ventures, Inc. | Perfluoro polycyclic compounds for use as synthetic blood and perfusion media |
JPS5331208A (en) * | 1976-09-02 | 1978-03-24 | Matsushita Electric Ind Co Ltd | Lubricator for closed compressor and the like |
JPS5924132B2 (ja) * | 1980-12-02 | 1984-06-07 | 株式会社 林原生物化学研究所 | 栄養補給用乳剤の製法 |
US4533254A (en) * | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
US4443480A (en) * | 1982-04-12 | 1984-04-17 | Children's Hospital Medical Center | Artificial blood and other gas transport agents |
US4497829A (en) * | 1982-07-27 | 1985-02-05 | The University Of Pennsylvania | Process for preparing perfluorochemical emulsion artificial blood |
US4397870A (en) * | 1982-07-27 | 1983-08-09 | The University Of Pennsylvania | Process for prolonging retention of emulsion particles in the bloodstream |
US4423077A (en) * | 1982-07-27 | 1983-12-27 | The University Of Pennsylvania | Perfluorochemical emulsion artificial blood |
JPS6033367A (ja) * | 1983-08-04 | 1985-02-20 | Nec Corp | アルミニウムのドライエッチング方法 |
DE3339236A1 (de) * | 1983-10-28 | 1985-05-09 | Bayer Ag | Arzneimittelzubereitung |
SE8505048L (sv) * | 1985-10-25 | 1987-04-26 | Nutritional Int Res Inst | Nutritionsemulsion med syretransporterande egenskaper |
ES2054658T3 (es) * | 1986-01-24 | 1994-08-16 | Childrens Hosp Medical Center | Metodo para la preparacion de una emulsion fisiologicamente aceptable. |
US4781676A (en) * | 1987-02-20 | 1988-11-01 | Air Products And Chemicals, Inc. | Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells |
US4866096A (en) * | 1987-03-20 | 1989-09-12 | Air Products And Chemicals, Inc. | Stable fluorochemical aqueous emulsions |
-
1987
- 1987-03-20 US US07/028,521 patent/US4895876A/en not_active Expired - Fee Related
-
1988
- 1988-03-14 EP EP88104014A patent/EP0282949B1/en not_active Expired - Lifetime
- 1988-03-14 DE DE8888104014T patent/DE3871195D1/de not_active Expired - Lifetime
- 1988-03-14 CA CA000561391A patent/CA1312011C/en not_active Expired - Lifetime
- 1988-03-14 ES ES198888104014T patent/ES2032887T3/es not_active Expired - Lifetime
- 1988-03-15 BR BR8801157A patent/BR8801157A/pt unknown
- 1988-03-18 MX MX010828A patent/MX169411B/es unknown
- 1988-03-18 ZA ZA881953A patent/ZA881953B/xx unknown
- 1988-03-18 JP JP63065545A patent/JPS63264521A/ja active Pending
- 1988-03-19 KR KR1019880002947A patent/KR900006830B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0282949B1 (en) | 1992-05-20 |
EP0282949A3 (en) | 1989-08-09 |
KR900006830B1 (ko) | 1990-09-22 |
EP0282949A2 (en) | 1988-09-21 |
KR880010755A (ko) | 1988-10-24 |
CA1312011C (en) | 1992-12-29 |
ZA881953B (en) | 1989-11-29 |
DE3871195D1 (de) | 1992-06-25 |
BR8801157A (pt) | 1988-10-18 |
US4895876A (en) | 1990-01-23 |
ES2032887T3 (es) | 1993-03-01 |
JPS63264521A (ja) | 1988-11-01 |
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