MD88C2 - Procedeu de obţinere a N-I2-(4-fluorfenil)-1-metilI-etil-N-metil-N-propinilaminei sub formă de racemat, sau L-izomer, sau de săruri ale lor - Google Patents
Procedeu de obţinere a N-I2-(4-fluorfenil)-1-metilI-etil-N-metil-N-propinilaminei sub formă de racemat, sau L-izomer, sau de săruri ale lorInfo
- Publication number
- MD88C2 MD88C2 MD94-0137A MD940137A MD88C2 MD 88 C2 MD88 C2 MD 88C2 MD 940137 A MD940137 A MD 940137A MD 88 C2 MD88 C2 MD 88C2
- Authority
- MD
- Moldova
- Prior art keywords
- obtaining
- propynylamine
- fluorphenyl
- ethyl
- methyl
- Prior art date
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Invenţia se referă la anume substituite, în particular la obţinerea N-[2-(4-fluorfenil)-1-metil]-etil-2N-meril-N-propinilaminei se posedă acţiune antidepersivă, ceea ce poate fi folosit în medicină. Scopul constă în crearea unei noi substanţe mai active din clasa indicată. Sinteza se efectuează prin condensarea compuşilor chimici 4-F-C6H4-CH2-CH(CH3)-NH-CH3 şi B-R, în care B-haloid, R = CH2-C=CH; CH2-CBr=CH2. În cazul când R=CH2CBr=CH2 produsul obţinut este supus dehidrohaloigenării şi produsul de destinaţie specială este separat sub formă de racemat, L-izomer, liber sau sub formă de sare necesară. Compuşii noi sunt mai puţin toxici, mai activi şi mai selectiv faţă de inhibarea substratului MAO-B la experimentare în vitro pe homogenatul creierului şi ficatului şobolanului.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU842124A HU207282B (en) | 1984-05-31 | 1984-05-31 | Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them |
| PCT/HU1985/000035 WO1985005617A1 (en) | 1984-05-31 | 1985-05-31 | Phenylisopropylamine derivative and its preparation |
| SU864015073A SU1487810A3 (ru) | 1984-05-31 | 1986-01-30 | СПОСОБ ПОЛУЧЕНИЯ N-[2-(4-ФТОР-. ФЕНИЛ)-1-МЕТИЛ >3ΤΗΠ-Ν-ΜΕΤΗΠ-Ν-ΠΡ0ПИНИЛАМИНА |
| SU864027653A SU1609443A3 (ru) | 1984-05-31 | 1986-06-16 | Способ получени N-[2-(4-фторфенил)-1-метил]-этил-N-метил-N-пропиниламина в виде рецемата или L-изомера, или их солей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD88B1 MD88B1 (ro) | 1994-11-30 |
| MD88C2 true MD88C2 (ro) | 1995-03-31 |
Family
ID=27269987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0137A MD88C2 (ro) | 1984-05-31 | 1994-04-21 | Procedeu de obţinere a N-I2-(4-fluorfenil)-1-metilI-etil-N-metil-N-propinilaminei sub formă de racemat, sau L-izomer, sau de săruri ale lor |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD88C2 (ro) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH52468A (de) * | 1910-07-19 | 1911-11-16 | Elektrometall Ab | Einrichtung an elektrischen Öfen zum Einblasen von Gas in dieselben zwecks Abkühlung der Elektroden und des Mauerwerkes |
| US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
-
1994
- 1994-04-21 MD MD94-0137A patent/MD88C2/ro active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH52468A (de) * | 1910-07-19 | 1911-11-16 | Elektrometall Ab | Einrichtung an elektrischen Öfen zum Einblasen von Gas in dieselben zwecks Abkühlung der Elektroden und des Mauerwerkes |
| US3485874A (en) * | 1966-05-04 | 1969-12-23 | Chinoin Gyogyszer Es Vegyeszet | Ortho and para bromophenyl isopropyl methylamines |
Also Published As
| Publication number | Publication date |
|---|---|
| MD88B1 (ro) | 1994-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20050530 |