MD4845B1 - Способ получения активного комплекса из личинок Lymantria dispar - Google Patents
Способ получения активного комплекса из личинок Lymantria dispar Download PDFInfo
- Publication number
- MD4845B1 MD4845B1 MDA20220008A MD20220008A MD4845B1 MD 4845 B1 MD4845 B1 MD 4845B1 MD A20220008 A MDA20220008 A MD A20220008A MD 20220008 A MD20220008 A MD 20220008A MD 4845 B1 MD4845 B1 MD 4845B1
- Authority
- MD
- Moldova
- Prior art keywords
- larvae
- obtaining
- temperature
- active complex
- lymantria
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 241000721703 Lymantria dispar Species 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 235000013312 flour Nutrition 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 239000002028 Biomass Substances 0.000 abstract 1
- RTIXKCRFFJGDFG-UHFFFAOYSA-N Chrysin Natural products C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 abstract 1
- 241000721696 Lymantria Species 0.000 abstract 1
- FGUBFGWYEYFGRK-HNNXBMFYSA-N Pinocembrin Natural products Cc1cc(C)c2C(=O)C[C@H](Oc2c1)c3ccccc3 FGUBFGWYEYFGRK-HNNXBMFYSA-N 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 208000013507 chronic prostatitis Diseases 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 235000012907 honey Nutrition 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- SUYJZKRQHBQNCA-LSDHHAIUSA-N pinobanksin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=CC=C1 SUYJZKRQHBQNCA-LSDHHAIUSA-N 0.000 abstract 1
- SUYJZKRQHBQNCA-UHFFFAOYSA-N pinobanksin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=CC=C1 SUYJZKRQHBQNCA-UHFFFAOYSA-N 0.000 abstract 1
- URFCJEUYXNAHFI-ZDUSSCGKSA-N pinocembrin Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)O)=CC=CC=C1 URFCJEUYXNAHFI-ZDUSSCGKSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 201000007094 prostatitis Diseases 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 235000020183 skimmed milk Nutrition 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/30—Rearing or breeding invertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/30—Rearing or breeding invertebrates
- A01K67/34—Insects
- A01K67/35—Silkworms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/90—Feeding-stuffs specially adapted for particular animals for insects, e.g. bees or silkworms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Environmental Sciences (AREA)
- Insects & Arthropods (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Birds (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Feed For Specific Animals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Изобретение относится к области фармацевтики, а именно к способам получения препаратов с противовоспалительным действием, предназначенных для лечения доброкачественной гиперплазии предстательной железы, связанной или не связанной с хроническим простатитом.Способ получения активного комплекса из личинок Lymantria dispar, согласно изобретению, включает выращивание насекомых Lymantria dispar до 4-го возраста в контролируемых условиях на стандартизированной среде, содержащей, г/кг: пшеничную муку 80-95, кукурузную муку 82-87, сухую растительную массу 110-120, сухое обезжиренное молоко 2,5-3,5, пчелиный мед 17-19, глицерин 10-12, пинобанксин 0,01-0,02, пиноцембрин 0,01-0,02, ацетат цинка двуводный 0,03-0,05, очищенную воду остальное, замораживание личинок при температуре -18°С, промывание личинок, первичное измельчение, лиофилизацию, измельчение при температуре -55°С, упаковку и хранение активного комплекса при температуре -18°С.Технический результат изобретения состоит в повышении количества биомассы с более высокой биологической активностью и содержания цинка и протеиногенных аминокислот, в том числе незаменимых.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220008A MD4845C1 (ru) | 2022-02-07 | 2022-02-07 | Способ получения активного комплекса из личинок Lymantria dispar |
| PCT/MD2023/000001 WO2023149794A1 (ru) | 2022-02-07 | 2023-01-24 | Способ получения активного комплекса из личинок lymantria dispar |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220008A MD4845C1 (ru) | 2022-02-07 | 2022-02-07 | Способ получения активного комплекса из личинок Lymantria dispar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4845B1 true MD4845B1 (ru) | 2023-02-28 |
| MD4845C1 MD4845C1 (ru) | 2024-05-31 |
Family
ID=85383304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20220008A MD4845C1 (ru) | 2022-02-07 | 2022-02-07 | Способ получения активного комплекса из личинок Lymantria dispar |
Country Status (2)
| Country | Link |
|---|---|
| MD (1) | MD4845C1 (ru) |
| WO (1) | WO2023149794A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4062903A4 (en) * | 2018-07-19 | 2023-05-03 | Ciuhrii, Ceslav | ACTIVE COMPLEX OF LYMANTRIA DISPAR LARVAE AND METHOD OF PRODUCTION THEREOF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4713C1 (ru) * | 2018-07-19 | 2021-04-30 | Чеслав ЧУХРИЙ | Способ получения активного комплекса из личинок Lymantria dispar |
-
2022
- 2022-02-07 MD MDA20220008A patent/MD4845C1/ru active IP Right Grant
-
2023
- 2023-01-24 WO PCT/MD2023/000001 patent/WO2023149794A1/ru not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4062903A4 (en) * | 2018-07-19 | 2023-05-03 | Ciuhrii, Ceslav | ACTIVE COMPLEX OF LYMANTRIA DISPAR LARVAE AND METHOD OF PRODUCTION THEREOF |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023149794A1 (ru) | 2023-08-10 |
| MD4845C1 (ru) | 2024-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued |