MD4404B1 - Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia - Google Patents
Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia Download PDFInfo
- Publication number
- MD4404B1 MD4404B1 MDA20150028A MD20150028A MD4404B1 MD 4404 B1 MD4404 B1 MD 4404B1 MD A20150028 A MDA20150028 A MD A20150028A MD 20150028 A MD20150028 A MD 20150028A MD 4404 B1 MD4404 B1 MD 4404B1
- Authority
- MD
- Moldova
- Prior art keywords
- synthesis
- compound
- quinazoline
- thiadiazole
- propylthio
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 230000002365 anti-tubercular Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000001747 exhibiting effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000000814 tuberculostatic agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la chimie şi medicină, şi anume la sinteza unui compus nou, care poate găsi aplicare în medicină în calitate de preparat antituberculos.Esenţa invenţiei constă în sinteza compusului 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă cu formula:,care manifestă activitate antituberculoasă.Procedeul de sinteză a compusului revendicat constă în aceea că la soluţia ce conţine 2-mercapto-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă şi trietilamină în acetonă la fierbere şi agitare se adaugă iodură de propil. Amestecul de reacţie se agită timp de 24 ore la reflux, apoi solventul se elimină pe evaporatorul rotativ, iar precipitatul format se spală cu apă, acetonă şi se usucă la aer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20150028A MD4404C1 (ro) | 2015-03-18 | 2015-03-18 | Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20150028A MD4404C1 (ro) | 2015-03-18 | 2015-03-18 | Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4404B1 true MD4404B1 (ro) | 2016-02-29 |
| MD4404C1 MD4404C1 (ro) | 2016-09-30 |
Family
ID=55447195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20150028A MD4404C1 (ro) | 2015-03-18 | 2015-03-18 | Compusul 2-(propiltio)-5H-[1,3,4]tiadiazolo[2,3-b]chinazolin-5-onă, care manifestă activitate antituberculoasă şi procedeu de sinteză a acestuia |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4404C1 (ro) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1558915A1 (ru) * | 1988-07-29 | 1990-04-23 | Пермский фармацевтический институт | 2-(5 @ -Нитрофурил)-2,3-дигидро-5Н-1,3,4-тиадиазоло[2,3-в]-хиназолинон-5, про вл ющий противомикробную активность |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| MD4118C1 (ro) * | 2010-09-02 | 2012-02-29 | Институт Химии Академии Наук Молдовы | Compuşi 1,3,4-oxadiazolici conţinând tiouree disubstituită, ce manifestă proprietăţi antituberculoase |
| MD4125C1 (ro) * | 2010-09-17 | 2012-03-31 | Inst De Chimie Al Academiei De Stiinte A Moldovei | Compuşi 1,3,4-oxadiazolici cu proprietăţi antituberculoase conţinând tiouree monosubstituită |
-
2015
- 2015-03-18 MD MDA20150028A patent/MD4404C1/ro not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MD4404C1 (ro) | 2016-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |