MD4178B1 - Process for producing 2-nitro-4,5-diphenylimidazole - Google Patents
Process for producing 2-nitro-4,5-diphenylimidazoleInfo
- Publication number
- MD4178B1 MD4178B1 MDA20120023A MD20120023A MD4178B1 MD 4178 B1 MD4178 B1 MD 4178B1 MD A20120023 A MDA20120023 A MD A20120023A MD 20120023 A MD20120023 A MD 20120023A MD 4178 B1 MD4178 B1 MD 4178B1
- Authority
- MD
- Moldova
- Prior art keywords
- diphenylimidazole
- nitro
- producing
- compounds
- coordinative
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to the field of chemistry, in particular to derivatives of 2-nitro-4,5-diarylimidazole that can be used as biologically active compounds, catalysts, etc.Summary of the invention consists in that it is proposed a process for producing 2-nitro-4,5-diphenylimidazole by the reaction of demetalation with a mineral acid at pH≤ 2 in aqueous medium of coordinative compounds of Co(II), Ni(II) and Zn(II) with 2-nitro-4,5-diphenylimidazole. After neutralization of the resulting mixture the target compound is extracted with a water-immiscible solvent and is isolated from the extract.The initial coordinative compounds can be obtained at the interaction of 4,5-diphenylimidazole with the nitrate of the corresponding metal in solvothermal conditions with in situnitration of heterocycle.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120023A MD4178C1 (en) | 2012-02-27 | 2012-02-27 | Process for producing 2-nitro-4,5-diphenylimidazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120023A MD4178C1 (en) | 2012-02-27 | 2012-02-27 | Process for producing 2-nitro-4,5-diphenylimidazole |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4178B1 true MD4178B1 (en) | 2012-07-31 |
MD4178C1 MD4178C1 (en) | 2013-02-28 |
Family
ID=46582440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20120023A MD4178C1 (en) | 2012-02-27 | 2012-02-27 | Process for producing 2-nitro-4,5-diphenylimidazole |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4178C1 (en) |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB700211A (en) * | 1950-07-21 | 1953-11-25 | Ciba Ltd | Manufacture of azo dyestuffs |
IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
US4199592A (en) * | 1978-08-29 | 1980-04-22 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-nitroimidazoles |
DE3835195A1 (en) * | 1988-10-15 | 1990-04-19 | Basf Ag | METHOD FOR PRODUCING P-NITROPHENYL IMIDAZOLES |
WO1991010662A1 (en) * | 1990-01-12 | 1991-07-25 | Rhone-Poulenc Rorer S.A. | 2-substituted 4,5-diphenyl-imidazoles |
RU2021249C1 (en) * | 1990-10-16 | 1994-10-15 | Индивидуально-частное предприятие "Ост-Вест" | Method of synthesis of aromatic 1,2-diketones |
PT101207A (en) * | 1993-02-26 | 1994-08-31 | Inst Nac De Engenharia E Tecno | PROCESS FOR THE NITRACAO OF AROMATIC COMPOUNDS IN SOFT AND NON-CORROSIVE CONDITIONS |
CN1736976A (en) * | 2005-08-30 | 2006-02-22 | 南京大学 | Use of aluminum nitrate in aromatic ring nitration |
US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
EP2128140B1 (en) * | 2007-01-23 | 2012-03-14 | Pola Pharma Inc. | Method for producing 2-nitroimidazole derivative |
MD4150C1 (en) * | 2011-10-11 | 2012-09-30 | Институт Химии Академии Наук Молдовы | Process for producing coordinative compounds of Co(II), Ni(II) and Zn(II) with 2-nitro-4,5-diphenylimidazole starting from 4,5-diphenylimidazole and nitrates of said metals |
-
2012
- 2012-02-27 MD MDA20120023A patent/MD4178C1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MD4178C1 (en) | 2013-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |