MD28C2 - Способ получения производных имидазола - Google Patents
Способ получения производных имидазолаInfo
- Publication number
- MD28C2 MD28C2 MD94-0091A MD940091A MD28C2 MD 28 C2 MD28 C2 MD 28C2 MD 940091 A MD940091 A MD 940091A MD 28 C2 MD28 C2 MD 28C2
- Authority
- MD
- Moldova
- Prior art keywords
- cooh
- propyl
- ch2oh
- alkyl
- product
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к способу получения новых производных имидазола.Целью изобретения является получение новых производных имидазода, обладающих более высокой биологической активностью, чем структурный аналог, с использованием известного метода алкилирования имидазолов.Цель достигается взаимодействием производного имидазола формулыпроизводным дифенилметила формулыв растворителе в присутствии основания в течение 1-10ч. при температуре от 20°C до температуры кипения растворителя.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14258088A | 1988-01-07 | 1988-01-07 | |
| US07/279,194 US5138069A (en) | 1986-07-11 | 1988-12-06 | Angiotensin II receptor blocking imidazoles |
| SU894613475A RU1814646C (ru) | 1988-01-07 | 1989-01-06 | Способ получени производных имидазола |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD28B1 MD28B1 (ro) | 1994-06-30 |
| MD28C2 true MD28C2 (ru) | 1995-01-31 |
Family
ID=26666193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0091A MD28C2 (ru) | 1988-01-07 | 1994-03-16 | Способ получения производных имидазола |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD28C2 (ru) |
-
1994
- 1994-03-16 MD MD94-0091A patent/MD28C2/ru active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet U.R.S.S. nr. 1694062, Int. Cl.5 C 07 D 403/10, 1988. * |
| Вейганд-Хильгетаг. Методы эксперимента в органической химии. М.: Химия. 1968 с. 413-468. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD28B1 (ro) | 1994-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20090105 |
|
| MK4A | Patent for invention expired |