MD28C2 - The method of obtaining the imidazole's derivatives - Google Patents
The method of obtaining the imidazole's derivativesInfo
- Publication number
- MD28C2 MD28C2 MD94-0091A MD940091A MD28C2 MD 28 C2 MD28 C2 MD 28C2 MD 940091 A MD940091 A MD 940091A MD 28 C2 MD28 C2 MD 28C2
- Authority
- MD
- Moldova
- Prior art keywords
- cooh
- propyl
- ch2oh
- alkyl
- product
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The use: In it's capacity of inhibitory of the agiottensine hormone. The essence: the product with a general formula:where R1 represents COOH or the groupR2 represents n-propyl or n-butyl,R3CZ, CF3, C2F5, C6H5 or COOH;R4 represents COOH; or CHO or CH2OH with the condition that then R4 represents CH2OH, R3 represents C2F5 and R2 represents n-propyl;(b) when R3 represents COOH, R4 is also COOH;(c) when R2 represents n-propyl, R3 represents C2F5 and R4 represents COOH, R1 constitutes the groupReagent 1: Product with formulawhere R2 has the indicated values: R5 represents CZ, CF3, C2F3, C6H5 or COO (C1-4 - alkyl; R6 represents CH2OH, CO2 (C1-4-alkyl) or CHO)).Reagent 2: Product with formulawhere X represents halogen, n represents toluene sylphonic or methylsulphonilox; R7 represents COO (C1-4 - alkyl), CN or the groupThe temperature of the dissolvent. A base is the catalyst.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14258088A | 1988-01-07 | 1988-01-07 | |
| US07/279,194 US5138069A (en) | 1986-07-11 | 1988-12-06 | Angiotensin II receptor blocking imidazoles |
| SU894613475A RU1814646C (en) | 1988-01-07 | 1989-01-06 | Method of synthesis of imidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD28B1 MD28B1 (en) | 1994-06-30 |
| MD28C2 true MD28C2 (en) | 1995-01-31 |
Family
ID=26666193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0091A MD28C2 (en) | 1988-01-07 | 1994-03-16 | The method of obtaining the imidazole's derivatives |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD28C2 (en) |
-
1994
- 1994-03-16 MD MD94-0091A patent/MD28C2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet U.R.S.S. nr. 1694062, Int. Cl.5 C 07 D 403/10, 1988. * |
| Вейганд-Хильгетаг. Методы эксперимента в органической химии. М.: Химия. 1968 с. 413-468. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD28B1 (en) | 1994-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20090105 |
|
| MK4A | Patent for invention expired |