MD28C2 - Procedeu de obţinere a derivaţilor imidazolului - Google Patents

Procedeu de obţinere a derivaţilor imidazolului

Info

Publication number
MD28C2
MD28C2 MD94-0091A MD940091A MD28C2 MD 28 C2 MD28 C2 MD 28C2 MD 940091 A MD940091 A MD 940091A MD 28 C2 MD28 C2 MD 28C2
Authority
MD
Moldova
Prior art keywords
cooh
propyl
ch2oh
alkyl
product
Prior art date
Application number
MD94-0091A
Other languages
English (en)
Russian (ru)
Other versions
MD28B1 (ro
Inventor
John Carini David
Jonas Vytautas Duncia John
Chor Bun Wong Pancras
Original Assignee
E.I. Du Pont De Nemours And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/279,194 external-priority patent/US5138069A/en
Priority claimed from SU894613475A external-priority patent/RU1814646C/ru
Application filed by E.I. Du Pont De Nemours And Company filed Critical E.I. Du Pont De Nemours And Company
Publication of MD28B1 publication Critical patent/MD28B1/ro
Publication of MD28C2 publication Critical patent/MD28C2/ro

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Întrebuinţarea: în calitate de inhibitor al hormonului de angiotensină. Esenţa: produs cu formula generalăîn care R1 reprezintă COOH sau grupaR2 reprezintă n-propil sau n-butil, R3Cl, CF3, C C6H5 sau COOH;R4 reprezintă COOH; sau CHO sau CH2OH, R3 reprezintă C2F5 şi R4 reprezintă n-propil; (b) când R3 reprezintă COOH, R4 este de asemenea COOH; (c) când R2 reprezintă n-propil, R3 reprezintă C2F5 şi R4 reprezintă COOH, R1 constituie grupaReactiv 1: produs cu formulaîn care R2 are valorile indicate R5 reprezintă Cl, CF3, CF3, C2F3, C6H5 sau COO (C1-4-alchil); R6 reprezintă CH2OH, CO2(C1-4-alchil) sau CHO.Reactiv 2: produs cu formulaîn care X reprezintă halogen, n reprezintă toluolsulfoniloxi sau metilsulfoniloxi; R7 reprezintă COO(C1-4-alchil), CN sau grupaTemperatura de la 20°C până la temperatura de fierbere a dizolvantului. Catalizator este o bază.
MD94-0091A 1988-01-07 1994-03-16 Procedeu de obţinere a derivaţilor imidazolului MD28C2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14258088A 1988-01-07 1988-01-07
US07/279,194 US5138069A (en) 1986-07-11 1988-12-06 Angiotensin II receptor blocking imidazoles
SU894613475A RU1814646C (ru) 1988-01-07 1989-01-06 Способ получени производных имидазола

Publications (2)

Publication Number Publication Date
MD28B1 MD28B1 (ro) 1994-06-30
MD28C2 true MD28C2 (ro) 1995-01-31

Family

ID=26666193

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0091A MD28C2 (ro) 1988-01-07 1994-03-16 Procedeu de obţinere a derivaţilor imidazolului

Country Status (1)

Country Link
MD (1) MD28C2 (ro)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Brevet U.R.S.S. nr. 1694062, Int. Cl.5 C 07 D 403/10, 1988. *
Вейганд-Хильгетаг. Методы эксперимента в органической химии. М.: Химия. 1968 с. 413-468. *

Also Published As

Publication number Publication date
MD28B1 (ro) 1994-06-30

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20090105

MK4A Patent for invention expired