MD224C2 - Procedeu de obţinere a derivaţilor oxadiazolalchilpurinei sau a sărurilor lor acido-aditive farmaceutic admisibile (variantele lui) - Google Patents
Procedeu de obţinere a derivaţilor oxadiazolalchilpurinei sau a sărurilor lor acido-aditive farmaceutic admisibile (variantele lui)Info
- Publication number
- MD224C2 MD224C2 MD94-0330A MD940330A MD224C2 MD 224 C2 MD224 C2 MD 224C2 MD 940330 A MD940330 A MD 940330A MD 224 C2 MD224 C2 MD 224C2
- Authority
- MD
- Moldova
- Prior art keywords
- formula
- reagent
- acidic additive
- oxadiazolalkylpurine
- farmaceutically
- Prior art date
Links
- 239000000654 additive Substances 0.000 title abstract 3
- 230000002378 acidificating effect Effects 0.000 title abstract 2
- 230000000996 additive effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- -1 cyclogexyl Chemical group 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- CHNUNORXWHYHNE-UHFFFAOYSA-N Oxadiazon Chemical class C1=C(Cl)C(OC(C)C)=CC(N2C(OC(=N2)C(C)(C)C)=O)=C1Cl CHNUNORXWHYHNE-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Utilizare: în medicină, în particular, ca remedii antitusive. Esenţa invenţiei: produsul - derivat al oxadiazolului cu formula I, în care A reprezintă C1-C4-alchilenă, R1 reprezintă C1-C4-alchil, oxi- sau clor-, sau carboxi-alchil (inferior), ciclohexil, fenil, oxifenil, carboxifenil, benzil, dimetoxibenzil, aminoalchil cu formula (CH2)nNR2R3, în care n este număr întreg de la 1 până la 3, R2 şi R3 reprezintă C1-C4-alchil sau împreună cu automul de azot formează ciclul piperidinic sau morfolinic, sau sărurile lor acido-aditive farmaceutic admisibile. Esenţa invenţiei: 1-a variantă, reactivul 1: oximul cu formula 2. Reactivul 2: esterul alchilic inferior al acidului R1-carbonic cu formula 3. Condiţiile reacţiei: încălzirea în mediul unui solvent organic în prezenţa etilatului de sodiu sau hidroxidului unui metal alcalin. Varianta a 2-a. Reactivul 1: oximul cu formula 2. Reactivul 2: anhidrida halogenului sau anhidrida acidului R1-carbonic cu formula 3. Condiţiile reacţiei: la interacţiunea reactivelor rezultă compusul intermediar cu formula 4, care se separă şi/sau se deshidratează (se ciclează) prin încălzire.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864230A HU197574B (en) | 1986-10-09 | 1986-10-09 | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
| SU874203547A RU2007404C1 (ru) | 1986-10-09 | 1987-10-09 | Способ получения производных оксадиазолалкилпурина или их фармацевтически приемлемых кислотно-аддитивных солей (его варианты) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD224B1 MD224B1 (ro) | 1995-06-30 |
| MD224C2 true MD224C2 (ro) | 1995-11-30 |
Family
ID=26317749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0330A MD224C2 (ro) | 1986-10-09 | 1994-08-25 | Procedeu de obţinere a derivaţilor oxadiazolalchilpurinei sau a sărurilor lor acido-aditive farmaceutic admisibile (variantele lui) |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD224C2 (ro) |
-
1994
- 1994-08-25 MD MD94-0330A patent/MD224C2/ro active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr. 190377, HU, Int. cl. C 07 D 473/08, 1984 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD224B1 (ro) | 1995-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20071008 |