MD20160112A2 - Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 - Google Patents
Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1Info
- Publication number
- MD20160112A2 MD20160112A2 MDA20160112A MD20160112A MD20160112A2 MD 20160112 A2 MD20160112 A2 MD 20160112A2 MD A20160112 A MDA20160112 A MD A20160112A MD 20160112 A MD20160112 A MD 20160112A MD 20160112 A2 MD20160112 A2 MD 20160112A2
- Authority
- MD
- Moldova
- Prior art keywords
- dopamine
- ligands
- compounds
- heteroaromatic compounds
- schizophrenia
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 2
- 208000010877 cognitive disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000000980 schizophrenia Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000024791 Schizotypal Personality disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001050 pharmacotherapy Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
În prezenta invenţie se dezvăluie, în parte, compuşi cu formula (I):(I)şi săruri farmaceutic acceptabile ale acestora; procedee de preparare a lor; compuşi intermediari folosiţi pentru prepararea lor; compoziţii ce conţin aceşti compuşi sau sărurile lor şi utilizarea lor pentru tratamentul tulburărilor D1-mediate (sau D1-asociate) incluzând, de exemplu, schizofrenia (de exemplu, simptomele ei cognitive şi negative), tulburarea de personalitate schizotipală, tulburarea cognitivă (de exemplu, tulburare cognitivă asociată cu schizofrenia, AD, PD sau terapie farmacologică), ADHD, boala Parkinson, anxietatea şi depresia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461984070P | 2014-04-25 | 2014-04-25 | |
PCT/IB2015/052594 WO2015162515A1 (en) | 2014-04-25 | 2015-04-09 | Heteroaromatic compounds and their use as dopamine d1 ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
MD20160112A2 true MD20160112A2 (ro) | 2017-06-30 |
Family
ID=53002687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160112A MD20160112A2 (ro) | 2014-04-25 | 2015-04-09 | Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 |
Country Status (27)
Country | Link |
---|---|
US (1) | US9688698B2 (ro) |
EP (1) | EP3134087B1 (ro) |
JP (1) | JP6190076B2 (ro) |
KR (1) | KR20160142401A (ro) |
CN (1) | CN106232118A (ro) |
AP (1) | AP2016009464A0 (ro) |
AU (1) | AU2015249496A1 (ro) |
BR (1) | BR112016023623A2 (ro) |
CA (1) | CA2946471C (ro) |
CL (1) | CL2016002678A1 (ro) |
CR (1) | CR20160493A (ro) |
CU (1) | CU20160155A7 (ro) |
DO (1) | DOP2016000290A (ro) |
EA (1) | EA201691831A1 (ro) |
EC (1) | ECSP16090804A (ro) |
IL (1) | IL247849A0 (ro) |
MD (1) | MD20160112A2 (ro) |
MX (1) | MX2016013968A (ro) |
NI (1) | NI201600160A (ro) |
PE (1) | PE20170008A1 (ro) |
PH (1) | PH12016501863A1 (ro) |
SG (1) | SG11201607990QA (ro) |
SV (1) | SV2016005306A (ro) |
TN (1) | TN2016000452A1 (ro) |
TW (1) | TWI553011B (ro) |
WO (1) | WO2015162515A1 (ro) |
ZA (1) | ZA201606716B (ro) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015162518A1 (en) | 2014-04-25 | 2015-10-29 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
JP6239149B2 (ja) | 2014-04-25 | 2017-11-29 | ファイザー・インク | 複素芳香族化合物およびそのドーパミンd1リガンドとしての使用 |
CA2946990A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heterocyclic compounds and their use as dopamine d1 ligands |
EP3137454A1 (en) | 2014-04-28 | 2017-03-08 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
CN109890824B (zh) | 2016-11-02 | 2022-05-24 | 詹森药业有限公司 | 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物 |
EP3535267B1 (en) * | 2016-11-02 | 2020-12-30 | Janssen Pharmaceutica NV | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors |
AR116635A1 (es) | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
AU651337B2 (en) | 1990-03-30 | 1994-07-21 | Dowelanco | Thienopyrimidine derivatives |
US5322847A (en) | 1992-11-05 | 1994-06-21 | Pfizer Inc. | Azabenzimidazoles in the treatment of asthma, arthritis and related diseases |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
ZA971896B (en) | 1996-03-26 | 1998-09-07 | Du Pont Merck Pharma | Aryloxy-and arythio-fused pyridines and pyrimidines and derivatives |
WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
AU2002345792A1 (en) | 2001-06-21 | 2003-01-08 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
EP1483268A2 (en) | 2002-03-01 | 2004-12-08 | Pfizer Inc. | Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents |
US20050284101A1 (en) * | 2004-06-24 | 2005-12-29 | Brandes Donald J | Method and apparatus for assembling strong, lightweight thermal panel and insulated building structure |
US20050153989A1 (en) | 2004-01-13 | 2005-07-14 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
CA2566158A1 (en) * | 2004-05-14 | 2005-11-24 | Abbott Laboratories | Kinase inhibitors as therapeutic agents |
GEP20105024B (en) | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
CA2572331A1 (en) | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | C-met modulators and method of use |
GB0502573D0 (en) | 2005-02-08 | 2005-03-16 | Topotarget As | Therapeutic compounds |
JP5138585B2 (ja) | 2005-05-05 | 2013-02-06 | アーディア・バイオサイエンシーズ・インコーポレイテッド | Hivの処置のための非ヌクレオシド逆転写酵素インヒビターとしてのジアリル−プリン、−アザプリンおよび−デアザプリン |
US8093264B2 (en) | 2005-05-20 | 2012-01-10 | Methylgene Inc. | Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling |
EP1746096A1 (en) * | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer |
TW200806675A (en) | 2006-01-30 | 2008-02-01 | Array Biopharma Inc | Heterobicyclic thiophene compounds and methods of use |
CA2651898A1 (en) | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions |
JP5583594B2 (ja) | 2007-12-10 | 2014-09-03 | バイエル・ヘルスケア・エルエルシー | 試験センサ内に試薬物質を被着させる方法 |
CA2709176C (en) * | 2007-12-14 | 2013-02-05 | Ardea Biosciences, Inc. | Reverse transcriptase inhibitors |
US9271962B2 (en) | 2008-03-17 | 2016-03-01 | Northeastern University | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors |
ES2616255T3 (es) | 2008-04-30 | 2017-06-12 | National Health Research Institutes | Compuestos de pirimidina bicíclicos condensados como inhibidores de las aurora cinasas |
US8946239B2 (en) | 2008-07-10 | 2015-02-03 | Duquesne University Of The Holy Spirit | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
WO2010118367A2 (en) | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
EP2475666A2 (en) | 2009-09-11 | 2012-07-18 | Trius Therapeutics, Inc. | Gyrase inhibitors |
AR079705A1 (es) | 2009-12-23 | 2012-02-15 | Biocryst Pharm Inc | Compuestos heterociclicos como inhibidores de janus quinasa |
KR101483215B1 (ko) | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
CN102558147B (zh) * | 2010-12-23 | 2014-09-17 | 江苏先声药物研究有限公司 | 化合物、制备方法及应用 |
MX363696B (es) | 2011-04-21 | 2019-03-28 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas. |
DE102011111400A1 (de) | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
EA201500402A1 (ru) * | 2012-11-08 | 2016-05-31 | Пфайзер Инк. | Гетероароматические соединения в качестве лигандов допамина d1 |
SG11201502763VA (en) * | 2012-11-08 | 2015-05-28 | Pfizer | Heteroaromatic compounds and their use as dopamine d1 ligands |
PT3013813T (pt) | 2013-06-27 | 2019-06-14 | Pfizer | Compostos heteroaromáticos e a sua utilização como ligandos de d1 de dopamina |
JP6239149B2 (ja) * | 2014-04-25 | 2017-11-29 | ファイザー・インク | 複素芳香族化合物およびそのドーパミンd1リガンドとしての使用 |
-
2015
- 2015-04-09 AU AU2015249496A patent/AU2015249496A1/en not_active Abandoned
- 2015-04-09 BR BR112016023623A patent/BR112016023623A2/pt not_active IP Right Cessation
- 2015-04-09 CA CA2946471A patent/CA2946471C/en not_active Expired - Fee Related
- 2015-04-09 PE PE2016002125A patent/PE20170008A1/es not_active Application Discontinuation
- 2015-04-09 CR CR20160493A patent/CR20160493A/es unknown
- 2015-04-09 WO PCT/IB2015/052594 patent/WO2015162515A1/en active Application Filing
- 2015-04-09 EP EP15718387.2A patent/EP3134087B1/en active Active
- 2015-04-09 MD MDA20160112A patent/MD20160112A2/ro not_active Application Discontinuation
- 2015-04-09 EA EA201691831A patent/EA201691831A1/ru unknown
- 2015-04-09 AP AP2016009464A patent/AP2016009464A0/en unknown
- 2015-04-09 KR KR1020167032876A patent/KR20160142401A/ko not_active Application Discontinuation
- 2015-04-09 SG SG11201607990QA patent/SG11201607990QA/en unknown
- 2015-04-09 JP JP2016564057A patent/JP6190076B2/ja not_active Expired - Fee Related
- 2015-04-09 MX MX2016013968A patent/MX2016013968A/es unknown
- 2015-04-09 TN TN2016000452A patent/TN2016000452A1/en unknown
- 2015-04-09 CN CN201580020992.7A patent/CN106232118A/zh active Pending
- 2015-04-22 TW TW104112873A patent/TWI553011B/zh not_active IP Right Cessation
- 2015-04-23 US US14/694,039 patent/US9688698B2/en active Active
-
2016
- 2016-09-15 IL IL247849A patent/IL247849A0/en unknown
- 2016-09-22 PH PH12016501863A patent/PH12016501863A1/en unknown
- 2016-09-28 ZA ZA2016/06716A patent/ZA201606716B/en unknown
- 2016-10-20 CL CL2016002678A patent/CL2016002678A1/es unknown
- 2016-10-21 NI NI201600160A patent/NI201600160A/es unknown
- 2016-10-24 CU CUP2016000155A patent/CU20160155A7/es unknown
- 2016-10-25 DO DO2016000290A patent/DOP2016000290A/es unknown
- 2016-10-25 SV SV2016005306A patent/SV2016005306A/es unknown
- 2016-11-25 EC ECIEPI201690804A patent/ECSP16090804A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN106232118A (zh) | 2016-12-14 |
MX2016013968A (es) | 2016-11-15 |
AU2015249496A1 (en) | 2016-09-29 |
US9688698B2 (en) | 2017-06-27 |
CA2946471A1 (en) | 2015-10-29 |
CA2946471C (en) | 2018-08-07 |
EP3134087A1 (en) | 2017-03-01 |
CL2016002678A1 (es) | 2017-03-10 |
JP6190076B2 (ja) | 2017-08-30 |
KR20160142401A (ko) | 2016-12-12 |
EA201691831A1 (ru) | 2017-02-28 |
SG11201607990QA (en) | 2016-11-29 |
PH12016501863A1 (en) | 2016-12-19 |
TN2016000452A1 (en) | 2018-04-04 |
PE20170008A1 (es) | 2017-03-17 |
BR112016023623A2 (pt) | 2017-08-15 |
JP2017513887A (ja) | 2017-06-01 |
CU20160155A7 (es) | 2017-05-10 |
EP3134087B1 (en) | 2020-03-18 |
DOP2016000290A (es) | 2017-04-16 |
WO2015162515A1 (en) | 2015-10-29 |
ECSP16090804A (es) | 2017-08-31 |
NI201600160A (es) | 2016-11-25 |
IL247849A0 (en) | 2016-11-30 |
TWI553011B (zh) | 2016-10-11 |
US20150307522A1 (en) | 2015-10-29 |
AP2016009464A0 (en) | 2016-09-30 |
ZA201606716B (en) | 2018-05-30 |
SV2016005306A (es) | 2017-07-28 |
TW201604197A (zh) | 2016-02-01 |
CR20160493A (es) | 2016-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015502502A1 (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
PH12016501863A1 (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
PH12015502658A1 (en) | 3,4-dihydroisoquinolin-2 (1h)-yl compounds | |
CL2015001358A1 (es) | Potenciadores del cftr deuterados | |
CL2015000096A1 (es) | Compuestos derivados de 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos, inhibidores de fosfodiestearasa 2 y/o 10; composicion farmaceutica; y su uso para prevencion o tratamiento de enfermedades del sistema nervioso, como deficiencia cognitiva, demencia, trastornos de ansiedad, enf. de alzheimer, enf. de parkinson, otros | |
PH12016501993A1 (en) | Heteroaromatic compounds and their use as dopamine d1 ligands | |
GEP20207149B (en) | Allosteric modulators of nicotinic acetylcholine receptors | |
UY37466A (es) | N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa | |
IN2014DN09826A (ro) | ||
CL2016001024A1 (es) | Compuestos derivados de pirido[4,3-b]pirazin-2-carboxamidas; procedimiento de preparacion; composicion farmaceutica y uso para el tratamiento de trastornos neurodegenerativos, esquizofrenia, depresion, entre otras enfermedades. | |
CL2008003138A1 (es) | Compuestos derivados de 6-(alcoxi o fenilalcoxi)-indan-1-alquil aminas aciladas; composicion farmaceutica; y uso para el tratamiento o prevencion de alteraciones melatoninergicos tales como depresion, alteraciones del sueno, diabetes, parkinson y enfermedad de alzheimer. | |
EA201491291A1 (ru) | АГОНИСТЫ mGlu 2/3 | |
IN2013MU03838A (ro) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Abandonment or withdrawal of application (patent for invention) |