MD177C2 - Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor - Google Patents

Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor

Info

Publication number
MD177C2
MD177C2 MD94-0241A MD940241A MD177C2 MD 177 C2 MD177 C2 MD 177C2 MD 940241 A MD940241 A MD 940241A MD 177 C2 MD177 C2 MD 177C2
Authority
MD
Moldova
Prior art keywords
alkyl
obtaining
nucleoside phosphorylase
revealed
arbitrary
Prior art date
Application number
MD94-0241A
Other languages
English (en)
Russian (ru)
Inventor
A.SECRIST John
David Erion Mark
A. Montgomery John
E. Ealick Steven
C. Guida Wayne
Niwas Shri
Original Assignee
Biocryst Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/429,100 external-priority patent/US4985433A/en
Priority claimed from US07/429,097 external-priority patent/US5008270A/en
Priority claimed from SU925011315A external-priority patent/RU2097384C1/ru
Application filed by Biocryst Pharmaceuticals Inc. filed Critical Biocryst Pharmaceuticals Inc.
Publication of MD177C2 publication Critical patent/MD177C2/ro

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Inhibitori ai purinnucleozidfosforilazei(I)Se dezvăluie o substanţă, care conţine 2-amino-7-(R)-3H, 5H-pirolo[3,2-d]pirimidină-4-on, în care R reprezintă ciclohexenil, ciclohexil sau -CH2-R1, în care R1 reprezintă grupa heteroaliciclică, piridinilică sau aliciclică arbitrar substituită. Se dezvăluie, de asemenea, o substanţă cu formula (I), în care R1 reprezintă H, NH2 sau OCH3, R2 reprezintă grupa ciclică din 5-7 atomi de carbon arbitrar substituită, ce conţine arbitrar unul sau mai mulţi heteroatomi, R3 şi R4 reprezintă H sau C1-4 alchil, m reprezintă 0-4, n reprezintă 0-6, p reprezintă 0-1, X reprezintă CN, CSNH2, PO(OH)2, COOH, SO2NH2, NH2,OH, CNHNH2, tetrazol sau triazol, COR5, în care R5 reprezintă C1-4 alchil, CF3, NH2 sau OC1-4 alchil, şi Y reprezintă O sau NH.
MD94-0241A 1989-10-31 1994-07-05 Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor MD177C2 (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/429,100 US4985433A (en) 1989-10-31 1989-10-31 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US07/429,097 US5008270A (en) 1989-10-31 1989-10-31 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US44279889A 1989-11-29 1989-11-29
SU925011315A RU2097384C1 (ru) 1989-10-31 1990-10-12 Производные 2-амино-7-(chr2r3)-3н,5н-пирроло[3,2-d]-пиримидин-4-она, способы их получения и способ селективного ингибирования пролиферации т-лимфоцитов млекопитающего и не оказывающий воздействия на b-лимфоциты

Publications (1)

Publication Number Publication Date
MD177C2 true MD177C2 (ro) 1996-01-31

Family

ID=62103981

Family Applications (2)

Application Number Title Priority Date Filing Date
MD940241D MD177F1 (ro) 1989-10-31 1994-07-05 Inhibitori purinnucleozidfosforilazei procedeu de obtinere a lor
MD94-0241A MD177C2 (ro) 1989-10-31 1994-07-05 Inhibitori ai purinnucleozidfosforilazei, procedeu de obţinere a lor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MD940241D MD177F1 (ro) 1989-10-31 1994-07-05 Inhibitori purinnucleozidfosforilazei procedeu de obtinere a lor

Country Status (1)

Country Link
MD (2) MD177F1 (ro)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. I Lim, R.S.Klein, and J.J.Fox,Tetrahedron Lett., 21, 1013, 1980; *
M.I., W.I.Ren, B.A.Otter, and R.S.Klein J. Org. Chem. 48, 780, 1983. *
M.I.Lim and R.S.Klein, Tetrahedron Lett. 22, 25, 1981; *
M.I.Lim, R.S.Klein, and J.J.Fox, J.Org.Chem. 44, 3826, 1979; *

Also Published As

Publication number Publication date
MD177F1 (ro) 1995-03-31

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