MD177C2 - Method of obtaining purin nucleoside phosphorylase - Google Patents

Method of obtaining purin nucleoside phosphorylase

Info

Publication number
MD177C2
MD177C2 MD94-0241A MD940241A MD177C2 MD 177 C2 MD177 C2 MD 177C2 MD 940241 A MD940241 A MD 940241A MD 177 C2 MD177 C2 MD 177C2
Authority
MD
Moldova
Prior art keywords
alkyl
obtaining
nucleoside phosphorylase
revealed
arbitrary
Prior art date
Application number
MD94-0241A
Other languages
Romanian (ro)
Russian (ru)
Inventor
A.SECRIST John
David Erion Mark
A. Montgomery John
E. Ealick Steven
C. Guida Wayne
Niwas Shri
Original Assignee
Biocryst Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/429,100 external-priority patent/US4985433A/en
Priority claimed from US07/429,097 external-priority patent/US5008270A/en
Priority claimed from SU925011315A external-priority patent/RU2097384C1/en
Application filed by Biocryst Pharmaceuticals Inc. filed Critical Biocryst Pharmaceuticals Inc.
Publication of MD177C2 publication Critical patent/MD177C2/en

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A substance is revealed which contains 2 amino-7-(R)-3H, 5H-pirolo [3,2-d pyrimidine-4-on, in which R represents cicloexenyl, ciclohexyl or CH2 - R1 in which R represents heteroalyciclyc group, pyridinyl or alyciclin arbitrary substitued a new substance is revealed with the formula (I) in which R1 represents H, NH2 or OCH3, R2 represents the cyclic group formed of 5-7 carbon atoms arbitrary sustitued, which contains one or more heteroatoms R3 and R4 represents H or C1-4 alkyl, m represents 0-4, n represents 0-6, p represents 0-1, x represents CN, CSNH2, PO(OH)2, COOH, SO2NH2, NH2 OHCNHNH2 tetrazol ortriazol, COR5 in which R5 represents C1-4 alkyl, CF3NH2 or OC1-4 alkyl and Y represents O or NH.
MD94-0241A 1989-10-31 1994-07-05 Method of obtaining purin nucleoside phosphorylase MD177C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/429,100 US4985433A (en) 1989-10-31 1989-10-31 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US07/429,097 US5008270A (en) 1989-10-31 1989-10-31 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US44279889A 1989-11-29 1989-11-29
SU925011315A RU2097384C1 (en) 1989-10-31 1990-10-12 Derivatives of amino-7-(chr2r3)-3h,5h-pyrrolo-[3,2-d]-pyrimidine-4-one, methods of their synthesis and a method of selective inhibition of mammalian t-lymphocytes proliferation and no effecting on chr2r3-lymphocytes

Publications (1)

Publication Number Publication Date
MD177C2 true MD177C2 (en) 1996-01-31

Family

ID=62103981

Family Applications (2)

Application Number Title Priority Date Filing Date
MD940241D MD177F1 (en) 1989-10-31 1994-07-05 Purinnucleoside phosphorylase inhibitors process for obtaining them
MD94-0241A MD177C2 (en) 1989-10-31 1994-07-05 Method of obtaining purin nucleoside phosphorylase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MD940241D MD177F1 (en) 1989-10-31 1994-07-05 Purinnucleoside phosphorylase inhibitors process for obtaining them

Country Status (1)

Country Link
MD (2) MD177F1 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. I Lim, R.S.Klein, and J.J.Fox,Tetrahedron Lett., 21, 1013, 1980; *
M.I., W.I.Ren, B.A.Otter, and R.S.Klein J. Org. Chem. 48, 780, 1983. *
M.I.Lim and R.S.Klein, Tetrahedron Lett. 22, 25, 1981; *
M.I.Lim, R.S.Klein, and J.J.Fox, J.Org.Chem. 44, 3826, 1979; *

Also Published As

Publication number Publication date
MD177F1 (en) 1995-03-31

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