MD1718Y - Metodă de tratament al trombozei venei porte la pacienţii cu ciroză hepatică - Google Patents
Metodă de tratament al trombozei venei porte la pacienţii cu ciroză hepatică Download PDFInfo
- Publication number
- MD1718Y MD1718Y MDS20220090A MDS20220090A MD1718Y MD 1718 Y MD1718 Y MD 1718Y MD S20220090 A MDS20220090 A MD S20220090A MD S20220090 A MDS20220090 A MD S20220090A MD 1718 Y MD1718 Y MD 1718Y
- Authority
- MD
- Moldova
- Prior art keywords
- catheter
- needle
- spleen
- solution
- portal vein
- Prior art date
Links
- 201000009454 Portal vein thrombosis Diseases 0.000 title abstract 2
- 208000019425 cirrhosis of liver Diseases 0.000 title abstract 2
- 210000000952 spleen Anatomy 0.000 abstract 4
- 230000003287 optical effect Effects 0.000 abstract 2
- 108010088751 Albumins Proteins 0.000 abstract 1
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000012276 Endovascular treatment Methods 0.000 abstract 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- QTCANKDTWWSCMR-UHFFFAOYSA-N costic aldehyde Natural products C1CCC(=C)C2CC(C(=C)C=O)CCC21C QTCANKDTWWSCMR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- ISTFUJWTQAMRGA-UHFFFAOYSA-N iso-beta-costal Natural products C1C(C(=C)C=O)CCC2(C)CCCC(C)=C21 ISTFUJWTQAMRGA-UHFFFAOYSA-N 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003240 portal vein Anatomy 0.000 abstract 1
- 210000000955 splenic vein Anatomy 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
- 238000007631 vascular surgery Methods 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Invenţia se referă la medicină, în special la chirurgia vasculară şi hepatologie şi poate fi utilizată pentru tratamentul endovascular al trombozei venei porte la pacienţii cu ciroză hepatică.Esenţa invenţiei constă în aceea că se efectuează un abord în regiunea subombilicală cu introducerea unui dispozitiv optic şi un abord sub rebordul costal stâng, în proiecţia splinei, cu introducerea unui trocar cu diametrul de 5 mm, prin care sub vizualizare cu dispozitivul optic se introduce un ac cu capătul bont, cu lungimea de 15…20 cm şi cu diametrul de 2…3 mm, care se introduce în parenchimul splinei. Apoi prin ac se introduce o substanţă de contrast şi sub controlul rentghenologic se introduce acul într-o ramură venoasă intrasplenică. Prin acul menţionat se introduce un cateter pe ghid, care trece prin ramura venoasă menţionată, apoi prin vena splenică şi vena portă, până în zona localizării trombului. După care se înlătură ghidul şi se aspiră masele trombotice, iar prin cateter se introduc preparate trombolitice şi anticoagulante. Apoi cateterul se tracţionează până la nivelul hilului splinei, iar concomitent cu extragerea lui prin canalul format se introduc două componente ale unui adeziv fibrinic, şi anume primul component include soluţie de fibrinogen 15...45 mg, iar al doilea component include un amestec de soluţie de trombină 25...100 UI, soluţie de 10% de albumină 10...20 ml, soluţie de aprotinină 250...1000 KIU şi soluţie de clorură de Ca2+ 15...30 µmol, cu plombarea canalului din parenchimul splenic. După care se înlătură cateterul şi plăgile se suturează.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20220090A MD1718Z (ro) | 2022-11-08 | 2022-11-08 | Metodă de tratament al trombozei venei porte la pacienţii cu ciroză hepatică |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20220090A MD1718Z (ro) | 2022-11-08 | 2022-11-08 | Metodă de tratament al trombozei venei porte la pacienţii cu ciroză hepatică |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD1718Y true MD1718Y (ro) | 2023-09-30 |
| MD1718Z MD1718Z (ro) | 2024-04-30 |
Family
ID=88236921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDS20220090A MD1718Z (ro) | 2022-11-08 | 2022-11-08 | Metodă de tratament al trombozei venei porte la pacienţii cu ciroză hepatică |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD1718Z (ro) |
-
2022
- 2022-11-08 MD MDS20220090A patent/MD1718Z/ro active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MD1718Z (ro) | 2024-04-30 |
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| FG9Y | Short term patent issued |