MD142C2 - Process for apovincaminic ethyl ester preparation - Google Patents
Process for apovincaminic ethyl ester preparationInfo
- Publication number
- MD142C2 MD142C2 MD94-0159A MD940159A MD142C2 MD 142 C2 MD142 C2 MD 142C2 MD 940159 A MD940159 A MD 940159A MD 142 C2 MD142 C2 MD 142C2
- Authority
- MD
- Moldova
- Prior art keywords
- apovincaminic
- ethyl ester
- ester preparation
- etherification
- acetonitryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000004494 ethyl ester group Chemical group 0.000 title abstract 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 abstract 2
- 238000006266 etherification reaction Methods 0.000 abstract 2
- XPARNGAWWCCOIM-UHFFFAOYSA-N 2-fluoro-1,3,5-trinitrobenzene Chemical compound [O-][N+](=O)C1=CC([N+]([O-])=O)=C(F)C([N+]([O-])=O)=C1 XPARNGAWWCCOIM-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to the heterocyclic compounds.The aim: desired product yield increasing and process simplification.The apovincaminic ethyl ester is prepared by etherification of the apovincaminic acide with the ethylic alcohol in the acetonitryl medium and the process is carried out in presence of 2-fluor-1,3,5-trinitrobenzene and 4-dimethylaminopyridine as etherification agent at room temperature during 3-5 hours.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES549105A ES8604956A1 (en) | 1985-11-20 | 1985-11-20 | Process for the obtention of the ethyl ester of the apovincaminic acid |
| SU864028528A SU1435153A3 (en) | 1985-11-20 | 1986-11-19 | Method of producing ethyl ester of apotartaric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD142B1 MD142B1 (en) | 1995-01-30 |
| MD142C2 true MD142C2 (en) | 1995-07-31 |
Family
ID=26156125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0159A MD142C2 (en) | 1985-11-20 | 1994-02-14 | Process for apovincaminic ethyl ester preparation |
Country Status (3)
| Country | Link |
|---|---|
| LT (1) | LT2245B (en) |
| LV (1) | LV5257A3 (en) |
| MD (1) | MD142C2 (en) |
-
1993
- 1993-06-22 LV LV930644A patent/LV5257A3/en unknown
- 1993-08-30 LT LTRP908A patent/LT2245B/en not_active IP Right Cessation
-
1994
- 1994-02-14 MD MD94-0159A patent/MD142C2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet nr. 2253750, DE, Int. cl. C 07 D 471/22, 1978- * |
| Brevet nr. 2265138, DE, Int. cl. C 07 471/22, 1977; * |
Also Published As
| Publication number | Publication date |
|---|---|
| LT2245B (en) | 1993-11-15 |
| LV5257A3 (en) | 1993-10-10 |
| MD142B1 (en) | 1995-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20061118 |