MC1526A1 - ES- AND AMIDES OF N- (N '- (2-CHLORETHYL) -N'-NITROSOCARBAMOYL) -OLIGOPEPTIDE AND PROCESS FOR THEIR PREPARATION - Google Patents

ES- AND AMIDES OF N- (N '- (2-CHLORETHYL) -N'-NITROSOCARBAMOYL) -OLIGOPEPTIDE AND PROCESS FOR THEIR PREPARATION

Info

Publication number
MC1526A1
MC1526A1 MC82EP8200191D MC1526D MC1526A1 MC 1526 A1 MC1526 A1 MC 1526A1 MC 82EP8200191 D MC82EP8200191 D MC 82EP8200191D MC 1526 D MC1526 D MC 1526D MC 1526 A1 MC1526 A1 MC 1526A1
Authority
MC
Monaco
Prior art keywords
oligopeptide
nitrosocarbamoyl
chlorethyl
amides
preparation
Prior art date
Application number
MC82EP8200191D
Other languages
French (fr)
Inventor
Gerhard Eisenbrand
Original Assignee
Deutsches Krebsforsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch
Publication of MC1526A1 publication Critical patent/MC1526A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compounds having the formula: <IMAGE> wherein: <IMAGE>R4 = -OCH3, -NH2, NH-R4, R4 being an oligopeptidic residue of which the terminal carboxyl group is blocked as a methyl ester or amide group. They are prepared by reacting the corresponding aminoacids or oligopeptides with an ester or an amide of a second aminoacid or of a second oligopeptide, in presence of an appropriate basic peptidic catalyst.
MC82EP8200191D 1981-09-03 1982-09-03 ES- AND AMIDES OF N- (N '- (2-CHLORETHYL) -N'-NITROSOCARBAMOYL) -OLIGOPEPTIDE AND PROCESS FOR THEIR PREPARATION MC1526A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3134923A DE3134923C1 (en) 1981-09-03 1981-09-03 N- [N '- (2-chloroethyl) -N'-nitroso-carbamoyl] oligopeptide esters and amides and process for their preparation
PCT/EP1982/000191 WO1983000860A1 (en) 1981-09-03 1982-09-03 Oligopeptidic ester and amide n-adn'-(2-chlorethyl)-n'-nitroso-carbomoylbd and production method thereof

Publications (1)

Publication Number Publication Date
MC1526A1 true MC1526A1 (en) 1984-04-13

Family

ID=6140795

Family Applications (1)

Application Number Title Priority Date Filing Date
MC82EP8200191D MC1526A1 (en) 1981-09-03 1982-09-03 ES- AND AMIDES OF N- (N '- (2-CHLORETHYL) -N'-NITROSOCARBAMOYL) -OLIGOPEPTIDE AND PROCESS FOR THEIR PREPARATION

Country Status (17)

Country Link
EP (1) EP0074103B1 (en)
JP (1) JPS58501769A (en)
AT (1) ATE17735T1 (en)
AU (1) AU8900982A (en)
BR (1) BR8207845A (en)
DD (1) DD209192A5 (en)
DE (2) DE3134923C1 (en)
DK (1) DK77583A (en)
FI (1) FI830768A0 (en)
GR (1) GR76534B (en)
HU (1) HU190643B (en)
IL (1) IL66689A (en)
MC (1) MC1526A1 (en)
NO (1) NO831475L (en)
WO (1) WO1983000860A1 (en)
YU (1) YU195982A (en)
ZA (1) ZA826481B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987263A (en) * 1959-02-16 1961-06-06 William R Senn Apparatus for granulating phosphate rock fertilizer or the like
FR2540491A1 (en) * 1983-02-08 1984-08-10 Centre Nat Rech Scient NOVEL NITROSOUREES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF
JPS6288472A (en) * 1985-10-14 1987-04-22 Sharp Corp Read and record control device for facsimile equipment

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5113722A (en) * 1974-07-23 1976-02-03 Suami T Shinkina nitoroshinyosojudotaino seizoho

Also Published As

Publication number Publication date
FI830768L (en) 1983-03-08
WO1983000860A1 (en) 1983-03-17
YU195982A (en) 1985-08-31
DK77583D0 (en) 1983-02-22
NO831475L (en) 1983-04-26
DD209192A5 (en) 1984-04-25
DK77583A (en) 1983-03-17
DE3268831D1 (en) 1986-03-13
JPS58501769A (en) 1983-10-20
DE3134923C1 (en) 1983-06-09
BR8207845A (en) 1983-08-30
FI830768A0 (en) 1983-03-08
AU8900982A (en) 1983-03-28
ZA826481B (en) 1983-07-27
IL66689A (en) 1986-02-28
ATE17735T1 (en) 1986-02-15
GR76534B (en) 1984-08-10
EP0074103B1 (en) 1986-01-29
HU190643B (en) 1986-09-29
EP0074103A1 (en) 1983-03-16

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