MA64568B1 - Composés hétérocycliques capables d'activer sting - Google Patents
Composés hétérocycliques capables d'activer stingInfo
- Publication number
- MA64568B1 MA64568B1 MA64568A MA64568A MA64568B1 MA 64568 B1 MA64568 B1 MA 64568B1 MA 64568 A MA64568 A MA 64568A MA 64568 A MA64568 A MA 64568A MA 64568 B1 MA64568 B1 MA 64568B1
- Authority
- MA
- Morocco
- Prior art keywords
- heterocyclic compounds
- compounds capable
- activating sting
- sting
- activating
- Prior art date
Links
- 230000003213 activating effect Effects 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 101000643024 Homo sapiens Stimulator of interferon genes protein Proteins 0.000 abstract 2
- 102100035533 Stimulator of interferon genes protein Human genes 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne des composés hétérocycliques de formule (I) capables d'activer STING (stimulateur des gènes de l'interféron).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21171155 | 2021-04-29 | ||
| PCT/EP2022/061379 WO2022229341A1 (fr) | 2021-04-29 | 2022-04-28 | Composés hétérocycliques capables d'activer sting |
| EP22727008.9A EP4330250B1 (fr) | 2021-04-29 | 2022-04-28 | Composés hétérocycliques capables d'activer sting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA64568B1 true MA64568B1 (fr) | 2025-03-28 |
Family
ID=75825418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA64568A MA64568B1 (fr) | 2021-04-29 | 2022-04-28 | Composés hétérocycliques capables d'activer sting |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US12065427B2 (fr) |
| EP (1) | EP4330250B1 (fr) |
| JP (1) | JP7634112B2 (fr) |
| KR (1) | KR20240004646A (fr) |
| CN (2) | CN118546123A (fr) |
| AR (1) | AR125477A1 (fr) |
| AU (1) | AU2022265323C1 (fr) |
| CA (1) | CA3214127A1 (fr) |
| CL (1) | CL2023002959A1 (fr) |
| CO (1) | CO2023014672A2 (fr) |
| CR (1) | CR20230509A (fr) |
| DK (1) | DK4330250T3 (fr) |
| DO (1) | DOP2023000234A (fr) |
| EC (1) | ECSP23069018A (fr) |
| ES (1) | ES3019235T3 (fr) |
| FI (1) | FI4330250T3 (fr) |
| HR (1) | HRP20250430T1 (fr) |
| HU (1) | HUE071621T2 (fr) |
| IL (1) | IL307977A (fr) |
| JO (1) | JOP20230270A1 (fr) |
| LT (1) | LT4330250T (fr) |
| MA (1) | MA64568B1 (fr) |
| MX (1) | MX2023012800A (fr) |
| PE (1) | PE20240069A1 (fr) |
| PL (1) | PL4330250T3 (fr) |
| PT (1) | PT4330250T (fr) |
| RS (1) | RS66626B1 (fr) |
| SI (1) | SI4330250T1 (fr) |
| TW (1) | TWI916562B (fr) |
| WO (1) | WO2022229341A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12065427B2 (en) * | 2021-04-29 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating STING |
| US20240174642A1 (en) * | 2022-10-26 | 2024-05-30 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating sting |
| JP2026510538A (ja) * | 2022-10-28 | 2026-04-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｔｉｎｇアンタゴニストとしての複素環化合物 |
| WO2024209363A1 (fr) | 2023-04-06 | 2024-10-10 | Pfizer Inc. | Composés dérivés d'acide indazole propionique substitués et leurs utilisations en tant qu'activateurs d'ampk |
| WO2026114957A1 (fr) | 2024-11-27 | 2026-06-04 | Boehringer Ingelheim International Gmbh | Dérivés de thiophène 2-amino-3-cyano spirocycliques annelés en tant que dégradeurs de kras pour le traitement du cancer |
| US20260146050A1 (en) | 2024-11-27 | 2026-05-28 | Boehringer Ingelheim International Gmbh | Kras degrading compounds comprising spirocyclic annulated 2 amino-3-cyano thiophenes |
| US20260146049A1 (en) | 2024-11-27 | 2026-05-28 | Boehringer Ingelheim International Gmbh | Spirocyclic annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012521429A (ja) | 2009-03-23 | 2012-09-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛治療用のｐ２ｘ３受容体アンタゴニスト |
| WO2012095781A1 (fr) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Dérivés d'indazole comme inhibiteurs des canaux sodiques |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| TWI848953B (zh) | 2018-06-09 | 2024-07-21 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| TWI873098B (zh) | 2018-07-03 | 2025-02-21 | 瑞士商諾華製藥公司 | 用於治療與sting活性相關之病症的化合物及組合物 |
| TW202028183A (zh) | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| TW202446772A (zh) | 2018-10-11 | 2024-12-01 | 日商小野藥品工業股份有限公司 | Ｓｔｉｎｇ促效化合物 |
| KR102702618B1 (ko) * | 2019-01-31 | 2024-09-06 | 히트젠 주식회사 | 면역조절제 |
| CN112521394A (zh) * | 2019-09-19 | 2021-03-19 | 中国药科大学 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
| PH12022550709A1 (en) * | 2019-09-25 | 2023-03-27 | Pfizer | Polyheterocyclic modulators of sting (stimulator of interferon genes) |
| TWI878355B (zh) | 2019-10-02 | 2025-04-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於癌症治療之多重專一性結合蛋白 |
| CN112869927B (zh) | 2019-11-29 | 2024-11-19 | 百安健康复医疗（深圳）有限公司 | 用于治疗膝骨性关节炎的矫正器 |
| CN114761394B (zh) | 2020-01-16 | 2024-03-29 | 浙江海正药业股份有限公司 | 吡啶或嘧啶类衍生物及其制备方法和用途 |
| AU2021228284A1 (en) | 2020-02-28 | 2022-09-29 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US12065427B2 (en) * | 2021-04-29 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds capable of activating STING |
-
2022
- 2022-04-27 US US17/730,395 patent/US12065427B2/en active Active
- 2022-04-28 MA MA64568A patent/MA64568B1/fr unknown
- 2022-04-28 KR KR1020237040758A patent/KR20240004646A/ko active Pending
- 2022-04-28 AR ARP220101113A patent/AR125477A1/es unknown
- 2022-04-28 FI FIEP22727008.9T patent/FI4330250T3/fi active
- 2022-04-28 EP EP22727008.9A patent/EP4330250B1/fr active Active
- 2022-04-28 AU AU2022265323A patent/AU2022265323C1/en active Active
- 2022-04-28 CR CR20230509A patent/CR20230509A/es unknown
- 2022-04-28 HU HUE22727008A patent/HUE071621T2/hu unknown
- 2022-04-28 IL IL307977A patent/IL307977A/en unknown
- 2022-04-28 TW TW111116155A patent/TWI916562B/zh active
- 2022-04-28 WO PCT/EP2022/061379 patent/WO2022229341A1/fr not_active Ceased
- 2022-04-28 CA CA3214127A patent/CA3214127A1/fr active Pending
- 2022-04-28 PE PE2023002941A patent/PE20240069A1/es unknown
- 2022-04-28 LT LTEPPCT/EP2022/061379T patent/LT4330250T/lt unknown
- 2022-04-28 CN CN202410587835.5A patent/CN118546123A/zh active Pending
- 2022-04-28 ES ES22727008T patent/ES3019235T3/es active Active
- 2022-04-28 SI SI202230106T patent/SI4330250T1/sl unknown
- 2022-04-28 DK DK22727008.9T patent/DK4330250T3/da active
- 2022-04-28 MX MX2023012800A patent/MX2023012800A/es unknown
- 2022-04-28 HR HRP20250430TT patent/HRP20250430T1/hr unknown
- 2022-04-28 PT PT227270089T patent/PT4330250T/pt unknown
- 2022-04-28 RS RS20250291A patent/RS66626B1/sr unknown
- 2022-04-28 PL PL22727008.9T patent/PL4330250T3/pl unknown
- 2022-04-28 CN CN202280030669.8A patent/CN117255784A/zh active Pending
- 2022-04-28 JP JP2023564644A patent/JP7634112B2/ja active Active
-
2023
- 2023-09-13 EC ECSENADI202369018A patent/ECSP23069018A/es unknown
- 2023-10-03 CL CL2023002959A patent/CL2023002959A1/es unknown
- 2023-10-20 DO DO2023000234A patent/DOP2023000234A/es unknown
- 2023-10-26 JO JOJO/P/2023/0270A patent/JOP20230270A1/ar unknown
- 2023-10-30 CO CONC2023/0014672A patent/CO2023014672A2/es unknown
-
2024
- 2024-03-06 US US18/596,986 patent/US20240270718A1/en active Pending
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