MA50651A - Récepteurs de lymphocytes t reconnaissant p53 mutée - Google Patents

Récepteurs de lymphocytes t reconnaissant p53 mutée

Info

Publication number
MA50651A
MA50651A MA050651A MA50651A MA50651A MA 50651 A MA50651 A MA 50651A MA 050651 A MA050651 A MA 050651A MA 50651 A MA50651 A MA 50651A MA 50651 A MA50651 A MA 50651A
Authority
MA
Morocco
Prior art keywords
mutated
lymphocyte receptors
lymphocyte
receptors
Prior art date
Application number
MA050651A
Other languages
English (en)
Inventor
Drew C Deniger
Winifred M Lo
Yong-Chen Lu
Parisa Malekzadeh
Maria R Parkhurst
Anna Pasetto
Paul F Robbins
Steven A Rosenberg
Rami Yoseph
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of MA50651A publication Critical patent/MA50651A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464448—Regulators of development
    • A61K39/46445—Apoptosis related proteins, e.g. survivin or livin
    • A61K39/464451—Apoptosis related proteins, e.g. survivin or livin p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
MA050651A 2017-09-29 2018-09-17 Récepteurs de lymphocytes t reconnaissant p53 mutée MA50651A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762565383P 2017-09-29 2017-09-29

Publications (1)

Publication Number Publication Date
MA50651A true MA50651A (fr) 2020-08-05

Family

ID=63714167

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050651A MA50651A (fr) 2017-09-29 2018-09-17 Récepteurs de lymphocytes t reconnaissant p53 mutée

Country Status (15)

Country Link
US (1) US11939365B2 (fr)
EP (1) EP3688027A1 (fr)
JP (2) JP7324193B2 (fr)
KR (1) KR20200064110A (fr)
CN (1) CN111386282A (fr)
AU (1) AU2018342246A1 (fr)
BR (1) BR112020006012A2 (fr)
CA (1) CA3077024A1 (fr)
CR (1) CR20200170A (fr)
EA (1) EA202090757A1 (fr)
IL (1) IL273515A (fr)
MA (1) MA50651A (fr)
MX (1) MX2020003504A (fr)
SG (1) SG11202002636PA (fr)
WO (1) WO2019067243A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3551221T3 (pl) 2016-12-08 2022-02-28 Immatics Biotechnologies Gmbh Nowe receptory komórek t i immunoterapia z ich zastosowaniem
WO2020237368A1 (fr) * 2019-05-27 2020-12-03 Provincial Health Services Authority Constructions d'immunothérapie ciblant des antigènes kras
JP2022538148A (ja) * 2019-06-27 2022-08-31 アメリカ合衆国 ｐ５３におけるＲ１７５Ｈ又はＹ２２０Ｃ変異を認識するＴ細胞受容体
CN113512124A (zh) * 2020-04-10 2021-10-19 香雪生命科学技术（广东）有限公司 一种识别hpv16的高亲和力tcr
CA3191186A1 (fr) * 2020-09-04 2022-03-10 Sanghyun Kim Recepteurs des lymphocytes t reconnaissant les mutations r175h ou y220c dans p53
JP2024507929A (ja) 2021-02-25 2024-02-21 アラウノス セラピューティクス インコーポレイテッド 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法
CN117957245A (zh) * 2021-05-07 2024-04-30 美国政府(由卫生和人类服务部的部长所代表) 识别p53中的c135y、r175h或m237i突变的t细胞受体
WO2023050063A1 (fr) * 2021-09-28 2023-04-06 溧阳瑅赛生物医药有限公司 Tcr reconnaissant hla-a*02:01/e629-38, et son utilisation
WO2023150562A1 (fr) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Méthodes d'activation et d'expansion de lymphocytes t
US20240035027A1 (en) * 2022-05-04 2024-02-01 University Of Massachusetts Oligonucleotides for pms2 modulation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770749B2 (en) * 2000-02-22 2004-08-03 City Of Hope P53-specific T cell receptor for adoptive immunotherapy
US7456263B2 (en) * 2001-06-05 2008-11-25 Altor Bioscience Corporation P53 binding T cell receptor molecules
EP1545204B1 (fr) 2002-09-06 2016-08-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Immunotherapie utilisant des lymphocytes specifiques d'un antigene selectionnes in vitro apres une chimiotherapie non myeloablative appauvrissant les lymphocytes
US8383099B2 (en) 2009-08-28 2013-02-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adoptive cell therapy with young T cells
WO2012129201A1 (fr) 2011-03-22 2012-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procédés de mise en croissance de lymphocytes infiltrant une tumeur dans contenants perméables au gaz
CA2920147C (fr) * 2013-08-07 2022-09-20 Yeda Research And Development Co. Ltd. Peptides capables de reactiver des proteines p53 mutantes
MX369513B (es) * 2014-02-14 2019-11-11 Univ Texas Receptores de antígenos quiméricos y métodos de realización.
JP2017514471A (ja) * 2014-04-23 2017-06-08 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム キメラ抗原受容体（ｃａｒ）並びにその製造及び使用方法
LT3149031T (lt) 2014-05-29 2020-05-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T ląstelių receptoriai prieš žmogaus papilomos virusą 16 e7
CN107074932A (zh) * 2014-10-02 2017-08-18 美国卫生和人力服务部 分离对癌症特异性突变具有抗原特异性的t细胞受体的方法
AU2014407540C1 (en) 2014-10-02 2021-07-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cells having antigenic specificity for a cancer-specific mutation
EP3265079A4 (fr) 2015-03-03 2019-01-02 Caris MPI, Inc. Profilage moléculaire du cancer
CA2984234C (fr) * 2015-05-01 2023-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procedes d'isolement de cellules t et de recepteurs des cellules t ayant une specificite antigenique pour une mutation specifique au cancer du sang peripherique
CR20200476A (es) 2015-05-20 2020-12-02 Dana Farber Cancer Inst Inc ANTÍGENOS COMPARTIDOS (Divisional 2017-0584)

Also Published As

Publication number Publication date
BR112020006012A2 (pt) 2020-10-06
EA202090757A1 (ru) 2020-08-21
JP7324193B2 (ja) 2023-08-09
KR20200064110A (ko) 2020-06-05
JP2023159112A (ja) 2023-10-31
SG11202002636PA (en) 2020-04-29
CR20200170A (es) 2020-11-23
US20200277352A1 (en) 2020-09-03
IL273515A (en) 2020-05-31
US11939365B2 (en) 2024-03-26
CA3077024A1 (fr) 2019-04-04
CN111386282A (zh) 2020-07-07
EP3688027A1 (fr) 2020-08-05
JP2021500010A (ja) 2021-01-07
WO2019067243A1 (fr) 2019-04-04
MX2020003504A (es) 2020-09-14
AU2018342246A1 (en) 2020-04-16

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