MA44479B1 - Arn transrepliquant - Google Patents

Arn transrepliquant

Info

Publication number
MA44479B1
MA44479B1 MA44479A MA44479A MA44479B1 MA 44479 B1 MA44479 B1 MA 44479B1 MA 44479 A MA44479 A MA 44479A MA 44479 A MA44479 A MA 44479A MA 44479 B1 MA44479 B1 MA 44479B1
Authority
MA
Morocco
Prior art keywords
present
rna
protein
alphavirus
replicase
Prior art date
Application number
MA44479A
Other languages
English (en)
Other versions
MA44479A (fr
Inventor
Ugur Sahin
Tim Beissert
Mario Perkovic
Original Assignee
Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
BioNTech SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh, BioNTech SE filed Critical Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
Publication of MA44479A publication Critical patent/MA44479A/fr
Publication of MA44479B1 publication Critical patent/MA44479B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07048—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne de manière générale des systèmes et des procédés appropriés pour une production protéinique de niveau élevé. Tandis qu'un ou plusieurs éléments de la présente invention sont dérivés d'un alphavirus, la présente invention ne nécessite pas de propagation de particules virales. En particulier, un système comprenant deux molécules d'arn séparées est prévu, comprenant chacune une séquence nucléotidique dérivée d'un alphavirus : une molécule d'arn comprend une construction d'arn pour exprimer une réplicase d'alphavirus et une molécule d'arn comprend un réplicon d'arn qui peut être répliqué par la réplicase en trans. La construction d'arn pour exprimer une réplicase d'alphavirus comprend une coiffe en position 5'. Il a été découvert de manière surprenante que la coiffe en position 5' est appropriée pour entraîner efficacement l'expression d'un transgène à partir du réplicon en trans. Le système de la présente invention permet l'expression d'une protéine d'intérêt dans une cellule ou un organisme, mais n'est pas associé à une formation non souhaitée de particules virales. Par conséquent, la présente invention est appropriée pour une production efficace et sûre d'une protéine d'intérêt, par exemple une protéine thérapeutique ou une protéine antigénique, telle qu'un vaccin, dans un organisme cible. L'invention concerne des procédés respectifs de production de protéines in vitro et in vivo ainsi que des utilisations médicales. La présente invention concerne également un adn codant pour les molécules d'arn de l'invention et des cellules comprenant les molécules d'arn de l'invention.
MA44479A 2016-03-21 2017-03-13 Arn transrepliquant MA44479B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2016/056160 WO2017162265A1 (fr) 2016-03-21 2016-03-21 Arn à réplication trans
PCT/EP2017/055813 WO2017162461A1 (fr) 2016-03-21 2017-03-13 Arn à réplication trans

Publications (2)

Publication Number Publication Date
MA44479A MA44479A (fr) 2021-04-21
MA44479B1 true MA44479B1 (fr) 2021-11-30

Family

ID=55586324

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44479A MA44479B1 (fr) 2016-03-21 2017-03-13 Arn transrepliquant

Country Status (26)

Country Link
US (1) US20200299724A1 (fr)
EP (2) EP3433368B1 (fr)
JP (2) JP7105193B2 (fr)
KR (1) KR102441725B1 (fr)
CN (2) CN109328233B (fr)
AU (1) AU2017236240B2 (fr)
BR (1) BR112018068391A2 (fr)
CA (1) CA3017285A1 (fr)
CY (1) CY1124689T1 (fr)
DK (1) DK3433368T3 (fr)
ES (1) ES2896927T3 (fr)
HR (1) HRP20211715T1 (fr)
HU (1) HUE058889T2 (fr)
IL (1) IL261327B1 (fr)
LT (1) LT3433368T (fr)
MA (1) MA44479B1 (fr)
MD (1) MD3433368T2 (fr)
MX (1) MX2018011384A (fr)
PL (1) PL3433368T3 (fr)
PT (1) PT3433368T (fr)
RS (1) RS62543B1 (fr)
RU (1) RU2752580C2 (fr)
SG (1) SG11201807378SA (fr)
SI (1) SI3433368T1 (fr)
WO (2) WO2017162265A1 (fr)
ZA (2) ZA201805520B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
EP4218805A1 (fr) 2015-07-21 2023-08-02 ModernaTX, Inc. Vaccins contre les maladies infectieuses
WO2017070624A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre des maladies tropicales
WO2019053056A1 (fr) * 2017-09-13 2019-03-21 Biontech Cell & Gene Therapies Gmbh Réplicon d'arn permettant d'exprimer un récepteur de lymphocyte t ou un récepteur de lymphocyte t artificiel
EP3681993A1 (fr) * 2017-09-13 2020-07-22 BioNTech RNA Pharmaceuticals GmbH Réplicon d'arn pour la reprogrammation de cellules somatiques
WO2019055807A1 (fr) 2017-09-14 2019-03-21 Modernatx, Inc. Vaccins à arn contre le virus zika
US10736957B2 (en) * 2017-12-19 2020-08-11 President And Fellows Of Harvard College Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences
WO2021138447A1 (fr) 2019-12-31 2021-07-08 Elixirgen Therapeutics, Inc. Administration transitoire basée sur la température d'acides nucléiques et de protéines à des cellules et des tissus
EP4103228A1 (fr) 2020-02-13 2022-12-21 Institut Pasteur Vaccin à base d'acide nucléique contre le coronavirus sars-cov-2
KR102462990B1 (ko) * 2020-03-17 2022-11-07 에이비온 주식회사 인비트로 트랜스크립트 mRNA 및 이를 함유하는 약학조성물
EP4171629A1 (fr) 2020-06-29 2023-05-03 GlaxoSmithKline Biologicals S.A. Adjuvants
US11771652B2 (en) 2020-11-06 2023-10-03 Sanofi Lipid nanoparticles for delivering mRNA vaccines
GB202020063D0 (en) 2020-12-17 2021-02-03 Imperial College Innovations Ltd RNA construct
GB202020061D0 (en) 2020-12-17 2021-02-03 Imp College Innovations Ltd RNA construct
GB202020064D0 (en) 2020-12-17 2021-02-03 Imperial College Innovations Ltd RNA construct
CN112852841A (zh) 2021-02-03 2021-05-28 郑州大学 一种高效表达目的蛋白的顺式复制子rna构建体
WO2022200574A1 (fr) 2021-03-26 2022-09-29 Glaxosmithkline Biologicals Sa Compositions immunogènes
WO2022228827A1 (fr) 2021-04-26 2022-11-03 Institut Pasteur Anticorps monoclonaux neutralisants humains contre le sras-cov-2 et leurs utilisations
WO2022234268A1 (fr) * 2021-05-04 2022-11-10 Mogrify Limited Conversion cellulaire
WO2022248353A1 (fr) 2021-05-24 2022-12-01 Glaxosmithkline Biologicals Sa Adjuvants
US20220396798A1 (en) * 2021-06-12 2022-12-15 Shi-Lung Lin Novel mrna composition and production method for use in anti-viral and anti-cancer vaccines
IL309408A (en) 2021-06-18 2024-02-01 Sanofi Sa Multivalent flu vaccines
WO2023020994A1 (fr) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Nouveaux procédés
WO2023020993A1 (fr) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Nouveaux procédés
WO2023020992A1 (fr) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Nouveaux procédés
WO2023021421A1 (fr) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Vaccins à base d'arn lyophilisés à faible dose et leurs procédés de préparation et d'utilisation
WO2023021427A1 (fr) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Lyophilisation de nanoparticules lipidiques (lnp) encapsulant de l'arn et leurs formulations
AU2021461416A1 (en) 2021-08-24 2024-02-22 BioNTech SE In vitro transcription technologies
WO2023056980A1 (fr) * 2021-10-09 2023-04-13 吴可行 Conception de molécules d'arn auto-réplicatives et leur application
AU2022372325A1 (en) 2021-10-18 2024-05-02 BioNTech SE Methods for determining mutations for increasing modified replicable rna function and related compositions and their use
EP4285933A1 (fr) 2022-05-30 2023-12-06 BioNTech SE Complexes oligosaccharides et utilisations
EP4286004A1 (fr) 2022-05-30 2023-12-06 BioNTech SE Composés et complexes d'oligosaccharide de disulfure
EP4169534A1 (fr) 2021-10-22 2023-04-26 BioNTech SE Complexes oligosaccharides et utilisations
EP4169580A1 (fr) 2021-10-22 2023-04-26 BioNTech SE Composés et complexes d'oligosaccharide
EP4285932A1 (fr) 2022-05-30 2023-12-06 BioNTech SE Complexes oligosaccharides et utilisations
EP4186528A1 (fr) 2021-11-30 2023-05-31 BioNTech SE Complexes oligosaccharides et utilisations
EP4286003A1 (fr) 2022-05-30 2023-12-06 BioNTech SE Composés et complexes d'oligosaccharide
WO2023067126A1 (fr) 2021-10-22 2023-04-27 BioNTech SE Composés et complexes oligosaccharidiques
EP4169579A1 (fr) 2021-10-22 2023-04-26 BioNTech SE Composés et complexes d'oligosaccharide de disulfure
WO2023067124A1 (fr) 2021-10-22 2023-04-27 BioNTech SE Composés et complexes d'oligosaccharides de disulfure
EP4286394A1 (fr) 2022-05-30 2023-12-06 BioNTech SE Composés et complexes d'oligosaccharide
WO2023067123A1 (fr) 2021-10-22 2023-04-27 BioNTech SE Complexes d'oligosaccharides et leurs utilisations
EP4169578A1 (fr) 2021-10-22 2023-04-26 BioNTech SE Composés et complexes d'oligosaccharide
WO2023067125A1 (fr) 2021-10-22 2023-04-27 BioNTech SE Complexes oligosaccharidiques et leurs utilisations
AU2022369405A1 (en) 2021-10-22 2024-05-09 BioNTech SE Oligosaccharide compounds and complexes
AR127585A1 (es) 2021-11-05 2024-02-07 Sanofi Sa Vacuna de arn de virus sincicial respiratorio
WO2023083434A1 (fr) 2021-11-09 2023-05-19 BioNTech SE Arn codant pour la peptidoglycane hydrolase et son utilisation pour le traitement d'une infection bactérienne
WO2023111262A1 (fr) 2021-12-17 2023-06-22 Sanofi Vaccin à base d'arn contre la maladie de lyme
WO2023214082A2 (fr) 2022-05-06 2023-11-09 Sanofi Séquences de signaux pour vaccins à base d'acides nucléiques
WO2023232747A1 (fr) 2022-05-30 2023-12-07 BioNTech SE Complexes pour l'administration d'acides nucléiques
WO2024044108A1 (fr) 2022-08-22 2024-02-29 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Vaccins contre les coronavirus
WO2024068674A1 (fr) 2022-09-26 2024-04-04 BioNTech SE Complexes d'acide nucléique et leurs utilisations
WO2024086549A1 (fr) * 2022-10-17 2024-04-25 The University Of North Carolina At Chapel Hill Alphavirus chimériques pour évolution dirigée
WO2024084462A1 (fr) 2022-10-21 2024-04-25 BioNTech SE Complexes d'acide nucléique et leurs utilisations
WO2024083345A1 (fr) 2022-10-21 2024-04-25 BioNTech SE Procédés et utilisations associés à des compositions liquides
WO2024094881A1 (fr) 2022-11-04 2024-05-10 Sanofi Vaccination à arn contre le virus respiratoire syncytial

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2353282C (en) * 1998-03-20 2013-02-27 State Queensland Primary Ind Control of gene expression
IL145221A0 (en) 1999-03-09 2002-12-01 Large Scale Biology Corp Unive Multiple component rna vector system for expression of foreign sequences
WO2002018585A2 (fr) * 2000-08-29 2002-03-07 Wyeth Holdings Corporation Encapsidation de particules de replicon de virus d'arn a chaine positive
EP2305299B1 (fr) * 2001-05-31 2017-03-01 GlaxoSmithKline Biologicals SA Particules de replicon d'alphavirus chimerique
US20030232324A1 (en) * 2001-05-31 2003-12-18 Chiron Corporation Chimeric alphavirus replicon particles
ES2330202T5 (es) * 2001-09-06 2014-01-20 Alphavax, Inc. Sistemas vectores basados en replicones de alfavirus
WO2003085114A1 (fr) 2002-04-01 2003-10-16 Walter Reed Army Institute Of Research Procede pour concevoir des sequences d'acides nucleiques de synthese pour l'expression optimale de proteines dans une cellule hote
US7442381B2 (en) * 2003-03-20 2008-10-28 Alphavax, Inc. Alphavirus replicons and helper constructs
EP2811027A1 (fr) * 2004-05-21 2014-12-10 Novartis Vaccines and Diagnostics, Inc. Vecteurs alphavirus pour vaccins contre le VRS et le PIV
WO2008119827A1 (fr) * 2007-04-02 2008-10-09 Fit Biotech Oy Produits de synthèse transréplicases
PL2167523T3 (pl) 2007-06-19 2014-12-31 Univ Louisiana State Synteza i zastosowanie anty-odwrotnych tiofosforanowych analogów kapu matrycowego RNA
AU2008266807B2 (en) * 2007-06-21 2012-08-16 Alphavax, Inc. Promoterless cassettes for expression of alphavirus structural proteins
EA022990B1 (ru) 2007-08-20 2016-04-29 Глаксо Груп Лимитед Способ получения клеточной линии млекопитающего, продуцирующей терапевтический белок
PL215513B1 (pl) 2008-06-06 2013-12-31 Univ Warszawski Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
DE102008061522A1 (de) 2008-12-10 2010-06-17 Biontech Ag Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung
EP2281579A1 (fr) 2009-08-05 2011-02-09 BioNTech AG Composition de vaccin comportant un ADN modifié 5'-Cap
WO2012006378A1 (fr) 2010-07-06 2012-01-12 Novartis Ag Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn
US9192661B2 (en) * 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
BR112013000392B8 (pt) * 2010-07-06 2022-10-04 Novartis Ag Composição farmacêutica contendo partícula de distribuição semelhante a vírion para moléculas de rna autorreplicantes e seu uso
CA2804591C (fr) 2010-07-06 2019-01-22 Novartis Ag Emulsions cationiques huile-dans-eau
LT4066855T (lt) 2010-08-31 2023-03-10 Glaxosmithkline Biologicals Sa Pegilintos liposomos, skirtos imunogeną koduojančios rnr tiekimui
BR112013004865A2 (pt) 2010-08-31 2016-06-07 Novartis Ag lípidos adequados para entrega lipossomal de codificadores de proteínas rna
PT4008357T (pt) 2010-08-31 2023-01-11 Glaxosmithkline Biologicals Sa Lipossomas pequenos para entrega de arn que codifica um imunogénio
ES2716243T3 (es) * 2010-10-11 2019-06-11 Glaxosmithkline Biologicals Sa Plataformas de suministro de antígenos
RU2649133C2 (ru) 2011-07-06 2018-03-29 Новартис Аг Катионные эмульсии масло-в-воде
EP3424495A1 (fr) 2011-07-06 2019-01-09 GlaxoSmithKline Biologicals S.A. Émulsions aqueuses contenant des acides nucléiques
ES2656050T3 (es) * 2011-07-06 2018-02-22 Glaxosmithkline Biologicals Sa Composiciones de combinación inmunogénica y usos de las mismas
EP2729126B1 (fr) 2011-07-06 2020-12-23 GlaxoSmithKline Biologicals SA Liposomes ayant un rapport n:p utile pour délivrance de molécules d'arn
SG11201400250UA (en) 2011-08-31 2014-03-28 Novartis Ag Pegylated liposomes for delivery of immunogen-encoding rna
JP6305925B2 (ja) * 2011-10-11 2018-04-18 ノバルティス アーゲー 組換え自己複製ポリシストロニックｒｎａ分子
BR122019027913B1 (pt) * 2011-11-11 2021-11-30 Variation Biotechnologies, Inc Partícula vírus-like, composição farmacêutica compreendendo a referida partícula e método para produção da mesma
WO2013143555A1 (fr) 2012-03-26 2013-10-03 Biontech Ag Formulation d'arn pour immunothérapie
SG10201607962RA (en) 2012-03-27 2016-11-29 Curevac Ag Artificial nucleic acid molecules
MX2019002345A (es) 2012-03-27 2022-08-24 Curevac Ag Moleculas artificiales de acido nucleico para la expresion mejorada de proteina o peptido.
WO2014071963A1 (fr) 2012-11-09 2014-05-15 Biontech Ag Procédé pour l'expression d'arn cellulaire
WO2014170493A2 (fr) * 2013-04-19 2014-10-23 Novartis Ag Vecteur d'alphavirus
WO2016005004A1 (fr) 2014-07-11 2016-01-14 Biontech Rna Pharmaceuticals Gmbh Stabilisation de séquences d'adn codant pour une séquence poly (a)
KR20200049856A (ko) * 2017-09-13 2020-05-08 비온테크 알엔에이 파마슈티컬스 게엠베하 세포에서 rna 발현을 향상시키는 방법

Also Published As

Publication number Publication date
EP3433368B1 (fr) 2021-10-06
MD3433368T2 (ro) 2021-12-31
KR20180127360A (ko) 2018-11-28
MA44479A (fr) 2021-04-21
CN109328233A (zh) 2019-02-12
JP2019509048A (ja) 2019-04-04
ZA201805520B (en) 2019-11-27
EP3964584A1 (fr) 2022-03-09
JP7421256B2 (ja) 2024-01-24
CA3017285A1 (fr) 2017-09-28
JP2022020634A (ja) 2022-02-01
BR112018068391A2 (pt) 2019-01-15
JP7105193B2 (ja) 2022-07-22
ES2896927T3 (es) 2022-02-28
WO2017162265A1 (fr) 2017-09-28
AU2017236240A1 (en) 2018-09-20
RU2018131783A3 (fr) 2020-07-14
IL261327A (en) 2018-10-31
DK3433368T3 (da) 2021-11-15
HUE058889T2 (hu) 2022-09-28
MX2018011384A (es) 2019-02-13
PT3433368T (pt) 2021-11-15
SI3433368T1 (sl) 2022-01-31
SG11201807378SA (en) 2018-10-30
RS62543B1 (sr) 2021-12-31
KR102441725B1 (ko) 2022-09-08
US20200299724A1 (en) 2020-09-24
EP3433368A1 (fr) 2019-01-30
CY1124689T1 (el) 2022-07-22
WO2017162461A1 (fr) 2017-09-28
RU2018131783A (ru) 2020-04-22
HRP20211715T1 (hr) 2022-02-18
LT3433368T (lt) 2021-11-25
ZA201905396B (en) 2021-03-31
RU2752580C2 (ru) 2021-07-29
CN115386596A (zh) 2022-11-25
IL261327B1 (en) 2024-04-01
AU2017236240B2 (en) 2022-11-17
PL3433368T3 (pl) 2021-12-27
CN109328233B (zh) 2022-10-11

Similar Documents

Publication Publication Date Title
MA44479B1 (fr) Arn transrepliquant
Fujita et al. Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases
Van der Jeught et al. Dendritic cell targeting mRNA lipopolyplexes combine strong antitumor T-cell immunity with improved inflammatory safety
KR20190110612A (ko) 활성화 종양유전자 돌연변이 펩티드를 인코드하는 면역조절 치료 mrna 조성물
MY193112A (en) Anti pd-1 and anti-lag3 antibodies for cancer treatment
WO2014172470A3 (fr) Procedes de mutation, de modification ou de modulation d'acide nucleique dans une cellule ou chez un mammifere non-humain
MA40713A1 (fr) Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie du cancer du pancréas et d'autres cancers
MA42072A1 (fr) Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre la cll et d'autres cancers
MA40813A1 (fr) Nouveaux peptides et combinaison de peptides destinés à être utilisés dans l'immunothérapie contre diverses tumeurs
MY185961A (en) Methods and compositions for gene editing in hematopoietic stem cells
MA43075A1 (fr) Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre le lymphome non hodgkinien et d'autres cancers
MA40794A1 (fr) Nouveaux peptides et combinaisons de peptides et d'échafaudages destinés à être utilisés en immunothérapie contre le carcinome hépatocellulaire (chc) et d'autres cancers
MA43466A1 (fr) Traitements du cancer de l'utérus
CY1123343T1 (el) Παραγωγη μιας τραπεζας μεσεγχυματικων στρωματικων κυτταρων απο τα ομαδοποιημενα μονοπυρηνα κυτταρα πολλαπλων δοτων μυελου των οστων
EA201790953A1 (ru) Изменение экспрессии гена в cart-клетках и их применения
Bahmani et al. Different sourced extracellular vesicles and their potential applications in clinical treatments
Bukari et al. Non-invasive delivery of therapeutics into the brain: the potential of aptamers for targeted delivery
Araldi et al. Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology
EA201492014A1 (ru) Получение ротавирус-подобных частиц в растениях
JP2022058995A (ja) 操作されたＴｒｅｇ細胞
CN114727947A (zh) 细胞外囊泡组合物
MA46140A (fr) Facteur de transcription nterf241 et ses procédés d'utilisation
JP2018534932A5 (fr)
De Bousser et al. T cell engaging immunotherapies, highlighting chimeric antigen receptor (CAR) T cell therapy
MA43482A1 (fr) Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre la leucémie myéloïde aiguë (lma) et d'autres cancers