MA42273A - Synthèse totale de shishijimicine a et d'analogues de celle-ci - Google Patents

Synthèse totale de shishijimicine a et d'analogues de celle-ci

Info

Publication number
MA42273A
MA42273A MA042273A MA42273A MA42273A MA 42273 A MA42273 A MA 42273A MA 042273 A MA042273 A MA 042273A MA 42273 A MA42273 A MA 42273A MA 42273 A MA42273 A MA 42273A
Authority
MA
Morocco
Prior art keywords
shishijimicin
analogues
total summary
total
Prior art date
Application number
MA042273A
Other languages
English (en)
French (fr)
Inventor
Ruofan Li
Zhaoyong Lu
Kyriacos C Nicolaou
Emmanouil N Pitsinos
Te-Ik Sohn
James Woods
Original Assignee
Univ Rice William M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rice William M filed Critical Univ Rice William M
Publication of MA42273A publication Critical patent/MA42273A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA042273A 2015-06-29 2016-06-29 Synthèse totale de shishijimicine a et d'analogues de celle-ci MA42273A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562186191P 2015-06-29 2015-06-29

Publications (1)

Publication Number Publication Date
MA42273A true MA42273A (fr) 2018-05-02

Family

ID=57609044

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042273A MA42273A (fr) 2015-06-29 2016-06-29 Synthèse totale de shishijimicine a et d'analogues de celle-ci

Country Status (19)

Country Link
US (1) US10590158B2 (enExample)
EP (1) EP3313389A1 (enExample)
JP (1) JP2018525346A (enExample)
KR (1) KR20180053294A (enExample)
CN (1) CN108348489A (enExample)
AR (1) AR105193A1 (enExample)
AU (1) AU2016286071A1 (enExample)
BR (1) BR112017028557A2 (enExample)
CA (1) CA2990206A1 (enExample)
CL (1) CL2017003500A1 (enExample)
HK (1) HK1254923A1 (enExample)
IL (1) IL256345A (enExample)
MA (1) MA42273A (enExample)
MX (1) MX2017016885A (enExample)
PE (1) PE20180658A1 (enExample)
PH (1) PH12018500014A1 (enExample)
RU (1) RU2018102808A (enExample)
TW (1) TW201713634A (enExample)
WO (1) WO2017004172A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110357785B (zh) * 2019-07-26 2020-03-24 东莞市领创环保材料科技有限公司 一种氰酸酯树脂增塑剂的制备方法
CN115197188B (zh) * 2021-04-12 2023-12-26 南开大学 一类具有五环骨架的倍半萜氢醌化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264586A (en) * 1991-07-17 1993-11-23 The Scripps Research Institute Analogs of calicheamicin gamma1I, method of making and using the same
US5261586A (en) * 1992-03-26 1993-11-16 Chen Jen Fu Yarn feeding device with a guiding flange
US5550246A (en) 1994-09-07 1996-08-27 The Scripps Research Institute Calicheamicin mimics
JP2003238584A (ja) * 2002-02-08 2003-08-27 Yamanouchi Pharmaceut Co Ltd 新規エンジイン化合物
TW200539855A (en) * 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
US10131682B2 (en) * 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules

Also Published As

Publication number Publication date
PH12018500014A1 (en) 2018-07-09
WO2017004172A1 (en) 2017-01-05
IL256345A (en) 2018-02-28
US10590158B2 (en) 2020-03-17
CL2017003500A1 (es) 2018-04-27
AU2016286071A8 (en) 2019-08-08
AU2016286071A1 (en) 2018-02-01
CN108348489A (zh) 2018-07-31
BR112017028557A2 (pt) 2018-09-04
AR105193A1 (es) 2017-09-13
RU2018102808A (ru) 2019-07-30
MX2017016885A (es) 2018-09-06
EP3313389A1 (en) 2018-05-02
US20180327439A1 (en) 2018-11-15
PE20180658A1 (es) 2018-04-17
JP2018525346A (ja) 2018-09-06
HK1254923A1 (zh) 2019-08-02
CA2990206A1 (en) 2017-01-05
TW201713634A (zh) 2017-04-16
WO2017004172A8 (en) 2018-01-11
KR20180053294A (ko) 2018-05-21
RU2018102808A3 (enExample) 2020-04-30

Similar Documents

Publication Publication Date Title
IL290154B1 (en) Benzopyrazole compounds and their analogs
NL301322I2 (nl) Repotrectinib en/of farmaceutisch aanvaardbare zouten daarvan
MA46180A (fr) Analogues de l'amyline
MA42036A (fr) Analogues nucléosidiques 5'-substitués
EP3516627A4 (en) AVATAR CREATION AND EDITING
LT3283107T (lt) Kompozicija apimanti ipilimumabo ir nivolumabo kombinaciją
EP3303634A4 (en) CAS9 VARIANTS AND METHOD FOR USE THEREOF
MA49715A (fr) Oligomères et conjugués d'oligomères
EP3324894A4 (en) LATERAL AND MEDIAL SWITCHING KNEE PROSTHESIS
EP3347334A4 (en) DEHYDROHALOGENICATION OF FLUOROCHOLE HYDROGEN
EP3710462A4 (en) BRARTEMICIN ANALOGA
IL264403A (en) Vortioxetine analogue and use and preparation thereof
MA44491A (fr) Prothèse totale de poignet et procédés associés
EP3407974A4 (en) Amlexanox Analogs
DK3709970T3 (da) Linezolidformuleringer
EP3344280A4 (en) EDUCATION OF BONE
MA42130A (fr) Combinaisons d'opioïdes et de n-acyléthanolamines
EP3387469A4 (en) ELEKTROFAZIENBESTIMMUNG
EP3037138A4 (en) HIGH-ELASTIC ARROW AND PROCESSING TECHNOLOGY THEREFOR
MA41216A (fr) Synthèse totale de trioxacarcine dc-45-a2 et préparation d'analogues de trioxacarcine
EP3024994A4 (en) BENT ANGLE CONSTRUCTION
UA33118S (uk) Підвіска «коловрат із зіркою русі»
UA33117S (uk) Підвіска «коловрат свєточ»
UA31424S (uk) Підвісок «зміст віри»
UA34199S (uk) Підвіска «громовник»