MA28335A1 - Agonistes du recepteur (vpac2) du type peptides activant l'adenylate cyclase hypophysaire (pacap) et procedes pharmacologiques d'utilisation de ces agonistes - Google Patents
Agonistes du recepteur (vpac2) du type peptides activant l'adenylate cyclase hypophysaire (pacap) et procedes pharmacologiques d'utilisation de ces agonistesInfo
- Publication number
- MA28335A1 MA28335A1 MA29206A MA29206A MA28335A1 MA 28335 A1 MA28335 A1 MA 28335A1 MA 29206 A MA29206 A MA 29206A MA 29206 A MA29206 A MA 29206A MA 28335 A1 MA28335 A1 MA 28335A1
- Authority
- MA
- Morocco
- Prior art keywords
- agonists
- vpac2
- receptor
- hypophysic
- pacap
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
Abstract
La présente invention fournit de nouveaux peptides qui agissent in vivo comme des agonistes du récepteur VPAC2. Il a été montré que ces polypeptides sécrétagogues de l'insuline abaissent la glycémie in vivo après une provocation par le glucose. Les polypeptides de la présente invention sont par ailleurs stables dans une formulation et ont des demi-vies prolongées. Les peptides de la présente invention offrent un traitement aux patients présentant une sécrétion d'insuline endogène réduite, par exemple les diabétiques de type 2. L'invention concerne en outre un procédé de traitement d'une maladie métabolique chez un mammifère comprenant l'administration d'une quantité efficace du point de vue thérapeutique desdits peptides audit mammifère.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53955004P | 2004-01-27 | 2004-01-27 | |
US56649904P | 2004-04-29 | 2004-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28335A1 true MA28335A1 (fr) | 2006-12-01 |
Family
ID=34830483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29206A MA28335A1 (fr) | 2004-01-27 | 2006-07-24 | Agonistes du recepteur (vpac2) du type peptides activant l'adenylate cyclase hypophysaire (pacap) et procedes pharmacologiques d'utilisation de ces agonistes |
Country Status (13)
Country | Link |
---|---|
US (1) | US20090143283A1 (fr) |
EP (1) | EP1713493A4 (fr) |
JP (1) | JP2007519739A (fr) |
KR (1) | KR20070009554A (fr) |
AU (1) | AU2005208911A1 (fr) |
BR (1) | BRPI0507177A (fr) |
CA (1) | CA2554475A1 (fr) |
EC (1) | ECSP066793A (fr) |
IL (1) | IL176705A0 (fr) |
MA (1) | MA28335A1 (fr) |
NO (1) | NO20063801L (fr) |
RU (1) | RU2006130691A (fr) |
WO (1) | WO2005072385A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101001639A (zh) * | 2004-06-12 | 2007-07-18 | 拜尔药品公司 | 血管活性肠肽(vip)/垂体腺苷酸环化酶活化肽(pacap)受体2(vpac2)激动剂的聚乙二醇化和使用方法 |
US20090280106A1 (en) * | 2005-05-06 | 2009-11-12 | Bayer Pharmaceuticals Corporation | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use |
WO2007050651A1 (fr) * | 2005-10-26 | 2007-05-03 | Eli Lilly And Company | Agonistes peptidiques sélectifs du récepteur vpac2 |
CA2797033C (fr) | 2010-04-22 | 2021-10-19 | Longevity Biotech, Inc. | Polypeptides tres actifs et procedes pour les preparer et les utiliser |
US9789164B2 (en) | 2013-03-15 | 2017-10-17 | Longevity Biotech, Inc. | Peptides comprising non-natural amino acids and methods of making and using the same |
CN108055848B (zh) | 2015-04-16 | 2021-10-01 | H.伦德贝克公司 | 抗pacap抗体及其用途 |
MX2018012470A (es) | 2016-04-15 | 2019-07-01 | Alder Biopharmaceuticals Inc | Anticuerpos anti pacap humanizados y usos de ellos. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU656230B2 (en) * | 1991-10-11 | 1995-01-27 | F. Hoffmann-La Roche Ag | Cyclic vasoactive peptides |
AU7726600A (en) * | 1999-09-28 | 2001-04-30 | Bayer Corporation | Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use |
AU2003219787A1 (en) * | 2002-02-14 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Formulation strategies in stabilizing peptides in organic solvents and in dried states |
EP1578358A2 (fr) * | 2002-07-12 | 2005-09-28 | Bayer Pharmaceuticals Corporation | Agonistes (vpac2) du recepteur de peptide activant l'adenylate cyclase pituitaire (pacap) et leurs methodes pharmacologiques |
-
2005
- 2005-01-27 KR KR1020067015124A patent/KR20070009554A/ko not_active Application Discontinuation
- 2005-01-27 EP EP05712166A patent/EP1713493A4/fr not_active Withdrawn
- 2005-01-27 AU AU2005208911A patent/AU2005208911A1/en not_active Abandoned
- 2005-01-27 US US10/586,124 patent/US20090143283A1/en not_active Abandoned
- 2005-01-27 WO PCT/US2005/002609 patent/WO2005072385A2/fr active Application Filing
- 2005-01-27 CA CA002554475A patent/CA2554475A1/fr not_active Abandoned
- 2005-01-27 RU RU2006130691/15A patent/RU2006130691A/ru not_active Application Discontinuation
- 2005-01-27 BR BRPI0507177-1A patent/BRPI0507177A/pt not_active IP Right Cessation
- 2005-01-27 JP JP2006551478A patent/JP2007519739A/ja active Pending
-
2006
- 2006-07-04 IL IL176705A patent/IL176705A0/en unknown
- 2006-07-24 MA MA29206A patent/MA28335A1/fr unknown
- 2006-08-25 EC EC2006006793A patent/ECSP066793A/es unknown
- 2006-08-25 NO NO20063801A patent/NO20063801L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1713493A4 (fr) | 2009-06-24 |
US20090143283A1 (en) | 2009-06-04 |
EP1713493A2 (fr) | 2006-10-25 |
CA2554475A1 (fr) | 2005-08-11 |
RU2006130691A (ru) | 2008-03-10 |
WO2005072385A3 (fr) | 2006-06-08 |
KR20070009554A (ko) | 2007-01-18 |
IL176705A0 (en) | 2006-10-31 |
AU2005208911A1 (en) | 2005-08-11 |
BRPI0507177A (pt) | 2007-06-26 |
ECSP066793A (fr) | 2006-11-16 |
JP2007519739A (ja) | 2007-07-19 |
NO20063801L (no) | 2006-10-26 |
WO2005072385A2 (fr) | 2005-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA28335A1 (fr) | Agonistes du recepteur (vpac2) du type peptides activant l'adenylate cyclase hypophysaire (pacap) et procedes pharmacologiques d'utilisation de ces agonistes | |
Henning et al. | Vasoactive intestinal peptide: cardiovascular effects | |
Drucker | Minireview: the glucagon-like peptides | |
Brown et al. | Brain peptide regulation of adrenal epinephrine secretion | |
Larsen et al. | Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats | |
Dogrukol-Ak et al. | Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects | |
Aronoff et al. | Glucose metabolism and regulation: beyond insulin and glucagon | |
Bratusch-Marrain et al. | Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans | |
DE60016393T2 (de) | Metabolische intervention mit glp-1 zur verbesserung der funktion von ischämischem und wiederdurchblutetem gewebe | |
Ludvik et al. | Amylin: history and overview | |
Jensen et al. | C-peptide induces a concentration-dependent dilation of skeletal muscle arterioles only in presence of insulin | |
Boey et al. | The role of peptide YY in regulating glucose homeostasis | |
CN103356996A (zh) | Glp-1用于制备治疗急性冠脉综合征的药物的用途 | |
Ahlborg et al. | Metabolic and vascular effects of circulating endothelin-1 during moderately heavy prolonged exercise | |
WO2007065226A1 (fr) | Fragments de vip et méthodes d'utilisation | |
CN106279400A (zh) | P8降糖肽的设计及其用途 | |
BR0312621A (pt) | Agonistas de receptor (vpac2) de peptìdeo de ativação de pituitária adenilato ciclase (pacap) | |
CN1487952A (zh) | 具有血管活性肠肽的生物学活性的用于治疗肺动脉和小动脉高压的化合物 | |
Uehlinger et al. | Pressure dependence of atrial natriuretic peptide during norepinephrine infusion in humans. | |
Bray | Food intake, sympathetic activity, and adrenal steroids | |
Plamboeck et al. | The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1 | |
Yokota et al. | PACAP stimulates glucose output from the perfused rat liver | |
Wang et al. | Cardiovascular actions of python bradykinin and substance P in the anesthetized python, Python regius | |
Antoniou et al. | Differential effects of the neuropeptide galanin on striatal acetylcholine release in anaesthetized and awake rats | |
Patil et al. | Role of insulin in management of type 2 diabetes mellitus |