LV12657A - Rapamycin formulation for iv injection - Google Patents

Rapamycin formulation for iv injection

Info

Publication number
LV12657A
LV12657A LV010033A LV010033A LV12657A LV 12657 A LV12657 A LV 12657A LV 010033 A LV010033 A LV 010033A LV 010033 A LV010033 A LV 010033A LV 12657 A LV12657 A LV 12657A
Authority
LV
Latvia
Prior art keywords
rapamycin
solution
weight percent
polyethylene glycol
percent
Prior art date
Application number
LV010033A
Other languages
English (en)
Other versions
LV12657B (lv
Inventor
Robert Paul Waranis
Maureen Murphy Harrison
Thomas Waymond Leonard
Robin Peter Enever
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of LV12657A publication Critical patent/LV12657A/lv
Publication of LV12657B publication Critical patent/LV12657B/lv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
LV010033A 1992-03-30 2001-03-06 Rapamicina kompozicija intravenozai (i/v) ievadisanai LV12657B (lv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86053092A 1992-03-30 1992-03-30

Publications (2)

Publication Number Publication Date
LV12657A true LV12657A (lv) 2001-05-20
LV12657B LV12657B (lv) 2001-09-20

Family

ID=25333426

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010033A LV12657B (lv) 1992-03-30 2001-03-06 Rapamicina kompozicija intravenozai (i/v) ievadisanai

Country Status (21)

Country Link
US (1) US5530006A (lv)
EP (1) EP0633783B1 (lv)
JP (1) JPH07505628A (lv)
KR (1) KR950700750A (lv)
AT (1) ATE193652T1 (lv)
AU (1) AU681579B2 (lv)
CA (1) CA2132636C (lv)
DE (1) DE69328829T2 (lv)
DK (1) DK0633783T3 (lv)
ES (1) ES2148224T3 (lv)
GR (1) GR3034293T3 (lv)
HU (2) HUT70947A (lv)
LV (1) LV12657B (lv)
MX (1) MX9301740A (lv)
NZ (1) NZ251628A (lv)
PH (1) PH30923A (lv)
PT (1) PT633783E (lv)
SG (1) SG49652A1 (lv)
TW (1) TW427903B (lv)
WO (1) WO1993019763A1 (lv)
ZA (1) ZA932224B (lv)

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US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
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US5985325A (en) * 1997-06-13 1999-11-16 American Home Products Corporation Rapamycin formulations for oral administration
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
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US6399626B1 (en) 2000-10-02 2002-06-04 Wyeth Hydroxyesters of 7-desmethylrapamycin
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PT1539157E (pt) 2002-09-18 2013-10-04 Univ Pennsylvania Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
US7585517B2 (en) * 2003-09-18 2009-09-08 Macusight, Inc. Transscleral delivery
FR2862872A1 (fr) * 2003-12-02 2005-06-03 Palbian Snc Composition a l'etat aqueux pour l'application perfusable d'un principe actif, notamment pharmacologique tel que le paracetamol.
US20050220835A1 (en) * 2004-03-30 2005-10-06 Jayaraman Ramesh B Agent eluting bioimplantable devices and polymer systems for their preparation
US7846940B2 (en) * 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
BRPI0608152A2 (pt) 2005-02-09 2009-11-10 Macusight Inc formulações para tratamento ocular
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
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US20090054381A1 (en) * 2005-10-04 2009-02-26 Nitromed, Inc. Methods for treating respiratory disorders
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Also Published As

Publication number Publication date
JPH07505628A (ja) 1995-06-22
EP0633783B1 (en) 2000-06-07
GR3034293T3 (en) 2000-12-29
DK0633783T3 (da) 2000-09-25
CA2132636A1 (en) 1993-10-14
AU681579B2 (en) 1997-09-04
KR950700750A (ko) 1995-02-20
NZ251628A (en) 1996-07-26
PH30923A (en) 1997-12-23
HU9402821D0 (en) 1994-12-28
ATE193652T1 (de) 2000-06-15
AU3939193A (en) 1993-11-08
CA2132636C (en) 2002-12-17
DE69328829T2 (de) 2000-10-12
ZA932224B (en) 1994-09-29
TW427903B (en) 2001-04-01
US5530006A (en) 1996-06-25
WO1993019763A1 (en) 1993-10-14
HUT70947A (en) 1995-11-28
HU211841A9 (en) 1995-12-28
LV12657B (lv) 2001-09-20
ES2148224T3 (es) 2000-10-16
EP0633783A1 (en) 1995-01-18
MX9301740A (es) 1993-09-01
DE69328829D1 (de) 2000-07-13
SG49652A1 (en) 1998-06-15
PT633783E (pt) 2000-11-30

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