LU83556A1 - Nouvelles compositions pharmaceutiques contenant de l'almitrine - Google Patents
Nouvelles compositions pharmaceutiques contenant de l'almitrine Download PDFInfo
- Publication number
- LU83556A1 LU83556A1 LU83556A LU83556A LU83556A1 LU 83556 A1 LU83556 A1 LU 83556A1 LU 83556 A LU83556 A LU 83556A LU 83556 A LU83556 A LU 83556A LU 83556 A1 LU83556 A1 LU 83556A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- almitrine
- doses
- respiratory
- ventilation
- blood
- Prior art date
Links
- OBDOVFRMEYHSQB-UHFFFAOYSA-N almitrine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C=2N=C(NCC=C)N=C(NCC=C)N=2)CC1 OBDOVFRMEYHSQB-UHFFFAOYSA-N 0.000 title claims description 59
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 229960005039 almitrine Drugs 0.000 claims description 56
- 206010021143 Hypoxia Diseases 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 5
- 208000018875 hypoxemia Diseases 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 description 28
- 238000009423 ventilation Methods 0.000 description 24
- 230000000241 respiratory effect Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 19
- 230000010412 perfusion Effects 0.000 description 17
- 239000008280 blood Substances 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 16
- 230000003555 analeptic effect Effects 0.000 description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- 239000002269 analeptic agent Substances 0.000 description 10
- 238000011282 treatment Methods 0.000 description 8
- 238000009826 distribution Methods 0.000 description 7
- 230000036387 respiratory rate Effects 0.000 description 7
- 230000009471 action Effects 0.000 description 5
- 108091008690 chemoreceptors Proteins 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 238000001990 intravenous administration Methods 0.000 description 5
- 210000003456 pulmonary alveoli Anatomy 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 210000002816 gill Anatomy 0.000 description 3
- 230000001146 hypoxic effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 206010049565 Muscle fatigue Diseases 0.000 description 2
- 208000008601 Polycythemia Diseases 0.000 description 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 208000000122 hyperventilation Diseases 0.000 description 2
- 230000000870 hyperventilation Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 201000004193 respiratory failure Diseases 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 230000003519 ventilatory effect Effects 0.000 description 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 1
- 125000006325 2-propenyl amino group Chemical group [H]C([H])=C([H])C([H])([H])N([H])* 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 101100268906 Mus musculus Acox1 gene Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- MRDBGMJEPGXQHJ-UHFFFAOYSA-N almitrine dimesylate Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C=2N=C(NCC=C)N=C(NCC=C)N=2)CC1 MRDBGMJEPGXQHJ-UHFFFAOYSA-N 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- -1 bis (4-fluoro phenyl) methyl Chemical group 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000984 branchial region Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002635 electroconvulsive therapy Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical class OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000003019 respiratory muscle Anatomy 0.000 description 1
- 238000002633 shock therapy Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 210000001321 subclavian vein Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8018074A FR2488509A1 (fr) | 1980-08-18 | 1980-08-18 | Nouvelles compositions pharmaceutiques contenant de l'almitrine |
| FR8018074 | 1980-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU83556A1 true LU83556A1 (fr) | 1982-04-14 |
Family
ID=9245242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU83556A LU83556A1 (fr) | 1980-08-18 | 1981-08-14 | Nouvelles compositions pharmaceutiques contenant de l'almitrine |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4364946A (cs) |
| AU (1) | AU550741B2 (cs) |
| BE (1) | BE890011A (cs) |
| CA (1) | CA1181694A (cs) |
| CH (1) | CH650152A5 (cs) |
| DE (1) | DE3132654A1 (cs) |
| FR (1) | FR2488509A1 (cs) |
| GB (1) | GB2082064B (cs) |
| GR (1) | GR75328B (cs) |
| IE (1) | IE52095B1 (cs) |
| IT (1) | IT1171461B (cs) |
| LU (1) | LU83556A1 (cs) |
| NZ (1) | NZ198062A (cs) |
| ZA (1) | ZA815664B (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2660558B1 (fr) * | 1990-04-05 | 1994-09-09 | Adir | Utilisation de l'almitrine pour l'obtention de medicaments destines au traitement du paludisme. |
| CN102549405B (zh) * | 2009-07-31 | 2015-12-16 | Mts系统公司 | 风力涡轮机传动系统测试组件 |
| US12410143B2 (en) | 2017-01-17 | 2025-09-09 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of ATP synthase |
| RU2020105742A (ru) * | 2017-07-13 | 2021-08-13 | Майкл Девид ФОРРЕСТ | Терапевтические модуляторы обратного режима атф-синтазы |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1256513A (cs) * | 1968-10-02 | 1971-12-08 |
-
1980
- 1980-08-18 FR FR8018074A patent/FR2488509A1/fr active Granted
-
1981
- 1981-08-13 IT IT49104/81A patent/IT1171461B/it active
- 1981-08-14 LU LU83556A patent/LU83556A1/fr unknown
- 1981-08-17 ZA ZA815664A patent/ZA815664B/xx unknown
- 1981-08-17 NZ NZ198062A patent/NZ198062A/xx unknown
- 1981-08-17 GR GR65808A patent/GR75328B/el unknown
- 1981-08-17 CA CA000383989A patent/CA1181694A/fr not_active Expired
- 1981-08-18 AU AU74277/81A patent/AU550741B2/en not_active Ceased
- 1981-08-18 BE BE0/205710A patent/BE890011A/fr not_active IP Right Cessation
- 1981-08-18 DE DE19813132654 patent/DE3132654A1/de not_active Withdrawn
- 1981-08-18 US US06/294,014 patent/US4364946A/en not_active Expired - Fee Related
- 1981-08-18 CH CH5348/81A patent/CH650152A5/fr not_active IP Right Cessation
- 1981-08-18 GB GB8125188A patent/GB2082064B/en not_active Expired
- 1981-08-18 IE IE1891/81A patent/IE52095B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE52095B1 (en) | 1987-06-10 |
| IE811891L (en) | 1982-02-18 |
| AU550741B2 (en) | 1986-04-10 |
| DE3132654A1 (de) | 1982-06-24 |
| GB2082064B (en) | 1985-06-26 |
| NZ198062A (en) | 1983-12-16 |
| BE890011A (fr) | 1982-02-18 |
| IT8149104A0 (it) | 1981-08-13 |
| CH650152A5 (fr) | 1985-07-15 |
| US4364946A (en) | 1982-12-21 |
| GR75328B (cs) | 1984-07-13 |
| FR2488509B1 (cs) | 1984-11-23 |
| IT1171461B (it) | 1987-06-10 |
| FR2488509A1 (fr) | 1982-02-19 |
| CA1181694A (fr) | 1985-01-29 |
| ZA815664B (en) | 1982-08-25 |
| AU7427781A (en) | 1982-02-25 |
| GB2082064A (en) | 1982-03-03 |
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