LU501113B1 - A Compound Prescription Of Chinese And Western Medicine For Treating Impotence - Google Patents
A Compound Prescription Of Chinese And Western Medicine For Treating Impotence Download PDFInfo
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract
The invention discloses a compound prescription of Chinese and Western medicine for treating impotence, which is made of Chinese medicine prescription and PDE5i inhibitor. The Chinese medicine prescription consists of Diaphragma juglandis Fructus, pig's kidney, Scutellaria barbata, Polygonum cuspidatum, Patrinia herb, Verbena, Portulaca, Achyranthes bidentata, Cynomorium songaricum Rupr, Lepidium meyenii, Ginseng, Hedyotis diffusa, Angelica sinensis, Lycium chinense, jujube, raw oyster, almond, peach kernel, Cowherb Seed, Poria, Radix Rehmanniae Preparata, cordyceps, Nidus Vespae, Tribulus terrestris, fructus cnidii, Earthworm, Radix Bupleuri; the PDE5i inhibitor is Sildenafil or Tadalafil. The invention combines Chinese and Western medicine, mainly sildenafil, Chinese prescription is the auxiliary, and the combination of main and auxiliary, so as to realize multiple treatment from local to overall, with high curative effect, remarkable effect and treatment of both symptoms and root causes.
Description
BL-5355 LU501113 A Compound Prescription Of Chinese And Western Medicine For Treating Impotence Technical Field
[0001] The invention relates to the field of medicine technology, in particular to a compound prescription of Chinese and Western medicine for treating impotence. Background
[0002] As we all know, normal male sexual function comprises sexual desire, sexual excitement, penile erection, intercourse, ejaculation and orgasm. This process is an extremely complex process involving the normal mental, neurological, endocrine system, vascular system and normal reproductive system, which is mainly controlled and dominated by the brain. The most common male sexual dysfunctions are erectile dysfunction and premature ejaculation, also known as impotence. Erectile dysfunction refers to continuous and repeated failure to achieve or maintain sufficient penile erection to complete a satisfactory sex life, premature ejaculation is generally believed that the penis can be erected during sexual intercourse but loses control of ejaculation, ejaculation occurs before or just after the penis is inserted into the vagina. Clinical western medicine treatment mainly adopts local treatment with drugs and hormone therapy, but western medicine mainly finds the pathogenesis at the molecular level from the physiopathological point of view, and quickly treats it at the cellular and molecular level, however, the current treatment of impotence with western medicine cannot treat people as a whole, although the treatment works quickly, the treatment will treat the symptoms but not the root cause, in traditional Chinese medicine, impotence falls into the categories of "inability to erect the penis", "tendon atrophy", "impotence", "erectile dysfunction”, and "fail to use the sexual function", the treatment of impotence in Chinese medicine is based on the whole, and its treatment achieves both symptoms and root causes. Summary of the invention
[0003] Therefore, based on the above background, the invention combines traditional Chinese and western medicine with complementary advantages to provide a compound prescription of Chinese and Western medicine for treating impotence, the treatment course is short and the 1
BL-5355 effect is significant, which can achieve both symptoms and root causes. L7S071 13
[0004] The technical scheme of the invention is as follows:
[0005] it is made of Chinese medicine prescription and PDES1 inhibitor;
[0006] the Chinese medicine prescription consists of Diaphragma juglandis Fructus, pig's kidney, Scutellaria barbata, Polygonum cuspidatum, Patrinia herb, Verbena, Portulaca, Achyranthes bidentata, Cynomorium songaricum Rupr, Lepidium meyenii, Ginseng, Hedyotis diffusa, Angelica sinensis, Lycium chinense, jujube, raw oyster, almond, peach kernel, Cowherb Seed, Poria, Radix Rehmanniae Preparata, cordyceps, Nidus Vespae, Tribulus terrestris, fructus cnidii, Earthworm, Radix Bupleuri;
[0007] the PDESi inhibitor is Sildenafil or Tadalafil.
[0008] Further, the raw materials in the Chinese medicine prescription are as follows in parts by weight:
[0009] 30 parts of Diaphragma juglandis Fructus, 30 parts of pig's kidney, 15 parts of Scutellaria barbata, 15 parts of Polygonum cuspidatum, 30 parts of Patrinia herb, 30 parts of Verbena, 30 parts of Portulaca, 15 parts of Achyranthes bidentata, 15 parts of Cynomorium songaricum Rupr, 30 parts of Lepidium meyenii, 10 parts of Ginseng, 15 parts of Hedyotis diffusa, 15 parts of Angelica sinensis, 15 parts of Lycium chinense, 30 parts of jujube, 30 parts of raw oyster, 15 parts of almond, 10 parts of peach kernel, 15 parts of Cowherb Seed, 30 parts of Poria, 15 parts of Radix Rehmanniae Preparata, 5 parts of cordyceps, 10 parts of Nidus Vespae, 15 parts of Tribulus terrestris, 15 parts of fructus cnidii, 10 parts of Earthworm, parts of Radix Bupleuri.
[0010] Further, the dosage ratio of the Chinese medicine prescription and PDES1 inhibitor is 10:1.
[0011] Further, the preparation method thereof is to pulverize the raw materials of the Chinese medicine prescription and mix them with the PDESi inhibitor, and then add common auxiliary materials to make candy tablets or honey pills.
[0012] Further, the PDES1 inhibitor is Sildenafil.
[0013] In the PDESi inhibitor of the invention, both Sildenafil or Tadalafil are a highly selective, long-acting PDESi inhibitor, and its efficacy lasts up to 36 hours, and its principle of treating impotence is that it can indirectly dilates the blood vessels of the cavernosum, thereby 2
BL-5355 increasing the effective concentration of "CGMP" by avoiding the metabolism and hydrolysis LUS0TTIS of "CGMP" cells that can promote the expansion of the cavernosum, under the continuous action of "CGMP", the cavernosum can maintain adequate and effective dilation and congestion to prevent impotence.
And the traditional Chinese medicine thinks impotence is a kind of liver depression kidney deficiency blood stasis disease, stagnation in liver meridian, excessive dampness-heat and emotion stimulation are the etiology and pathogenesis, the external manifestations are the intermingled deficiency and excess, excessive indulgence in sexual activity, kidney deficiency and liver depression are the main characteristics of the case, kidney deficiency is the main pathological trend, and blood stasis is the final pathological trend, therefore, starting from the whole of impotence disease, it should be the treatment principle of soothing liver and relieving depression, nourishing kidney and promoting coronary circulation, in the Chinese medicine prescription of the invention, Diaphragma juglandis Fructus: arresting seminal emission and arresting polyuria, hemostasis and arresting leucorrhea; pig's kidney: nourishing kidney and enriching yin, urinating smoothly and urine output is increased; Scutellaria barbata: clearing away heat and toxic material, removing blood stasis and diuretic; Polygonum cuspidatum: promoting blood circulation and stopping pain, clearing heat and promoting diuresis, detoxifying and promoting defecation, resolving phlegm and relieving cough; Patrinia herb: clearing away heat and toxic material, removing blood stasis and expelling pus; Verbena: promoting blood circulation and removing blood stasis, detoxifying; Portulaca: clearing away heat and toxic material, eliminating dampness and arresting leucorrhea; Achyranthes bidentata: promoting blood circulation and menstruation, nourishing liver and kidney, strengthening the bones and muscles; Cynomorium songaricum Rupr: nourishing liver and kidney, regulating physiological function, balancing nutrition and promoting blood circulation; Lepidium meyenii: enhancing immune function, anti-fatigue, anti-anemia, regulating endocrine, improving sexual function, Ginseng: invigorating qi for relieving desertion, invigorating spleen for benefiting lung, soothing the nerves; Hedyotis diffusa: clearing away heat and removing dampness, eliminating the nodules and relieving pain, diuresis and detoxification; Angelica sinensis: enriching blood and promoting blood circulation, regulating menstruation and relieving pain, moistening intestine; Lycium chinense: nourishing the liver and kidney, benefiting the eyes; Jujube: strengthening
3
BL-5355 the spleen and stomach, nourishing blood for tranquillization, eliminating or reducing the side LUS0TTIS effects of drugs; raw oyster: tranquilization with heavy material, subduing yang to nourish yin, softening the hardness and eliminating the nodules; almond: antitussive, anti-asthmatic, enhancing human immunity, delaying aging, regulating blood lipid; peach kernel: promoting blood circulation to remove stasis and moistening intestines to relieve constipation; Cowherb Seed: promoting blood circulation and menstruation; Poria: clearing damp and promoting diuresis, invigorating the spleen and calming the heart; Radix Rehmanniae Preparata: nourishing yin and supplementing blood, supplying vital essence and marrow; Cordyceps: nourishing the kidney and lungs, stopping bleeding and resolving phlegm; Nidus Vespae: invigorating kidney and Yang, nourishing Yin and invigorating kidney, strengthening essence and tonifying kidney; Tribulus terrestris: inhibiting the hyperactivity of liver, soothing liver-qi stagnation, clearing eyes, dispelling the wind and cold and relieving itching; fructus cnidi: warming the kidney, eliminating dampness, dispelling the wind and cold, killing insects; Earthworm: clearing heat and calming shock, dredging collateral, relieving asthma and diuresis; Radix Bupleuri: reconciling superficies and interior, soothing the liver, invigorating the spleen and promoting clarity and reducing turbidity in the stomach.
[0014] The Chinese medicine prescription of the invention is the combination of various drugs, and has the effects of soothing the liver and relieving depression, nourishing blood and liver, promoting blood circulation and dredging collaterals, removing blood stasis, tonifying the kidney and revitalizing flaccidity, impotence is treated as a whole. The treatment of impotence by sildelafil in the invention is from direct action therapy on the patient at the molecular level and plays a major therapeutic role, the Chinese prescription focuses on conditioning and plays an auxiliary role, but the effective time is too long, in the treatment of impotence with the compound prescription of the invention can not only quickly improve the symptoms of impotence, meet the needs of the basic sexual life of impotence patients, and enhance psychological self-confidence under the action of drug treatment mainly composed of Sildenafil, at the same time, this psychological change can improve the liver qi stagnation, in this case, under the conditioning of medicines such as liver-soothing, kidney-tonifying and blood-stasis removing, and in turn, it plays a positive role in the treatment of Sildenafil, and finally achieves the effect of local and overall treatment; the invention not only has a good 4
BL-5355 therapeutic effect on pathological impotence, but also has a good therapeutic effect on LUS0TTIS psychological impotence.
[0015] Adopting the above technical scheme, the advantageous effects are as follows:
[0016] The invention combines Chinese and Western medicine, mainly sildenafil, Chinese prescription is the auxiliary, and the combination of main and auxiliary, so as to realize multiple treatment from local to overall, with high curative effect, remarkable effect and treatment of both symptoms and root causes. Description of Embodiments
[0017] In order to make the object, technical scheme and advantages of the embodiments of the invention more clear, the technical scheme of the embodiments of the invention will be clearly and completely described in combination with the embodiments of the invention, obviously, the described embodiments are part of the embodiments of the invention, but not all of the embodiments. Based on the embodiments of the invention, all other embodiments obtained by those skilled in this art without making creative labor are covered by the invention.
[0018] Embodiment 1: a compound prescription of Chinese and Western medicine for treating impotence, which is made of Chinese medicine prescription and PDES1 inhibitor;
[0019] the raw materials in the Chinese medicine prescription are as follows in parts by weight:
[0020] 30 parts of Diaphragma juglandis Fructus, 30 parts of pig's kidney, 15 parts of Scutellaria barbata, 15 parts of Polygonum cuspidatum, 30 parts of Patrinia herb, 30 parts of Verbena, 30 parts of Portulaca, 15 parts of Achyranthes bidentata, 15 parts of Cynomorium songaricum Rupr, 30 parts of Lepidium meyenii, 10 parts of Ginseng, 15 parts of Hedyotis diffusa, 15 parts of Angelica sinensis, 15 parts of Lycium chinense, 30 parts of jujube, 30 parts of raw oyster, 15 parts of almond, 10 parts of peach kernel, 15 parts of Cowherb Seed, 30 parts of Poria, 15 parts of Radix Rehmanniae Preparata, 5 parts of cordyceps, 10 parts of Nidus Vespae, 15 parts of Tribulus terrestris, 15 parts of fructus cnidii, 10 parts of Earthworm, 15 parts of Radix Bupleuri.
[0021] The PDESi inhibitor is Sildenafil.
BL-5355
[0022] The dosage ratio of the Chinese medicine prescription and PDESi inhibitor is 10:1. LUS0TTIS
[0023] The pig's kidney in this embodiment is fresh.
[0024] In this embodiment, the raw material of the Chinese medicine prescription is ground and mixed with PDESi inhibitor, and common auxiliary materials are added to make candy tablets, 0.5g each, and 2-3 tablets are taken at a time.
[0025] The almonds and peach kernels in the Chinese medicine prescription of the invention are all processed and used after detoxification by methods commonly used in the art.
[0026] Embodiment 2: clinical efficacy
[0027] Thirty patients with liver-stagnation impotence diagnosed from 2016 to 2019 were selected and randomly divided into three groups according to the method of drawing lots, namely control group 1, control group 2, observation group 3, the patients of control group 1 were 22 to 51 years old, with an average age of (35.24 6.89) years; the courses of diseases were 5-60 months; the patients of control group 2 were 20 to 51 years old, with an average age of (34.68 6.63) years; the courses of diseases were 4-61 months; the patients of observation group were 21 to 50 years old, with an average age of (34.42-46.57) years; the courses of diseases were 4.5-59 months, there was no statistically significant difference in age and course of disease among the three groups of patients, and they were comparable.
[0028] Western medicine diagnostic criteria:
[0029] (1) Under effective stimulation, if an adult man is unable to continuously achieve or maintain a sufficiently firm penile erection to complete satisfactory sexual intercourse, and has been ill for more than 3 months, at the same time, the score of the questionnaire on international index erectile function-5 (IIEF-5) is < 21 points, he will be diagnosed as ED. (2) From the first sexual intercourse, ejaculation often or always occurs about 1 min after insertion into the vagina, and ejaculation is always or almost always unable to be delayed, he will be diagnosed as PE. Both (1) and (2) are satisfied.
[0030] Chinese medicine diagnostic criteria:
[0031] it conforms to the Chinese medicine syndrome differentiation standard of Liver stagnation and kidney deficiency. Main symptoms: soreness and weakness of waist and knees, distending pain in the chest and hypochondriac regions; secondary symptoms: depression, dizziness, tinnitus, chest tightness and long sigh out, sex apathy, purple tongue, weak pulse.
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BL-5355
[0032] Exclusion criteria: L7S071 13
[0033] (1) patients with severe organic ED or PE; (2) no normal sex life; (3) patients who have used other methods to treat PE or ED within 3 months; (4) taking drugs that affected penile erectile function during the observation period.
[0034] Criterion of therapeutical effect:
[0035] Cure: IIEF-5 > 22 points and IELT > 2min;
[0036] Significantly effective: IIEF-5 < 22 points but an increase of 5 points or more than before, and IELT is significantly prolonged,
[0037] Valid: IIEF-5 < 22 points but increased by 2 to 4 points and IELT has been extended,
[0038] Invalid: IIEF-5 < 22 points but an increase of <I point from the previous or no increase or decrease, and no extension or shortening of IELT.
[0039] The total effective rate is the sum of cure, significantly effective and valid.
[0040] Grouped administration: control group 1 was given 5 mg Sildenafil oral tablets 1 to 2 hours before going to bed every night, control group 2 was given capsules made of the Chinese medicine, 4 capsules per day (0.25g/capsule), observation group was given the honey pills prepared in embodiment 2, continuous administration for 2 months.
[0041] In control group 1, 2 cases were cured, 1 case was significantly effective, 4 cases were valid, and the total effective rate was 70%; in control group 2, 3 cases were cured, 2 cases were significantly effective, 3 cases were valid, and the total effective rate was 80.07%; in the observation group, 5 cases were cured, and 3 cases were significantly effective, 1 case is valid, and the effective rate is 90.0%.
[0042] Embodiment 3: Typical cases
[0043] Case 1: Mr. Sun, male, 31 years old, impotence for 2 years, penis inability to erect, Chinese medicine diagnosed liver stagnation and kidney deficiency with blood stasis, after taking the honey pills prepared in embodiment 2, after taking the honey pills for 1 week, the penis felt pumping, he was able to get an erection, he continued taking the medicine for 2 months and healed.
[0044] Case 2: Mr. Zhao, male, 42 years old, impotence for more than 1 year, the penis cannot be erected, the Chinese medicine diagnosed as kidney deficiency and blood stasis, after taking the candy tablets prepared in embodiment 1, after taking the candy tablets for 10 consecutive 7
BL-5355 days, the penis can be fully erected, he continued taking the medicine for 2 months and healed, LUS0TTIS and half a year after healed and stopped the medicine, the erection of the penis remained normal.
[0045] The invention and its embodiments are described above, this description is not restrictive, and what is shown is only one of the embodiments of the invention, and the actual structure is not limited to this. All in all, if those skilled in the art receives its enlightenment, without deviating from the object of the invention, and without creatively designing structures and embodiments similar to the technical scheme of the invention shall fall within the protection scope of the invention.
8
Claims (4)
1. A compound prescription of Chinese and Western medicine for treating impotence, it is made of Chinese medicine prescription and PDES1 inhibitor; the Chinese medicine prescription consists of Diaphragma juglandis Fructus, pig's kidney, Scutellaria barbata, Polygonum cuspidatum, Patrinia herb, Verbena, Portulaca, Achyranthes bidentata, Cynomorium songaricum Rupr, Lepidium meyenii, Ginseng, Hedyotis diffusa, Angelica sinensis, Lycium chinense, jujube, raw oyster, almond, peach kernel, Cowherb Seed, Poria, Radix Rehmanniae Preparata, cordyceps, Nidus Vespae, Tribulus terrestris, fructus cnidii, Earthworm, Radix Bupleuri; the PDES1 inhibitor is Sildenafil or Tadalafil.
2. A compound prescription of Chinese and Western medicine for treating impotence according to claim 1, wherein the raw materials in the Chinese medicine prescription are as follows in parts by weight: 30 parts of Diaphragma juglandis Fructus, 30 parts of pig's kidney, 15 parts of Scutellaria barbata, 15 parts of Polygonum cuspidatum, 30 parts of Patrinia herb, 30 parts of Verbena, 30 parts of Portulaca, 15 parts of Achyranthes bidentata, 15 parts of Cynomorium songaricum Rupr, 30 parts of Lepidium meyenii, 10 parts of Ginseng, 15 parts of Hedyotis diffusa, 15 parts of Angelica sinensis, 15 parts of Lycium chinense, 30 parts of jujube, 30 parts of raw oyster, 15 parts of almond, 10 parts of peach kernel, 15 parts of Cowherb Seed, 30 parts of Poria, 15 parts of Radix Rehmanniae Preparata, 5 parts of cordyceps, 10 parts of Nidus Vespae, 15 parts of Tribulus terrestris, 15 parts of fructus cnidii, parts of Earthworm, 15 parts of Radix Bupleuri.
3. A compound prescription of Chinese and Western medicine for treating impotence according to claim 2, wherein the dosage ratio of the Chinese medicine prescription and PDESi inhibitor is 10:1.
4. A compound prescription of Chinese and Western medicine for treating impotence according to claim 1, wherein the preparation method thereof is to pulverize the raw materials of the Chinese medicine prescription and mix them with the PDESi inhibitor, and then add common auxiliary materials to make candy tablets or honey pills.
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