LU501050B1 - Chinese medicinal ointment for treating animal trauma and preparation method thereof - Google Patents
Chinese medicinal ointment for treating animal trauma and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Abstract
A Chinese medicinal ointment for treat animal trauma and its preparation method, comprising the following components: Radix Arnebiae decoction pieces: Boswellia carterii, Commiphora myrrha, Phellodendron chinense, Panax notoginseng, Daemonoropsdraco, Borneol powder = 15: 12: 8: 8: 2: 2: 1; Panax notoginseng and Daemonoropsdraco are grinded to 300 meshes; Radix Arnebiae, Boswellia carterii, Commiphora myrrha and Phellodendron chinense are crushed to 80 meshes; Radix Arnebiae, Boswellia carterii, Commiphora myrrha and Phellodendron chinense is put into medicinal soybean oil at 80 degree Celsius to be leached for 60 minutes at constant temperature, heating the filtrate to 80 degree Celsius, adding Panax notoginseng and Daemonoropsdraco powder, add borneol, add vaseline (45 percent), lanolin (7 percent) and beeswax (4 percent). The ointment contains 44 percent dried medicinal herbs, 45 percent vaseline, 7 percent lanolin and 4 percent beeswax. The ratio of medicinal soybean oil to traditional Chinese medicine powder is 25 (mL): 8 (g).
Description
Description HUS01050 Chinese medicinal ointment for treating animal trauma and preparation method thereof
TECHNICAL FIELD The invention belongs to the field of veterinary medicine, and is an external Chinese medicinal ointment for treating animal wound.
BACKGROUND Trauma is a common clinical disease of animals. After trauma, animals are difficult to bandage, lack of self-protection consciousness, and are prone to trauma infection. External use of traditional Chinese medicine for treating animal trauma is one of the most precious treasures left to human beings by traditional Chinese veterinary medicine. However, at present, there is no traditional Chinese medicine ointment and veterinary drug product for treating animal trauma in veterinary field. In order to develop traditional Chinese medicine ointment preparation for treating animal trauma, members of our team started research from traditional Chinese medicine composition, preparation formula, pharmaceutical technology and pharmacology and pharmacodynamics. The Chinese medicinal ointment developed by the invention for external treatment of trauma is based on the principle of “activating blood and dissolving stasis, rush down and recover effects, eliminating dampness and promoting granulation, promoting granulation and wound healing” according to the traditional veterinary theory of treating animal trauma. The research in the laboratory takes rats and dogs as the research objects, and repeatedly screens and optimizes the traditional Chinese medicine formula, prescription composition, preparation technology and so on through its clinical therapy. The results of veterinary clinical trials show that the developed ointment of traditional Chinese medicine has the effects of anti-infection, analgesia and wound healing. The traditional Chinese medicine ointment is used to treat animal wounds. After the wounds heal, the scar surface is smooth and the scar is small.
SUMMARY Ointment formulation: Chinese medicine composition: Radix Arnebiae, Phellodendron chinense, Boswellia carterii, Commiphora myrrha, Panax notoginseng, Daemonoropsdraco and Borneol. Ingredients: Vaseline, lanolin and beeswax. The liquid substrate is medicinal soybean oil.
Composition ratio of ointment preparation prepared in laboratory 7507050 Chinese herbs: Radix Arnebiae 150g, Phellodendron chinense 120g, Boswellia carterii 80g, Commiphora myrrha 80g, Panax notoginseng 20g, Daemonoropsdraco 20g, Borneol 10g. Excipients: Vaseline 480g, lanolin 80g and beeswax 40g.
Liquid adjuvant: medicinal soybean oil 1500MI.
Efficacy of traditional Chinese medicine ointment This ointment is suitable for skin injuries (including fresh wounds and old wounds) and skin infections caused by fungi or bacteria in various animals. Has hemostatic, analgesic, antiseptic and granulation promoting effects, and can accelerate wound healing.
The invention has the following advantages (1) Compared with traditional ointment preparation, it improves the utilization rate of active ingredients of traditional Chinese medicine, and its preparation process is more scientific. (2) Pure traditional Chinese medicine preparation, without any antibacterial western veterinary drugs; (3) it has good analgesic and myogenic effects, can promote the regulation of collagen expression and accelerate the repair of damaged tissues; (4) improve the quality of wound healing, the scar is smooth and flat, and the scar area is small. (5) Traditional Chinese medicine ointment has good sterilization (including common bacteria and fungi), and can control wound infection.
Study on the treatment of trauma with traditional Chinese medicine ointment Main research contents of Chinese herbal ointment on rat trauma model The healing effect of traditional Chinese medicine ointment in treating wounds On the third day after the trauma, the wounds on both sides of the back of the rat had begun to scab, and the contraction was not obvious. On the 7th day after trauma, the wound healing degree of the anti-corrosion and promoting granulation ointment side was obviously better than that of the control side, and the wound was smooth. On the 10th day after trauma, the scab on the side of Chinese herbal ointment had completely fallen off, and the wound edge was covered with hair. On the 14th day after trauma, the wounds on both sides of the back of rats were covered with new epidermis, and the wound contracted obviously. The wound area on the side of Chinese herbal ointment was significantly smaller than that on the control side, which indicated that Chinese herbal ointment could significantly promote wound healing. The results are shown in Table 1. On the 14th day after trauma, the wounds on both sides of the back of 7507050 rats were covered with new epidermis, and the wound contracted obviously.
The wound area on the side of Chinese herbal ointment was significantly smaller than that on the control side, which indicated that Chinese herbal ointment could significantly promote wound healing.
The results are shown in Table 1. Table 1 Effects of both sides on wound healing rate in rats (%) Group 3d 7d 10d 14d medicine ointment side “Blank control side 0.0249 0.2808 0.3398 0.6413 The area of scar after wound healing treated with Chinese herbal ointment The prognosis scar area of Chinese herbal ointment side is significantly smaller than that of blank control side (p<0.01), indicating that Chinese herbal ointment can significantly reduce the prognosis scar area.
The results are shown in Table 2. Table 2 Effects of both sides on the area of scar in the prognosis of rats (mm2) © Grow Prognostioscararea ointment side © Blankcontrolside 0.187840.0240 Analgesic effect of traditional Chinese medicine ointment Compared with the control group, the pain threshold of the Chinese herbal ointment group 60min after administration was significantly higher than that of the control group (P < 0.05). The pain threshold at 90min and 120min was significantly higher than that of the control group (P<0.01). The results are shown in Table 3. Compared with the control group, the time of the first writhing in the Chinese herbal ointment group was significantly longer, and the number of writhing in 20 minutes was significantly less than that in the control group (P<0.01), which indicated that Chinese herbal ointment had a certain analgesic effect, and the results are shown in Table 4.
Table 3 Effect of traditional Chinese medicine ointment on analgesic effect of hot plate method in mice Pain threshold Pain threshold at different time after administration Cs) Dosage before Group RE (g/cm?) administration 30min 60min 90min 120min (s) Traditional 1 24.78+2.26 — 22.00£4.69 2950+831% 4267£13.994 45.00+13.274 Chinese medicine ointment group Model control 1 23.56+2.89 15.83£3.48 20.50+5.50 22.50+3.50 28.67+5.64 group Note: Different letters are marked in the upper right corner, A: represents extremely significant difference (P<0.01), a: represents significant difference (P<0.05). The following tables are the same.
Table 4 The effect of traditional Chinese medicine ointment on the analgesic effect of acetic acid writhing in mice The time of the first Group Dosage (g/cm?) Torsion number (20min) torsion (min) Traditional Chinese 0.2 9.75+2.76* 14.303.234 medicine ointment group Model control group 0.2 7,54+1.33 24.20+3.70 Anti-inflammatory effect of traditional Chinese medicine ointment According to the mouse foot swelling test caused by egg white, compared with the negative control group, the Chinese herbal ointment group and the positive control group can significantly inhibit the inflammatory toe swelling at all time points (P<0.01), and the results are shown in Table 5; from the test of xylene-induced ear swelling in mice, it can be seen that compared with the negative control group, the Chinese herbal ointment group and the positive control group can significantly inhibit the ear swelling in mice (P<0.01), indicating that Chinese herbal ointment has obvious inhibitory effect on the ear swelling in mice caused by xylene, and the results are shown in Table 6.
Table 5 Effect of traditional Chinese medicine ointment on mouse foot swelling caused by egg white Dosage Degree of toe swelling at different time after inflammation (mm) Group ES (g/cm?) 0.5h 1h 2h 4h 6h Traditional 0.2 1.110.074 0.840.084 0.610.204 0.300.114 0.13+0.104 Chinese medicine ointment group Positive 0.2 1.240.184 0.990.144 0.820.094 0.45+0.104 0.180.05° control group Negative 0.2 1.84+0.28 1.46#0.21 1.17#0.21 0.77#0.17 0.27+0.04 control group Table 6 Effect of traditional Chinese medicine ointment on xylene-induced ear swelling in mice Swelling inhibition rate Group Dosage (g/cm?) Swelling degree (g) (%) Traditional Chinese 0.2 0.0010+0.00124 24.19 medicine ointment group Positive control group 0.2 0.0018+0.00064 46.18 Negative control group 0.2 0.0035+0.0007 — Safety evaluation of traditional Chinese medicine ointment Acute toxicity test results The acute toxicity test showed that there was no significant difference in body weight between the experimental group and the blank control group, but the weight gain of the skin damaged group slowed down, which was mainly caused by traumatic stress.
The results are shown in Table 7. Table 7 Changes of body weight before and after administration in each group (g) Body weight before Group Body weight 7 days after administration administration Blank control group 164.00+11.07 157.86+10.01 High dose group of damaged skin traditional Chinese medicine 165.40+£14.99 155,72+13.51 ointment Middle dose group of damaged 165.00+9.38 157.00+8.41 skin traditional Chinese medicine LUS01050 ointment Low dose group of damaged skin traditional Chinese medicine 165.80+11.63 155.64+10.18 ointment High dose group of intact skin traditional Chinese medicine 164.80+16.57 160.92+10.08 ointment Middle dose group of intact skin traditional Chinese medicine 166.40+6.73 156.96#3.16 ointment Low dose group of intact skin traditional Chinese medicine 165.80+11.12 160.22+13.22 ointment Skin irritation test results No erythema and edema were found in the damaged skin and intact skin at 1h, 24h, 48h and 72h after administration, and no erythema and edema were found in the observation for one week after withdrawal.
Therefore, the traditional Chinese medicine ointment is considered as a drug with no obvious skin irritation, and the results are shown in Table 8. Table 8 Results of skin irritation test in each group Average score Stimulation intensity Group Test substances == 1h 24h 48h 72h 1h 24h 48h 72h Damaged Blank control 0 0 0 0 0 0 0 0 skin group Matrix group 0 0 0 0 0 0 0 0 Traditional Chinese 0 0 0 0 0 0 0 0 medicine ointment group intact Blank control 0 0 0 0 0 0 0 0 skin group Matrix group 0 0 0 0 0 0 0 0 Chinese medicine 0 0 0 0 0 0 0 0 ointment group Skin allergy test The experimental comparison of sensitization reaction score and sensitization rate between
. . . . . LU501050 the Chinese herbal ointment group and the group without Chinese herbal ointment and the positive drug group shows that the Chinese herbal ointment group and the group without Chinese herbal ointment have no skin sensitization, and the results are shown in Tables 9 and
10. Table 9 The results of anaphylaxis test of each group Average score of allergic reaction Group Animal number ———en At once 24h 48h 72h Traditional 10 0 0 0 0 Chinese medicine ointment group Traditional 10 0 0 0 0 Chinese medicine ointment matrix 2,4- 10 4.8 4.8 4 4 dinitrochlorobenze ne Table 10 The results of sensitization rate test of each group Animal Sensitization rate (%) Group -_— Sensitization intensity number At once 24h 48h 72h Traditional Chinese 10 0 0 0 0 Nonsensitization medicine ointment group Traditional Chinese 10 0 0 0 0 Nonsensitization medicine ointment matrix 2,4- 10 100 100 100 100 Extreme sensitization dinitrochlorobenzene Note: average score of allergic reaction = (total score of erythema formation+total score of water formation)/total number of animals; Sensitization rate = number of positive animals/total number of tested animalsx 100% (positive reaction is erythema or edema of skin) Application of Traditional Chinese Medicine Ointment in Treating Dog Trauma Using surgical techniques, 9 local mongrel dogs were anesthetized to make a round skin defect trauma model with a diameter of 2 cm. Rubber promoting granulation Ointment purchased in pharmacies was used as the drug control group, and Chinese medicine ointment was used as the blank control group. The experiment was divided into three groups: Chinese medicine ointment group (S), rubber Promoting granulation ointment group (X) and Chinese medicine ointment-free group (M), with 3 dogs in each group. 7507050 Clinical Observation As shown in the figure, within one week of administration, there was little change in each group. On the 14th day after administration, the wounds in group S and group X were almost covered by epithelium, while the wound edges in group M were still obvious after modeling, and scar tissue was formed in all the wounds of three groups of animals. 21 days after the operation, the wound had been completely covered by the batch, but the fur inside the wound did not grow again and formed scar tissue. Both the S group and the X group were better than the M group; after half a month and one month after wound healing, the wound hair still did not grow, but the scar tissue decreased over time. On the whole, the healing quality of traditional Chinese medicine ointment is better than that of the finished medicine rubber skin-promoting ointment and the group without traditional Chinese medicine ointment. See attached picture 1 Healing rate of traditional Chinese medicine ointment in treating wounds The wound area of each group of dogs was measured on 1, 7, 14, 21 days after the operation, and then the wound healing rate was calculated, and the average value was obtained. The wound healing rate of dogs showed an increasing trend with time. Compared with M group, the wound healing rate of S group and X group increased significantly on 7th and 14th day (P<0.05). Among them, the S group increased significantly (P<0.01). Compared with M group, the average wound healing time of S group and X group increased significantly (P<0.05). Among them, the S group increased significantly (P<0.01). On 21st day after operation, compared with M group, there was no significant difference in each group. The results are shown in Table 11.
Table 11 Healing rate of traditional Chinese medicine ointment (%) Group add X group 18.7700+2.77638** 84 2667+1.86559* 98.0700+1.82590 Note: Group S: Chinese herbal ointment, Group X: Rubber promoting granulation ointment, and Group M: Chinese herbal ointment-free group. *P<0.05, which means there 1s significant difference compared with M group; **P<0.01, which means there is a significant difference compared with M group. “P<0.05, which is significant compared with group X.
Effect of Chinese herbal ointment on wound healing time and scar area 7507050 As shown in the chart, compared with Group M, the wound healing time of Group S in Chinese herbal ointment group is significantly different, and that of Group X in rubber promoting granulation ointment group is significantly different, which shows that both Chinese herbal ointment and rubber promoting granulation ointment can obviously shorten the wound healing time and promote wound healing, but Chinese herbal ointment is better than rubber promoting granulation ointment. The results are shown in Table 12. Compared with group M, there are significant differences between group S and group X, which shows that the effect of Chinese herbal ointment is equivalent to that of rubber promoting granulation ointment, and both of them can significantly reduce the area of prognosis scar. The results are shown in Table
13. Table 12 Effect of traditional Chinese medicine ointment on healing time (D) Group Average healing time (d) Prognosis scar area S group 16.0000£2.00000%* 0.1281+0.0351** X group 18.6667+1.52753* 0.1352+0.0271** M group 22.0000+1.00000 0.4378+0.0224 Note: S group: traditional Chinese medicine ointment group, X group: rubber skin regeneration ointment, M group: no traditional Chinese medicine ointment group. "P<0.05, representing a significant difference compared with the M group; “P<0.01, representing a very significant difference compared with the M group. “P<0.05, which means it is significant compared with group X.
BRIEF DESCRIPTION OF THE FIGURES Figure 1 shows the wound healing in each time period, S group: traditional Chinese medicine ointment group, X group: rubber skin regeneration ointment, M group: no traditional Chinese medicine ointment group.
DESCRIPTION OF THE INVENTION The composition and compatibility of a traditional Chinese medicine ointment formula for treating animal trauma: Radix Arnebiae decoction pieces: Boswellia carterii decoction pieces: Commiphora myrrha decoction pieces: Phellodendron chinense decoction pieces: Panax notoginseng decoction pieces: Daemonoropsdraco decoction pieces.: Borneol decoction pieces =15: 12: 8:
8: 2:2:1. The main material is medicinal soybean oil, and the auxiliary materials are vaseline, 7507050 beeswax and lanolin. Among them, that ratio of traditional Chinese medicine to adjuvant (except medicinal soybean oil) is 44% of traditional Chinese medicine powder, and the preparation method of an external traditional Chinese medicine ointment for treating animal trauma is as follows: (1) a certain amount of Panax notoginseng and Daemonoropsdraco are proportioned according to a certain proportion, and superfine grinding is carried out until the grinding particle size reaches 300 meshes for later use.
(2) A certain amount of Radix Arnebiae decoction pieces, Boswellia carterii decoction pieces, Commiphora myrrha decoction pieces and Phellodendron chinense decoction pieces are proportioned according to a certain proportion, and then crushed to 80 meshes for later use.
(3) According to the ratio of medicinal soybean oil to traditional Chinese medicine powder, itis 25 (mL): 8 (g).
(4) A certain amount of Radix Arnebiae, Boswellia carterii, Commiphora myrrha, and Phellodendron chinense powder are leached in a certain amount of medicinal soybean oil at 80°C and maintained at a constant temperature. The leaching time is 60 minutes with constant stirring during the extraction.
(5) Separating the above leaching solution, and removing impurities by centrifugal method: 3000 rpm, centrifuging for 10 minutes, and collecting the above filtrate.
(6) Heat the filtrate to about 80°C and keep the temperature constant. Add a certain amount of Panax notoginseng and Daemonoropsdraco powder, and fully stir.
(7) Add a certain amount of Borneol, stir well, and let it melt.
(8) Add a certain amount of vaseline (45%), lanolin (7%) and beeswax (4%), and stir constantly to fully melt and mix.
(9) Packaging: quickly put a certain amount of liquid medicine into the prescribed medicine bottle while it is hot, and seal the bottle mouth after it is solidified.
(10) Sterilization: sterilize the sealed medicine bottle with Co60.
Usage: It is used to treat wounds of skin and deep tissues caused by various pathogenic factors.
Usage:
When applying, after cleaning the wound, apply the ointment evenly to the wound.
If it is 7507050 bandaged after application, use the medicine once every 2 days.
After application, do not bandage, and take the medicine once a day.
Claims (3)
1. À traditional Chinese medicine ointment for treating animal trauma, characterized in that it is prepared from the following raw materials: Chinese medicine ingredients: Radix Arnebiae, Phellodendron chinense, Boswellia carterii, Commiphora myrrha, Panax notoginseng, Daemonoropsdraco and Borneol; matrix ingredients: vaseline, lanolin and beeswax; liquid: medicinal soybean oil.
2. The traditional Chinese medicine ointment for treating animal trauma according to claim 1 is characterized in that the components in parts by weight are: Radix Arnebiae decoction pieces: Boswellia carterii decoction pieces: Commiphora myrrha decoction pieces: Phellodendron chinense decoction pieces: Panax notoginseng powder: Daemonoropsdraco powder: Borneol powder = 15: 12: 8: 8: 2: 2: 1; the main ingredient is medicinal soybean oil, and the auxiliary ingredients are vaseline, beeswax, and lanolin; among them, the ratio of Chinese medicine and auxiliary materials (except medicinal soybean oil) is: Chinese medicine powder is 44%, vaseline is 45%, lanolin is 7%, and beeswax is 4%.
3. The preparation method of traditional Chinese medicine ointment for treating animal trauma according to claim 1 is characterized by comprising the following steps: (1) the above-mentioned ratio of Panax notoginseng and Daemonoropsdraco are proportioned according to a certain proportion, and superfine grinding is carried out until the grinding particle size reaches 300 meshes for later use; (2) the above-mentioned ratio of Radix Arnebiae decoction pieces, Boswellia carterii decoction pieces, Commiphora myrrha decoction pieces and Phellodendron chinense decoction pieces are proportioned according to a certain proportion, and then crushed to 80 meshes for later use; (3) the ratio of medicinal soybean oil to traditional Chinese medicine powder is 25 (mL): 8 (9); (4) the above-mentioned ratio of powder of Radix Arnebiae, Boswellia carterii, Commiphora myrrha and Phellodendron chinense is put into a certain amount of medicinal soybean oil at 80°C to be leached, and the constant temperature is maintained, and the leaching time is 60 minutes, during which it is continuously stirred;
(5) separating the above leaching solution, adopting centrifugal impurity removal method: 7507050 3000 rpm, centrifuging for 10 minutes, and collecting the filtrate;
(6) heating the filtrate to about 80°C and keeping the temperature constant; adding a certain amount of Panax nofoginseng powder and Daemonoropsdraco powder, and fully stir;
(7) add borneol in the above proportion, and fully stir until it is dissolved;
(8) add vaseline (45%), lanolin (7%) and beeswax (4%) in the above proportion, stir constantly to fully melt and mix, quickly put a certain amount of liquid medicine into the prescribed medicine bottle while it is hot, and seal the bottle mouth after it is solidified.
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| LU501050A LU501050B1 (en) | 2021-12-21 | 2021-12-21 | Chinese medicinal ointment for treating animal trauma and preparation method thereof |
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| LU501050A LU501050B1 (en) | 2021-12-21 | 2021-12-21 | Chinese medicinal ointment for treating animal trauma and preparation method thereof |
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2021
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| FG | Patent granted |
Effective date: 20220621 |