LU500069B1 - Skin care product containing hyaluronic acid (or a salt thereof) and a plant stem cell extract - Google Patents

Abstract

The invention relates to a composition containing 0.03 to 3.0% by weight of hyaluronic acids and / or salts thereof, 0.01 to 1.5% by weight of an anti-glycation agent and 0.03 to 3.0% by weight of hyaluronic acids -% of a plant stem cell extract.

Description

SKIN CARE PRODUCT LU500069 Description The present invention is in the field of cosmetics and relates to a skin care product, in particular a composition for a mask or skin cream and the mask or skin cream. Numerous compositions, particularly in the form of masks and skin creams, are offered as skin care products to counteract the aging of the skin and to moisturize the skin. It is particularly desirable with such products that the moisture (supply) of the skin is improved, the number of wrinkles (skin folds) reduced, the elasticity of the skin increased, the skin's suppleness increased, the skin's radiance increased, the skin's freshness increased, the complexion is refined, any existing feeling of tension is reduced and / or reddening of the skin is reduced.

The compositions of masks and skin creams are at least partially aqueous, so that there is a breeding ground for microbial infestation. The microbial infestation can be remedied with preservatives. However, it is increasingly preferred to reduce the use of preservatives or to do without them entirely, among other things because preservatives can cause incompatibilities. It is also increasingly preferred to use predominantly natural solubilizers or surfactants.

It is therefore an object of the invention to provide a composition, in particular in the form of a mask or skin cream, which has at least one effect selected from i) improving the moisture (supply) of the skin, ii) reducing wrinkles in the skin (skin folds), iii) increase the elasticity of the skin, iv) increase the suppleness of the skin, v) increase the radiance of the skin, vi) increase the freshness of the skin, vii) refine the complexion, vili) reduce the feeling of tension and ix) reduce the redness of the Causes skin and is preferably poor in preservatives. The composition preferably contains a natural solubilizer or a natural surfactant.

At least one of the objects mentioned is achieved by a composition according to a first aspect of the invention, a mask according to a second aspect of the invention, a kit according to a third aspect of the invention, a skin cream according to a fourth aspect of the invention, a method according to a fifth aspect the

Invention, a use according to a sixth aspect of the invention and / or LU500069 a method according to a seventh aspect of the invention.

The term “a” can also be read as “at least one”. The verbs “comprise” and “contain” and their conjugations also include the verb “consist of” and its conjugations. The embodiments of any aspect or various aspects of the invention can be combined in any form, unless the context clearly indicates otherwise. In a first aspect, the invention comprises a composition containing 0.03 to 3.0% by weight of hyaluronic acids and / or salts thereof, 0.01 to 1.5% by weight of an anti-glycation agent and 0.03 to 3.0% by weight of a plant stem cell extract. The total of 100% by weight of the composition is formed in all embodiments of the invention preferably by water and optionally by further ingredients. The composition shows surprisingly good effects on the skin and is well tolerated The basic building block of hyaluronic acid is an aminodisaccharide composed of D-glucuronic acid and N-acetyl-D-glucosamine alternating in (1-3) - (1-4) -B-glycosidic bonds According to the invention, sodium salts of hyaluronic acid are preferably used as hyaluronic acids and / or salts thereof. Short- and / or long-chain, in particular short- and long-chain, hyaluronic acid are preferably used. An anti-glycation agent is a compound that inhibits glycation. Glycation plays a role in aging and changes in the collagen and laminin of the extracellular matrix. Glycation is the non-enzymatic reaction of glucose and other reducing sugars with proteins to form glycoproteins. In aldoses, glycation usually proceeds with condensation with free amino groups of the protein to form the Schiff base and subsequent Amadori rearrangement to the 1-deoxyketosyl derivative of the protein. In the further course, dehydration and cross-linking of proteins lead to "advanced glycation end products" (AGE). In the context of the invention, polyphenols and in particular isoquercetin are preferred as anti-glycation agents. Of course, the 2nd

Composition in addition to the one anti-glycation agent, preferably polyphenol, ~~ LU500069 particularly preferably contains isoquercetin, another or further anti-glycation agent (then a total of more than 1.5% by weight anti-glycation agent). Plant stem cell extracts and their production are known to the person skilled in the art, e.g. from Daniela, Lulli et al. “Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells” (Mediators of inflammation vol. 2012 (2012): 498373) known.

Further preferred embodiments are given in the subclaims.

The composition is preferably a liquid composition at room temperature (25 ° C). In other words, the composition is preferably a liquid (at room temperature (25 ° C)).

In a preferred embodiment, the composition contains 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, hylauronic acids and salts thereof, 0.03 to 0.5% by weight, preferably 0.04 to 0.1% by weight, anti-glycation agent and 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of a plant stem cell extract.

In a preferred embodiment, the composition contains 0.0001 to 1% by weight, preferably 0.001 to 0.5% by weight, particularly preferably 0.01 to 0.1% by weight, lecithin, 0.0001 to 1% by weight %, preferably 0.001 to 0.5% by weight, particularly preferably 0.01 to 0.3% by weight, gel former, 1 to 25% by weight, preferably 4 or 7 to 20% by weight, one or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms and at least 50% by weight, preferably at least 60 or 63% by weight, of water.

Lecithin is a natural dissolving agent or a natural surfactant. The composition of this embodiment surprisingly forms a physically stable single or multiphase system. A phase separation, in particular the formation of droplets due to oily or greasy compounds, or sedimentation or precipitation can not be observed. This is important for a 3 stable, effective and appealing product. Furthermore, this special LUS00069 composition helps with preservation, i.e. microbial stabilization. Lecithins are preferably derived from soy, sunflower, rapeseed, fish, milk and / or eggs, non-animal sources such as soy, sunflower and / or rapeseed being preferred. In the context of this invention, de-oiled lecithin fractions can be used. This means that the lecithins are essentially free of non-polar lipids such as fatty acids and triglycerides. The content of non-polar lipids such as fatty acids and triglycerides is then less than 3% by weight. The lecithins preferably contain a proportion of polar lipids (acetone-insoluble substance) of 90 to 100% by weight. The lecithins preferably comprise de-oiled fractions with a preferred content of phosphatidylcholine of 30% by weight to 100% by weight.

At least one gelling agent selected from the group consisting of alginic acid, alginates, agar-agar, carrageenan, locust bean gum, guar gum, guar hydroxypropyltrimonium chloride, tragacanth, gum arabic, karaya gum, tara gum, gellan, xanthan gum and sclerotium gum can be selected as the gelling agent. At least one gelling agent is particularly preferably selected from the group consisting of gellan, xanthan, sclerotium gum and guar hydroxypropyltrimonium chloride. The composition particularly preferably contains the three gelling agents gellan, xanthan and sclerotium gum.

Particularly preferred mono-, di- and trihydric alcohols having 2 to 6 carbon atoms are glycerol, ethanol, propylene glycol and / or pentylene glycol. The ethanol is preferably undenatured. In a preferred embodiment, the composition contains as an alcohol or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and 2 to 10% by weight of at least one further alcohol selected from monohydric, dihydric and trihydric alcohols with 2 to 6 carbon atoms, preferably a) 5 to 10% by weight ethanol or b) 1 to 5% by weight ethanol and 1 up to 5% by weight of glycerine.

4th

The combination contributes to the microbial and physical stability of the LU500069 composition. In a preferred embodiment, the composition is liquid, transparent and has one or more phases. Due to the special composition, the composition is liquid, transparent and single or multi-phase. In a preferred embodiment, the plant stem cell extract contains an extract from a callus culture of the Edelweiss (Leontopodium alpinum). The extract from the callus culture of the Edelweiss (Leontopodium alpinum) preferably contains leontopodic acid (leontopodic acid). The extract from the callus culture of the Edelweiss (Leontopodium alpinum) preferably contains a defined and reproducible amount of leontopodic acid (leontopodic acid).

In a preferred embodiment, the extract from the callus culture of Edelweiss (Leontopodium alpinum) is a glycerol-based extract.

In a preferred embodiment, the extract from a callus culture of Edelweiss (Leontopodium alpinum) is the crude extract or ECC55 from Daniela, Lulli et al. “Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells” (Mediators of inflammation vol. 2012 (2012): 498373).

In these embodiments, the composition contains one or more alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, preferably 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and b) 1 to 5% by weight of ethanol and 1 to 5% by weight of glycerin.

In a preferred alternative embodiment, the plant stem cell extract contains an extract from a callus culture of the lotus flower (Nelumbo nucifera). In this alternative embodiment, the composition preferably contains a bleaching agent. In this alternative embodiment, the composition contains, in a preferred embodiment, 0.1 to 1% by weight of an extract from the fruit of the pear (Pyrus communis) and / or 0.1 to 1% by weight of an extract from the real root Licorice (Glycyrrhiza glabra). In this 5 alternative embodiment, the composition contains as one alcohol or 1500069 several alcohols selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms, preferably 1 to 5% by weight propylene glycol, 1 to 5% by weight pentylene glycol and a) 5 to 10 weight percent ethanol.

The extract from the root of real liquorice (Glycyrrhiza glabra) preferably contains a defined and reproducible amount of glabridin. The extract from the root of real liquorice (Glycyrrhiza glabra) preferably contains at least 50% by weight of glabridin. Glabridin is used in cosmetics as a bleaching agent against pigment spots and for skin lightening. The extract from the root of the real sweet wood (Glycyrrhiza glabra) or glabridin is a bleaching agent in the sense of the alternative embodiment according to the invention.

In a preferred embodiment, the composition contains 0.001 to 1.0% by weight, preferably 0.01 to 0.1% by weight, glycyrrhizic acid and / or a salt thereof, 0.001 to 0.5% by weight, preferably 0 , 01 to 0.1% by weight, squalane, 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, extract from Dunaliella Salina, 0.001 to 0.5% by weight , preferably 0.01 to 0.1% by weight, tocopherol and 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, ergothioneine.

The compound glycyrrhizic acid or a salt thereof also includes glycyrrhizate, preferably dipotassium glycyrrhizate.

In a preferred embodiment, the composition contains no further preservatives in addition to the ingredients mentioned so far, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.

A particularly well-contracted product is thus obtained. Due to the special formulation of the composition, sufficient microbiological stability is achieved and critical preservatives are superfluous.

In a second aspect, the invention relates to a mask comprising a composition according to the invention and a carrier matrix, the composition according to the invention being arranged on and / or in the carrier matrix.

6th

In a preferred embodiment, the carrier matrix is (essentially) an LU500069 mechanical or shaping framework. In other words, the function of the carrier matrix is (essentially) to absorb the composition / liquid, transfer it to the skin and release it there again. In yet other words, the carrier matrix is suitable for absorbing the composition / liquid, transferring it to the skin and releasing it to the skin on the skin. The carrier matrix can contain organic and / or inorganic components. The ingredients can be natural and / or synthetic. It is crucial that the carrier matrix absorbs the composition / liquid and releases it on the skin to the skin. The carrier matrix can preferably be sterilized.

In a preferred embodiment, the mask is a face mask.

In a preferred embodiment, the carrier matrix is a cloth, a woven fabric or a fleece, in particular a cloth. In a preferred embodiment, regenerated fibers and / or cellulose fibers, in particular regenerated cellulose fibers, form the carrier matrix and / or the cloth, fabric or fleece. In other words, the carrier matrix preferably contains cellulose fibers, in particular regenerated cellulose fibers. Wipes made from regenerated cellulose fibers are preferred and are sold under the name Tencel ™.

A cellulose regenerated fiber cloth gives the skin a particularly good feel during use. A cellulose regenerated fiber cloth is more absorbent than cotton and is also extremely tear-resistant when it is soaked with the composition according to the invention.

In a preferred embodiment, the mask comprises a carrier matrix impregnated with the composition according to the invention, in particular a cloth impregnated with the composition according to the invention.

It should be particularly emphasized that in one embodiment the mask does not contain any further preservatives in addition to the compounds mentioned above, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.

7th

In a third aspect, the invention relates to a kit for producing an LU500069 mask according to the invention, the kit comprising a carrier matrix and a composition according to the invention. The kit preferably contains two compartments and the carrier matrix and the composition according to the invention are each arranged in one compartment in the kit. In one embodiment the kit is a plastic bag with two compartments. Each compartment is tightly sealed. The carrier matrix, in particular the cloth, is preferably sterile. In other words, the carrier matrix, in particular the cloth, was preferably sterilized. The composition according to the invention is microbially stable and does not have to (but can in certain embodiments) be sterilized. In addition to the ingredients mentioned herein, the composition according to the invention preferably contains no further preservatives. The carrier matrix preferably does not contain any preservatives.

Stored soaked carrier matrices or cloths require increased microbial stabilization through increased use of preservatives. By separating the carrier matrix and the composition according to the invention, the microbial stability of the product is increased and preservatives can be dispensed with. The kit is preferably designed in such a way that the two compartments are separated by a pressure-sensitive membrane. Pressure-sensitive means that the membrane loses its function (ruptures) when pressure is applied and the separation into two components is abolished. In other words, when pressure is exerted on the composition according to the invention in a compartment, pressure is also applied to the pressure-sensitive membrane, as a result of which the membrane tears and the composition according to the invention is applied to the carrier matrix. The mask is made directly from / in the kit. The consumer can then apply the freshly made mask. In other words, the consumer produces the mask by exerting pressure on the composition according to the invention and thus the pressure-sensitive membrane.

In a fourth aspect, the invention relates to a skin cream. In other words, in this aspect the composition according to the invention is a skin cream. The skin cream is in particular a face cream.

8th

For a skin cream, it is necessary, compared to certain preferred LU500069 embodiments of the first and second aspects of the invention, to increase the viscosity of the composition according to the invention and, if necessary, to add fats. The skin cream contains 0.03 to 3.0% by weight of hyaluronic acids and / or salts thereof, 0.01 to 1.5% by weight of an anti-glycation agent and 0.03 to 3.0% by weight of one plant stem cell extract. In a preferred embodiment, the anti-glycation agent is a polyphenol, particularly preferably isoquercetin.

In a preferred embodiment, the skin cream contains 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, hylauronic acids and salts thereof, 0.03 to 0.5% by weight, preferably 0.04 to 0.1% by weight, anti-glycation agent and 0.05 to 2.0% by weight, preferably 0.1 to 1.0% by weight, of a plant stem cell extract.

In a preferred embodiment, the plant stem cell extract contains an extract from a callus culture of the Edelweiss (Leontopodium alpinum). In a preferred alternative embodiment, the plant stem cell extract contains an extract from a callus culture of the lotus flower (Nelumbo nucifera). In this alternative embodiment, the composition preferably contains a bleaching agent. In this alternative embodiment, the composition contains, in a preferred embodiment, 0.1 to 1% by weight of an extract from the fruit of the pear (Pyrus communis) and / or 0.1 to 1% by weight of an extract from the real root Licorice (Glycyrrhiza glabra).

The extract from the root of the real sweet wood (Glycyrrhiza glabra) preferably contains a defined and reproducible amount of glabridin. The extract from the root of the real sweet wood (Glycyrrhiza glabra) preferably contains at least 50% by weight of glabridin. Glabridin is used in cosmetics as a bleaching agent against pigment spots and for skin lightening. The extract from the root of real liquorice (Glycyrrhiza glabra) or glabridin is a bleaching agent in the sense of the alternative embodiment according to the invention.

9

In a preferred embodiment, the composition contains 0.001 to 1.0 LU500069% by weight, preferably 0.01 to 0.1% by weight, glycyrrhizic acid and / or a salt thereof, 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, squalane, 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, extract from Dunaliella Salina, 0.001 to 0.5% by weight %, preferably 0.01 to 0.1% by weight, tocopherol and 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, ergothioneine. The compound glycyrrhizic acid or a salt thereof also includes glycyrrhizate, preferably dipotassium glycyrrhizate. In a fifth aspect, the invention relates to a method for anti-aging treatment of the skin, in particular the facial skin, wherein a composition according to the invention, a mask according to the invention and / or a skin cream according to the invention is applied to the skin, in particular facial skin.

The invention also relates to a method for at least one of i) improving the moisture (supply) of the skin, ii) reducing wrinkles in the skin (skin folds), iii) increasing the elasticity of the skin, iv) increasing the suppleness of the skin, v ) Increase the radiance of the skin, vi) increase the freshness of the skin, vii) refine the complexion, viii) reduce the feeling of tension and ix) reduce the reddening of the skin, in particular i) improve the moisture (supply) of the skin and / or ii ) Reduction of wrinkles in the skin (skin folds), the method comprising the application of a composition according to the invention, a mask according to the invention and / or a skin cream according to the invention to the skin, in particular facial skin.

The method is preferably a non-medical and / or cosmetic method.

In a preferred embodiment, the mask according to the invention and / or the skin cream according to the invention is applied to the skin for a period of 5 to 30 minutes, preferably 10 to 20 minutes, particularly preferably about 15 minutes. The composition according to the invention can also be applied to the skin for a period of more than 5 to 30 minutes, preferably 10 to 20 minutes, particularly preferably about 15 minutes; in particular, the composition according to the invention can remain on the skin after the LU500069 mask according to the invention and / or the skin cream according to the invention has been removed from the skin.

In a preferred embodiment, the composition according to the invention, the mask according to the invention and / or the skin cream according to the invention is applied one to three times a week, in particular once a week. In a preferred embodiment, the composition according to the invention, the mask according to the invention and / or the skin cream according to the invention is applied at least once a week, preferably once a week, for at least four weeks. When applying the composition according to the invention, the mask according to the invention and / or the skin cream according to the invention at least once a week, preferably once a week, for at least four weeks, the method is in particular a method for reducing wrinkles in the skin (skin folds) and / or for Increase in skin radiance. In a sixth aspect, the invention relates to the use of a composition according to the invention, a mask according to the invention, a kit according to the invention and / or a skin cream according to the invention for achieving at least one effect selected from i) improving the moisture (supply) of the skin, ii) reducing wrinkles in the skin (skin folds), iii) increase the elasticity of the skin, iv) increase the suppleness of the skin, v) increase the radiance of the skin, vi) increase the freshness of the skin, vii) refine the skin's appearance and viii) reduce the feeling of tension and ix) Reduction of the reddening of the skin, in particular i) improvement of the moisture (supply) of the skin, ii) reduction of wrinkles in the skin (skin folds). At least one of these effects is achieved by the composition according to the invention, the mask according to the invention, the skin cream according to the invention and / or the kit according to the invention.

11

In a seventh aspect, the invention relates to a method for producing a mask according to the invention, comprising - providing a composition according to the invention, - providing a carrier matrix, - applying the composition according to the invention to the carrier matrix. In a preferred embodiment, the application of the composition according to the invention to the carrier matrix comprises soaking the carrier matrix, preferably a cloth, in the composition according to the invention.

In a preferred embodiment, the method is carried out by the user / consumer of the mask.

The production is preferably carried out using the kit according to the invention, preferably with the kit containing two compartments and the carrier matrix and the composition according to the invention each being arranged in one compartment. Preferably the two compartments are separated by a pressure sensitive membrane. The application of the composition according to the invention to the carrier matrix preferably comprises exerting pressure on the compartment that contains the composition according to the invention in such a way that the pressure-sensitive membrane loses its function (tears) and the separation into two components is abolished. The composition according to the invention is pressed into the compartment which contains the carrier matrix. Thus, when pressure is exerted on the composition according to the invention and the pressure-sensitive membrane, the composition according to the invention is applied to the carrier matrix.

The mask is therefore preferably produced directly from / in the kit. The consumer can then apply the freshly made mask. In other words, the consumer makes the mask by applying pressure to the pressure sensitive membrane. Stored soaked wipes require increased microbial stabilization through increased use of preservatives. By separating the carrier matrix and the composition according to the invention, the microbial stability of the product is increased and preservatives can be dispensed with.

12th

The invention is explained further below with the aid of an example.

LU500069 Example 84 volunteers tested a face mask according to the invention with a composition according to the invention.

The subjects used the mask once a week for about 15 minutes for four weeks.

During the test phase, the subjects did not change their usual skin care routine.

The subjects rated the product after the first and fourth use.

The test subjects each received the masks as a kit.

The kit is a plastic bag with two compartments, each compartment being tightly sealed.

The two compartments are separated by a pressure sensitive membrane.

One compartment contains a sterilized regenerated cellulose fiber cloth (Tencel ™) as a carrier matrix and the other compartment contains the composition according to the invention (“serum”). The mask is made from the kit by the user.

The serum is applied to the regenerated cellulose fiber cloth by manually exerting pressure on the compartment containing the serum.

This tears the pressure-sensitive membrane and the serum is pressed into the compartment that contains the regenerated cellulose fiber cloth.

The serum is thus applied to the regenerated cellulose fiber cloth.

If necessary, the user can manually support the soaking of the regenerated cellulose fiber cloth in the serum, e.g. by kneading or applying further pressure.

Then the user opens the plastic bag, removes the mask and applies it to his face.

By separating the regenerated cellulose fiber cloth and serum, the microbial stability of the product is increased and preservatives can be dispensed with.

The serum is transparent and liquid at 25 ° C.

The serum contains 0.5% by weight of hyaluronic acids and / or salts thereof, 0.08% by weight of isoquercetin, 0.5% by weight of extract from a callus culture of edelweiss, 4% by weight of glycerine, 0, 05% by weight lecithin, 0.1% by weight gelling agent, 2.5% by weight ethanol, 2.5% by weight propylene glycol, 2.5% by weight pentylene glycol, 0.05% by weight Dipotassium glycyrrhizate, 0.05% by weight squalane, 0.05% by weight extract from Dunaliella Salina, 0.05% by weight tocopherol and 13

0.05 wt% ergothioneine.

The sum to 100% by weight of the serum is formed by LUS00069 water.

In addition to the ingredients mentioned so far, the serum does not contain any further preservatives, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof.

The serum is physically and microbially stable.

Most of the test persons rated the product very positively.

In particular, the following effects were confirmed: i) Improvement of the moisture (s supply) of the skin, ii) Reduction of wrinkles in the skin (skin folds), iii) Increasing the elasticity of the skin, iv) Increasing the suppleness of the skin, v) Increasing the Radiance of the skin, vi) increasing the freshness of the skin, vii) refining the complexion, viii) reducing the feeling of tension and ix) reducing the reddening of the skin.

In other words, the product is suitable for the anti-aging treatment of the skin.

The exact evaluation is summarized in Tables 1 to 3.

In the tables, the percentage indicates the percentage of the 84 test persons who rated the property accordingly.

It is also noticeable that the effects of reducing wrinkles in the skin (skin folds) and increasing the radiance of the skin were again increased between the first and fourth weeks. | Approval | Neutral position | Rejection | Mask feels very good on the skin after rapid absorption, remaining serum after 89% 5% 6% Table 1. 14

Evaluation after the first application LU500069 Increase in radiance of 63% 21% 15% skin Increase in elasticity of 83% 10% 7% skin Increase in suppleness 92% 5% 4% of skin Improve moisture (supply) of 81% 14% 5% skin Table 2. Evaluation after the fourth application Increase in the radiance of the 74% 18% 8% skin Increase in the elasticity of the 68% 21% 11% skin Improvement in the moisture (supply) of the 74% 14% 12% skin Table 3.

Claims (15)

Claims LU500069 1. Composition containing 0.03 to 3.0% by weight of hyaluronic acids and / or salts thereof, 0.01 to 1.5% by weight of an anti-glycation agent and 0.03 to 3.0% by weight % of a plant stem cell extract. 2. Composition according to at least claim 1, characterized in that the anti-glycation agent is isoquercetin. 3. Composition at least according to claim 1 or 2, characterized by 0.0001 to 1 wt .-% lecithin, 0.0001 to 1 wt .-% gel former, 1 to 25 wt .-% of an alcohol or more alcohols selected from , di- and trihydric alcohols with 2 to 6 carbon atoms and at least 50% by weight of water. 4. Composition according to at least one of the preceding claims, characterized in that the composition as an alcohol or more alcohols selected from mono-, di- and trihydric alcohols having 2 to 6 carbon atoms, 1 to 5 wt .-% propylene glycol, 1 to 5% by weight of pentylene glycol and 2 to 10% by weight of at least one further alcohol selected from monohydric, dihydric and trihydric alcohols having 2 to 6 carbon atoms. 5. Composition according to at least one of the preceding claims, characterized in that the composition is liquid, transparent and monophasic or multiphase. 6. Composition according to at least one of the preceding claims, 16 characterized in that LUS00069 a) the plant stem cell extract contains an extract from a callus culture of the lotus flower (Nelumbo nucifera) and the composition preferably contains a bleaching agent or b) the plant stem cell extract contains an extract from a Contains callus culture of edelweiss (Leontopodium alpinum). 7. Composition according to at least one of the preceding claims, characterized in that the composition 0.001 to 1.0 wt .-%, preferably 0.01 to 0.1 wt .-%, glycyrrhizic acid and / or a salt thereof, 0.001 to 0 , 5% by weight, preferably 0.01 to 0.1% by weight, squalane, 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, extract from Dunaliella Salina, Contains 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, tocopherol and 0.001 to 0.5% by weight, preferably 0.01 to 0.1% by weight, ergothioneine . 8. Composition according to at least one of the preceding claims, characterized in that the composition contains no further preservatives, in particular no p-hydroxybenzoic acid esters, benzoic acid and / or salts thereof. 9. Mask comprising a composition according to at least one of claims 1 to 8 and a carrier matrix, the composition being arranged on and / or in the carrier matrix. 10. Mask according to at least claim 9, characterized in that the carrier matrix contains cellulose fibers, in particular regenerated cellulose fibers. 11. Kit for producing a mask at least according to claim 9 or 10, wherein the kit comprises a carrier matrix and a composition according to at least one of claims 1 to 8. 17th 12. The composition of at least claim 1, wherein the composition | LV500069 is a skin cream. 13. A method for anti-aging treatment of the skin, wherein a composition according to at least one of claims 1 to 8, a mask according to at least one of claims 9 to 10 and / or a skin cream according to at least claim 12 is applied to the skin. 14. Use of a composition according to at least one of claims 1 to 8, a mask according to at least one of claims 9 to 10, a kit according to at least claim 11 and / or a skin cream according to at least claim 12 to achieve at least one effect selected from i) improvement the moisture (supply) of the skin, ii) reduction of skin wrinkles, iii) increase the elasticity of the skin, iv) increase the suppleness of the skin, v) increase the radiance of the skin, vi) increase the freshness of the skin, vii) refine the skin Skin texture and viii) reduction of feeling of tension. 15. A method for producing a mask at least according to claim 9 or 10, comprising - providing a composition according to one of claims 1 to 8, - providing a carrier matrix, - applying the composition according to one of claims 1 to 8 to the carrier matrix. 18th