LU101935B1 - Salicylic acid raspberry powder tablets and preparation method thereof - Google Patents

Salicylic acid raspberry powder tablets and preparation method thereof Download PDF

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Publication number
LU101935B1
LU101935B1 LU101935A LU101935A LU101935B1 LU 101935 B1 LU101935 B1 LU 101935B1 LU 101935 A LU101935 A LU 101935A LU 101935 A LU101935 A LU 101935A LU 101935 B1 LU101935 B1 LU 101935B1
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Prior art keywords
salicylic acid
raspberry powder
powder
acid raspberry
tablet
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LU101935A
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French (fr)
Inventor
Wenfang Zhang
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Qinghai Qicaihua Biological Tech Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the technical field of health food production, in particular to a salicylic acid raspberry powder tablet and preparation method thereof. The salicylic acid raspberry powder tablet is composed of salicylic acid raspberry powder, yak milk powder, starch, microcrystalline cellulose and sucrose. The salicylic acid raspberry powder tablet of the invention has obvious raspberry unique fragrance, suitable for sweet and sour, uniform and delicate texture, more comprehensive nutritional compatibility with yak milk powder, has antipyretic and analgesic effects, anti-inflammatory and anti-rheumatic effects, neuralgia, muscle pain, joint pain, and rheumatic pain have good relief effects and are easy to store and carry.

Description

| Salicylic acid raspberry powder tablets and preparation method thereof LU101935
TECHNICAL FIELD The invention relates to the technical field of health food production, in particular to a salicylic acid raspberry powder tablet and preparation method thereof.
BACKGROUND Raspberry is also known as Marlin, commonly known as tray, rubus, rose spinaceae, rubus is a perennial deciduous small berry fruit tree. The fruit is soft and juicy, with bright color and pleasant aroma. In addition to sugar, acid, amino acid, vitamin C and other ingredients, the fruit also contains a high content of anthocyanins, and rare tannins, SOD enzymes, flavonoids, raspberry ketones, salicylic acid and other physiological activities substance. Salicylic acid, ortho-hydroxybenzoic acid, is a simple phenolic fecal substance widely produced in plants. Salicylic acid exists in both free and bound forms in plants. Bound salicylic acid is formed by combining the hydroxyl group of free salicylic acid with glucose to prevent the excessive content of free salicylic acid from affecting the plant. In some specific cases, there is a conversion of bound salicylic acid It is free salicylic acid. Salicylic acid is natural aspirin. It has antipyretic and analgesic effects, anti-inflammatory and anti-rheumatic effects. It has a good relief effect on colds, fever, neuralgia, muscle pain, joint pain and rheumatic pain. Salicylic acid is ancient in raspberry fruit and leaves. It is a heat-reducing medicine for the treatment of flu and pharyngitis. Long-term consumption of raspberries has a certain preventive effect on cardiovascular and cerebrovascular diseases such as hypertension and atherosclerosis and colon cancer. Therefore, people are in urgent need of healthy ecological products that are healthy, safe and beneficial to the body and mind. Raspberry is the best choice as a plant berry with the same ee ————————
| | source of medicine and food. LU101935
SUMMARY OF THE INVENTION Based on the above problems, the object of the present invention is to provide a salicylic acid raspberry powder tablet and a preparation method thereof.
The invention provides a salicylic acid raspberry powder tablet, the salicylic acid raspberry powder tablet is composed of the following components by weight percentage: salicylic acid raspberry powder 8-45%, yak milk powder 18-70%, starch 5-15%, microcrystalline cellulose 2-16%, sucrose 4-15%.
Further, the salicylic acid raspberry powder tablet is composed of the following components by weight: 38% portion of salicylic acid raspberry powder, 39% yak milk powder, 12% starch, 5% microcrystalline cellulose, and 6% sucrose.
Further, the salicylic acid raspberry powder is obtained by washing, crushing, grinding, centrifuging, extracting, evaporating, dissolving and freeze-drying raspberries. The yak milk powder is commercially available yak milk powder. The invention also provides a method for preparing salicylic acid raspberry powder tablets, which specifically includes the following steps: Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing fresh raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 59, trichloroacetic acid and diethyl ether, shake well and extract for 12h, then centrifuge; Extract the upper ether water phase in the solution after centrifugation. The water phase is extracted twice more with ether, and then the ether water phase is combined; after the extracted ether water phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid to maintain the original performance of the sample. Step 2: Mixing, granulating, and tableting: Mix salicylic acid raspberry powder, yak milk -_—_—_—-_-—_—_—_—_—_—_—_—_—_—_—_—_— “—Æ—
| powder, starch, microcrystalline cellulose, and sucrose in the above proportions, and thehU101935 granulate, whole, and tablet to obtain salicylic acid Raspberry powder tablets. Beneficial effect of the present invention: The salicylic acid raspberry powder tablet of the present invention has obvious raspberry unique fragrance, suitable for sweet and sour, uniform and fine texture, more comprehensive nutrition with yak milk powder, has antipyretic and analgesic effects, anti-inflammatory and anti-rheumatic It has a good relief effect on cold, fever, neuralgia, muscle pain, joint pain and rheumatic pain; and it is easy to store and carry. The extraction method of raspberry salicylic acid adopts the ethanol extraction method, which simplifies the extraction step and saves time; the recovery rate of salicylic acid in the detected raspberry is 97%, which is generally higher than other extraction methods; freeze-drying technology is used Maintain the original performance of the product.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The technical solutions of the present invention will be described clearly and completely in conjunction with the embodiments below. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present invention. Example 1 A salicylic acid raspberry powder tablet, the salicylic acid raspberry powder tablet is composed of the following components by weight percentage: salicylic acid raspberry powder 45%, yak milk powder 44%, starch 5%, microcrystalline cellulose 2 %, sucrose 4%. A method for preparing salicylic acid raspberry powder tablets specifically includes the following steps:
| Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing freshU101935 raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 5% trichloroacetic acid and diethyl ether, shake well and extract for 12h, then centrifuge; Extract the upper ether water phase in the solution after centrifugation. The water phase is extracted twice more with ether, and then the ether water phase is combined; after the extracted ether water phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid to maintain the original performance of the sample. Step 2: Mixing, granulating, and tableting: after mixing 45% of salicylic acid raspberry powder prepared in step 1, 44% of commercially available yak milk powder, 5% starch, 2% microcrystalline cellulose and 4% sucrose Granulation, whole-graining and tabletting to prepare salicylic acid raspberry powder tablets. Example 2 A salicylic acid raspberry powder tablet, the salicylic acid raspberry powder tablet 1s composed of the following components by weight percentage: salicylic acid raspberry powder 38%, yak milk powder 18%, starch 13%, microcrystalline cellulose 16 %, sucrose 15%. A method for preparing salicylic acid raspberry powder tablets specifically includes the following steps: Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing fresh raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 5% trichloroacetic acid and diethyl ether, shake and extract for 12h, then centrifuge; Extract the upper ether aqueous phase in the solution after centrifugation. The aqueous phase is extracted twice again with ether, and then the ether aqueous phase is combined; after the extracted ether aqueous phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added
EE
| Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid t6.U101935 maintain the original performance of the sample.
Step 2: Mixing, granulating, and tableting: after mixing 38% of salicylic acid raspberry powder prepared in step 1, 18% of commercially available yak milk powder, 13% of starch, 16% of microcrystalline cellulose and 15% of sucrose Granulation, whole-graining and tabletting to prepare salicylic acid raspberry powder tablets.
Example 3 A salicylic acid raspberry powder tablet, the salicylic acid raspberry powder tablet is composed of the following components by weight percentage: salicylic acid raspberry powder 8%, yak milk powder 70%, starch 15%, microcrystalline cellulose 2 %, sucrose 2%. A method for preparing salicylic acid raspberry powder tablets specifically includes the following steps: Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing fresh raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 5% trichloroacetic acid and diethyl ether, shake and extract for 12h, then centrifuge; Extract the upper ether aqueous phase in the solution after centrifugation.
The aqueous phase is extracted twice again with ether, and then the ether aqueous phase is combined; after the extracted ether aqueous phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid to maintain the original performance of the sample.
Step 2: Mixing, granulating, and tableting: after mixing 8% of salicylic acid raspberry powder prepared in step 1, 70% of commercially available yak milk powder, 15% of starch, 2% of microcrystalline cellulose and 5% of sucrose Granulation, whole-graining and tabletting to prepare salicylic acid raspberry powder tablets.
Example 4 _—_
| 6 A salicylic acid raspberry powder tablet, the salicylic acid raspberry powder tablet i6.U101935 composed of the following components by weight percentage: salicylic acid raspberry powder 38%, yak milk powder 39%, starch 12%, microcrystalline cellulose 5 %, sucrose 6%. A method for preparing salicylic acid raspberry powder tablets specifically includes the following steps: Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing fresh raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 5% trichloroacetic acid and diethyl ether, shake and extract for 12h, then centrifuge; Extract the upper ether aqueous phase in the solution after centrifugation.
The aqueous phase is extracted twice again with ether, and then the ether aqueous phase is combined; after the extracted ether aqueous phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid to maintain the original performance of the sample.
Step 2: Mixing, granulating, and tableting: after mixing 38% of salicylic acid raspberry powder prepared in step 1, 39% of commercially available yak milk powder, 12% starch, 5% microcrystalline cellulose and 6% sucrose Granulation, whole-graining and tabletting to prepare salicylic acid raspberry powder tablets.
Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, and substitutions can be made to these embodiments without departing from the principle and spirit of the present invention And variations, the scope of the present invention is defined by the appended claims and their equivalents.

Claims (5)

; | Claims LU101935
1. À salicylic acid raspberry powder tablet, wherein that the salicylic acid raspberry powder tablet is composed of the following components by weight percentage: salicylic acid raspberry powder 8-45%, yak milk powder 18~70%, starch 5—15%, microcrystalline cellulose 2— 16%, sucrose 4—15%.
2. A salicylic acid raspberry powder tablet according to claim 1, wherein that the salicylic acid raspberry powder tablet is composed of the following components in weight percentage: 38% of salicylic acid raspberry powder, Yak milk powder 39%, starch 12%, microcrystalline cellulose 5%, sucrose 6%.
3. A salicylic acid raspberry powder tablet according to claim 1 or 2, wherein that aspberries are washed, crushed, ground, centrifuged, extracted, evaporated, dissolved and freeze-dried to obtain salicylic acid raspberry powder.
4. A method for preparing salicylic acid raspberry powder tablets, specifically including the following steps: Step 1: Preparation of salicylic acid raspberry powder: after washing and crushing fresh raspberries, fully grind the pulp and place it in a centrifuge tube, add an appropriate amount of 5% trichloroacetic acid and diethyl ether, shake well and extract for 12h, then centrifuge; Extract the upper ether water phase in the solution after centrifugation. The water phase is extracted twice more with ether, and then the ether water phase is combined; after the extracted ether water phase is vacuum-rotated to dryness, 50% methanol and 50% acetate buffer are added Solution, dissolve it to obtain free salicylic acid; use free freeze drying of free salicylic acid to maintain the original performance of the sample; Step 2: Mixing, granulating, and tableting: Mix salicylic acid raspberry powder, yak milk powder, starch, microcrystalline cellulose, and sucrose in the above proportions, and then granulate, whole, and tablet to obtain salicylic acid raspberry powder tablets. ===
LU101935A 2020-07-21 2020-07-21 Salicylic acid raspberry powder tablets and preparation method thereof LU101935B1 (en)

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LU101935A LU101935B1 (en) 2020-07-21 2020-07-21 Salicylic acid raspberry powder tablets and preparation method thereof

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Effective date: 20210126