LT5098B - Cream compositions for ageing skin - Google Patents

Abstract

The present invention claims compositions for creams against skin ageing comprising (in % by weight on total weight of composition) 0,04-9,5 of moisturizers, 2-11 softeners, 0,5-8,0 antioxidants, 1,5-8 emulsifiers, 0,0005-0,1 preservatives, 0-0,5 odorous composition. Compositions claimed comprise natural materials characterized by excellent moisturizing, regenerating and nourishing properties.

Description

The present invention relates to the field of cosmetics and relates to compositions of a complex of anti-aging creams for use in the care of developing facial skin, which contains moisturizing, emollient, healing and antioxidant ingredients which maintain, moisturize, heal and nourish the skin.

Skin aging is known to reduce water content. Aging changes in water-salt metabolism lead to dehydration, which is associated with a decrease in the amount of protein in the subcutaneous layer and their ability to swell and bind water. Decreased moisture in the skin, especially in the stratum Comeum, is the cause of its drying, which already causes the appearance of wrinkles and loss of elasticity. That's why cosmetology researchers around the world are working on cosmetic products that can retain moisture in the skin, normalizing the water's saline metabolism, forming a mechanical film on the skin's surface that prevents moisture from evaporating quickly.

In addition to the natural aging of the skin associated with the human age, the skin is constantly exposed to external factors that also cause it to age. One of the theories of skin aging is Harman's Free Radical Theory (Harman HJ, Fisher AB, "Antioxidant Defenses" in Oxygen and the Living Process, Gilbert DL (Editor), 1981; Darr D, FridovichI, "Free Radical in Cutaneus Biology" J . Invest. Dermatol.1994, 102, 671-675); Ilaccaeamep P. «Ceo6odHO paduKcuibHan meopuz cmapema». Humepebto c β.ΧαρΜαηοΜ. Hacmb 1, AjibMūHax Kocm &Med.l998; 2, 7-13). Free radicals resulting from exposure to ultraviolet rays, environmental pollutants, chemicals on the skin. initiates a chain reaction that results in a variety of degradation and degeneration processes resulting in skin cell inferiority and disruption of the regenerative process in the production of new cells in the basement membrane and increased evaporation of skin water through the damaged epidermis.

Over the past decade, anti-aging products have risen to one of the forefront in the cosmetics market. These cosmetics contain antioxidants, which neutralize free radicals and eliminate their activity.

From U.S. Pat. 4973473 (issued 1990) known to moisturize the skin (0.25-10% gluconamides, 0.2-2% mucopolysaccharides such as hyaluronic acid or its salts), 0.05-8% of the skin's structure proteins such as glycoproteins, collagen, elastin, etc. and 0.1-5% of skin-muscle-astringent agents such as arnica extract, lower alcohols, lactic acid, and others. However, aging or damaged skin is not enough, it needs vitamins, healing components and antioxidants.

Known hydrating dandruff cream for developing skin (RU Patent 2048803 A61K 7/00, 1995), in which the polysaccharide mitylan-glucose complex is the primary moisturizer. In said cream, polyethylsiloxane liquids form a film on the skin and prevent water from evaporating from the skin. However, isopropyl myristate and isopropyl palmitate in the composition are substances with pronounced comedogenic properties (skin pores clogging). Their effect on the skin is negative, not positive. The cream does not contain any antioxidant anti-aging agents or biostimulants necessary for the regeneration of aging skin.

The nearest known anti-aging cream, which contains vitamins (tetravit '), natural extracts as antioxidants, in addition to moisturizing and emollient components (RU Patent 2038073, A61K 7/48 1995). This cream contains the following antioxidants: Herbal Extracts: St. John's Wort or Spruce Shoots Extract, Ginseng or Chamomile + St John's Wort Extract; emollients: olive oil, cocoa butter, beeswax, hydrating agents: glycerol, urea, and ~ 70% water.

Extracts of various plants also have an anti-inflammatory function.

However, the cream base, the structuring agents have the side-effects of acetylated lanolin, a comedogenic substance. Beeswax and cocoa butter are potentially allergenic substances.

The emulsifier complex used in this cream gives a sufficiently "heavy" and "coarse" emulsion.

We have only discovered one patent (RU 2043764, 1995), which claims a face cream that uses cosmetic cedar balm (2.5-3.5% of the total composition) as a biologically active substance. This balm is uncharacterized in the patent description, so its properties and origin are unknown. It contains cosmetic cedar balm along with spirit walnut leaf extract, isop essential oil and olive oil. However, the base consisting of water with oxyethylated lanolin, stearin, stearate and olive oil gives' a heavy and bulky cream emulsion.

In today's market, there is a demand not for classic cosmetic products that meet the definition but for highly effective products that have regenerative, antioxidant or activating properties based on natural substances. All this has yet to be combined with aesthetic and sensory factors. The consumer does not like hard-to-absorb creams that leave an impression of oily appearance on the skin. Priority is given to light, quick-absorbing creams that leave an impression of matte skin. For this purpose it is necessary to use a completely different emulsifier complex consisting of hydrophilic and hydrophobic emulsifiers, together with activation of various bioactive substance complexes and obtaining a microemulsion with a particle diameter of up to 3 microns.

The object of the present invention is to provide formulations of creams that meet the requirements of today's face and neck creams from aesthetic and organoleptic point having moisturizing, antioxidant and activating effects. The present invention provides a series of anti-aging cream compositions: regenerating (type I), moisturizing (type II), anti-aging cream (III) and anti-wrinkle cream (type IV).

The present invention proposes the use of a range of natural substances such as Siberian cedar balm, sea buckthorn extract, ginkgo extract, calendula extract, vitamins and D-panthenol as bioactive components in cream compositions. In addition to healing properties of the skin, they also improve the blood circulation of the skin and play an antioxidant role.

The wetting (hydrating) agents of the present invention include low molecular weight alcohols such as hexadecanol, polyhydric alcohols such as glycerol, sorbitol, low molecular weight polyacrylamide, carbomer, phospholipid complex lecithin and mucopolysaccharide. Their compositions use from 1% to 9.5% by weight.

Emollients (emollients) include natural oils such as olive oil, grape seed oil, castor oil, cucumber oil, castor oil, and synthetic fats: octyldodecanol, arachidyl benehyl alcohol, dicapril ether. They act indirectly by softening the stratum corneum, reducing moisture loss to the outside and allowing the skin to moisturize itself. Their compositions use from 2 to 11% by weight.

Cream formulations are additionally supplemented with vitamins having antioxidant properties, such as vitamin A (retinol palmitate), vitamin E (tocopherol acetate) and vitamin C (ascorbic palmitate) or their compounds. Vitamins A, E and C included in the creams are a classic combination of anti-aging cosmetics. Their compositions use from 0.5 to 1.5% by weight.

In addition to the vitamins mentioned above, natural products such as marigold extract, sea buckthorn oil, Siberian cedar balm and D-panthenol also play an antioxidant role. Their compositions use from 1.0 to 7.0% by weight. Oils acting as emollients also have an antioxidant effect: primrose, grape seed, cucumber.

Emulsifiers for use in the present invention include emulsifiers consisting of hydrophilic and hydrophobic surfactants (P A V) such as cetearyl alcohol, cetearyl glucoside, arachidyl glucoside, Lauret 7 and ethyl linoleate. They form emulsion complexes, which allow structuring agents, bioactive materials, fats and water to form the desired microemulsion in special installations during the emulsification process. Triethanolamine is used as the EIA neutralizing agent. Their compositions use from 2.0 to 7.0% by weight.

Kinetin (phytohormone) and L-carnitine (vitamin B _T ) are used as cream structuring agents. Their compositions optionally use 0.6%.

If preservatives are used in the cream, they are the universal methylchloromethyl isothiazolinone (MCMI) and another preservative that provides for the isolation of gram-positive and gram-negative bacteria such as methyldibromoglutaronitrile. Their compositions use from 0.0005 to 0.1% by weight.

Castor oil is used as a solvent to dissolve Siberian cedar vermicelli.

The thickener and gelling agent in the compositions of the creams use a carbomer which also has moisturizing properties.

The amounts of the materials used in the compositions can be given in a very wide range, but it is important that both the amount of cosmetic effect and the proper consistency of the cream is ensured.

Material Characteristics

The main biologically active ingredient in all of the creams provided is Siberian Cedar {Pinus sibirica} Balm, a 1: 1 mixture of Siberian Cedar, a live blend of castor oil. It is an extremely active biological product which is rich in nutrients, unsaturated acids, essential oils, carotenoids, chlorophyll, complex of vitamins C, E, K, D, P, trace elements and macronutrients. Complex flavonoid complexes positively influence the immune system of living organisms and act as antioxidants. Siberian cedar balm is one of the most effective remedies for inflammatory and allergic skin conditions. Various clinical trials of cedar balm cosmetics for more than a decade have shown that either the balm itself has a strong healing effect on problem skin or a strong synergistic effect with other herbs. It is especially suitable where the body lacks essential polyunsaturated fatty acids. Because of its broad biological activity, it is included in all of the creams of the present invention. Its use in a cosmetic composition is described in RU patent no. 2043764, issued May 1995

Olive oil is another component that is included in all creams provided. It is high in unsaturated fatty acids such as about 60% linolenic acid, 15-20% oleic acid, 10-20% palmitic acid, 410% α-linolenic acid, tocopherol (vitamin E) 2000 IU, provitamin A, phytosterols. Olive oil is known as a softener in cosmetics, has regenerating and moisturizing properties, is suitable for sensitive, dry skin. Its use as a emollient in cosmetic compositions is described in U.S. Pat. 4488564.

Grape seed oil, which contains about 70% linoleic acid as a component, has a better penetration into the epidermis and a longer duration of action. By virtue of its antioxidant activity, it surpasses vitamins C and E, has anti-inflammatory effect, stimulates collagen synthesis, used in cosmetics for prevention of skin shrinkage, because it prevents evaporation of water from the skin. Its use in cosmetic compositions is described in RU patent no. 2180837, effective as of 27.03.2001.

Nutmeg (Primula Peris L.) oil contains about 70% linoleic acid and about 10% γ-linolenic acid. In cosmetics, it has a dual effect of reducing water evaporation from the epidermis and activating enzymes that promote cell division of the basal layer. Linoleic acid is one of the building blocks of the lipid membrane, and γ-linolenic acid not only penetrates deeper into the skin, but also strengthens the barrier that retains water in the skin. In healthy organisms, γ-linolenic acid is formed from linoleic by the action of the relevant enzymes. However, factors such as age, stress, diabetes, and so forth. this process is disrupted. The skin starts to lack γ-linolenic acid, so its external supplementation offers great benefits.

Castor oil has no irritating and sensitizing properties, is non-comedogenic, hardly oxidizing, has moisturizing and softening properties, used to treat burns, wounds, ulcers, dandruff.

Lecithin is a complex of phospholipids derived from soybeans, consisting of lecithin, cephalin, fatty acids and vitamins. It is a natural antioxidant rich in phosphorus, as well as a moisturizer and amphoteric emulsifier. Its use in cosmetic compositions is described in U.S. Pat. 6348199 (issued 2002).

Sea-buckthorn oil (Hippophae rhaminoides), rich in carotene, vitamins C, B _1? B ₆ , Pi, organic acids, flavonoids, coumarins, salicylic, ascorbic acids, phytostearins and others. used as one of the bioactive substances. Sea buckthorn oil is a complex complex with antioxidant and healing properties. It is used in cosmetics for the treatment and prevention of blackheads, as well as for the treatment of burns, scars, scaling of the skin and chipping. Except for its moisturizing, antioxidant effect, it is a unique composition of natural bioactive substances that has a positive effect on the skin, heals minor skin lesions and enhances its elasticity.

Cucumber oil (Borago oleum) γ - linoleic acid <40%, linolenic acid <25%. γ-Linoleic acid is produced in the body from linolenic acid and activates hormonal substances that have a major impact on many body functions, especially the skin. Linolenic acid is known to significantly reduce water evaporation from the skin. Therefore, apart from its functions as a natural emollient, it also plays the role of a skin firming agent.

Ginkgo biloba extract is used to improve peripheral blood flow. In addition, it has anti-inflammatory properties and absorbs UV rays.

Calendula (Callendula officinalis) extract contains essential oils allenulin, carotene, lycopene, organic acids, saponins, protein substances. It has bactericidal, regenerative, sedative properties, heals various skin diseases, wounds, eczema, minor burns.

Sorbitol - Shia Hydroxyl Aliphatic Alcohol (Glucitol) found in seaweed, rowan juice, starchy fruits. Because it is a highly hydroscopic material, it is used as a moisturizing component in cosmetics. It also influences the texture of the product, giving it extra softness, ductility and softness. It is a great substitute for glycerol and glycols in recipes. Its use in cosmetic products is described in EP no. 0277641.

Hyaluronic acid is a mucopolysaccharide analogous to that found in the human body. Hyaluronic acid is the medium for many reactions. It allows bioflavonoid activity to occur, binds water to the skin and prevents it from freezing at low temperatures. Hyaluronic acid forms a moisturizing film on the skin, which in turn allows the skin to heal faster. Its use in cosmetic compositions is described in U.S. Pat. 4303676,4582865, 4636524 and 4973473.

Polyacrylamide - a widely used anionic-type synthetic polymer that readily swells in water. Used as a thickener and gelling agent in cosmetic products. Swollen and bound by water, polyacrylamide holds it on the skin, giving it a refreshing feeling.

Soy sterols have an estrogenic effect, are used in cosmetics for dry and normal skin care and are included in the excellent emulsifiers described in U.S. Pat. 6348199.

Lauret 7 is a polyethylene glycol ether of lauryl alcohol having emulsifying properties and its use in cosmetic compositions is described in U.S. Pat. 6348199.

The water used in the present invention is distilled and serves both as a carrier for the cosmetic composition and as a moisturizer.

Most of the components of the compositions are obtained from Dragoco (AT) and BASF (DE).

The fragrance composition is from Jean Niel SA (France) and is intended for creams.

The compositions are prepared according to known procedures by individually preparing each phase and then mixing them. The main devices used in the production of creams are reactors, homogenizers and mixers of various sizes and uses.

The following are examples of the most suitable formulations of creams and their general method of production.

Examples of cream formulations

Type I cream (regenerating cream) composition,% by weight:

Hexadecane 5-7%

Hexadecanol 5-7%

Olive oil 3%

Cetearyl alcohol 1-2%

Cetearet 20 2-4%

Trilaureth phosphate 2-3%

Octyl stearate 2%

Glycerol stearate 5-6%

Lecithin 1%

Grape seed oil 1%

Castor oil 1%

Cucumber Oil 1%

Castor oil 1%

Siberian Cedar Balm 1%

Tocopherol Acetate (Vit. E) 0.5%

Retinol Palmitate (Vitamin A) 0.5%

Ascorbic palmitate (Vit. C) 0.5%

Scent composition 0.5%

Imidazolidinyl urea 0.3%

Methylchloroisothiazolinone / methylisothiazolinone (MCI / MI) 0.1%

Water remaining up to 100%.

Phase A: Add the following components to the container with mixer: cetearyl alcohol, Siberian cedar balm, ceteareth-20, trilaureth-4-phosphate, glycerol stearate, octyl stearate, hexadecane, hexadecanol and heat to 70 ° C with stirring. The temperature is then allowed to drop to 36-38 ° C, then added: olive oil, grape seed oil, nutmeg, cucumber, castor oil, and mix again until homogenous. The back adds lecithin and vitamins such as tocopherol acetate and retinol palmitate.

Phase B: The water is mixed with ascorbic palmitate and heated to 38 ° C with imidalzolidinyl urea and MCI / MI, D-panthenol added.

Phase A is mixed with phase B and stirred in the reactor until an emulsion is formed. After it has cooled to + 35 ° C, phase C: perfume composition is added. The mass is then homogenized and packaged.

Vitamins A, E and C included in the proposed formulation are a classic combination of anti-aging cosmetics. Vitamin A (retinol palmitate) is more present in this cream than in simple creams to activate the regenerative process. The proposed Type 1 cream meets all the requirements of anti-aging cosmetics, and is highly aesthetic and organoleptically pleasing.

The bioactive components of this cream have antioxidant and regenerative properties and also have water retention properties.

A type II cream formulation is proposed which contains special moisturizers along with bioactive substances.

II tin (moisturizing cream-eel). % by weight: Olive oil 3% Cetearyl alcohol 2% Cetearyl glucoside 3% Arachidyl glucoside 2% Grape seed oil 3% Glycerol stearate 8-10% Octyl stearate 6-8% Hexadecan 5% Dicapril ether 4-5% Carbomer 0.5% Triethanolamine 0.3% Marigold extract 5% Ginkgo Extract 0.5% Tocopherol acetate (vit. E) 0.5% Ethyl Linoleate 0.5% Ascorbic palmitate (vit. C) 0.5% Lecithin 1% Castor oil 1%

MCI / MI

A fragrant composition

0.0005% 0.3%

Water remaining up to 100%.

Phase A: Distilled water is mixed with the carbomer. For the carbomer

40 ° C and added marigold and ginkgo extracts, ascorbic palmitate, triethanolamine and MCI / MI.

Phase B: Fatty Fraction Components: Olive Oil, Cetearyl Alcohol, Cetearyl Glucoside, Dicaproyl Ether, Grape Seed Oil, Glyceryl Stearate, Octyl Stearate, Arachyldiglucoside, Ethyl Linoleate, Hexadecane, Lecithin, Siberian Cedar Balsam and Cilicin Colomic, a homogeneous mass will be formed. Phase A and B are further mixed and mixing is continued until the mass has cooled to +35 ° C.

Phase C: Phases A and B are mixed and when cooled to 35 ° C, the flavoring composition and vitamin E (tocopherol acetate) are added. Mix again and homogenise.

The resulting cream-gel has a light consistency, is organoleptically pleasing, leaves a feeling of freshness on the skin and does not feel any greasy film. Highly appreciated in clinical trials by recipients and dermatologists.

In this cream, the gel is obtained by the action of a carbomer as a gelling agent. It uses a complex of emulsifiers consisting of cetearyl glucoside, cetearyl alcohol together with arachidyl glucoside. The combination of Vitamin E and C forms an antioxidant shield.

Proposed type III cream (anti-aging),% by weight:

Hexadecane 3-5%

Isohexadecane 3-5%

Caprylic / capric acid triglyceride 8-10%

Olive oil 3%

Sorbitol 2-3% Polyacrylamide 2-3% Cetearyl glucoside 1-1.5% Cetearyl alcohol 1-2% Lauret 7 0.1% Tocopherol acetate (vit. A) 0.5-1% Soya sterols 1% Ascorb Silane (Vit. C) 0.5-1% Castor oil 1% Siberian Cedar Balm 1% D-panthenol 1% Hyaluronic acid 0.3% A fragrant composition 0.5% Methyldibromoglutaronitrile 0.04% MCI / MI 0.0005% Water remaining up to 100%. Phase A: Distilled water is mixed with sorbitol, polyacrylamide and

hyaluronic acid, ascorbic silane and D-panthenol. Allow to swell and heat to 42 ° C with stirring.

Phase B: Synthetic fats are added to the blender jar: Hexadecane, Isohexadecane, Triglyceride of caprylic / caproic acid, heated to 70 ° C with stirring. The following are added: olive oil, castor oil, soy sterols, Siberian cedar balm, emulsifier complex: cetearyl glucoside, cetearyl alcohol, Lauret 7.

Phases A and B are further mixed in the reactor, no longer heated, and stirring continues until the mixture cools to +35 ° C.

Phase C: Tocopherol acetate, flavoring composition and preservatives are added to the mass obtained by mixing phases A and B: methyldibromoglutaronitrile and

MCI / MI. The mass is stirred again in the reactor and then homogenized.

Special moisturizers are used in this type of cream: sorbitol, polyacrylamide and hyaluronic acid. Hyaluronic acid, together with Vitamin E and Vitamin C in this type of cream composition, forms a unique antioxidant complex in which all parts of the system activate each other. The fat components of the cream have been selected from a combination of synthetic and natural materials.

Combining the above fats and bioactive substances, we select the appropriate emulsifier complex consisting of cetearyl glucoside, cetearyl

of alcohol, Lauret-7. This complex gives a stable emulsion that is easily distributed on the skin.

Two substances are selected as preservatives for the said composition: methyldibromoglutaronitrile and MCI / ML One preservative is not sufficient for microbiological standards in the aging process. By using two preservatives, artificially aging the creams and testing archival specimens, the creams retain properties that meet bacterial (gram-positive and gram-negative), microbial, mold, fungal, yeast contamination standards.

The resulting cream composition is organoleptically pleasing, has moisturizing and antioxidant properties and has an original composition. The complex of hydrating substances gives a stronger moisturizing effect than single substances. The antioxidant complex of Siberian cedar balm, vitamin E and vitamin C has a long-lasting effect and one component of the complex activates another.

Suggested Type IV Cream Comnosis (Wrinkle Prevention),% by Weight: Hexadecan 3-5% Isohexadecane 3-5% Octyldodecanol 3-5% Olive oil 3%

1.5%

1.5% 1%

3.5%

0.3% 8%

1%

0.5%

0.3%

0.3%

0.5% 5%

0.5%

0.5% 1%

0.04% 0.0005%

Arachidylbenehyl alcohol

Polyacrylamide

Arachidyl glucoside

Cetearyl glucoside

Lauret 7

Glycerol

Castor oil

Soya sterols

L-chitin

Kinetin

Tocopherol acetate

Marigold extract

Sea buckthorn oil

D-panthenol

Siberian Cedar Balm

Methyldibromoglutaronitrile

MCI / MI

Water remaining up to 100%.

Phase A consists of water, glycerol, D-panthenol, marigold extract. They are all poured into a mixing bowl and heated to 38 ° C with stirring.

Phase B: It consists of hexadecane isohexane, octyldodecanol, arachidyl benehyl alcohol, arachidyl glucoside, cetearyl glucoside, Lauret 7. The solids are pulverized, mixed and heated to 60 ° C. After cooling to 36-38 ° C, castor oil, soy sterols, kinetin, L-carnitine, Siberian cedar balm, buckthorn oil are added. The mixture is stirred at the same temperature.

Phase C: Phases A and B are added to the reactor, stirred, preservatives methyldibromoglutaronitrile and MCI / MI added. After stirring at + 35 ° C, the resulting mass is homogenized.

The cream base consists of water, emulsifiers, synthetic and natural oils: hexadecane, isohexadecane, octyldodecanol, emulsifier complex selected from arachidyl glucoside, cetearyl glucoside, Lauret 7, soy sterols wounds.

The antioxidant complex includes marigold extract, sea buckthorn oil and Siberian cedar balm.

This cream contains a previously unidentified biologically active component - sea buckthorn oil.

Clinical Trials of Compositions

All four formulations of anti-aging creams have been clinically tested and well-evaluated by dermatologists. They all combine a moisturizing and antioxidant effect. All four proposed formulations allow for the production of a harmless, effective, stable hydrating and antioxidant cosmetic cream with a good texture and a pleasant scent.

The antioxidant effect was investigated by chemoluminescence peroxide oxidation of lipid models (lipid model exposed to peroxide, has a higher glow than lipid and cream mass model exposed to peroxide). The results of the study showed that the creams have an antioxidant effect and are able to neutralize free radicals by the action of creams.

Analysis of clinical trial results

Prior to using the regenerative cream, 17 volunteers underwent patch tests. Covered appliqués were placed on the inside of the forehead for 24 hours. The results of the study for all 17 volunteers - negative, i.e. the cream patches did not cause redness, allergies or other irritation.

The next step in the clinical trial was to apply the cream openly on clean face for 1 hour in the morning. The cream has good bioavailability, good absorption, no allergenic or irritant effects.

The third stage of clinical evaluation was characterized by parameters such as fatness, elasticity of skin, change in the appearance of wrinkles on the skin.

Each of the presented creams was distributed to 10 volunteers who had dry skin and used the creams for 1 month. After one month, dryness of most of the recipients was reduced, skin elasticity was partially or completely restored, and the appearance of wrinkles became more even. Those recipients who had dandruff or focal dermatitis repaired the skin after 7-12 days.

The hydrating properties of the creams were investigated using an electrometric system ^etc. Tecomskinsensor ⁿ (TECOM, Germany / Each cream was tested on four volunteers aged 35-55 with no visual fixation of skin pathologies. In the first stage, the electrodes were fixed at a distance of 3 cm from the skin without a cream, and the electrical conductivity was measured. in the table.

Average change in electrical conductivity of the facial skin under the action of the cream (derived from 4 doses)

Yesterday No. Type of cream Exposed facial skin electricity conductivity amplitude in relative in units without cream with cream 1. Type I cream 0.87 2.1 2. Type II cream 1.02 1.93 3. Type III cream 1.24 2.2 4. Type IV cream 0.96 2.14

Increased electrical conductivity indicates an increase in skin moisture, i.e. cream formulations have a moisturizing effect.

Thus, thanks to the original formula, the proposed creams have a complex effect on aging skin, moisturizing and antioxidant effect. Analyzing the results obtained experimentally and examining the clinical results, it can be concluded that the creams are non-toxic, non-irritating and allergenic, have anti-inflammatory effect, improve functional skin condition and can be used for dry, aging and normal skin care to slow the appearance of wrinkles dryness and premature aging.

Claims (7)

DEFINITION OF INVENTION 1. Anti-aging cream formulations containing moisturizers, emollients, antioxidants, emulsifiers and preservatives, characterized in that they contain 0.04 to 9.5% by weight of moisturizers, 2 to 11% by weight of emollients, 0 5 to 8% by weight of antioxidants, 1.5 to 8% by weight of emulsifiers, 0.0005 to 0.1% by weight of preservatives, 0 to 0.5% by weight of flavoring composition, and optionally 0.6% by weight skin-forming agents based on the total amount of the composition. Compositions according to claim 1, characterized in that the wetting agents are selected from hexadecanol, lecithin, glycerol, polyacrylamide, sorbitol and hyaluronic acid. Compositions according to claims 1 and 2, characterized in that the emollients are selected from olive oil, castor oil, dicapril ether, octyldodecanol and arachidylbenehyl alcohol. Compositions according to claims 1-3, characterized in that the antioxidants are selected from grape seed oil, castor oil, cucumber oil, vitamin A, vitamin E, vitamin C or compounds thereof, Siberian cedar balm, calendula extract, ginkgo oil, sea buckthorn oil and D-panthenol. Compositions according to claim 3, characterized in that the abovementioned vitamins are present in an amount of 0.5 to 1.5% by weight, based on the total amount of the composition. Compositions according to claims 1-4, characterized in that the emulsifiers are selected from cetearyl alcohol, cetearet 20, cetearyl glucoside, arachidyl glucoside, lecithin, ethyl linoleate, laureth 7 and soy sterols. 6. Compositions according to claims 1-5, wherein the preservatives are selected from methylchloroisothiazolinone / methylisothiazolinone and methyldibromoglutaronitrile. Compositions according to claims 1-6, characterized in that the structuring agents are selected from kinetin and L-carnitine.