LT4661B - Medikamentai prieš nevaisingumą ir vaisingumo skatinimui - Google Patents
Medikamentai prieš nevaisingumą ir vaisingumo skatinimui Download PDFInfo
- Publication number
- LT4661B LT4661B LT99-101A LT99101A LT4661B LT 4661 B LT4661 B LT 4661B LT 99101 A LT99101 A LT 99101A LT 4661 B LT4661 B LT 4661B
- Authority
- LT
- Lithuania
- Prior art keywords
- sperm
- lidocaine
- endometriosis
- peritoneal fluid
- pharmaceutical composition
- Prior art date
Links
- 208000000509 infertility Diseases 0.000 title claims abstract description 21
- 230000036512 infertility Effects 0.000 title claims abstract description 21
- 231100000535 infertility Toxicity 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 title claims abstract description 6
- 230000035558 fertility Effects 0.000 claims abstract description 15
- 239000003589 local anesthetic agent Substances 0.000 claims abstract description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 62
- 229960004194 lidocaine Drugs 0.000 claims description 59
- 238000011282 treatment Methods 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims description 8
- 229920002674 hyaluronan Polymers 0.000 claims description 8
- 229940099552 hyaluronan Drugs 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 4
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 4
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims description 4
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 210000000683 abdominal cavity Anatomy 0.000 claims description 3
- 229960003150 bupivacaine Drugs 0.000 claims description 3
- 229960002409 mepivacaine Drugs 0.000 claims description 3
- 229960001807 prilocaine Drugs 0.000 claims description 3
- 229960001549 ropivacaine Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 12
- 238000011835 investigation Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 210000003567 ascitic fluid Anatomy 0.000 description 50
- 201000009273 Endometriosis Diseases 0.000 description 30
- 238000011534 incubation Methods 0.000 description 29
- 210000004027 cell Anatomy 0.000 description 22
- 210000000265 leukocyte Anatomy 0.000 description 20
- 206010057249 Phagocytosis Diseases 0.000 description 14
- 239000002609 medium Substances 0.000 description 14
- 230000008782 phagocytosis Effects 0.000 description 14
- 230000016087 ovulation Effects 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 230000004083 survival effect Effects 0.000 description 9
- 230000000750 progressive effect Effects 0.000 description 8
- 230000004720 fertilization Effects 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 238000003744 In vitro fertilisation Methods 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 239000004809 Teflon Substances 0.000 description 5
- 229920006362 Teflon® Polymers 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 230000004899 motility Effects 0.000 description 5
- 210000003024 peritoneal macrophage Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000002939 deleterious effect Effects 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 210000000287 oocyte Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000001464 adherent effect Effects 0.000 description 3
- 230000003444 anaesthetic effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
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- 231100000502 fertility decrease Toxicity 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000027758 ovulation cycle Effects 0.000 description 3
- 230000035935 pregnancy Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000035899 viability Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 208000007514 Herpes zoster Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 210000001109 blastomere Anatomy 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
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- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 208000021267 infertility disease Diseases 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 208000007984 Female Infertility Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010021928 Infertility female Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- 229920002274 Nalgene Polymers 0.000 description 1
- 241000337007 Oceania Species 0.000 description 1
- 206010034238 Pelvic adhesions Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical class [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- 230000000996 additive effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
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- 239000006143 cell culture medium Substances 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 1
- 229960003608 clomifene Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000001733 follicular fluid Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 238000011221 initial treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002357 laparoscopic surgery Methods 0.000 description 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000029849 luteinization Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N mandelic acid Chemical compound OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940052264 other local anesthetics in atc Drugs 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 239000006174 pH buffer Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000003307 reticuloendothelial effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000019100 sperm motility Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100001265 toxicological assessment Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/800,737 US5977143A (en) | 1997-02-15 | 1997-02-15 | Medicament against infertility which reduces phagocytosis of spermatozoa in women |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT99101A LT99101A (en) | 2000-03-27 |
| LT4661B true LT4661B (lt) | 2000-05-25 |
Family
ID=25179227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT99-101A LT4661B (lt) | 1997-02-15 | 1999-08-12 | Medikamentai prieš nevaisingumą ir vaisingumo skatinimui |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5977143A (de) |
| EP (1) | EP1001771B1 (de) |
| JP (1) | JP3497513B2 (de) |
| KR (1) | KR20000071053A (de) |
| CN (1) | CN1248915A (de) |
| AT (1) | ATE295169T1 (de) |
| AU (1) | AU743346B2 (de) |
| BR (1) | BR9807370A (de) |
| CA (1) | CA2280685C (de) |
| DE (1) | DE69830176T2 (de) |
| EE (1) | EE9900346A (de) |
| ES (1) | ES2245022T3 (de) |
| HU (1) | HUP0001342A3 (de) |
| IL (1) | IL131267A0 (de) |
| IS (1) | IS5152A (de) |
| LT (1) | LT4661B (de) |
| LV (1) | LV12450B (de) |
| NO (1) | NO321663B1 (de) |
| NZ (1) | NZ337504A (de) |
| PL (1) | PL335419A1 (de) |
| SK (1) | SK110599A3 (de) |
| TR (1) | TR199901958T2 (de) |
| WO (1) | WO1998035676A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000053183A1 (en) * | 1997-02-15 | 2000-09-14 | Edelstam Inc. | Medicament against dysmenorrhoea and premenstrual syndrome |
| US8425892B2 (en) | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US9849102B2 (en) | 2010-05-19 | 2017-12-26 | Isifer Ab | Treatment for reducing inflammation |
| DK3364959T3 (da) * | 2015-10-23 | 2022-10-17 | Isifer Ab | Sammensætning til behandling af infertilitet hos et kvindeligt subjekt |
| KR101802090B1 (ko) * | 2016-09-26 | 2017-11-27 | 서울대학교산학협력단 | 탈락막 자궁내막 세포를 포함하는 자궁내막 손상의 치료용 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0507160A1 (de) | 1991-03-30 | 1992-10-07 | Teikoku Seiyaku Kabushiki Kaisha | Äusserliches auf der Haut anzuwendedes Lidocain enthaltendes Arzneimittel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2704147B1 (fr) | 1993-04-22 | 1995-07-21 | Leguern Jacques | Composition régénératrice des cellules et son application en milieu médical, vétérinaire et agricole. |
-
1997
- 1997-02-15 US US08/800,737 patent/US5977143A/en not_active Expired - Lifetime
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1998
- 1998-02-09 DE DE69830176T patent/DE69830176T2/de not_active Expired - Lifetime
- 1998-02-09 JP JP53582598A patent/JP3497513B2/ja not_active Expired - Lifetime
- 1998-02-09 KR KR1019997007322A patent/KR20000071053A/ko not_active Ceased
- 1998-02-09 CN CN98802557A patent/CN1248915A/zh active Pending
- 1998-02-09 TR TR1999/01958T patent/TR199901958T2/xx unknown
- 1998-02-09 HU HU0001342A patent/HUP0001342A3/hu unknown
- 1998-02-09 AU AU62703/98A patent/AU743346B2/en not_active Expired
- 1998-02-09 EE EEP199900346A patent/EE9900346A/xx unknown
- 1998-02-09 NZ NZ337504A patent/NZ337504A/xx not_active IP Right Cessation
- 1998-02-09 ES ES98904958T patent/ES2245022T3/es not_active Expired - Lifetime
- 1998-02-09 AT AT98904958T patent/ATE295169T1/de not_active IP Right Cessation
- 1998-02-09 PL PL98335419A patent/PL335419A1/xx unknown
- 1998-02-09 EP EP98904958A patent/EP1001771B1/de not_active Expired - Lifetime
- 1998-02-09 CA CA002280685A patent/CA2280685C/en not_active Expired - Lifetime
- 1998-02-09 IL IL13126798A patent/IL131267A0/xx unknown
- 1998-02-09 WO PCT/US1998/002267 patent/WO1998035676A1/en not_active Ceased
- 1998-02-09 SK SK1105-99A patent/SK110599A3/sk unknown
- 1998-02-09 BR BR9807370-2A patent/BR9807370A/pt not_active IP Right Cessation
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1999
- 1999-08-11 IS IS5152A patent/IS5152A/is unknown
- 1999-08-12 LT LT99-101A patent/LT4661B/lt not_active IP Right Cessation
- 1999-08-13 NO NO19993921A patent/NO321663B1/no not_active IP Right Cessation
- 1999-09-08 LV LVP-99-119A patent/LV12450B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0507160A1 (de) | 1991-03-30 | 1992-10-07 | Teikoku Seiyaku Kabushiki Kaisha | Äusserliches auf der Haut anzuwendedes Lidocain enthaltendes Arzneimittel |
Non-Patent Citations (11)
| Title |
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| A.F. HANEY ET AL.: "Peritoneal Fluid Cell Populations in Infertility Patients", FERTILITY AND STERILITY, 1981, pages 696 - 698 |
| BAILEY-PRIDHAM DD ET AL.: "Follicular fluid lidocaine levels during transvaginal oocyte retrieval", FERTIL STERIL., 1990, pages 171 - 173 |
| CURRO, F.A. ET AL.: "Toxicological Assessment of Lidocaine in the Pregnant Rat", J DENT RES, 1985, pages 1214 - 1218 |
| GRETA A.B. EDELSTAM ET AL.: "Hyaluronan and Myeloperoxidase in Human Peritoneal Fluid During Genital Inflammation,", INFLAMMATION, 1994, pages 13 - 21 |
| J. HALME ET AL.: "Peritoneal Macrophages From Patients With Endometriosis Release Growth Factor Activity in Vitro", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 1988, pages 1044 - 1049 |
| JOUKO HALME: "Role of Periotoneal Inflammation in Endometriosis-associated Infertility", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1991, pages 266 - 274 |
| MUSCATO JJ, HANEY AF, WEINBERG JB.: "Sperm phagocytosis by human peritoneal macrophages: a possible cause of infertility in endometriosis", AM J OBSTET GYNECOL., 1982, pages 503 - 510 |
| OAK MK CHANTLER EN, VAUGHAN WILLIAMS CA, ELST: "Sperm Survival Studies in Peritoneal Fluid from Infertile Women with Endometriosis and Unexplained Infertility", CLINICAL REPRODUCTION AND FERTILITY, 1985), pages 297 - 303 |
| SUGINAMI H, YANO K, WATANABE K, MATSUURA S.: "A factor inhibiting ovum capture by the oviductal fimbriae present in endometriosis peritoneal fluid", FERTIL STERIL., 1986, pages 1140 - 1146 |
| TAHIR A MAHMOOD, TEMPLETON A. A.: "Pathophysiology of mild endometriosis. Review of Literature", HUMAN REPRODUCTION, 1990, pages 765 - 784 |
| ZIMMERMAN ER ET AL.: "Semen preparation with the Sperm Select system versus a washing technique", FERTIL STERIL., 1994, pages 269 - 275, XP002912258 |
Also Published As
| Publication number | Publication date |
|---|---|
| LV12450B (en) | 2000-10-20 |
| DE69830176T2 (de) | 2006-01-26 |
| US5977143A (en) | 1999-11-02 |
| EP1001771A1 (de) | 2000-05-24 |
| HUP0001342A3 (en) | 2000-10-30 |
| HUP0001342A2 (hu) | 2000-09-28 |
| EE9900346A (et) | 2000-02-15 |
| IL131267A0 (en) | 2001-01-28 |
| PL335419A1 (en) | 2000-04-25 |
| CA2280685A1 (en) | 1998-08-20 |
| DE69830176D1 (de) | 2005-06-16 |
| ATE295169T1 (de) | 2005-05-15 |
| EP1001771A4 (de) | 2000-09-27 |
| AU6270398A (en) | 1998-09-08 |
| ES2245022T3 (es) | 2005-12-16 |
| JP3497513B2 (ja) | 2004-02-16 |
| WO1998035676A1 (en) | 1998-08-20 |
| LV12450A (lv) | 2000-04-20 |
| CA2280685C (en) | 2004-06-29 |
| NO993921D0 (no) | 1999-08-13 |
| NZ337504A (en) | 2001-01-26 |
| SK110599A3 (en) | 2000-11-07 |
| AU743346B2 (en) | 2002-01-24 |
| NO321663B1 (no) | 2006-06-19 |
| CN1248915A (zh) | 2000-03-29 |
| KR20000071053A (ko) | 2000-11-25 |
| IS5152A (is) | 1999-08-11 |
| EP1001771B1 (de) | 2005-05-11 |
| BR9807370A (pt) | 2000-03-14 |
| NO993921L (no) | 1999-08-13 |
| LT99101A (en) | 2000-03-27 |
| JP2000513737A (ja) | 2000-10-17 |
| TR199901958T2 (xx) | 1999-12-21 |
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| MM9A | Lapsed patents |
Effective date: 20020209 |