LT2838888T - Tiadiazolidindionai kaip gsk-3 inhibitoriai - Google Patents
Tiadiazolidindionai kaip gsk-3 inhibitoriaiInfo
- Publication number
- LT2838888T LT2838888T LTEP13705492.0T LT13705492T LT2838888T LT 2838888 T LT2838888 T LT 2838888T LT 13705492 T LT13705492 T LT 13705492T LT 2838888 T LT2838888 T LT 2838888T
- Authority
- LT
- Lithuania
- Prior art keywords
- thiadiazolidinediones
- gsk
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382066 | 2012-02-24 | ||
| PCT/EP2013/053554 WO2013124413A1 (en) | 2012-02-24 | 2013-02-22 | Thiadiazolidinediones as gsk-3 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2838888T true LT2838888T (lt) | 2017-08-10 |
Family
ID=47747639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13705492.0T LT2838888T (lt) | 2012-02-24 | 2013-02-22 | Tiadiazolidindionai kaip gsk-3 inhibitoriai |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9371299B2 (pt-PT) |
| EP (1) | EP2838888B1 (pt-PT) |
| JP (2) | JP6073377B2 (pt-PT) |
| AU (2) | AU2013224041B2 (pt-PT) |
| CA (1) | CA2865351C (pt-PT) |
| CY (1) | CY1119231T1 (pt-PT) |
| DK (1) | DK2838888T3 (pt-PT) |
| ES (1) | ES2632428T3 (pt-PT) |
| HK (1) | HK1207366A1 (pt-PT) |
| HR (1) | HRP20170964T1 (pt-PT) |
| HU (1) | HUE035089T2 (pt-PT) |
| IN (1) | IN2014DN07885A (pt-PT) |
| LT (1) | LT2838888T (pt-PT) |
| NZ (1) | NZ630615A (pt-PT) |
| PL (1) | PL2838888T3 (pt-PT) |
| PT (1) | PT2838888T (pt-PT) |
| SI (1) | SI2838888T1 (pt-PT) |
| WO (1) | WO2013124413A1 (pt-PT) |
| ZA (1) | ZA201406225B (pt-PT) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2838888T (pt) | 2012-02-24 | 2017-07-18 | Asd Therapeutics Partners Llc | Tiadiazolidinedionas como inibidores da gsk-3 |
| KR102168088B1 (ko) | 2013-03-14 | 2020-10-20 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 상피 줄기 세포 확장 및 배양을 위한 조성물 및 방법 |
| CN106794175B (zh) * | 2014-06-12 | 2020-06-09 | 西达-赛奈医疗中心 | 用于治疗癌症的组合物 |
| IL299964A (en) | 2014-09-03 | 2023-03-01 | Massachusetts Inst Technology | Preparations, systems and methods for producing hair cells in the inner ear to treat hearing loss |
| CA3010610A1 (en) | 2016-01-08 | 2017-07-13 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| CA3048220A1 (en) | 2016-12-30 | 2018-07-05 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| EP3837352A1 (en) | 2018-08-17 | 2021-06-23 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
| BR112021007208A2 (pt) * | 2018-10-16 | 2021-08-10 | Italia Technology Alliance S.R.L. | máquina de enrolamento com um sistema de avaliação do material de manta sendo processado e método |
| US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1286964B1 (en) | 2000-05-11 | 2007-07-04 | Consejo Superior de Investigaciones Cientificas | Heterocyclic inhibitors of glycogen synthase kinase gsk-3 |
| ES2166328B1 (es) * | 2000-05-11 | 2003-09-16 | Consejo Superior Investigacion | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
| EP1586318A1 (en) * | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinones as GSK-3 inhibitors |
| KR100837785B1 (ko) * | 2007-01-17 | 2008-06-13 | 한국화학연구원 | 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물 |
| PT2838888T (pt) | 2012-02-24 | 2017-07-18 | Asd Therapeutics Partners Llc | Tiadiazolidinedionas como inibidores da gsk-3 |
-
2013
- 2013-02-22 PT PT137054920T patent/PT2838888T/pt unknown
- 2013-02-22 IN IN7885DEN2014 patent/IN2014DN07885A/en unknown
- 2013-02-22 SI SI201330704T patent/SI2838888T1/sl unknown
- 2013-02-22 AU AU2013224041A patent/AU2013224041B2/en active Active
- 2013-02-22 NZ NZ630615A patent/NZ630615A/en unknown
- 2013-02-22 PL PL13705492T patent/PL2838888T3/pl unknown
- 2013-02-22 EP EP13705492.0A patent/EP2838888B1/en active Active
- 2013-02-22 DK DK13705492.0T patent/DK2838888T3/en active
- 2013-02-22 JP JP2014558118A patent/JP6073377B2/ja active Active
- 2013-02-22 LT LTEP13705492.0T patent/LT2838888T/lt unknown
- 2013-02-22 US US14/380,623 patent/US9371299B2/en active Active
- 2013-02-22 CA CA2865351A patent/CA2865351C/en active Active
- 2013-02-22 WO PCT/EP2013/053554 patent/WO2013124413A1/en active Application Filing
- 2013-02-22 ES ES13705492.0T patent/ES2632428T3/es active Active
- 2013-02-22 HU HUE13705492A patent/HUE035089T2/hu unknown
-
2014
- 2014-08-25 ZA ZA2014/06225A patent/ZA201406225B/en unknown
-
2015
- 2015-08-14 HK HK15107867.8A patent/HK1207366A1/xx unknown
-
2016
- 2016-05-16 US US15/155,437 patent/US9469618B2/en active Active
-
2017
- 2017-01-04 JP JP2017000211A patent/JP6518270B2/ja active Active
- 2017-06-26 HR HRP20170964TT patent/HRP20170964T1/hr unknown
- 2017-07-12 CY CY20171100737T patent/CY1119231T1/el unknown
- 2017-10-20 AU AU2017248556A patent/AU2017248556B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150038538A1 (en) | 2015-02-05 |
| IN2014DN07885A (pt-PT) | 2015-04-24 |
| EP2838888B1 (en) | 2017-04-12 |
| DK2838888T3 (en) | 2017-07-17 |
| AU2013224041B2 (en) | 2017-08-24 |
| HUE035089T2 (hu) | 2018-05-02 |
| ZA201406225B (en) | 2016-05-25 |
| CY1119231T1 (el) | 2018-02-14 |
| PT2838888T (pt) | 2017-07-18 |
| SI2838888T1 (sl) | 2017-09-29 |
| EP2838888A1 (en) | 2015-02-25 |
| JP6518270B2 (ja) | 2019-05-22 |
| US9469618B2 (en) | 2016-10-18 |
| ES2632428T3 (es) | 2017-09-13 |
| HRP20170964T1 (hr) | 2017-10-06 |
| PL2838888T3 (pl) | 2017-12-29 |
| JP2015508092A (ja) | 2015-03-16 |
| US9371299B2 (en) | 2016-06-21 |
| NZ630615A (en) | 2015-09-25 |
| AU2017248556B2 (en) | 2018-08-09 |
| WO2013124413A1 (en) | 2013-08-29 |
| HK1207366A1 (en) | 2016-01-29 |
| AU2013224041A1 (en) | 2014-09-25 |
| AU2017248556A1 (en) | 2017-11-09 |
| CA2865351A1 (en) | 2013-08-29 |
| CA2865351C (en) | 2019-08-20 |
| JP6073377B2 (ja) | 2017-02-01 |
| JP2017081974A (ja) | 2017-05-18 |
| US20160257660A1 (en) | 2016-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1210775A1 (en) | Imidazotriazinecarbonitriles useful as kinase inhibitors | |
| HK1212348A1 (en) | Autotaxin inhibitors | |
| HK1208442A1 (en) | Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk | |
| HK1211921A1 (en) | Inhibitor compounds | |
| HK1201200A1 (en) | Substituted pyrrolidine-2-carboxamides -2- | |
| PT2920149T (pt) | Compostos de 3-aminocicloalquil como inibidores de ror-gama-t e utilizações dos mesmos | |
| HK1200830A1 (en) | Substituted pyrrolidine-2-carboxamides -2- | |
| HK1207366A1 (en) | Thiadiazolidinediones as gsk-3 inhibitors gsk-3 | |
| SG11201501173SA (en) | PI3Kδ INHIBITOR | |
| HK1206724A1 (en) | Substituted benzothienopyrimidines | |
| SG11201500973WA (en) | Amino-quinolines as kinase inhibitors | |
| HK1209422A1 (en) | Fbxo3 inhibitors fbxo3 | |
| HK1209105A1 (en) | Vegfr3 inhibitors vegfr3 | |
| HK1209104A1 (en) | Vegfr3 inhibitors vegfr3 | |
| EP2934541A4 (en) | NORIBOGAINE SUBSTITUTE | |
| HK1206022A1 (zh) | 取代的咪唑並噠嗪 | |
| GB201211019D0 (en) | Inhibitor compounds | |
| ZA201504305B (en) | Autotaxin inhibitors | |
| AP2015008541A0 (en) | Autotaxin inhibitors | |
| GB201216008D0 (en) | Novel use of GSK-3 inhibitors |