LT2013060A - Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas - Google Patents

Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas

Info

Publication number
LT2013060A
LT2013060A LT2013060A LT2013060A LT2013060A LT 2013060 A LT2013060 A LT 2013060A LT 2013060 A LT2013060 A LT 2013060A LT 2013060 A LT2013060 A LT 2013060A LT 2013060 A LT2013060 A LT 2013060A
Authority
LT
Lithuania
Prior art keywords
crystals
calcium hydroxyapatite
hours
dissolved
solution
Prior art date
Application number
LT2013060A
Other languages
English (en)
Other versions
LT6147B (lt
Inventor
Aivaras Kareiva
Original Assignee
Uab Mokslinių Tyrimų Plėtros Laboratorija
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Mokslinių Tyrimų Plėtros Laboratorija filed Critical Uab Mokslinių Tyrimų Plėtros Laboratorija
Priority to LT2013060A priority Critical patent/LT6147B/lt
Priority to EP14162300.9A priority patent/EP2810917B1/en
Publication of LT2013060A publication Critical patent/LT2013060A/lt
Publication of LT6147B publication Critical patent/LT6147B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • C01B25/324—Preparation from a reaction solution obtained by acidifying with an acid other than orthophosphoric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/025—Explicitly spheroidal or spherical shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0254—Platelets; Flakes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/027—Fibers; Fibrils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/10—Particle morphology extending in one dimension, e.g. needle-like
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/20—Particle morphology extending in two dimensions, e.g. plate-like
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/30—Particle morphology extending in three dimensions
    • C01P2004/32—Spheres
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/62—Submicrometer sized, i.e. from 0.1-1 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Išradimas priskiriamas prie cheminių junginių, pasižyminčių akyta struktūra, konkrečiai prie norimos morfologijos kalcio hidroksiapatito nanokristalų, skirtų skeleto sutrikimams gydyti, gavimo. Siūlomo išradimo tikslas – gauti norimos morfologijos ir dydžio kalcio hidroksiapatitių nanokristalus. Tikslas pasiekiamas tuo, kad siūlomame būde ruošia du tirpalus:a) 2,5-5,0 masės% kalcio acetato bei 1,2-2,4 masės % diamonio vandenilio tetroksofosfato atskirai ištirpina 80-120 ml distiliuoto vandens, juos maišo prie 25-65 oC; b)1,15-2,25 masės % vyno rūgšties (TA) tirpina 90-100 ml distiliuoto vandens, o 4,4-8,8 masės % etilendiamintetraacto rūgšties (EDTA), 5,85-11,7 masės % 1,2-diamincikloheksantetraacto (DCTA) ištirpina 100ml vandens ir 22ml 10 % amoniakinio vandens tirpale, maišo, tirpalą b) pila į tirpalą a), maišo 15-20 val. 65-75 oC, gautą gelį džiovina 20-24 h 100 oC, o sumaltą dar iškaitina 5 h 900-1200 oC. Keičiant kompleksą sudarančių reagentų (DCTA, EDTA ir TA) molinį santykį galima keisti kalcio hidroksiapatito paviršiaus morfologiją.
LT2013060A 2013-06-04 2013-06-04 Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas LT6147B (lt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LT2013060A LT6147B (lt) 2013-06-04 2013-06-04 Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas
EP14162300.9A EP2810917B1 (en) 2013-06-04 2014-03-28 A method for producing calcium hydroxyapatite nano-crystals of the desired morphology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2013060A LT6147B (lt) 2013-06-04 2013-06-04 Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas

Publications (2)

Publication Number Publication Date
LT2013060A true LT2013060A (lt) 2014-12-29
LT6147B LT6147B (lt) 2015-04-27

Family

ID=50389914

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2013060A LT6147B (lt) 2013-06-04 2013-06-04 Norimos morfologijos kalcio hidroksiapatito nanokristalų gavimo būdas

Country Status (2)

Country Link
EP (1) EP2810917B1 (lt)
LT (1) LT6147B (lt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109475473A (zh) 2016-07-14 2019-03-15 荷兰联合利华有限公司 包含含有阳离子杀菌剂的复合材料颗粒的口腔护理组合物
CN110885071B (zh) * 2019-12-17 2021-07-09 衢州学院 一种微米级超长钙基蠕虫状胶束模板及羟基钙磷灰石晶须
CN114886782B (zh) * 2022-05-07 2023-06-16 深圳市博威凯特科技有限公司 一种基于纳米羟基磷灰石的活态钙复合物及其制备方法和应用

Also Published As

Publication number Publication date
LT6147B (lt) 2015-04-27
EP2810917B1 (en) 2016-04-13
EP2810917A1 (en) 2014-12-10

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