LT2009032A - Alfa-hidroksialkilintų liekanų konversija biomolekulėse, naudojant metiltransferazes - Google Patents
Alfa-hidroksialkilintų liekanų konversija biomolekulėse, naudojant metiltransferazesInfo
- Publication number
- LT2009032A LT2009032A LT2009032A LT2009032A LT2009032A LT 2009032 A LT2009032 A LT 2009032A LT 2009032 A LT2009032 A LT 2009032A LT 2009032 A LT2009032 A LT 2009032A LT 2009032 A LT2009032 A LT 2009032A
- Authority
- LT
- Lithuania
- Prior art keywords
- alpha
- targeted
- conversion
- biomolecules
- methyltransferases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
- G01N2333/91011—Methyltransferases (general) (2.1.1.)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Šis išradimas apima alfa-hidroksialkilintų liekanų biomolekulėje tikslinę konversiją veikiant nukreipiančiajai metiltransferazei, būtent metiltransferazės taikiniuose esančių alfa-hidroksialkilo grupių pašalinimą, susidarant nemodifikuotoms liekanoms arba alfa-hidroksialkilintų grupių modifikuotose liekanose derivatizaciją, kovalentiškai prijungiant nekofaktorinius junginius, kurių formulė HQ-LX, kur X žymi funkcinę grupę arba reporterinę grupę, prijungtą per jungtuką L, ir QH yra parinktas išHS-, HSe-, HO- H2N-, HN3 arba HCN ir veikiant nukreipiančiajai metiltransferazei. Tolimesnis modifikuotų liekanų konversijos vystymas apima biomolekulės tikslinio žymėjimo būdą ir hidroksimetilintų liekanų biomolekulėje nustatymo (aptikimo) būdą pagal šį išradimą.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2009023A LT5708B (en) | 2009-04-02 | 2009-04-02 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
LT2009032A LT5706B (en) | 2009-04-02 | 2009-05-08 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
US13/262,738 US8889352B2 (en) | 2009-04-02 | 2010-04-01 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
US13/262,340 US8822146B2 (en) | 2009-04-02 | 2010-04-01 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
EP10712086.7A EP2414527B1 (en) | 2009-04-02 | 2010-04-01 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
PCT/EP2010/054437 WO2010115847A1 (en) | 2009-04-02 | 2010-04-01 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
EP10714602.9A EP2414528B1 (en) | 2009-04-02 | 2010-04-01 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
PCT/EP2010/054436 WO2010115846A1 (en) | 2009-04-02 | 2010-04-01 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
US14/542,770 US9505797B2 (en) | 2009-04-02 | 2014-11-17 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
US15/293,232 US20170067093A1 (en) | 2009-04-02 | 2016-10-13 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2009023A LT5708B (en) | 2009-04-02 | 2009-04-02 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
LT2009032A LT5706B (en) | 2009-04-02 | 2009-05-08 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
Publications (2)
Publication Number | Publication Date |
---|---|
LT2009032A true LT2009032A (lt) | 2010-11-25 |
LT5706B LT5706B (en) | 2011-01-25 |
Family
ID=42300437
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT2009023A LT5708B (en) | 2009-04-02 | 2009-04-02 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
LT2009032A LT5706B (en) | 2009-04-02 | 2009-05-08 | Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT2009023A LT5708B (en) | 2009-04-02 | 2009-04-02 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
Country Status (4)
Country | Link |
---|---|
US (4) | US8822146B2 (lt) |
EP (2) | EP2414527B1 (lt) |
LT (2) | LT5708B (lt) |
WO (2) | WO2010115846A1 (lt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
LT5708B (en) | 2009-04-02 | 2011-01-25 | Biotechnologijos Inst | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
US20120064521A1 (en) * | 2010-09-09 | 2012-03-15 | James Yen | Detection of dna hydroxymethylation |
AT511856A1 (de) * | 2011-09-01 | 2013-03-15 | Univ Graz Tech | Mittel und verfahren zur alkylierung |
GB201119903D0 (en) | 2011-11-17 | 2011-12-28 | Univ Vilnius | Nucleic acid production and sequence analysis |
GB201119904D0 (en) * | 2011-11-17 | 2011-12-28 | Univ Vilnius | Analysis of methylation sites |
EP3425065B1 (en) | 2011-12-13 | 2021-04-21 | Oslo Universitetssykehus HF | Methods and kits for detection of methylation status |
ES2669512T3 (es) | 2012-11-30 | 2018-05-28 | Cambridge Epigenetix Limited | Agente oxidante para nucleótidos modificados |
EP3280793A4 (en) * | 2015-04-06 | 2018-10-03 | The Regents of the University of California | Methods for determining base locations in a polynucleotide |
WO2017059245A2 (en) | 2015-09-30 | 2017-04-06 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
US11518779B2 (en) | 2018-07-09 | 2022-12-06 | Victoria Link Limited | Inhibitors of DNMT1 as anticancer therapeutic agents |
GB2580963B (en) * | 2019-02-01 | 2021-03-31 | Hemispherian As | Cancer therapies |
CN110470754B (zh) * | 2019-07-31 | 2021-05-04 | 武汉大学 | 一种高效液相色谱法测定虫草中虫草素含量的方法 |
WO2022023753A1 (en) | 2020-07-30 | 2022-02-03 | Cambridge Epigenetix Limited | Compositions and methods for nucleic acid analysis |
CN112730554B (zh) * | 2020-12-09 | 2022-09-09 | 山东师范大学 | 一种电极、包含该电极的生物传感器的制备及其在检测甲基转移酶中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI981790A0 (fi) | 1998-07-14 | 1998-08-20 | Markku Rosnell | Väline siiman käsittelmiseksi |
US6875750B1 (en) | 1998-07-29 | 2005-04-05 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Aziridine compounds and methods of making and using them |
EP1712557A1 (en) | 2005-04-14 | 2006-10-18 | RWTH Aachen | New s-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases |
US7465544B2 (en) | 2006-01-11 | 2008-12-16 | Wisconsin Alumni Research Foundation | Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use |
LT5708B (en) | 2009-04-02 | 2011-01-25 | Biotechnologijos Inst | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases |
-
2009
- 2009-04-02 LT LT2009023A patent/LT5708B/lt not_active IP Right Cessation
- 2009-05-08 LT LT2009032A patent/LT5706B/lt not_active IP Right Cessation
-
2010
- 2010-04-01 WO PCT/EP2010/054436 patent/WO2010115846A1/en active Application Filing
- 2010-04-01 WO PCT/EP2010/054437 patent/WO2010115847A1/en active Application Filing
- 2010-04-01 EP EP10712086.7A patent/EP2414527B1/en not_active Not-in-force
- 2010-04-01 EP EP10714602.9A patent/EP2414528B1/en not_active Not-in-force
- 2010-04-01 US US13/262,340 patent/US8822146B2/en not_active Expired - Fee Related
- 2010-04-01 US US13/262,738 patent/US8889352B2/en not_active Expired - Fee Related
-
2014
- 2014-11-17 US US14/542,770 patent/US9505797B2/en not_active Expired - Fee Related
-
2016
- 2016-10-13 US US15/293,232 patent/US20170067093A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
LT5706B (en) | 2011-01-25 |
EP2414528B1 (en) | 2014-05-07 |
US8889352B2 (en) | 2014-11-18 |
US20150093752A1 (en) | 2015-04-02 |
EP2414527A1 (en) | 2012-02-08 |
LT5708B (en) | 2011-01-25 |
US20170067093A1 (en) | 2017-03-09 |
WO2010115846A1 (en) | 2010-10-14 |
LT2009023A (lt) | 2010-10-25 |
US20120094280A1 (en) | 2012-04-19 |
WO2010115847A1 (en) | 2010-10-14 |
EP2414527B1 (en) | 2015-05-20 |
US8822146B2 (en) | 2014-09-02 |
EP2414528A1 (en) | 2012-02-08 |
US9505797B2 (en) | 2016-11-29 |
US20120088238A1 (en) | 2012-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 20210508 |