KR970700201A - NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-ALPHA-ALPHA-ALKYLAMINYLAMIDE FOR THE SYNTHESIS OF EL-ASPARTIL-DI- α-AMINOALKANOYL- (S) -N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS) - Google Patents

NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-ALPHA-ALPHA-ALKYLAMINYLAMIDE FOR THE SYNTHESIS OF EL-ASPARTIL-DI- α-AMINOALKANOYL- (S) -N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS)

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KR970700201A
KR970700201A KR1019960703374A KR19960703374A KR970700201A KR 970700201 A KR970700201 A KR 970700201A KR 1019960703374 A KR1019960703374 A KR 1019960703374A KR 19960703374 A KR19960703374 A KR 19960703374A KR 970700201 A KR970700201 A KR 970700201A
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cho
chemical mixture
aspartyl
artificial sweeteners
butyl
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안젤로 리홍 디
제임스 쥐. 스위니
조지 에이. 3세 킹
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에드와르토 엠, 카레라스
더 코카-콜라 컴파니
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Publication of KR970700201A publication Critical patent/KR970700201A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

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Abstract

본 발명은 인공 감미료 혼합물의 조합을 위해 사용될 수 있는 화학적 혼합물, 특히, L-아스파르틸-D-α-아미노알카노일-(S)-N-α-알킬벤질 아마이드의 조합을 위해 사용될 수 있는 화학적 중간 생성물에 관한 것이다.The present invention relates to the use of a chemical mixture which can be used for the combination of artificial sweetener mixtures, in particular for the combination of L-aspartyl-D- alpha -aminoalkanoyl- (S) -N- Chemical intermediates.

Description

인간 감미료로 사용할 수 있는 엘-아스파르틸-디-알파-아미노알카노일-(에스)-엔-알파-알킬벤질 아마이드의 합성용 새로운 중간 생성물(NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPATYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS)NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPATYL-D-ALPHA-ALPHA-ALKYLAMINYLAMIDE FOR THE SYNTHESIS OF EL-ASPARTIL-DI- α-AMINOALKANOYL- (S) -N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS)

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (35)

다음과 같은 구조를 갖는 D-아미노산-(S)-α-알킬벤질 아마이드로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of D-amino acid- (S) -? - alkylbenzyl amides having the following structure: 여기서 X = H, CO2CH2φ,CHO 또는 CO2-터셔리 - 부틸.Where X = H, CO 2 CH 2 Ph , CHO or CO 2 - tertiary-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3) CH 2 CH 3 또는 φ 그리고Or φ and R' = CH3, CH2CH3, CH(CH3)2, CH2CH2CH3, CH2CH2CH2CH3 R '= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH 2 CH 3, CH 2 CH 2 CH 2 CH 3 CH2CH(CH3)2, CH(CH3)CH2CH3, 또는 φCH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 , or φ 제1항에 있어서, 상기 D-아미노산-(S)-α-알킬벤질아마이드는 X = H, 그리고 R" = R' =CH2CH3를 갖는 상기 구조, X = H, 그리고 R" =CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = H, 그리고 R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = H, R" =CH(CH3)2그리고 R' = CH3를 갖는 상기 구조, X = H, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CO3CH2φ그리고 R" = R' = CH2CH3를 갖는 상기 구조, X =CO2CH2φ,R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X =CO2CH2φ,R" = CH2CH3, 그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ,R" = CH(CH3)2그리고 R' = CH3를 같는 상기 구조 X = CO2CH2φ, R" = CH(CH3)2, 그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO 그리고 R" = R' =CH2CH3를 갖는 상기 구조 X = CHO, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CHO, 그리고 R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조 그리고 X = CHO, R" = CH(CH3)2그리고 R' = CH2CH|3를 갖는 상기 구조로 구성되는 기(基)로부터 선택된 화학적 혼합물.The composition of claim 1 wherein said D-amino acid- (S) -? - alkylbenzylamide has the structure X = H and R "= R '= CH 2 CH 3 , X = H, and R" = CH 3 and R '= the structure having a CH 2 CH 3, X = H , and R "= CH 2 CH 3 and R' = the structure having a CH 3, X = H, R " = CH (CH 3) 2 and, the structure, X = H, R having a = CH 3 "= CH (CH 3) 2 and R 'R = CH 2 CH the structure having a 3, X = CO 3 CH 2φ and R" = R' = CH 2 CH 3 , X = CO 2 CH 2 ? , R "= CH 3 and R '= CH 2 CH 3 , X = CO 2 CH 2 ? , R" = CH 2 CH 3 , and R '= the structure having a CH 3, X = CH 2 CH 2φ, R "= CH (CH 3) 2 and R' = a CH 3 gatneun the structure X = CO 2 CH 2φ, R " = CH (CH 3 ) 2, and R '= the above structure, X = having a CH 2 CH 3 CHO and R "= R' = the structure having a CH 2 CH 3 X = CHO, R" = CH 3 and R '= CH 2 CH 3 , X = CHO, R " = CH 2 CH 3 and R '= the structure having a CH 3, X = CHO, and R "= CH (CH 3) 2 and R' = the structure having a CH 3 and X = CHO, R" = CH (CH 3) 2 and R '= CH 2 CH | chemical mixture selected from groups (基) consisting of the structure having a 3. 제1항에 있어서 X = H : 그리고 R" = R' = CH2CH3인 화학적 혼합물.And R "= R '= CH 2 CH 3 chemical mixture of claim 1, wherein X = H in. 제1항에 있어서 X = H : R" = CH3: 그리고 R' = CH2CH3인 화학적 혼합물.The method of claim 1, wherein X = H: R "= CH 3: and R '= CH 2 CH 3 chemical mixture. 제1항에 있어서 X = H : R" = CH2CH3: 그리고 R' = CH3인 화학적 혼합물.The chemical mixture according to claim 1, wherein X = H: R "= CH 2 CH 3 : and R '= CH 3 . 제1항에 있어서 X = H : R" = CH(CH3)2: 그리고 R' = CH3인 화학적 혼합물.The method of claim 1, wherein X = H: R "= CH (CH 3) 2: and R '= CH 3 the chemical mixture. 제1항에 있어서 X = H : R" = CH(CH3)2: 그리고 R' = CH2CH3인 화학적 혼합물.The chemical mixture according to claim 1, wherein X = H: R "= CH (CH 3 ) 2 and R '= CH 2 CH 3 . 제1항에 있어서 X = CHO 그리고 R" = R' = CH2CH3인 화학적 혼합물.X = CHO and R "= R '= CH 2 CH 3 chemical mixture according to claim 1. 제1항에 있어서 X = CH0 : R" = CH3: R' = CH2CH3인 화학적 혼합물. R "= CH 3:: R '= CH 2 CH 3 X = CH0 chemical mixture according to claim 1. 제1항에 있어서 X = CHO : R" = CH2CH3: 그리고 R' = CH3인 화학적 혼합물.The chemical mixture according to claim 1 wherein X = CHO: R " = CH 2 CH 3 : and R '= CH 3 . 제1항에 있어서 X = CH0 : R" = CH(CH3)2: 그리고 R' = CH3인 화학적 혼합물. R "= CH (CH 3) 2:: X = CH0 according to claim 1, and R '= CH 3 the chemical mixture. 제1항에 있어서 X = CHO : R" = CH(CH3)2: 그리고 R' = CH2CH3인 화학적 혼합물.The chemical mixture according to claim 1 wherein X = CHO: R " = CH (CH 3 ) 2 and R '= CH 2 CH 3 . 제1항에 있어서 X = C02CH2φ, : R" = R' = CH2CH3인 화학적 혼합물.The chemical mixture according to claim 1, wherein X = CO 2 CH 2 ? , wherein R "= R '= CH 2 CH 3 . 제1항에 있어서 X = C02CH2φ, : R" = CH3: 그리고 R' = CH2CH3인 화학적 혼합물.X = C0 2 CH 2φ, according to claim 1, wherein: R "= CH 3: and R '= CH 2 CH 3 chemical mixture. 제1항에 있어서 X = C02CH2φ, : R" = CH2CH3: 그리고 R' = CH3인 화학적 혼합물.The chemical mixture according to claim 1, wherein X = CO 2 CH 2 ? , R "= CH 2 CH 3, and R '= CH 3 . 제1항에 있어서 X = C02CH2φ, : R" = CH(CH3)2: 그리고 R' = CH3인 화학적 혼합물.The chemical mixture according to claim 1, wherein X = CO 2 CH 2 φ , R "= CH (CH 3 ) 2, and R '= CH 3 . 제1항에 있어서 X = C02CH2φ, : R" = CH(CH3)2: 그리고 R' = CH2CH3인 화학적 혼합물.X = C0 2 CH 2φ, according to claim 1, wherein: R "= CH (CH 3 ) 2: and R '= CH 2 CH 3 chemical mixture. 다음과 같은 구조를 갖는 D-아미노산-(S)-α-알킬벤질 아마이드로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of D-amino acid- (S) -? - alkylbenzyl amides having the following structure: 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and R' = CH3, CH2CH3, CH(CH3)2, CH2CH2CH3, CH2CH2CH2CH3, R '= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3, 또는 φCH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 , or φ 제18항에 있어서, 상기 (S)-α-알킬벤질 아마이드는 X = C02CH2φ, 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CHO 그리고 R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조 그리고 X = CHO, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조로 구성되는 기로부터 선택된 화학적 혼합물.19. The method of claim 18, wherein the (S) -α- alkyl benzylamide is X = C0 2 CH 2φ, and R "= R '= CH 2 having the structure CH 3, X = C0 2 CH 2φ, R" = CH 3 and R 'the structure having a = CH 2 CH 3, X = C0 2 CH 2φ, R "= CH 2 CH 3 and R' = CH 3 the above structure, X = CH 2 CH 2φ, R having" = CH (CH 3) 2 and R '= the above structure, X = having a CH 3 CH 2 CH 2φ, R "= CH (CH 3) 2 and R' = the structure having a CH 2 CH 3, X = CHO, R "= R '= the structure having a CH 2 CH 3, X = CHO , R" = CH 3 and R' = CH 2 above structure, X = having a CH 3 CHO, R "= CH 2 CH 3 , and R '= CH the structure, X = CHO having from 3 and R "= CH (CH 3) 2 and R' = CH wherein the structure having from 3 and X = CHO, R" = CH (CH 3) 2 and R '= CH chemical mixture selected from the group consisting of the structure having a 2 CH 3. 다음 구조를 갖는 L-아스파르틸-D-아미노산-(S)-α-알킬벤질 아마이드로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of L-aspartyl-D-amino acid- (S) -? - alkylbenzyl amides having the following structure: 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and R' = CH3, CH2CH3, CH(CH3)2, CH2CH2CH3, CH2CH2CH2CH3, R '= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH)CH2CH3, 또는 φCH 2 CH (CH 3 ) 2 , CH (CH) CH 2 CH 3 , or φ 제20항에 있어서, 상기 (S)-α-알킬벤질 아마이드는 X = C02CH2φ, 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2, 그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CHO 그리고 R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 그리고 X = CHO R" = CH(CH|3)2그리고 R' = CH2CH3를 갖는 상기 구조로 구성되는 기로부터 선택된 화학적 혼합물.21. The method of claim 20, wherein the (S) -α- alkyl benzylamide is X = C0 2 CH 2φ, and R "= R '= CH 2 having the structure CH 3, X = C0 2 CH 2φ, R" = CH 3 and R 'the structure having a = CH 2 CH 3, X = C0 2 CH 2φ, R "= CH 2 CH 3 and R' = CH 3 the above structure, X = CH 2 CH 2φ, R having" = CH (CH 3) 2, and R '= CH 3 the structure, X = having a CH 2 CH 2φ, R "= CH (CH 3) 2 and R' = the structure having a CH 2 CH 3, X = CHO , The structure having the above structure with R "= R '= CH 2 CH 3 , X = CHO, R" = CH 3 and R' = CH 2 CH 3 , X = CHO, R "= CH 2 CH 3 and R '= the structure having a CH 3, X = CHO and R "= CH (CH 3) 2 and R' = a with a CH 3 and X = CHO R" = CH ( CH | 3) 2 and R '= CH chemical mixture selected from the group consisting of the structure having a 2 CH 3. 다음 구조를 갖는 L-아스파르틸-D-아미노산-(S)-α-알킬벤질 아마이드로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of L-aspartyl-D-amino acid- (S) -? - alkylbenzyl amides having the following structure: 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and R' = CH3, CH2CH3, CH(CH3)2, CH2CH2CH3, CH2CH2CH2CH3, R '= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH2(CH3)2, CH(CH3)CH2CH3, 또는 φCH 2 CH 2 (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 , or φ 제22항에 있어서, 상기 (S)-α-알킬벤질 아마이드는 X = C02CH2φ, 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2, 그리고 R' = CH3를 갖는 상기 구조, X = CH2CH2φ, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CHO 그리고 R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조 그리고 X = CHO, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조로 구성되는 기로부터 선택된 화학적 혼합물.23. The method of claim 22, wherein (S) -α- alkyl benzylamide is X = C0 2 CH 2φ, and R "= R '= CH 2 having the structure CH 3, X = C0 2 CH 2φ, R" = CH 3 and R 'the structure having a = CH 2 CH 3, X = C0 2 CH 2φ, R "= CH 2 CH 3 and R' = CH 3 the above structure, X = CH 2 CH 2φ, R having" = CH (CH 3) 2, and R '= CH 3 the structure, X = having a CH 2 CH 2φ, R "= CH (CH 3) 2 and R' = the structure having a CH 2 CH 3, X = CHO , And the above structure with R "= R '= CH 2 CH 3 , X = CHO, R" = CH 3 and R' = CH 2 CH 3 , X = CHO, R "= CH 2 CH 3 and R '= the above structure, X = having a CH 3 CHO and R "= CH (CH 3) 2 and R' = the structure having a CH 3 and X = CHO, R" = CH (CH 3) 2 and R '= CH 2 chemical mixture selected from the group consisting of the structure having a CH 3. 다음 구조를 구성되는 보호된 L-아스파르틸-D-아미노산-(S)-α-알킬벤질아마이드로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of protected L-aspartyl-D-amino acid- (S) - alpha -alkylbenzyl amide, 여기서 X = H, C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = H, CO 2 CH 2 Ph , CHO or CO 2 - tertiary-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and R' = CH3, CH2CH3, CH(CH3)2, CH2CH2CH3, CH2CH2CH2CH3, R '= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3, 또는 φCH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 , or φ 제24항에서 있어서 상기된 (S)-α-알킬벤질 아마이드는 X = H, 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = H, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = H, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = H, R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조, X = H, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CO2CH2φ, R" = R' = CH|2CH3를 갖는 상기 구조, X = CO2CH2ψ, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CO2CH2φ, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조, X = CO2CH2φ,R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조, X = C02CH2φ, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO 그리고 R" = R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH3그리고 R' = CH2CH3를 갖는 상기 구조, X = CHO, R" = CH2CH3그리고 R' = CH3를 갖는 상기 구조 X = CHO 그리고 R" = CH(CH3)2그리고 R' = CH3를 갖는 상기 구조 그리고 X = CHO, R" = CH(CH3)2그리고 R' = CH2CH3를 갖는 상기 구조로 구성되는 기로부터 선택된 화학적 혼합물.(S) -? - alkylbenzyl amide of claim 24 wherein X = H and R "= R '= CH 2 CH 3 , X = H, R" = CH 3 and R' CH = CH (CH 3 ) 2 and R '= CH 3 , with the above structure with CH 2 CH 3 , X = H, R "= CH 2 CH 3 and R' = CH 3 , X = H, R "= CH (CH 3 ) 2 and R '= CH 2 CH 3 , X = CO 2 CH 2φ , R" = R' 2 CH 3 , X = CO 2 CH 2 ψ , R "= CH 3 and R '= CH 2 CH 3 , X = CO 2 CH 2 Φ , R" = CH 2 CH 3 and R' = the above structure, X = having a CH 3 CO 2 CH 2φ, R "= CH (CH 3) 2 and R '= CH 3 the structure, X = C0 2 CH 2φ, R having the" = CH (CH 3) 2 and the above structure with R '= CH 2 CH 3 , X = CHO and R "= R' = CH 2 CH 3 , X = CHO, R" = CH 3 and R '= CH 2 CH 3 the above structure, X = CHO, R "= CH 2 CH 3 , and R the structure having a '= the structure with CH 3 X = CHO and R" = CH (CH 3) 2 and R' = CH 3 having and X = CHO, R "= CH (CH 3) 2 and R '= CH 2 chemical mixture selected from the group consisting of the structure having a CH 3. 다음 구조를 갖는 L-아스파르틸-D-아미노산으로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of L-aspartyl-D-amino acids having the following structure: 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and Y = CH3,CH2φ또는 터셔리-부틸 : 그리고 X는 Y = CH2φ일때 CO2CH|2φ에 해당되지 않는다.Y = CH 3, CH 2φ or tert-butyl: and X is Y = CH 2φ when CO 2 CH | It does not correspond to 2φ . 제26항에서 있어서 상기 L-아스파르틸-D-아미노산은 X = CHO 그리고 R" = CH2CH3그리고 Y = CH3를 갖는 상기 구조 X = CHO, R" = CH3그리고 Y = CH3를 갖는 상기 구조 그리고 X = CHO, R" = CH(CH3)2그리고 Y = CH3를 갖는 상기 구조로 구성되는 기로부터 선택된 화학적 혼합물.In in claim 26 wherein the amino acid is L- aspartyl -D- X = CHO and R "= CH 2 CH 3 and Y = the structure with CH 3 X = CHO, R" = CH 3 and Y = CH 3 the structure and X = CHO, R "having a = CH (CH 3) 2 and chemical mixture selected from the group consisting of the structure having a Y = CH 3. 다음 구조를 갖는 D-아미노산 옥사졸리디논으로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of D-amino acid oxazolidinone having the following structure: 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R" = CH3, CH2CH3, CH(CH3)2, CH2CH|2CH3, CH2CH2CH2CH3, R "= CH 3, CH 2 CH 3, CH (CH 3) 2, CH 2 CH | 2 CH 3, CH 2 CH 2 CH 2 CH 3, CH2CH(CH3)2, CH(CH3)CH2CH3 CH 2 CH (CH 3 ) 2 , CH (CH 3 ) CH 2 CH 3 또는 φ 그리고Or φ and R' = H, CH3, CH2CH3, CH(CH3)2, C(CH3)|3, CH2CH2CH3, R '= H, CH 3, CH 2 CH 3, CH (CH 3) 2, C (CH 3) | 3 , CH 2 CH 2 CH 3 , CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, φ 또는 CCl3 CH 2 CH 2 CH 2 CH 3 , CH 2 CH (CH 3) 2, CH (CH 3) CH 2 CH 3, φ 3 or CCl 제28항에 있어서, X = C02CH2φ: 그리고30. The method of claim 28, X = C0 2 CH 2φ: and R" = CH3, CH2CH3, CH(CH3)2: 그리고 R "= CH 3, CH 2 CH 3, CH (CH 3) 2: and R' = H, C(CH3)2, φ 또는 CCl3 R '= H, C (CH 3) 2, φ 3 or CCl 다음과 같은 구조를 갖는 L-아스파르틱산 옥사졸리디논으로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물.A chemical mixture which can be used for the combination of artificial sweeteners consisting of L-aspartic acid oxazolidinone having the following structure. 여기서 X = C02CH2φ,CHO 또는 C02-터셔리 - 부틸.Where X = C0 2 CH 2φ, CHO or C0 2 - tert-butyl. R' = H, CH3, CH2CH3, CH(CH3)2, C(CH3)|3, CH2CH2CH3, R '= H, CH 3, CH 2 CH 3, CH (CH 3) 2, C (CH 3) | 3 , CH 2 CH 2 CH 3 , CH2CH2CH2CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, φ 또는 CCl3 CH 2 CH 2 CH 2 CH 3 , CH 2 CH (CH 3) 2, CH (CH 3) CH 2 CH 3, φ 3 or CCl 제30항에 있어서, X = C02CH2φ, 그리고 R' = H, C(CH3)3, φ 또는 CCl3,31. The method of claim 30, X = C0 2 CH 2φ, and R '= H, C (CH 3) 3, φ or CCl 3, 제30항에 있어서, X = C02CH2φ, 그리고 R' = C(CH3)3, φ 또는 CCl3,31. The method of claim 30, X = C0 2 CH 2φ, and R '= C (CH 3) 3, φ or CCl 3, N-카르보벤질옥시-N-하이드록시메틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, N-카르보벤질옥시-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, D-α-아미노부티릭산-(S)-에틸벤질 아마이드, β-메틸-N-포르밀-L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, β-메틸-N-카르보벤질옥시-L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, β-메틸-L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, (D)-3-카르보벤질옥시-4-에틸-5-옥사졸리디논, N-카르보벤질옥시-N-하이드록시메틸-L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드,N-카르보벤질옥시-L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, L-아스파르틸-D-α-아미노부티릭산-(S)-α-에틸벤질 아마이드, β-메틸-N-포르밀-L-아스파르틸-D-α-아미노부티릭산으로 구성되는 기로부터 선택된 혼합물로 구성되는 인공 감미료의 조합을 위해 사용할 수 있는 화학적 혼합물(S) -? - ethylbenzylamide, N-carbobenzyloxy-D-? -Aminobutyric acid - (S) -? - aminobutyric acid- α-aminobutyric acid- (S) -α-ethylbenzylamide, D- α-aminobutyric acid- (S) -ethylbenzylamide, β-methyl-N-formyl-L-aspartyl- (S) -? - ethylbenzylamide,? -Methyl-L-aspartyl-ethylbenzylamide,? -Methyl-N-carbobenzyloxy-L-aspartyl- (D) -3-carbobenzyloxy-4-ethyl-5-oxazolidinone, N-carbobenzyloxy-N-hydroxy (S) -? - ethylbenzyl amide, N-carbobenzyloxy-L-aspartyl-D-? -Aminobutyric acid- (S) (S) -? - ethylbenzyl amide,? -methyl-N-formyl-L-aspartyl-D-? - aminobutyric acid-L-aspartyl- Aminobutyric acid Chemical mixtures that can be used for the combination of an artificial sweetener consisting of a mixture selected from groups 제1항 내지 제 17항의 화학적 혼합물의 염에 있어서, 상기 염은 황산염, 말레이트, 염화 수소, 탄산염, 인산염, 구연산염, 아세테이트, 주석산염 그리고 안식향산염, 또는 다른 적당한 염들로 구성되는 기로부터 선택된 화학적 혼합물의 염.The salt of the chemical mixture of any one of claims 1 to 17, wherein the salt is selected from the group consisting of sulfate, maleate, hydrogen chloride, carbonate, phosphate, citrate, acetate, tartrate and benzoate, or other suitable salts. Salt of the mixture. 제24항과 제25항의 화학적 혼합물의 염에 있어서, X = H, 상기 염은 황산염, 말레이트, 염화 수소, 탄산염, 인산염, 구연산염, 아세테이트, 주석산염 그리고 안식향산염 그리고 적당한 다른 염인 화학적 혼합물의 염.The salt of the chemical mixture of claims 24 and 25 wherein X = H, the salt is a salt of a chemical mixture of a sulfate, maleate, hydrogen chloride, carbonate, phosphate, citrate, acetate, tartrate and benzoate and a suitable other salt .
KR1019960703374A 1993-12-22 1994-12-22 NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-ALPHA-ALPHA-ALKYLAMINYLAMIDE FOR THE SYNTHESIS OF EL-ASPARTIL-DI- α-AMINOALKANOYL- (S) -N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS) KR970700201A (en)

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NO962620D0 (en) 1996-06-20
FI962592A (en) 1996-06-20
CA2179376A1 (en) 1995-06-29
TW282450B (en) 1996-08-01
ZA9410199B (en) 1995-09-04
FI962592A0 (en) 1996-06-20
EP0736037A1 (en) 1996-10-09
IL111990A0 (en) 1995-03-15
WO1995017418A2 (en) 1995-06-29
NO962620L (en) 1996-08-19
AU1442995A (en) 1995-07-10
WO1995017418A3 (en) 1995-10-19
PE25195A1 (en) 1995-09-29
JPH09507076A (en) 1997-07-15

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