PE25195A1 - SYNTHESIS OF L-ASPARTIL-D-AMINOALCANOIL- (S) -O-ALKYLBENCIL AMIDE USED AS ARTIFICIAL SWEETENER - Google Patents
SYNTHESIS OF L-ASPARTIL-D-AMINOALCANOIL- (S) -O-ALKYLBENCIL AMIDE USED AS ARTIFICIAL SWEETENERInfo
- Publication number
- PE25195A1 PE25195A1 PE1994257675A PE25767594A PE25195A1 PE 25195 A1 PE25195 A1 PE 25195A1 PE 1994257675 A PE1994257675 A PE 1994257675A PE 25767594 A PE25767594 A PE 25767594A PE 25195 A1 PE25195 A1 PE 25195A1
- Authority
- PE
- Peru
- Prior art keywords
- aminoalcanoil
- alkylbencil
- aspartil
- synthesis
- artificial sweetener
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
Abstract
SE REFIERE AL COMPUESTO D-AMINO ACIDO-(S)-O-ALQUILBENCILAMIDA DE FORMULA I, DONDE: 1) X ES H, CH2CH2-ARILO, CHO, COO-TERTBUTILO; 2) R" ES UN ALQUILO C1-C4, ARILO; 3) R` ES UN ALQUILO C1-C4, ARILO; EL CUAL ES UN INTERMEDIO QUE PUEDE REACCIONAR POR DOS VIAS: 1) VIA DIPEPTIDO INTERMEDIO, 2) VIA AMINA INTERMEDIA; EN AMBOS CASOS SEGUIDAS DICHAS VIAS POR DESPROTECCION DE LOS GRUPOS FUNCIONALES, PRODUCIENDOSE EL ENDULZANTEREFERS TO D-AMINO ACID- (S) -O-ALKYLBENCILAMIDE COMPOUND OF FORMULA I, WHERE: 1) X IS H, CH2CH2-ARYL, CHO, COO-TERTBUTYL; 2) R "IS A C1-C4 ALKYL, ARYL; 3) R` IS A C1-C4 ALKYL, ARYL; WHICH IS AN INTERMEDIATE THAT CAN REACT IN TWO WAYS: 1) INTERMEDIATE VIA AMINA; IN BOTH CASES FOLLOWED, THESE WAYS FOR DEPROTECTION OF THE FUNCTIONAL GROUPS, PRODUCING THE SWEETENER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17199693A | 1993-12-22 | 1993-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE25195A1 true PE25195A1 (en) | 1995-09-29 |
Family
ID=22625935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1994257675A PE25195A1 (en) | 1993-12-22 | 1994-12-22 | SYNTHESIS OF L-ASPARTIL-D-AMINOALCANOIL- (S) -O-ALKYLBENCIL AMIDE USED AS ARTIFICIAL SWEETENER |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0736037A1 (en) |
JP (1) | JPH09507076A (en) |
KR (1) | KR970700201A (en) |
AU (1) | AU1442995A (en) |
CA (1) | CA2179376A1 (en) |
FI (1) | FI962592A0 (en) |
IL (1) | IL111990A0 (en) |
NO (1) | NO962620L (en) |
PE (1) | PE25195A1 (en) |
TW (1) | TW282450B (en) |
WO (1) | WO1995017418A2 (en) |
ZA (1) | ZA9410199B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5002196A (en) * | 1995-03-28 | 1996-10-16 | Novo Nordisk A/S | Immunosuppressive agents |
US8044173B2 (en) | 2005-09-13 | 2011-10-25 | University Of Reading | Asymmetric synthesis of peptides |
GB0518667D0 (en) * | 2005-09-13 | 2005-10-19 | Univ Reading The | Method |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411925A (en) * | 1980-01-21 | 1983-10-25 | Pfizer Inc. | Branched amides of L-aspartyl-d-amino acid dipeptides |
US4730076A (en) * | 1985-12-18 | 1988-03-08 | Nippon Kayaku Kabushiki Kaisha | Process for producing α-aspartyl-phenylalanine ester |
AT394854B (en) * | 1986-06-12 | 1992-07-10 | Biochemie Gmbh | Process for the preparation of N-L-alpha-aspartyl-L- phenylalanine (lower) alkyl esters |
DK0379917T3 (en) * | 1989-01-26 | 1995-12-11 | Bayer Ag | Optically active (meth) acrylic acid propellants, their preparation, their polymerization for optically active polymers and their use |
US5286509A (en) * | 1992-06-22 | 1994-02-15 | The Coca-Cola Company | L-aspartyl-D-α-aminoalkanoyl-(S)-N-alpha-alkylbenzyl amides useful as artificial sweeteners |
-
1994
- 1994-12-15 IL IL11199094A patent/IL111990A0/en unknown
- 1994-12-21 ZA ZA9410199A patent/ZA9410199B/en unknown
- 1994-12-22 AU AU14429/95A patent/AU1442995A/en not_active Abandoned
- 1994-12-22 KR KR1019960703374A patent/KR970700201A/en not_active Application Discontinuation
- 1994-12-22 EP EP95906070A patent/EP0736037A1/en not_active Withdrawn
- 1994-12-22 PE PE1994257675A patent/PE25195A1/en not_active Application Discontinuation
- 1994-12-22 JP JP7517595A patent/JPH09507076A/en active Pending
- 1994-12-22 CA CA002179376A patent/CA2179376A1/en not_active Abandoned
- 1994-12-22 WO PCT/US1994/014770 patent/WO1995017418A2/en not_active Application Discontinuation
-
1995
- 1995-01-16 TW TW084100341A patent/TW282450B/zh active
-
1996
- 1996-06-20 NO NO962620A patent/NO962620L/en unknown
- 1996-06-20 FI FI962592A patent/FI962592A0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW282450B (en) | 1996-08-01 |
ZA9410199B (en) | 1995-09-04 |
NO962620L (en) | 1996-08-19 |
FI962592A (en) | 1996-06-20 |
CA2179376A1 (en) | 1995-06-29 |
AU1442995A (en) | 1995-07-10 |
JPH09507076A (en) | 1997-07-15 |
IL111990A0 (en) | 1995-03-15 |
FI962592A0 (en) | 1996-06-20 |
KR970700201A (en) | 1997-01-08 |
EP0736037A1 (en) | 1996-10-09 |
WO1995017418A2 (en) | 1995-06-29 |
NO962620D0 (en) | 1996-06-20 |
WO1995017418A3 (en) | 1995-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |