KR970074778A - 피리미딘 유도체의 제조방법 - Google Patents

피리미딘 유도체의 제조방법 Download PDF

Info

Publication number
KR970074778A
KR970074778A KR1019960014538A KR19960014538A KR970074778A KR 970074778 A KR970074778 A KR 970074778A KR 1019960014538 A KR1019960014538 A KR 1019960014538A KR 19960014538 A KR19960014538 A KR 19960014538A KR 970074778 A KR970074778 A KR 970074778A
Authority
KR
South Korea
Prior art keywords
fluorophenylamino
methyl
dimethyl
tetrahydroisoquinolin
pyrimidine hydrochloride
Prior art date
Application number
KR1019960014538A
Other languages
English (en)
Other versions
KR0177294B1 (ko
Inventor
홍유화
이영남
김홍배
Original Assignee
김태훈
주식회사 유한양행
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19457730&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR970074778(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 김태훈, 주식회사 유한양행 filed Critical 김태훈
Priority to KR1019960014538A priority Critical patent/KR0177294B1/ko
Priority to IN1094DE1997 priority patent/IN186440B/en
Priority to AU27133/97A priority patent/AU712970B2/en
Priority to PCT/KR1997/000073 priority patent/WO1997042186A1/en
Priority to ES97920966T priority patent/ES2165052T3/es
Priority to RU98121687/04A priority patent/RU2174978C2/ru
Priority to PT97920966T priority patent/PT900214E/pt
Priority to DK97920966T priority patent/DK0900214T3/da
Priority to DE69706981T priority patent/DE69706981T2/de
Priority to EP97920966A priority patent/EP0900214B1/en
Priority to CN97194367A priority patent/CN1097591C/zh
Priority to AT97920966T priority patent/ATE206117T1/de
Priority to US09/171,579 priority patent/US5990311A/en
Priority to CA002253906A priority patent/CA2253906C/en
Priority to JP53975697A priority patent/JP3160297B2/ja
Priority to CNB021247854A priority patent/CN1190427C/zh
Priority to CA002358479A priority patent/CA2358479C/en
Publication of KR970074778A publication Critical patent/KR970074778A/ko
Publication of KR0177294B1 publication Critical patent/KR0177294B1/ko
Application granted granted Critical
Priority to HK99104379A priority patent/HK1019336A1/xx
Priority to JP2000198538A priority patent/JP2001055379A/ja
Priority to US09/667,428 priority patent/US6252076B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 하기 일반식(Ⅰ)의 화합물과 1-메틸-1,2,3,4-테트라히드로이소퀴놀린을 반응시켜 우수한 가역적인 프로톤펌프 저해효과로 위산분비를 효과적으로 억제하여 항궤양제로 사용가능한 5,6-디메틸-2-(4-플루오로페닐아미노)-4-(1-메틸-1,2,3,4-테트라히드로이소퀴놀린-2-일)피리미딘·염산염의 제조방법에 관한 것이다.
상기에서 Hal은 할로겐을 나타낸다.

Description

피리미딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(Ⅰ)의 화합물과 1-메틸-1,2,3,4-테트라히드로이소퀴놀린을 반응시키는 것을 특징으로 하는 5,6-디메틸-2-(4-플루오로페닐아미노)-4-(1-메틸-1,2,3,4-테트라히드로이소퀴놀린-2-일)피리미딘·염산염의 제조방법
    상기에서 Hal은 할로겐을 나타낸다.
  2. 제1항에 있어서, 반응용매가 N,N-디메틸포름아미드, n-부탄올, n-펜탄올, n-헥산올, 디메틸설폭사이드, 에틸렌글리콜, 1,2-프로필렌글리콜 또는 이들의 혼합물인 것을 특징으로 하는 5,6-디메틸-2-(4-플루오로페닐아미노)-4-(1-메틸-1,2,3,4-테트라히드로이소퀴놀린-2-일)피리미딘·염산염의 제조방법.
  3. 제1항 또는 제2항에 있어서, 염기가 트리에틸아민, N,N-디메틸아닐닌, 피리딘, 또는 포타슘아세테이트인 것을 특징으로 하는 5,6-디메틸-2-(4-플루오로페닐아미노)-4-(1-메틸-1,2,3,4-테트라히드로이소퀴놀린-2-일)피리미딘·염산염의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960014538A 1996-05-04 1996-05-04 피리미딘 유도체의 제조방법 KR0177294B1 (ko)

Priority Applications (20)

Application Number Priority Date Filing Date Title
KR1019960014538A KR0177294B1 (ko) 1996-05-04 1996-05-04 피리미딘 유도체의 제조방법
IN1094DE1997 IN186440B (ko) 1996-05-04 1997-04-29
CN97194367A CN1097591C (zh) 1996-05-04 1997-04-30 制备嘧啶衍生物的方法
CA002253906A CA2253906C (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives
ES97920966T ES2165052T3 (es) 1996-05-04 1997-04-30 Procedimiento para la preparacion de derivados de pirimidina.
RU98121687/04A RU2174978C2 (ru) 1996-05-04 1997-04-30 Способ получения производных пиримидина, промежуточные продукты и способ их получения
PT97920966T PT900214E (pt) 1996-05-04 1997-04-30 Processo para a preparacao de derivados da pirimidina
DK97920966T DK0900214T3 (da) 1996-05-04 1997-04-30 Fremgangsmåde til fremstilling af pyrmidin-derivater
DE69706981T DE69706981T2 (de) 1996-05-04 1997-04-30 Verfahren zur herstellung von pyrimidin-derivaten
EP97920966A EP0900214B1 (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives
AU27133/97A AU712970B2 (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives
AT97920966T ATE206117T1 (de) 1996-05-04 1997-04-30 Verfahren zur herstellung von pyrimidin-derivaten
US09/171,579 US5990311A (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives
PCT/KR1997/000073 WO1997042186A1 (en) 1996-05-04 1997-04-30 Process for preparation of pyrimidine derivatives
JP53975697A JP3160297B2 (ja) 1996-05-04 1997-04-30 ピリミジン誘導体の製造方法
CNB021247854A CN1190427C (zh) 1996-05-04 1997-04-30 制备嘧啶衍生物的方法
CA002358479A CA2358479C (en) 1996-05-04 1997-04-30 4-substituted-2-(4-fluorophenylamino)-5,6 dimethylpyrimidine
HK99104379A HK1019336A1 (en) 1996-05-04 1999-10-07 Process for preparation of pyrimidine derivatives
JP2000198538A JP2001055379A (ja) 1996-05-04 2000-06-30 １−メチル−１，２，３，４−テトラヒドロイソキノリンの製造方法
US09/667,428 US6252076B1 (en) 1996-05-04 2000-09-21 Process for preparation of pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960014538A KR0177294B1 (ko) 1996-05-04 1996-05-04 피리미딘 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR970074778A true KR970074778A (ko) 1997-12-10
KR0177294B1 KR0177294B1 (ko) 1999-03-20

Family

ID=19457730

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960014538A KR0177294B1 (ko) 1996-05-04 1996-05-04 피리미딘 유도체의 제조방법

Country Status (2)

Country Link
KR (1) KR0177294B1 (ko)
IN (1) IN186440B (ko)

Also Published As

Publication number Publication date
IN186440B (ko) 2001-09-01
KR0177294B1 (ko) 1999-03-20

Similar Documents

Publication Publication Date Title
KR870004030A (ko) 축합 이미다조 피리딘 유도체
KR950003267A (ko) 아미노-치환된 티오에테르의 제조방법
JP2006511635A5 (ko)
KR870007133A (ko) 1-아릴피라졸의 제조방법
RU98121687A (ru) Способ получения производных пиримидина
DK0900214T3 (da) Fremgangsmåde til fremstilling af pyrmidin-derivater
CA2272014A1 (en) N-aryl/heteroaryl-substituted heterocycles
RU2001103900A (ru) Усовершенствованный способ синтеза 5-метокси-2-[(4-метокси-3,5-диметил-2-пиридил)метил]сульфинил-1н-бензимидазола
KR970074778A (ko) 피리미딘 유도체의 제조방법
DK0806413T3 (da) 2-substituerede viatmin D3-derivater
KR960007594A (ko) 2,3- 다리걸친 1,4-디히드로피리딘, 그의 제조 방법 및 그의 약제로서의 용도
KR940018368A (ko) 알킬 2-알킬-4-플루오로메틸티아졸카르복실레이트의 제조방법
KR960037665A (ko) 트리아진 유도체의 제조방법
DK1558560T3 (da) Fremgangsmåde til fremstilling af 2,6-dihalogen-para-trifluormenthylanilin
KR840008146A (ko) N-페닐-n'-(피리디닐-n-옥사이드)우레아의 제조방법
KR890009879A (ko) 5- 아미노-1- 페닐-4-니트로피라졸의 제조방법
FI872980A0 (fi) Isokinolinfoereningar, vilka har en kvaevesubstituent i 4-positionen och vilka har kardiotona fosfodiesterasfraktion iii-inhiberade egenskaper och/eller njurvasodilatoriska egenskaper.
MXPA01008308A (es) Proceso para la preparacion de compuestos de 6-(perfluoroalquil) uracilo.
KR870010008A (ko) 1-아릴-5-아미노 피라졸의 제조방법
KR960022468A (ko) 클로로메틸피리딘의 제조방법
KR970006300A (ko) 벤질리딘 아미노에스테르 구조를 갖는 제초성 피리미딘 화합물의 제조방법
DK1405843T3 (da) Fremgangsmåde til fremstilling af aminostilbenderivater
KR970074772A (ko) 신규의 피리미딘 유도체 및 그의 제조방법
DE3271755D1 (en) 5-aminomethyl-2,3-dihydro-2-oxo-1h-imidazole-4-carboxylic acid derivatives
CA2117209A1 (en) 2-substituted-5-chlorimidazoles

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20130109

Year of fee payment: 16

FPAY Annual fee payment

Payment date: 20140110

Year of fee payment: 17

FPAY Annual fee payment

Payment date: 20150127

Year of fee payment: 18

FPAY Annual fee payment

Payment date: 20160108

Year of fee payment: 19

FPAY Annual fee payment

Payment date: 20180109

Year of fee payment: 21

FPAY Annual fee payment

Payment date: 20190129

Year of fee payment: 22

FPAY Annual fee payment

Payment date: 20200213

Year of fee payment: 23