KR970074758A - Title: Novel aryl isocyanide derivatives having inhibition of tyrosinase activity and inhibition of melanin biosynthesis and methods for producing the same - Google Patents

Title: Novel aryl isocyanide derivatives having inhibition of tyrosinase activity and inhibition of melanin biosynthesis and methods for producing the same Download PDF

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Publication number
KR970074758A
KR970074758A KR1019960014310A KR19960014310A KR970074758A KR 970074758 A KR970074758 A KR 970074758A KR 1019960014310 A KR1019960014310 A KR 1019960014310A KR 19960014310 A KR19960014310 A KR 19960014310A KR 970074758 A KR970074758 A KR 970074758A
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South Korea
Prior art keywords
inhibition
alkoxycarbonyl
hydroxy
alkyl
hydrogen
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KR1019960014310A
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Korean (ko)
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KR0171266B1 (en
Inventor
이현호
이영호
김경애
최종권
이상화
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성재갑
주식회사 Lg 화학
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Priority to KR1019960014310A priority Critical patent/KR0171266B1/en
Publication of KR970074758A publication Critical patent/KR970074758A/en
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Publication of KR0171266B1 publication Critical patent/KR0171266B1/en

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Abstract

The present invention relates to a novel arylisocyanide derivative of the general formula (I) having a tyrosinase activity inhibiting activity and a process for producing the same.

Wherein R, R 1 and R 2 represent each independently a hydrogen, methyl or methoxy, R 3 and R 4 are the case where R 3 is hydrogen R 4 is C 1 -C 4 alkoxycarbonyl C 1 -C 4 alkyl , C 1 -C 4 alkoxycarbonyl C 3 -C 4 alkenyl, C 3 -C 5 alkoxy unsubstituted or substituted by hydroxy or t-butyldimethylsilyloxy, hydroxy C 3 -C 5 alkyl Or when R 4 is hydrogen, R 3 is substituted by C 1 -C 4 alkoxycarbonyl C 1 -C 4 alkoxycarbonyl C 3 -C 4 alkenyl, hydroxy or t-butyldimethylsilyloxy, C 3 -C 5 alkoxy, hydroxyC 3 -C 5 alkyl.

Description

Title: Novel aryl isocyanide derivatives having inhibition of tyrosinase activity and inhibition of melanin biosynthesis and methods for producing the same

Since this is a trivial issue, I did not include the contents of the text.

Claims (8)

An aryl isocyanide derivative of general formula (I) Wherein R, R 1 and R 2 represent each independently a hydrogen, methyl or methoxy, R 3 and R 4 are the case where R 3 is hydrogen and R4 is C 1 -C 4 alkoxycarbonyl C 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonyl C 3 -C 4 alkenyl, C 3 -C 5 alkoxy unsubstituted or substituted by hydroxy or t-butyldimethylsilyloxy, hydroxyC 3 -C 5 alkyl or , When R 4 is hydrogen, R 3 is C 1 -C 4 alkoxycarbonyl C 1 -C 4 alkyl C 1 -C 4 alkoxycarbonyl C 3 -C 4 alkenyl, hydroxy or t-butyldimethylsilyloxy C 3 -C 5 alkoxy, hydroxy C 3 -C 5 alkyl, which is unsubstituted or substituted by hydroxy. 2. The compound according to claim 1, wherein R < 1 > and R < 2 > are hydrogen. A process for preparing a compound represented by the following general formula (I) by reacting a compound represented by the following general formula (III) in a solvent in the presence of a substituted sulfonyl chloride and a base. Wherein R 1 , R 2 , R 3 and R 4 are as defined in claim 1. The process according to claim 3, wherein the solvent is at least one selected from the group consisting of chloroform, dichloromethane, diethyl ether, tetrahydrofuran, dimethylformamide and dimethylacetamide. 4. The method according to claim 3, wherein the base is at least one selected from the group consisting of triethylamine and pyridine. 4. The process of claim 3, wherein the substituted sulfonyl chloride is one selected from methanesulfonyl chloride, benzenesulfonyl chloride and 4-toluenesulfonyl chloride. The process according to claim 3, wherein the reaction temperature is from -30 to 30 ° C. The process according to claim 3, wherein the compound of formula (III) is prepared by formylation of an amine of the following formula (II) with formic acid or ethyl formate. ※ Note: It is disclosed by the contents of the first application.
KR1019960014310A 1996-05-02 1996-05-02 New arylisocyanide derivative having tyrosinase-deactivation and melanine biosynthesis inhibiting the function KR0171266B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019960014310A KR0171266B1 (en) 1996-05-02 1996-05-02 New arylisocyanide derivative having tyrosinase-deactivation and melanine biosynthesis inhibiting the function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960014310A KR0171266B1 (en) 1996-05-02 1996-05-02 New arylisocyanide derivative having tyrosinase-deactivation and melanine biosynthesis inhibiting the function

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KR970074758A true KR970074758A (en) 1997-12-10
KR0171266B1 KR0171266B1 (en) 1999-03-30

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KR1019960014310A KR0171266B1 (en) 1996-05-02 1996-05-02 New arylisocyanide derivative having tyrosinase-deactivation and melanine biosynthesis inhibiting the function

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