KR970065510A - Novel isocyanato-cyclo-pentenyl acetic acid ester derivatives having inhibitory activity against tyrosinase activity and melanin biosynthesis and methods for producing the same - Google Patents

Novel isocyanato-cyclo-pentenyl acetic acid ester derivatives having inhibitory activity against tyrosinase activity and melanin biosynthesis and methods for producing the same Download PDF

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KR970065510A
KR970065510A KR1019960009232A KR19960009232A KR970065510A KR 970065510 A KR970065510 A KR 970065510A KR 1019960009232 A KR1019960009232 A KR 1019960009232A KR 19960009232 A KR19960009232 A KR 19960009232A KR 970065510 A KR970065510 A KR 970065510A
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South Korea
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producing
acetic acid
same
pentenyl
cyclo
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KR1019960009232A
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Korean (ko)
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KR0171267B1 (en
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이영호
김경애
이현호
최종권
이상화
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성재갑
주식회사 Lg 화학
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/10—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of rings other than six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 타이로시네이즈 활성저해능 및 멜라닌 생합성 저해능을 갖는 하기 일반식 (Ⅰ)의 신규한 (3-이소시아노-사이클로펜트-2-엔일)아세트산의 에스테르 유도체 및 그의 제조방법에 관한 것이다.The present invention relates to an ester derivative of the novel (3-isocyano-cyclopent-2-enyl) acetic acid of the following general formula (I) having an inhibitory activity on tyrosinase activity and an ability to inhibit melanin biosynthesis, and a process for producing the same.

상기 식에서, R은 수소, C1-C10알킬 또는 아릴을 나타낸다.Wherein, R represents hydrogen, C 1 -C 10 alkyl or aryl.

Description

타이로시네이즈 활성저해 및 멜라닌 생합성 저해능을 갖는 신규의 이소시아노-사이클로-펜테닐 아세트산 에스테르 유도체 및 그의 제조방법Novel isocyanato-cyclo-pentenyl acetic acid ester derivatives having inhibitory activity against tyrosinase activity and melanin biosynthesis and methods for producing the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (9)

하기 일반식 (Ⅰ)로 나타내는 화합물:A compound represented by the following general formula (I): 상기 식에서, R은 수소, C1-C10알킬 또는 아릴을 나타낸다.Wherein, R represents hydrogen, C 1 -C 10 alkyl or aryl. 제1항에 있어서, R이 C1-C4알킬인 화합물.The method of claim 1, wherein, R is C 1 -C 4 alkyl. 하기 일반식 (Ⅷ)화합물을 용매중에서 염기 존재하에 반응시켜 하기 일반식 (Ⅰ)의 화합물을 제조하는 방법.Reacting a compound represented by the following general formula (VIII) in a solvent in the presence of a base to produce a compound represented by the following general formula (I). 상기 식에서, R은 제1항에서 정의한 바와 같고, R′는 메탄설포닐, 벤젠설포닐 또는 4-톨루엔설포닐을 나타낸다.Wherein R is as defined in claim 1 and R 'represents methanesulfonyl, benzenesulfonyl or 4-toluenesulfonyl. 제3항에 있어서, 염기가 디아자바이사이클로운데센(DBU) 및 디아자바이사이클로노넨(DBN)중에서 선택된 1종인 방법.The process according to claim 3, wherein the base is one selected from diazabicyclo-undecene (DBU) and diazabicyclononene (DBN). 제3항에 있어서, 일반식 (Ⅷ)의 화합물이 하기 일반식(Ⅶ)의 포름아미드 화합물을 용매중에서 염기 존재하에서 치환된 설포닐클로라이드와 반응시켜 제조한 것인 방법.4. The process of claim 3 wherein the compound of formula (VIII) is prepared by reacting a formamide compound of formula (VII) with a substituted sulfonyl chloride in the presence of a base in a solvent. 상기 식에서, R은 제1항에서 정의한 바와 같다.Wherein R is as defined in claim 1. 제3항 또는 5항에 있어서, 용매가 클로로포름, 디클로로메탄, 톨루엔 및 벤젠중에서 선택된 1종 이상인 방법.The process according to claim 3 or 5, wherein the solvent is at least one selected from chloroform, dichloromethane, toluene and benzene. 제5항에 있어서, 염기가 트리에틸아민 및 피리딘 중에서 선택된 1종인 방법.6. The process of claim 5, wherein the base is one selected from the group consisting of triethylamine and pyridine. 제5항에 있어서, 치환된 설포닐크로라이드가 메탄설포닐클로라이드, 벤젠설포닐클로라이드 및 4-톨루엔설포닐클로라이드 중에서 선택된 1종인 방법.6. The process of claim 5, wherein the substituted sulfonyl chloride is one selected from methanesulfonyl chloride, benzenesulfonyl chloride and 4-toluenesulfonyl chloride. 제5항에 있어서, 반응온도가 -10 내지 0℃인 방법.The process according to claim 5, wherein the reaction temperature is from -10 to 0 ° C. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960009232A 1996-03-29 1996-03-29 Novel isocyano-cyclo-pentanyl acetic acid ester derivative controlling effect against tyrosinase activity and melanine biosynthesis, and process for preparing the same KR0171267B1 (en)

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KR1019960009232A KR0171267B1 (en) 1996-03-29 1996-03-29 Novel isocyano-cyclo-pentanyl acetic acid ester derivative controlling effect against tyrosinase activity and melanine biosynthesis, and process for preparing the same

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KR1019960009232A KR0171267B1 (en) 1996-03-29 1996-03-29 Novel isocyano-cyclo-pentanyl acetic acid ester derivative controlling effect against tyrosinase activity and melanine biosynthesis, and process for preparing the same

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KR970065510A true KR970065510A (en) 1997-10-13
KR0171267B1 KR0171267B1 (en) 1999-03-30

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