KR960040373A - 골절 치료제 및 골절의 치료 방법 - Google Patents
골절 치료제 및 골절의 치료 방법 Download PDFInfo
- Publication number
- KR960040373A KR960040373A KR1019960041162A KR19960041162A KR960040373A KR 960040373 A KR960040373 A KR 960040373A KR 1019960041162 A KR1019960041162 A KR 1019960041162A KR 19960041162 A KR19960041162 A KR 19960041162A KR 960040373 A KR960040373 A KR 960040373A
- Authority
- KR
- South Korea
- Prior art keywords
- fracture
- parathyroid hormone
- therapeutic agent
- fractures
- administering
- Prior art date
Links
- 206010017076 Fracture Diseases 0.000 title claims abstract 13
- 238000000034 method Methods 0.000 title claims abstract 10
- 239000003814 drug Substances 0.000 title claims abstract 9
- 229940079593 drug Drugs 0.000 title abstract 2
- 102000003982 Parathyroid hormone Human genes 0.000 claims abstract description 10
- 108090000445 Parathyroid hormone Proteins 0.000 claims abstract description 10
- 239000000199 parathyroid hormone Substances 0.000 claims abstract description 10
- 229960001319 parathyroid hormone Drugs 0.000 claims abstract description 10
- 208000010392 Bone Fractures Diseases 0.000 claims abstract 9
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 7
- 238000002347 injection Methods 0.000 claims abstract 3
- 239000007924 injection Substances 0.000 claims abstract 3
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 2
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 1
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 238000000879 optical micrograph Methods 0.000 description 4
- 230000002611 ovarian Effects 0.000 description 3
- 238000002679 ablation Methods 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
종래에는 골절치유기간을 감소시키려는 끊임없는 노력에도 불구하고, 골절부위에 새로운 뼈를 효과적으로 형성할 수 있는 약제가 개발되지 못하였다. 반면에 부갑상선 호르몬 및/또는 부갑상선호르몬의 유도체를 주성분으로 하는 골절치료제는 환자에게 주사로 간단히 투여하는 방법으로, 골절부위에 새로운 뼈를 형성하는 효과가 크고 치료 시간도 단축할 수 있는 괄목할 만한 치료제이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 난소를 절제안한 백서뼈를 10배확대한 광학 현미경사진, 제2도는 난소를 절제한후, 비히클치료한백서뼈를 10배확대한 광학 현미경사진, 제3도는 난소를 절제한후, 본 발명의 저농도의 부갑상선호르몬을 투여한 백서뼈를 10배 확대한 광학현미경 사진, 제4도는 난소를 절제한후, 본 발명의 고농도의 부갑상선호르몬을 투여한 백서 뼈를 10배 확대한 광학현미경사진.
Claims (7)
- 부갑상선호르몬 및/또는 부갑상선호르몬의 유도체를 주성분으로 하는 골절치료제.
- 제1항에 있어서, 상기 부갑상선호르몬 유도체는 부갑상선호르몬(1∼84)분절의 변형체, 부갑상선호르몬(1∼84)아미노산의 변형체, 부갑상선 호르몬 수용체를 선택적으로 자극하는 유기화합물로 이루어진 그룹중에서 선택되는 것인 골절치료제.
- 제1항의 골절치료제를 환자에게 투여하는 공정을 포함하는 골절의 치료방법.
- 제3항에 있어서, 상기 치료제를 투입하는 방법은 주사, 비강 및 경구투여 방법중에서 선택되는 것인 골절의 치료방법.
- 부갑상선호르몬 및 이 호르몬의 유도체를 분비하도록 조작된 플라스미드를 주성분으로 하는 골절치료제.
- 제5항의 골절치료제를 환자에게 투여하는 공정을 포함하는 골절의 치료방법.
- 제5항에 있어서, 상기 치료제를 투여하는 방법은 주사, 비강 및 경구투여 방법중에서 선택되는 것인 골절의 치료방법.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960041162A KR100283138B1 (ko) | 1996-09-20 | 1996-09-20 | 골절 치료제 및 골절의 치료 방법 |
| JP9060084A JPH10101575A (ja) | 1996-09-20 | 1997-02-28 | 骨折治療剤及び骨折の治療方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960041162A KR100283138B1 (ko) | 1996-09-20 | 1996-09-20 | 골절 치료제 및 골절의 치료 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR960040373A true KR960040373A (ko) | 1996-12-17 |
| KR100283138B1 KR100283138B1 (ko) | 2001-03-02 |
Family
ID=19474558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960041162A KR100283138B1 (ko) | 1996-09-20 | 1996-09-20 | 골절 치료제 및 골절의 치료 방법 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH10101575A (ko) |
| KR (1) | KR100283138B1 (ko) |
-
1996
- 1996-09-20 KR KR1019960041162A patent/KR100283138B1/ko not_active IP Right Cessation
-
1997
- 1997-02-28 JP JP9060084A patent/JPH10101575A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10101575A (ja) | 1998-04-21 |
| KR100283138B1 (ko) | 2001-03-02 |
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