KR960034206A - Method for preparing cephalosporin intermediate - Google Patents
Method for preparing cephalosporin intermediate Download PDFInfo
- Publication number
- KR960034206A KR960034206A KR1019950007076A KR19950007076A KR960034206A KR 960034206 A KR960034206 A KR 960034206A KR 1019950007076 A KR1019950007076 A KR 1019950007076A KR 19950007076 A KR19950007076 A KR 19950007076A KR 960034206 A KR960034206 A KR 960034206A
- Authority
- KR
- South Korea
- Prior art keywords
- dimethylaminoethyl
- tetrazol
- amino
- carboxylic acid
- preparing
- Prior art date
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- Cephalosporin Compounds (AREA)
Abstract
본 발명은 세포티암 및 그 에스테르의 함성에 유용한 중간체인 7β-아미노-3-Ⅱ1-(2-디메틸아미노에틸)-1Ⅱ-테트라졸-5-일[티오메닐]-세프-3-엠-4-카르복실산 1/2황산염의 제조방법을 제공하며, 이방법은 7β-어미노세팔로스포린산과 5-머르캅토-1-(2-N,N-디메틸아미노에틸)-1Ⅱ-테트라졸을 황산 존재하 유기용매와 산무수물 존재하에 반응시키고, 이어 반응 혼합물을 알콜류로 희석하여 염기로 pⅡ를 조정하여 결정로 얻는것을 특징으로 한다.The present invention relates to 7β-amino-3-II1- (2-dimethylaminoethyl) -1II-tetrazol-5-yl [thiomenyl] -sef-3-m-, which is an intermediate useful for the containment of cytothioma and its esters. Provided is a method for preparing 4-carboxylic acid 1/2 sulfate, which comprises 7β-aminocephalosporinic acid and 5-mercapto-1- (2-N, N-dimethylaminoethyl) -1II-tetrazole. The reaction mixture is reacted in the presence of sulfuric acid in the presence of an organic solvent and an acid anhydride, and then the reaction mixture is diluted with alcohols to adjust pII with a base to obtain crystals.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950007076A KR960034206A (en) | 1995-03-30 | 1995-03-30 | Method for preparing cephalosporin intermediate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950007076A KR960034206A (en) | 1995-03-30 | 1995-03-30 | Method for preparing cephalosporin intermediate |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960034206A true KR960034206A (en) | 1996-10-22 |
Family
ID=66553014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950007076A KR960034206A (en) | 1995-03-30 | 1995-03-30 | Method for preparing cephalosporin intermediate |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR960034206A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100432425B1 (en) * | 2000-11-16 | 2004-05-22 | 씨제이 주식회사 | Novel method for preparation of cephem derivatives or salts thereof |
-
1995
- 1995-03-30 KR KR1019950007076A patent/KR960034206A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100432425B1 (en) * | 2000-11-16 | 2004-05-22 | 씨제이 주식회사 | Novel method for preparation of cephem derivatives or salts thereof |
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