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세푸록심 에스테르 유도체의 제조방법Process for preparing cefuroxime ester derivative
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (2)
다음 구조식(Ⅰ)로 표시되는 세푸록심의 에스테르 유도체를 제조함에 있어서, 다음 구조식(Ⅱ)의 설포네이트 화합물과 아세트알데히드를 반응시켜서 다음 구조식(Ⅲ)의 설포네이트 화합물을 제조하고, 이를 곧 바로 다음 구조식(Ⅳ)의 세푸록심무기염과 에스테르화반응시켜서 되는 것을 특징으로 하는 세푸록심 에스테르 유도체의 제조방법.In preparing an ester derivative of cefuroxime represented by the following structural formula (I), a sulfonate compound of the following structural formula (II) is reacted with acetaldehyde to prepare a sulfonate compound of the following structural formula (III), which is immediately followed by A process for producing a cefuroxime ester derivative, characterized in that it is subjected to esterification with a cefuroxime inorganic salt of formula (IV).이때, R은 메틸기나 p-톨루일기를 나타내며, M은 Na 또는 K를 나타낸다.In this case, R represents a methyl group or p-toluyl group, and M represents Na or K.제 1 항에 있어서, 에스테르화반응은 크라운 에테르를 촉매로 사용하여 실시하는 것을 특징으로 하는 방법.The process according to claim 1, wherein the esterification reaction is carried out using crown ether as a catalyst.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870006412A1987-06-241987-06-24
Process for preparing cefuroxime ester derivative
KR890000498A
(en)
Method for preparing 2-hydroxymethylene-3,3-dialkoxypropanenitrile alkali metal salt and method for obtaining alcoholic slurry of the above compound from its synthesis reaction mixture