KR960003731A - 인조눈물용으로서 사용하기 위한 안과용 조제물 - Google Patents
인조눈물용으로서 사용하기 위한 안과용 조제물 Download PDFInfo
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- KR960003731A KR960003731A KR1019950022047A KR19950022047A KR960003731A KR 960003731 A KR960003731 A KR 960003731A KR 1019950022047 A KR1019950022047 A KR 1019950022047A KR 19950022047 A KR19950022047 A KR 19950022047A KR 960003731 A KR960003731 A KR 960003731A
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- South Korea
- Prior art keywords
- mmol
- preparation
- artificial tear
- ophthalmic preparation
- ophthalmic
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract 27
- 239000000607 artificial tear Substances 0.000 title claims abstract 20
- 229910001415 sodium ion Inorganic materials 0.000 claims abstract 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 4
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims abstract 3
- 206010015946 Eye irritation Diseases 0.000 claims abstract 3
- 231100000013 eye irritation Toxicity 0.000 claims abstract 3
- 229940014041 hyaluronate Drugs 0.000 claims abstract 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims abstract 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 claims abstract 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract 2
- 238000009472 formulation Methods 0.000 claims abstract 2
- 206010023332 keratitis Diseases 0.000 claims abstract 2
- 201000010666 keratoconjunctivitis Diseases 0.000 claims abstract 2
- 229910001425 magnesium ion Inorganic materials 0.000 claims abstract 2
- 229910001414 potassium ion Inorganic materials 0.000 claims abstract 2
- 239000002562 thickening agent Substances 0.000 claims abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- 235000011148 calcium chloride Nutrition 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 1
- 235000019800 disodium phosphate Nutrition 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 229940085991 phosphate ion Drugs 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- -1 phosphorus ion Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
점성농후제로서 분자량 500,000∼4,000,000돌턴을 가지며 나트륨염형태의 농도 0.05－2중량%의 히알루로네이트와, 최소량으로 40mmol/1의 나트륨이온, 12mmol/1의 칼륨이온, 0.4mmol/1의 칼슘이온, 0.4mmol/1의 마그네슘이온, 50mmol/1의 염소이온, 7mmol/1의 인이온 및 0.7mmol/1의 시트레이트이온을 함유하는 인조눈물로서 사용하기 위한 안과용 조제물, 오스모몰농도 140－280280mmol/1의 상기 조제물은 건성각결막염의 처리에 유용하여 인조눈물 사용의 권될때, 예를들어 주위환경 또는 콘택트렌즈에 의해 생긴 눈의 자극의 치료를 위해 투여될 수 있다.
Description
내용없음
Claims (16)
- 점성농후제로서 농도 0.05－2중량%의 히알루론산염과, 히알루론산염에 함유된 나트륨이온을 포함하지 않는 이온종의 최소량으로 40mmol/1의 나트륨이온, 12mmol/1의 칼륨이온, 0.4mmol/1의 칼슘이온, 0.4mmol/1의 마그네슘이온, 50mmol/1의 염소이온, 7mmol/1의 인산염이온 및 물을 함유하는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 또한 적어도 0.7mmol/1의 킬레이트물질을 함유하는 것을 특징으로 하는 안과용 조제물.
- 제2항에 있어서, 킬레이트물질은 시트레이트인 것인 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제3항에 있어서, 히알루론산염에 함유된 나트륨이온을 포함하지 않는 하기의 농도의 이온종을 함유하는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.Na+ 40－95mmol/1 Cl－ 50－150mmol/1K+ 12－28mmol/1 HPO4= 7－20mmol/1Ca++ 0.4－1.5mmol/1 시트레이트 0.7－2.5mmol/1Mg++ 0.4－1.0mmol/1 히알루로네이트 0.05－2중량%
- 제1항에 있어서, 상기 조제물은 또한 적어도 7mmol/1의 아세테이트이온을 함유하는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 또한 적어도 5mmol/1의 중탄산염을 함유하는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 또한 적어도 1mmol/1의 EDTA를 함유하는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 히알루로네이트는 분자량 500,000－4,000,000돌턴을 갖는 소듐히알루로네이트인 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 저장성을 가지며, 140－280mOsm/1의 오스모몰농도를 갖는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 2sec－1의 전단률에서 10.0－200.0cps의 점도와 1000sec－1의 전단률에서 10－5sec의 점도를 갖는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항에 있어서, 상기 조제물은 6.8－7.6pH를 갖는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제4항에 있어서, 상기 조제물은 하기의 조성을 갖는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.mg/100ml mmol/1소듐 히알루로네이트 250 6.2NaCl 279.2 47.77KCl 103.3 13.85Na2HPO4 12H2O 322.2 9.0Na3 시트레이트 26.0 1.05MgCl2 6H2O 9.2 0.45CaCl2 2H2O 6.9 0.6pH=7.32 및 오스모몰농도=150mOsm/1
- 제1항에 있어서, 상기 안과용조제물속에 함유된 나트륨이온의 총량은 40－95mmol/1로 구성되는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제1항－제12항중의 한 항에 있어서, 인조눈물로서 사용하기 위한 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.
- 제13항에 있어서, 상기 인조눈물은 건성각결막염 또는 눈의 자극을 치료하는데 사용되는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조성물.
- 제14항에 있어서, 상기 눈의 자극은 주위환경조건 또는 콘택즈렌즈에 의해 생기는 것을 특징으로 하는 인조눈물로서 사용하기 위한 안과용 조제물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940485A IT1273011B (it) | 1994-07-25 | 1994-07-25 | Preparato oftalmico per l'uso come lacrima artificiale |
| ITRM94A000485 | 1994-07-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR960003731A true KR960003731A (ko) | 1996-02-23 |
| KR100444727B1 KR100444727B1 (ko) | 2006-03-30 |
Family
ID=11402665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950022047A KR100444727B1 (ko) | 1994-07-25 | 1995-07-25 | 인조눈물용으로서사용하기위한안과용조제물 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5770628A (ko) |
| EP (1) | EP0698388B1 (ko) |
| JP (1) | JP3795105B2 (ko) |
| KR (1) | KR100444727B1 (ko) |
| AT (1) | ATE187637T1 (ko) |
| CA (1) | CA2154533C (ko) |
| CZ (1) | CZ287223B6 (ko) |
| DE (1) | DE69513902T2 (ko) |
| DK (1) | DK0698388T3 (ko) |
| ES (1) | ES2142976T3 (ko) |
| GR (1) | GR3032958T3 (ko) |
| IT (1) | IT1273011B (ko) |
| PL (1) | PL180836B1 (ko) |
| PT (1) | PT698388E (ko) |
| ZA (1) | ZA956165B (ko) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2742336B1 (fr) * | 1995-12-19 | 1998-03-06 | Chauvin Lab Sa | Collyre destine notamment au traitement de l'oeil sec |
| DE19910654C2 (de) * | 1998-09-07 | 2000-12-07 | Univ Leipzig | Infusionslösung für die Makulachirurgie |
| IT1306123B1 (it) * | 1999-04-02 | 2001-05-30 | Technopharma Sa | Soluzione oftalmica viscosizzata con azione detergente sulle lenti acontatto. |
| DE19938668B4 (de) * | 1999-08-14 | 2006-01-26 | Bausch & Lomb Inc. | Tränenersatzmittel |
| US6716970B2 (en) * | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
| US20050080043A1 (en) * | 2000-09-20 | 2005-04-14 | Lee Shahinian | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
| AU2002232437A1 (en) * | 2000-12-20 | 2002-07-01 | Alcon Universal Ltd. | Ophthalmic lubricating solution adapted for use in lasik surgery |
| US6878694B2 (en) * | 2000-12-20 | 2005-04-12 | Alcon, Inc. | Ophthalmic irrigating solution adapted for use in lasik surgery |
| DE10161149B4 (de) * | 2001-12-12 | 2007-03-08 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Heparin-haltigem Ophthalmikum |
| DE10161110A1 (de) * | 2001-12-12 | 2003-06-26 | Ursapharm Arzneimittel Gmbh | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
| IL165910A0 (en) * | 2002-07-03 | 2006-01-15 | Pericor Science Inc | Compositions of hyaluronic acid and methods of use |
| US6806364B2 (en) * | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
| US6828356B2 (en) * | 2002-07-29 | 2004-12-07 | Ast Products, Inc. | Preparation of ophthalmic compositions |
| ITMI20022353A1 (it) * | 2002-11-06 | 2004-05-07 | Farmaceutici S R L | Composizione di un preparato per gli occhi con attivita' antiallergica, antibatterica e disarrossante. |
| FR2849383B1 (fr) | 2002-12-26 | 2005-09-30 | Jean Noel Thorel | Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| US20040167480A1 (en) * | 2003-02-21 | 2004-08-26 | Advanced Medical Optics, Inc. | Administration of multiple viscoelastic solutions with a multi-compartment syringe |
| JPWO2005082384A1 (ja) * | 2004-02-27 | 2008-03-06 | 株式会社日本トリム | 人工生理的塩類溶液およびその製造方法 |
| US20050215516A1 (en) * | 2004-03-29 | 2005-09-29 | Claudio Bucolo | New free-radical scavenger containing viscoelastic composition, methods of use and package |
| FR2871059B1 (fr) * | 2004-06-03 | 2007-01-05 | Oreal | Composition artificielle de type fluide lacrymal et son utilisation. |
| EP2147686A1 (en) * | 2004-10-01 | 2010-01-27 | Menicon Co., Ltd. | Method for packaging contact lenses |
| WO2006085351A1 (en) * | 2005-02-09 | 2006-08-17 | Safilens S.R.L. | Contact lens, method for producing same, and pack for storage and maintenance of a contact lens |
| DE102005055275A1 (de) | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
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| JP4644305B1 (ja) * | 2010-05-12 | 2011-03-02 | 喜美雄 川村 | 点眼薬及びその製造方法 |
| AT511164A1 (de) | 2011-03-03 | 2012-09-15 | Croma Pharma Gmbh | Verwendung eines viskoelastischen fluids zur herstellung eines medizinproduktes für die chirurgische behandlung des auges |
| KR101134340B1 (ko) * | 2011-06-10 | 2012-04-09 | 주식회사 휴온스 | 안과질환 예방 또는 치료용 점안제 조성물 |
| FR2986703B1 (fr) | 2012-02-09 | 2015-01-16 | Horus Pharma | Dispositif de conditionnement et de distribution d'un produit a usage ophtalmique |
| CN102885767A (zh) * | 2012-11-02 | 2013-01-23 | 江苏吉贝尔药业有限公司 | 一种新的盐酸奥洛他定滴眼液及其制备方法 |
| WO2016104705A1 (ja) | 2014-12-26 | 2016-06-30 | 生化学工業株式会社 | 眼の自覚症状を改善する剤および方法 |
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| ITUB20152542A1 (it) | 2015-07-28 | 2017-01-28 | Altergon Sa | Formulati oftalmici a base di complessi cooperativi di acido ialuronico a basso e alto peso molecolare |
| AR108280A1 (es) * | 2016-05-05 | 2018-08-08 | Acraf | Composición oftálmica que comprende una combinación sinérgica de glucógeno y ácido hialurónico o sal del mismo |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
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| US4409205A (en) | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| WO1984004681A1 (en) | 1983-05-25 | 1984-12-06 | Alcon Lab Inc | Ophthalmic solution |
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| CA1263606A (en) | 1985-05-29 | 1989-12-05 | Jeffrey P. Gilbard | Non-toxic opthalmic preparations |
| IL80298A (en) | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| EP0323522A4 (en) * | 1987-07-07 | 1989-08-30 | Santen Pharmaceutical Co Ltd | ARTIFICIAL TEAR. |
| DE69017559T3 (de) * | 1989-07-24 | 2002-06-06 | Allergan Pharmaceuticals Irela | Stabile Lösung von Hyaluronat in einem isotonen Salzmilieu. |
| JP2887485B2 (ja) | 1989-08-09 | 1999-04-26 | 花王株式会社 | 油性化粧料 |
-
1994
- 1994-07-25 IT ITRM940485A patent/IT1273011B/it active IP Right Grant
-
1995
- 1995-07-21 DE DE69513902T patent/DE69513902T2/de not_active Expired - Lifetime
- 1995-07-21 ES ES95111514T patent/ES2142976T3/es not_active Expired - Lifetime
- 1995-07-21 EP EP95111514A patent/EP0698388B1/en not_active Expired - Lifetime
- 1995-07-21 PT PT95111514T patent/PT698388E/pt unknown
- 1995-07-21 US US08/505,095 patent/US5770628A/en not_active Expired - Lifetime
- 1995-07-21 DK DK95111514T patent/DK0698388T3/da active
- 1995-07-21 AT AT95111514T patent/ATE187637T1/de active
- 1995-07-24 JP JP20842695A patent/JP3795105B2/ja not_active Expired - Fee Related
- 1995-07-24 PL PL95309753A patent/PL180836B1/pl unknown
- 1995-07-24 CZ CZ19951913A patent/CZ287223B6/cs not_active IP Right Cessation
- 1995-07-24 CA CA002154533A patent/CA2154533C/en not_active Expired - Lifetime
- 1995-07-25 KR KR1019950022047A patent/KR100444727B1/ko not_active IP Right Cessation
- 1995-07-25 ZA ZA956165A patent/ZA956165B/xx unknown
-
2000
- 2000-03-14 GR GR20000400658T patent/GR3032958T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA956165B (en) | 1996-03-07 |
| CA2154533C (en) | 2007-01-16 |
| ES2142976T3 (es) | 2000-05-01 |
| DK0698388T3 (da) | 2000-05-08 |
| CZ287223B6 (en) | 2000-10-11 |
| JPH08169835A (ja) | 1996-07-02 |
| ITRM940485A1 (it) | 1996-01-25 |
| CZ191395A3 (en) | 1996-02-14 |
| EP0698388B1 (en) | 1999-12-15 |
| IT1273011B (it) | 1997-07-01 |
| PT698388E (pt) | 2000-05-31 |
| US5770628A (en) | 1998-06-23 |
| JP3795105B2 (ja) | 2006-07-12 |
| DE69513902T2 (de) | 2000-05-18 |
| PL309753A1 (en) | 1996-02-05 |
| DE69513902D1 (de) | 2000-01-20 |
| ITRM940485A0 (it) | 1994-07-25 |
| KR100444727B1 (ko) | 2006-03-30 |
| ATE187637T1 (de) | 2000-01-15 |
| CA2154533A1 (en) | 1996-01-26 |
| GR3032958T3 (en) | 2000-07-31 |
| PL180836B1 (pl) | 2001-04-30 |
| EP0698388A1 (en) | 1996-02-28 |
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