ES2142976T3 - Preparacion oftalmica para utilizacion en lagrimas artificiales. - Google Patents
Preparacion oftalmica para utilizacion en lagrimas artificiales.Info
- Publication number
- ES2142976T3 ES2142976T3 ES95111514T ES95111514T ES2142976T3 ES 2142976 T3 ES2142976 T3 ES 2142976T3 ES 95111514 T ES95111514 T ES 95111514T ES 95111514 T ES95111514 T ES 95111514T ES 2142976 T3 ES2142976 T3 ES 2142976T3
- Authority
- ES
- Spain
- Prior art keywords
- ions
- mmol
- ophthalmic preparation
- treatment
- artificial tear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000607 artificial tear Substances 0.000 title abstract 3
- 150000002500 ions Chemical class 0.000 abstract 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229940014041 hyaluronate Drugs 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
PREPARACION OFTALMICA PARA SU USO COMO LAGRIMA ARTIFICIAL QUE CONTIENE HIALURONATO COMO ESPESANTE DE LA VISCOSIDAD, PREFERENTEMENTE EN LA FORMA DE SAL SODICA Y QUE TIENE UN PESO MOLECULAR DE 500.000 A 4.000.000 DE DALTONS, CON UNA CONCENTRACION DE ENTRE 0,05 Y 2% DEL PESO, ASI COMO LAS SIGUIENTES CANTIDADES MINIMAS DE LAS SIGUIENTES ESPECIES IONICAS: 40MMO/L IONES SODICOS, 12 MMOL/L IONES POTASICOS, 0,4 MMOL/L IONES CALCICOS, 0,4 MMOL/L IONES MAGNESICOS, 50 MMOL/L IONES DE CLORURO, 7 MMOL/L IONES DE FOSFATO Y, PREFERENTEMENTE 0,7 MMOL/L IONES DE CITRATO. LA FORMULACION, QUE TIENE UNA OSMOLALIDAD DE 140 A 280 MOSM/L, ES UTIL PARA EL TRATAMIENTO DE LA KERATOCONJUNTIVITIS SECA Y PUEDE ADMINISTRARSE SIEMPRE QUE EL USO DE LAGRIMA ARTIFICIAL SEA ACONSEJABLE, P. EJ. EN EL TRATAMIENTO DE IRRITACIONES OCULARES CAUSADAS POR CONDICIONES AMBIENTALES O LENTES DE CONTACTO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940485A IT1273011B (it) | 1994-07-25 | 1994-07-25 | Preparato oftalmico per l'uso come lacrima artificiale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2142976T3 true ES2142976T3 (es) | 2000-05-01 |
Family
ID=11402665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95111514T Expired - Lifetime ES2142976T3 (es) | 1994-07-25 | 1995-07-21 | Preparacion oftalmica para utilizacion en lagrimas artificiales. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5770628A (es) |
| EP (1) | EP0698388B1 (es) |
| JP (1) | JP3795105B2 (es) |
| KR (1) | KR100444727B1 (es) |
| AT (1) | ATE187637T1 (es) |
| CA (1) | CA2154533C (es) |
| CZ (1) | CZ287223B6 (es) |
| DE (1) | DE69513902T2 (es) |
| DK (1) | DK0698388T3 (es) |
| ES (1) | ES2142976T3 (es) |
| GR (1) | GR3032958T3 (es) |
| IT (1) | IT1273011B (es) |
| PL (1) | PL180836B1 (es) |
| PT (1) | PT698388E (es) |
| ZA (1) | ZA956165B (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2742336B1 (fr) * | 1995-12-19 | 1998-03-06 | Chauvin Lab Sa | Collyre destine notamment au traitement de l'oeil sec |
| DE19910654C2 (de) * | 1998-09-07 | 2000-12-07 | Univ Leipzig | Infusionslösung für die Makulachirurgie |
| IT1306123B1 (it) * | 1999-04-02 | 2001-05-30 | Technopharma Sa | Soluzione oftalmica viscosizzata con azione detergente sulle lenti acontatto. |
| DE19938668B4 (de) * | 1999-08-14 | 2006-01-26 | Bausch & Lomb Inc. | Tränenersatzmittel |
| US6716970B2 (en) * | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
| US20050080043A1 (en) * | 2000-09-20 | 2005-04-14 | Lee Shahinian | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
| WO2002049610A2 (en) * | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Ophthalmic irrigating solution adapted for use in lasik surgery |
| WO2002049611A2 (en) * | 2000-12-20 | 2002-06-27 | Alcon, Inc. | Ophthalmic lubricating solution adapted for use in lasik surgery |
| DE10161110A1 (de) * | 2001-12-12 | 2003-06-26 | Ursapharm Arzneimittel Gmbh | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
| DE10161149B4 (de) * | 2001-12-12 | 2007-03-08 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Heparin-haltigem Ophthalmikum |
| RU2005102604A (ru) * | 2002-07-03 | 2005-09-10 | Перикор Сайенс, Инк. (Us) | Композиция гиалуроновой кислоты и способы применения |
| US6828356B2 (en) * | 2002-07-29 | 2004-12-07 | Ast Products, Inc. | Preparation of ophthalmic compositions |
| US6806364B2 (en) * | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
| ITMI20022353A1 (it) * | 2002-11-06 | 2004-05-07 | Farmaceutici S R L | Composizione di un preparato per gli occhi con attivita' antiallergica, antibatterica e disarrossante. |
| FR2849383B1 (fr) | 2002-12-26 | 2005-09-30 | Jean Noel Thorel | Composition trophique en milieu aqueux, et ses applications, notamment en ophtalmologie |
| US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
| US20040167480A1 (en) * | 2003-02-21 | 2004-08-26 | Advanced Medical Optics, Inc. | Administration of multiple viscoelastic solutions with a multi-compartment syringe |
| WO2005082384A1 (ja) * | 2004-02-27 | 2005-09-09 | Nihon Trim Co., Ltd. | 人工生理的塩類溶液およびその製造方法 |
| US20050215516A1 (en) * | 2004-03-29 | 2005-09-29 | Claudio Bucolo | New free-radical scavenger containing viscoelastic composition, methods of use and package |
| FR2871059B1 (fr) * | 2004-06-03 | 2007-01-05 | Oreal | Composition artificielle de type fluide lacrymal et son utilisation. |
| DE602005018515D1 (de) * | 2004-10-01 | 2010-02-04 | Menicon Co Ltd | Verfahren zur sterilisation verpackter kontaktlinsen mit verpackungslösung |
| ATE429209T1 (de) * | 2005-02-09 | 2009-05-15 | Safilens S R L | Kontaktlinse, verfahren zu ihrer herstellung und packung zur aufbewahrung und pflege einer kontaktlinse |
| DE102005055275A1 (de) | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
| US20080050335A1 (en) * | 2006-07-25 | 2008-02-28 | Osmotica Corp. | Ophthalmic Solutions |
| US20080153908A1 (en) * | 2006-12-20 | 2008-06-26 | Jani Dharmendra M | Method of Treating Mucin Deficiency with an Active Pharmaceutical and Related Composition |
| US20080275030A1 (en) | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
| US9579341B2 (en) | 2007-05-16 | 2017-02-28 | Johnson & Johnson Consumer Inc. | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods |
| US8609634B2 (en) * | 2007-05-16 | 2013-12-17 | Mcneil-Ppc, Inc. | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods |
| US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
| US20090036404A1 (en) * | 2007-08-02 | 2009-02-05 | Macleod Steven K | Ophthalmic compositions comprising a carboxyl-modified fructan or a salt thereof |
| AU2008310956B2 (en) * | 2007-10-08 | 2014-08-07 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors |
| US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| US9096819B2 (en) | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US20100203165A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| US20100286010A1 (en) * | 2008-09-03 | 2010-11-11 | Erning Xia | Ophthalmic Compositions with Hyaluronic Acid |
| US20100178317A1 (en) * | 2009-01-09 | 2010-07-15 | Burke Susan E | Lens Care Solutions with Hyaluronic Acid |
| IT1394223B1 (it) | 2009-05-15 | 2012-06-01 | Thea Sas Lab | Kit per la valutazione e la selezione personalizzata di lacrime artificiali |
| US9017725B2 (en) * | 2009-06-09 | 2015-04-28 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| CA2803059A1 (en) | 2009-06-19 | 2010-12-23 | Altos Vision Limited | Time-release and micro-dose formulations for topical application of estrogen and estrogen analogs or other estrogen receptor modulators in the treatment of dry eye syndrome, and methods of preparation and application |
| US8283463B2 (en) | 2010-02-09 | 2012-10-09 | Bausch & Lomb Incorporated | Sterile hyaluronic acid solutions |
| JP4644305B1 (ja) * | 2010-05-12 | 2011-03-02 | 喜美雄 川村 | 点眼薬及びその製造方法 |
| AT511164A1 (de) | 2011-03-03 | 2012-09-15 | Croma Pharma Gmbh | Verwendung eines viskoelastischen fluids zur herstellung eines medizinproduktes für die chirurgische behandlung des auges |
| KR101134340B1 (ko) * | 2011-06-10 | 2012-04-09 | 주식회사 휴온스 | 안과질환 예방 또는 치료용 점안제 조성물 |
| FR2986703B1 (fr) | 2012-02-09 | 2015-01-16 | Horus Pharma | Dispositif de conditionnement et de distribution d'un produit a usage ophtalmique |
| CN102885767A (zh) * | 2012-11-02 | 2013-01-23 | 江苏吉贝尔药业有限公司 | 一种新的盐酸奥洛他定滴眼液及其制备方法 |
| ES2822474T3 (es) * | 2014-12-26 | 2021-05-04 | Seikagaku Kogyo Co Ltd | Agente que comprende ácido hialurónico que tiene un cinamato de aminoalquilo unido covalentemente al mismo para mejorar síntomas subjetivos en los ojos |
| US20170014339A1 (en) * | 2015-07-17 | 2017-01-19 | i.com medical GmbH | Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute |
| ITUB20152542A1 (it) | 2015-07-28 | 2017-01-28 | Altergon Sa | Formulati oftalmici a base di complessi cooperativi di acido ialuronico a basso e alto peso molecolare |
| AR108280A1 (es) * | 2016-05-05 | 2018-08-08 | Acraf | Composición oftálmica que comprende una combinación sinérgica de glucógeno y ácido hialurónico o sal del mismo |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US10561682B1 (en) * | 2019-04-01 | 2020-02-18 | Judith Boston | Treatment of ischemic conditions, hypoxic conditions, conditions related to a hypoxia-induction factor, or conditions related to reactive oxygen species with oxygen-containing liquids |
| EP3827818A1 (en) * | 2019-11-26 | 2021-06-02 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409205A (en) | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| WO1984004681A1 (en) | 1983-05-25 | 1984-12-06 | Alcon Lab Inc | Ophthalmic solution |
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| CA1263606A (en) * | 1985-05-29 | 1989-12-05 | Jeffrey P. Gilbard | Non-toxic opthalmic preparations |
| IL80298A (en) * | 1986-10-14 | 1993-01-31 | Res & Dev Co Ltd | Eye drops |
| WO1989000044A1 (en) * | 1987-07-07 | 1989-01-12 | Santen Pharmaceutical Co., Ltd. | Artificial lacrima |
| DE69017559T3 (de) * | 1989-07-24 | 2002-06-06 | Allergan Pharmaceuticals (Ireland) Ltd., Irvine | Stabile Lösung von Hyaluronat in einem isotonen Salzmilieu. |
| JP2887485B2 (ja) | 1989-08-09 | 1999-04-26 | 花王株式会社 | 油性化粧料 |
-
1994
- 1994-07-25 IT ITRM940485A patent/IT1273011B/it active IP Right Grant
-
1995
- 1995-07-21 DK DK95111514T patent/DK0698388T3/da active
- 1995-07-21 AT AT95111514T patent/ATE187637T1/de active
- 1995-07-21 PT PT95111514T patent/PT698388E/pt unknown
- 1995-07-21 ES ES95111514T patent/ES2142976T3/es not_active Expired - Lifetime
- 1995-07-21 US US08/505,095 patent/US5770628A/en not_active Expired - Lifetime
- 1995-07-21 DE DE69513902T patent/DE69513902T2/de not_active Expired - Lifetime
- 1995-07-21 EP EP95111514A patent/EP0698388B1/en not_active Expired - Lifetime
- 1995-07-24 PL PL95309753A patent/PL180836B1/pl unknown
- 1995-07-24 CZ CZ19951913A patent/CZ287223B6/cs not_active IP Right Cessation
- 1995-07-24 JP JP20842695A patent/JP3795105B2/ja not_active Expired - Fee Related
- 1995-07-24 CA CA002154533A patent/CA2154533C/en not_active Expired - Lifetime
- 1995-07-25 ZA ZA956165A patent/ZA956165B/xx unknown
- 1995-07-25 KR KR1019950022047A patent/KR100444727B1/ko not_active IP Right Cessation
-
2000
- 2000-03-14 GR GR20000400658T patent/GR3032958T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2154533C (en) | 2007-01-16 |
| DK0698388T3 (da) | 2000-05-08 |
| US5770628A (en) | 1998-06-23 |
| ITRM940485A1 (it) | 1996-01-25 |
| CZ287223B6 (en) | 2000-10-11 |
| DE69513902T2 (de) | 2000-05-18 |
| KR960003731A (ko) | 1996-02-23 |
| JP3795105B2 (ja) | 2006-07-12 |
| GR3032958T3 (en) | 2000-07-31 |
| CA2154533A1 (en) | 1996-01-26 |
| PL180836B1 (pl) | 2001-04-30 |
| PT698388E (pt) | 2000-05-31 |
| PL309753A1 (en) | 1996-02-05 |
| CZ191395A3 (en) | 1996-02-14 |
| JPH08169835A (ja) | 1996-07-02 |
| ATE187637T1 (de) | 2000-01-15 |
| IT1273011B (it) | 1997-07-01 |
| ITRM940485A0 (it) | 1994-07-25 |
| EP0698388A1 (en) | 1996-02-28 |
| DE69513902D1 (de) | 2000-01-20 |
| EP0698388B1 (en) | 1999-12-15 |
| KR100444727B1 (ko) | 2006-03-30 |
| ZA956165B (en) | 1996-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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