KR950704235A - 벤질아민 유도체(benzylamine derivatives) - Google Patents
벤질아민 유도체(benzylamine derivatives)Info
- Publication number
- KR950704235A KR950704235A KR1019950701681A KR19950701681A KR950704235A KR 950704235 A KR950704235 A KR 950704235A KR 1019950701681 A KR1019950701681 A KR 1019950701681A KR 19950701681 A KR19950701681 A KR 19950701681A KR 950704235 A KR950704235 A KR 950704235A
- Authority
- KR
- South Korea
- Prior art keywords
- benzylamine derivative
- salt
- defined above
- group
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical class NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title claims 3
- 150000003939 benzylamines Chemical class 0.000 claims abstract 22
- 150000003839 salts Chemical class 0.000 claims abstract 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract 5
- 230000001430 anti-depressive effect Effects 0.000 claims abstract 3
- 239000000935 antidepressant agent Substances 0.000 claims abstract 3
- 229940005513 antidepressants Drugs 0.000 claims abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 125000005843 halogen group Chemical group 0.000 claims abstract 3
- 239000004480 active ingredient Substances 0.000 claims 8
- -1 amine compound Chemical class 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 229940122490 Sigma receptor antagonist Drugs 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- PBEJTRAJWCNHRS-UHFFFAOYSA-N 2-phenylmethoxybenzaldehyde Chemical compound O=CC1=CC=CC=C1OCC1=CC=CC=C1 PBEJTRAJWCNHRS-UHFFFAOYSA-N 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- OPLYZUDOVHOVGR-UHFFFAOYSA-N n-[[2-[(4-chlorophenyl)methoxy]phenyl]methyl]-n-methylcyclopropanamine Chemical compound C1CC1N(C)CC1=CC=CC=C1OCC1=CC=C(Cl)C=C1 OPLYZUDOVHOVGR-UHFFFAOYSA-N 0.000 claims 1
- MEAQUEQRJDVIOA-UHFFFAOYSA-N n-[[3-[(4-chlorophenyl)methoxy]phenyl]methyl]-n-methylcyclopropanamine Chemical compound C1CC1N(C)CC(C=1)=CC=CC=1OCC1=CC=C(Cl)C=C1 MEAQUEQRJDVIOA-UHFFFAOYSA-N 0.000 claims 1
- ABQVYOBQJIEGIE-UHFFFAOYSA-N n-[[4-[(4-chlorophenyl)methoxy]phenyl]methyl]-n-methylcyclopropanamine Chemical compound C1CC1N(C)CC(C=C1)=CC=C1OCC1=CC=C(Cl)C=C1 ABQVYOBQJIEGIE-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 2
- 230000000049 anti-anxiety effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21414793 | 1993-08-30 | ||
| JP93-214147 | 1993-08-30 | ||
| JP4400394 | 1994-03-15 | ||
| JP94-44003 | 1994-03-15 | ||
| PCT/JP1994/001332 WO1995006630A1 (en) | 1993-08-30 | 1994-08-11 | Benzylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950704235A true KR950704235A (ko) | 1995-11-17 |
Family
ID=26383844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950701681A Ceased KR950704235A (ko) | 1993-08-30 | 1994-08-11 | 벤질아민 유도체(benzylamine derivatives) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5550292A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0666840A1 (cg-RX-API-DMAC7.html) |
| KR (1) | KR950704235A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1114106A (cg-RX-API-DMAC7.html) |
| AU (1) | AU667280B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2147356A1 (cg-RX-API-DMAC7.html) |
| PH (1) | PH30825A (cg-RX-API-DMAC7.html) |
| TW (1) | TW260661B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1995006630A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980941A (en) * | 1997-08-20 | 1999-11-09 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
| US5840334A (en) * | 1997-08-20 | 1998-11-24 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
| US5986141A (en) * | 1998-09-29 | 1999-11-16 | Eastman Chemical Company | Process for the production of cyclopropanemethylamine |
| EP1634598A1 (en) * | 2004-09-07 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Use of piperazine derivatives and analogues for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687865A (en) * | 1986-06-04 | 1987-08-18 | E. R. Squibb & Sons, Inc. | Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists |
| ZA885824B (en) * | 1987-08-14 | 1989-04-26 | Merrell Dow Pharma | Novel antidepressants |
| IL94466A (en) * | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| CA2071897A1 (en) * | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| AU676993B2 (en) * | 1991-06-27 | 1997-04-10 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| DE4132013A1 (de) * | 1991-09-26 | 1993-04-01 | Basf Ag | Neue phenylbenzylamine und diese enthaltende arzneimittel |
| JP2768008B2 (ja) * | 1991-10-04 | 1998-06-25 | 大正製薬株式会社 | アルコキシフェニルアルキルアミン誘導体 |
| DE4216941A1 (de) * | 1992-05-22 | 1993-11-25 | Basf Ag | Para-substituierte Benzylamine und diese enthaltende therapeutische Mittel |
| DE4327365A1 (de) * | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
-
1994
- 1994-08-11 CN CN94190643A patent/CN1114106A/zh active Pending
- 1994-08-11 WO PCT/JP1994/001332 patent/WO1995006630A1/en not_active Ceased
- 1994-08-11 KR KR1019950701681A patent/KR950704235A/ko not_active Ceased
- 1994-08-11 EP EP94922362A patent/EP0666840A1/en not_active Ceased
- 1994-08-11 US US08/428,114 patent/US5550292A/en not_active Expired - Fee Related
- 1994-08-11 AU AU73505/94A patent/AU667280B2/en not_active Ceased
- 1994-08-11 CA CA002147356A patent/CA2147356A1/en not_active Abandoned
- 1994-08-16 TW TW083107505A patent/TW260661B/zh active
- 1994-08-30 PH PH48875A patent/PH30825A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7350594A (en) | 1995-03-22 |
| CN1114106A (zh) | 1995-12-27 |
| TW260661B (cg-RX-API-DMAC7.html) | 1995-10-21 |
| CA2147356A1 (en) | 1995-03-09 |
| PH30825A (en) | 1997-10-17 |
| WO1995006630A1 (en) | 1995-03-09 |
| AU667280B2 (en) | 1996-03-14 |
| EP0666840A1 (en) | 1995-08-16 |
| US5550292A (en) | 1996-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19950429 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19960506 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19980911 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19981130 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19980911 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |