KR950703543A - 트롬빈 저해물질로써 치환된 페닐알라닌 피페라지도 유도체 - Google Patents

트롬빈 저해물질로써 치환된 페닐알라닌 피페라지도 유도체

Info

Publication number
KR950703543A
KR950703543A KR1019940703574A KR19940703574A KR950703543A KR 950703543 A KR950703543 A KR 950703543A KR 1019940703574 A KR1019940703574 A KR 1019940703574A KR 19940703574 A KR19940703574 A KR 19940703574A KR 950703543 A KR950703543 A KR 950703543A
Authority
KR
South Korea
Prior art keywords
pct
thrombin inhibitor
piperazine derivative
derivative substituted
phenylalanine
Prior art date
Application number
KR1019940703574A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR950703543A publication Critical patent/KR950703543A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019940703574A 1993-02-10 1994-10-10 트롬빈 저해물질로써 치환된 페닐알라닌 피페라지도 유도체 KR950703543A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH40593 1993-02-10
CH282793 1993-09-20
PCT/CH1994/000026 WO1994018185A1 (de) 1993-02-10 1994-02-09 Piperazide von substituierten phenylalanin-derivativen als thrombin inhibitoren

Publications (1)

Publication Number Publication Date
KR950703543A true KR950703543A (ko) 1995-09-20

Family

ID=25684484

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940703574A KR950703543A (ko) 1993-02-10 1994-10-10 트롬빈 저해물질로써 치환된 페닐알라닌 피페라지도 유도체

Country Status (11)

Country Link
US (1) US5607937A (ko)
EP (1) EP0635008B1 (ko)
JP (1) JPH07509731A (ko)
KR (1) KR950703543A (ko)
AT (1) ATE223392T1 (ko)
AU (1) AU5878194A (ko)
CA (1) CA2133761A1 (ko)
CZ (1) CZ245994A3 (ko)
DE (1) DE59410179D1 (ko)
HU (1) HUT68042A (ko)
WO (1) WO1994018185A1 (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5776718A (en) * 1995-03-24 1998-07-07 Arris Pharmaceutical Corporation Reversible protease inhibitors
KR0173034B1 (ko) * 1995-04-28 1999-03-30 성재갑 선택적 트롬빈 억제제
TW438591B (en) * 1995-06-07 2001-06-07 Arris Pharm Corp Reversible cysteine protease inhibitors
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602294D0 (en) * 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
ATE230399T1 (de) * 1996-08-14 2003-01-15 Astrazeneca Ab Substituierte pyrimidinderivate und ihre pharmazeutische anwendung
GB9621814D0 (en) * 1996-10-19 1996-12-11 British Biotech Pharm Metalloproteinase inhibitors
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
AU5999798A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
JP2001511798A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物
KR100373373B1 (ko) * 1997-04-03 2003-05-16 주식회사 엘지생명과학 선택적트롬빈억제제
KR19980075899A (ko) * 1997-04-03 1998-11-16 성재갑 선택적 트롬빈 억제제
KR19980077254A (ko) * 1997-04-17 1998-11-16 성재갑 선택적 트롬빈 억제제
ATE334975T1 (de) 1997-05-30 2006-08-15 Takeda Pharmaceutical Sulfonamidderivate, ihre herstellung und verwendung
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
EP1054005A4 (en) 1998-02-05 2003-02-05 Takeda Chemical Industries Ltd SULFAMIDE DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR USE
ES2189455T3 (es) 1998-07-20 2003-07-01 Wilex Ag Nuevos agentes inhibidores de la urocinasa.
US7342018B2 (en) 1998-07-20 2008-03-11 Wilex Ag Urokinase inhibitors and uses thereof
US7745441B1 (en) * 1998-09-18 2010-06-29 Wilex Ag Urokinase inhibitors
EP1140878A1 (en) 1999-01-02 2001-10-10 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them ( inhibitio of factor xa activity )
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
EP1127884A1 (en) * 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US6538017B2 (en) 2001-03-09 2003-03-25 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
AU2003219039A1 (en) 2002-03-11 2003-09-22 Curacyte Ag Urokinase inhibitors, production and use thereof
US7056923B2 (en) * 2002-12-11 2006-06-06 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10322191B4 (de) * 2003-05-16 2014-02-27 The Medicines Company (Leipzig) Gmbh N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
US11130780B2 (en) 2015-03-09 2021-09-28 Washington University Inhibitors of growth factor activation enzymes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD142804A3 (de) * 1977-11-07 1980-07-16 Wagner Guenter Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
CA2073776A1 (en) * 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives

Also Published As

Publication number Publication date
HUT68042A (en) 1995-03-22
DE59410179D1 (de) 2002-10-10
WO1994018185A1 (de) 1994-08-18
US5607937A (en) 1997-03-04
JPH07509731A (ja) 1995-10-26
CZ245994A3 (en) 1995-10-18
ATE223392T1 (de) 2002-09-15
EP0635008A1 (de) 1995-01-25
CA2133761A1 (en) 1994-08-18
EP0635008B1 (de) 2002-09-04
HU9402923D0 (en) 1995-01-30
AU5878194A (en) 1994-08-29

Similar Documents

Publication Publication Date Title
KR950703543A (ko) 트롬빈 저해물질로써 치환된 페닐알라닌 피페라지도 유도체
AU2733997A (en) N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-one derivatives as factor xa inhibitors
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
GR3033827T3 (en) New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
YU41801A (sh) Derivati fenilglicina
TW334418B (en) Stilbene derivatives and pharmaceutical compositions
BR9810459A (pt) sais nìtricos dos inibidores de ace
CA2226256A1 (en) New thrombin inhibitors, their preparation and use
NO963370D0 (no) Nye mercaptoacetylamido-1,3,4,5-tetrahydro-benzo[cÅazepin-3-on-disulfidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
CA2294059A1 (en) New amidino derivatives and their use as thrombin inhibitors
ATE153670T1 (de) Peptidboronsäurederivate mit protease inhibierenden aktivität
TR199900486T2 (xx) Aziniloksi ve fenoksi-diaril-karbonasit t�revleri.
TR199801704T2 (xx) Serin proteaz inhibit�rleri.
DK0883405T3 (da) Aminoproteaseinhibitorer
YU21100A (sh) Izohinolini kao urokinazni inhibitori
DE69709933D1 (en) Aromatische amidinderivate als selektive thrombininhibitoren
BR9610876A (pt) Inibidores de protease de guanidino
TR200001909T2 (tr) Matris metaloprotez inhibitörleri.
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
EP0466944A4 (en) 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same
DK0832085T3 (da) Phosphinsyrederivater med metallopeptidaseinhiberende aktivitet
AU3617489A (en) A peptide with antihypertensive activity
DK0716658T3 (da) Glycosylamider af 2-aminocylamino-2-desoxysukkerarter
ATE293605T1 (de) Fluorierte 3,4-dihydrochinolin-derivative als nos-inhibitoren

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid