KR950702625A - 비살포성 효소의 제조방법(process for dust-free enzyme manufacture) - Google Patents

비살포성 효소의 제조방법(process for dust-free enzyme manufacture) Download PDF

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KR950702625A
KR950702625A KR1019950700195A KR19950700195A KR950702625A KR 950702625 A KR950702625 A KR 950702625A KR 1019950700195 A KR1019950700195 A KR 1019950700195A KR 19950700195 A KR19950700195 A KR 19950700195A KR 950702625 A KR950702625 A KR 950702625A
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granules
enzyme
coating
core
porous material
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KR1019950700195A
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시도니우스 마리아 안델라 칼
페이젠 잔
딜리센 마크
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한스 발터 라벤
기스트-브로카데스 나암로제 베노오트하프
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Publication of KR950702625A publication Critical patent/KR950702625A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38672—Granulated or coated enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/98—Preparation of granular or free-flowing enzyme compositions

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Confectionery (AREA)

Abstract

새로운 효소과립은 개선된 성질을 제공한다.
과립은 입자내로 효소용액이 들어가도록 허용하는 양호한 구멍크기와 구멍크기 분포를 가지는 코어입자에 기초를 두고 있다. 따라서 코어물질은 액체형태로 효소를 포함하고 있어서 분말로 된 효소를 가공처리 해야하는 결점이 제거된다.
더욱 양호한 유동성과 계량성질이 달성된다. 효소함유과립은 필름형성 고분자 물질로 코팅하는 것이 바람직하다. 이들 과립은 낮은 살포성과 개선된 기계적 강도를 가진다. 또한 이들 효소과립의 제조방법이 제공된다.

Description

비살포성 효소의 제조방법(PROCESS FOR DUST-FREE ENZYME MANUFACTURE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 코어가 다공성물질로 이루어져서 과립에 존재하는 효소(들)(의 일부)가 코어내로 흡수되는 것을 특징으로 하는 과립.
  2. 코어가 다공성물질로 이루어져서 과립에 존재하는 효소(들)(의 일부)가 코어내로 흡수되는 외부보호층으로 코팅된 것을 특징으로 하는 과립.
  3. 코어가 다공성물질로 이루어져서 과립에 존재하는 효소(들)(의 일부)가 코어내로 흡수되고, 몇 개의 코팅층으로 코팅되며, 상기 코팅층은 예를들어 (다른) 효소, 안정제, 착색제를 함유할 수 있고 제어된 방출을 얻을 수 있는 것을 특징으로 하는 과립.
  4. 과립은 다공성물질로 이루어지고, 수성 또는 비수성 효소용액 또는 슬러리와 접촉시켜서 효소가 과립내로 흡수되게 하며, 필요한 경우에 제2항과 제3항에 기재된 생성물을 얻기 위해서 외부보호층 또는 몇 개의 코팅층으로 과립으로 코팅시키는 것을 특징으로 하는 비살포성 효소과립의 제조방법.
  5. 제4항에 있어서, 과립은 다공성물질로 이루어지고 수성 또는 비수성 효소용액 또는 슬러리와 접촉시켜서 혼합기에서 효소가 과립내로 흡수되는 것을 특징으로 하는 제조방법.
  6. 제5항에 있어서, 장치는 유동상 건조기 인 것을 특징으로 하는 방법.
  7. 제4항에 있어서, 제2항과 제3항에 기재된 생성물을 얻기 위해서 외부보호층 또는 몇 개의 코팅층으로 과립을 코팅하고 코팅은 혼합기 안에서 행해지는 것을 특징으로 하는 방법.
  8. 제7항에 있어서, 코팅은 유동상 건조기에서 행해지는 것을 특징으로 하는 방법.
  9. 제4항에 있어서, 전체과정이 하나의 장치에서 행해지는 것을 특징으로 하는 방법.
  10. 제9항에 있어서, 전체과정이 유동상 건조기에서 행해지는 것을 특징으로 하는 방법.
  11. 개질 셀룰로오스(들)(의 혼합물)로 이루어진 코팅층에 있어서, 화합물 또는 화합물(들)이 코팅과정 동안 과립의 응집과 점착을 막기 위해서 첨가되는 것을 특징으로 하는 코팅층.
  12. 제11항에 있어서, 첨가된 화합물이 탈크인 것을 특징으로 하는 코팅층.
  13. 효소함유수성 또는 비수성액체를 채운 다공성물질에 코팅물질을 도포하는 방법에 의해서 입자의 강도가 현저하게 증가된 것을 특징으로 하는 과립.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950700195A 1993-05-18 1994-05-18 비살포성 효소의 제조방법(process for dust-free enzyme manufacture) KR950702625A (ko)

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Application Number Priority Date Filing Date Title
EP93201428 1993-05-18
EP93201428.5 1993-05-18
PCT/EP1994/001642 WO1994026883A2 (en) 1993-05-18 1994-05-18 Process for dust-free enzyme manufacture

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KR950702625A true KR950702625A (ko) 1995-07-29

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EP (1) EP0675952A1 (ko)
KR (1) KR950702625A (ko)
CN (1) CN1110059A (ko)
AU (1) AU677342B2 (ko)
CA (1) CA2140530A1 (ko)
FI (1) FI950183A (ko)
PL (1) PL307854A1 (ko)
WO (1) WO1994026883A2 (ko)

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US5851975A (en) * 1995-05-29 1998-12-22 Kao Corporation Enzyme-containing granulated substance and preparation process thereof
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
JP4842414B2 (ja) 1996-04-12 2011-12-21 ノボザイムス アクティーゼルスカブ 酵素含有顆粒及びその製造のための方法
TW409035B (en) 1997-06-04 2000-10-21 Gist Brocades Bv Starch-based enzyme granulates
EP0913468A3 (en) * 1997-07-22 2001-06-13 Dsm N.V. Bread improving comüposition
US6083538A (en) * 1997-07-22 2000-07-04 Dsm N.V. Bread improving composition
EP1042458B1 (en) * 1997-12-23 2003-11-12 Novozymes A/S A process for immobilisation of enzymes
US6156548A (en) 1997-12-23 2000-12-05 Novo Nordisk A/S Immobilization of enzymes with a fluidized bed for use in an organic medium
US6630436B1 (en) 1998-10-30 2003-10-07 The Procter & Gamble Company Impact resistant solid component
GB2343191A (en) * 1998-10-30 2000-05-03 Procter & Gamble Low dusting components for detergent compositions
KR20010042579A (ko) 1999-02-10 2001-05-25 윌리암 로엘프 드 보에르 사료-효소 함유 과립
DE19929257A1 (de) * 1999-06-25 2000-12-28 Basf Ag Polymerbeschichtete, granulierte enzymhaltige Futtermittelzusätze und Verfahren zu deren Herstellung
JP4309137B2 (ja) 2001-05-18 2009-08-05 ダニスコ エイ／エス 酵素を使用した練り粉の調製方法
PL207550B1 (pl) 2002-01-15 2010-12-31 Basf Ag Sposób wytwarzania granulatu, granulat, sposób wytwarzania paszy dla zwierząt, kompozycja pokarmowa oraz zastosowanie granulatu
US7611877B2 (en) 2002-01-15 2009-11-03 Basf Aktiengesellschaft Granulates containing feed-enzymes
AU2005263954B2 (en) 2004-07-16 2011-04-07 Dupont Nutrition Biosciences Aps Enzymatic oil-degumming method
DE102006053071A1 (de) * 2006-11-10 2008-05-15 Ab Enzymes Gmbh Protein-enthaltender Stoff mit erhöhter Temperaturstabilität
US9560877B2 (en) 2012-03-13 2017-02-07 General Mills, Inc. Cereal-based product with improved eating quality fortified with dietary fiber and/or calcium
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FR2446317A1 (fr) * 1979-01-12 1980-08-08 Solvay Granules complexes contenant des substances proteiniques actives et procedes pour leur fabrication, leur utilisation, et leur regeneration
US4689297A (en) * 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
DE3682443D1 (de) * 1985-06-28 1991-12-19 Procter & Gamble Granulierte zusammensetzung enthaltend ein trockenes bleichmittel und ein stabiles enzym.
US5177013A (en) * 1989-07-31 1993-01-05 Ajinomoto Co., Inc. Preparation of an immobilized lipase having a low water content without drying
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EP0542351B1 (en) * 1991-11-11 1996-01-17 Akzo Nobel N.V. Process for the preparation of salt granulates

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Publication number Publication date
WO1994026883A3 (en) 1995-03-02
EP0675952A1 (en) 1995-10-11
CN1110059A (zh) 1995-10-11
CA2140530A1 (en) 1994-11-24
WO1994026883A2 (en) 1994-11-24
AU6970594A (en) 1994-12-12
FI950183A0 (fi) 1995-01-16
AU677342B2 (en) 1997-04-17
FI950183A (fi) 1995-01-16
PL307854A1 (en) 1995-06-26

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