KR950700920A - 5-o-데소사미닐에리쓰로노라이드a 유도체 - Google Patents

5-o-데소사미닐에리쓰로노라이드a 유도체

Info

Publication number
KR950700920A
KR950700920A KR1019940703540A KR19940703540A KR950700920A KR 950700920 A KR950700920 A KR 950700920A KR 1019940703540 A KR1019940703540 A KR 1019940703540A KR 19940703540 A KR19940703540 A KR 19940703540A KR 950700920 A KR950700920 A KR 950700920A
Authority
KR
South Korea
Prior art keywords
derivative
desosaminylerythronolide
oxo
substituted
alkyl
Prior art date
Application number
KR1019940703540A
Other languages
English (en)
Other versions
KR100244729B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR950700920A publication Critical patent/KR950700920A/ko
Application granted granted Critical
Publication of KR100244729B1 publication Critical patent/KR100244729B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Fats And Perfumes (AREA)
  • Amplifiers (AREA)
KR1019940703540A 1992-04-22 1993-04-21 5-0-데소사미닐에리쓰로노라이드a유도체 KR100244729B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP101492/1992 1992-04-22
JP10149292 1992-04-22
PCT/JP1993/000516 WO1993021199A1 (en) 1992-04-22 1993-04-21 5-o-desosaminylerythronolide a derivative

Publications (2)

Publication Number Publication Date
KR950700920A true KR950700920A (ko) 1995-02-20
KR100244729B1 KR100244729B1 (ko) 2000-02-15

Family

ID=14302174

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019940703540A KR100244729B1 (ko) 1992-04-22 1993-04-21 5-0-데소사미닐에리쓰로노라이드a유도체
KR1019940703541A KR0166996B1 (ko) 1992-04-22 1993-04-21 5-o-데소사미닐에리쓰로노라이드a 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019940703541A KR0166996B1 (ko) 1992-04-22 1993-04-21 5-o-데소사미닐에리쓰로노라이드a 유도체

Country Status (12)

Country Link
US (2) US5591837A (ko)
EP (2) EP0638585B1 (ko)
KR (2) KR100244729B1 (ko)
AT (2) ATE145212T1 (ko)
AU (2) AU662420B2 (ko)
BR (1) BR1100235A (ko)
CA (2) CA2118488C (ko)
DE (2) DE69305987T2 (ko)
DK (2) DK0638585T3 (ko)
ES (2) ES2096915T3 (ko)
GR (2) GR3019787T3 (ko)
WO (2) WO1993021199A1 (ko)

Families Citing this family (58)

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USRE38426E1 (en) * 1995-10-09 2004-02-10 Aventis Pharma S.A. 5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
ES2218604T3 (es) * 1995-11-08 2004-11-16 Abbott Laboratories Derivados triciclicos de eritromicina.
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
US5747466A (en) * 1995-11-08 1998-05-05 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
KR100523679B1 (ko) * 1996-09-04 2005-10-26 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
HUP0000198A3 (en) * 1996-11-27 2000-09-28 Taisho Pharmaceutical Co Ltd Erythromycin a derivatives
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
BR9809489A (pt) * 1997-05-29 2000-06-20 Abbott Lab Composto, processo para preparar o mesmo, e, composição farmacêutica e processo para tratar infecções bacterianas.
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
US5780604A (en) * 1997-09-26 1998-07-14 Abbott Laboratories 11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
CO4990960A1 (es) * 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
PA8461401A1 (es) 1997-10-29 2000-05-24 Pfizer Prod Inc Derivados de eritromicina triciclicos
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
FR2777282B1 (fr) * 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
ES2199524T3 (es) 1998-04-24 2004-02-16 Pfizer Products Inc. Derivados 9a,11b-deshidro de 9-oxima-3-ceto-6-o-metileritromicina.
AU3439899A (en) * 1998-06-03 1999-12-20 Pfizer Products Inc. Tricyclic 3-keto derivatives of 6-o-methylerythromycin
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
US6569836B2 (en) 1999-12-02 2003-05-27 Abbott Laboratories 6-O-alkyl-2-nor-2-substituted ketolide derivatives
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US6753318B1 (en) * 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US7022679B2 (en) * 2002-05-13 2006-04-04 Enanta Pharmaceuticals, Inc. Processes for the preparation of 6-11 bicyclic erythromycin derivatives
JP2005536465A (ja) * 2002-05-13 2005-12-02 エナンタ ファーマシューティカルズ インコーポレイテッド ６，１１二環式エリスロマイシン誘導体
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7163906B2 (en) * 2004-11-04 2007-01-16 Chevron Phillips Chemical Company, Llp Organochromium/metallocene combination catalysts for producing bimodal resins
US7229972B2 (en) 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
US7419962B2 (en) 2004-12-07 2008-09-02 Enanta Pharmaceuticals, Inc. 3,6-bicyclolides
TW200635600A (en) 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
US7291602B2 (en) 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
CN103193840A (zh) 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
US20070298811A1 (en) * 2006-06-21 2007-12-27 Lockheed Martin Corporation System for predicting bandwidth capacity
WO2009006403A2 (en) * 2007-06-29 2009-01-08 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylase (hdac) inhibitors and methods of making and using thereof
US8871728B2 (en) 2007-06-29 2014-10-28 Georgia Tech Research Corporation Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
NZ584159A (en) * 2007-09-17 2012-08-31 Enanta Pharm Inc 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175150A (en) * 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
WO1992009614A1 (fr) * 1990-11-28 1992-06-11 Taisho Pharmaceutical Co., Ltd. Derive de 6-o-methylerythromycine a
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives

Also Published As

Publication number Publication date
AU4022293A (en) 1993-11-18
DE69301916D1 (de) 1996-04-25
GR3019787T3 (en) 1996-07-31
EP0638584A1 (en) 1995-02-15
CA2118488C (en) 2002-11-05
DK0638584T3 (da) 1996-04-15
AU4022393A (en) 1993-11-18
ES2087737T3 (es) 1996-07-16
DE69305987T2 (de) 1997-03-06
WO1993021200A1 (fr) 1993-10-28
EP0638584A4 (en) 1994-12-23
KR950700921A (ko) 1995-02-20
GR3021992T3 (en) 1997-03-31
US5631355A (en) 1997-05-20
DE69305987D1 (de) 1996-12-19
AU662420B2 (en) 1995-08-31
US5591837A (en) 1997-01-07
BR1100235A (pt) 2002-04-30
DK0638585T3 (da) 1996-12-02
KR100244729B1 (ko) 2000-02-15
CA2118489C (en) 1999-07-13
ATE135707T1 (de) 1996-04-15
ES2096915T3 (es) 1997-03-16
EP0638585A1 (en) 1995-02-15
AU661585B2 (en) 1995-07-27
DE69301916T2 (de) 1996-08-08
EP0638584B1 (en) 1996-03-20
EP0638585B1 (en) 1996-11-13
CA2118488A1 (en) 1993-10-23
EP0638585A4 (en) 1995-04-19
KR0166996B1 (ko) 1999-01-15
ATE145212T1 (de) 1996-11-15
CA2118489A1 (en) 1993-10-23
WO1993021199A1 (en) 1993-10-28

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