KR950023403A - 치은증식 억제제 조성물 - Google Patents
치은증식 억제제 조성물 Download PDFInfo
- Publication number
- KR950023403A KR950023403A KR1019940000279A KR19940000279A KR950023403A KR 950023403 A KR950023403 A KR 950023403A KR 1019940000279 A KR1019940000279 A KR 1019940000279A KR 19940000279 A KR19940000279 A KR 19940000279A KR 950023403 A KR950023403 A KR 950023403A
- Authority
- KR
- South Korea
- Prior art keywords
- gingival
- inhibitor composition
- acid
- present
- diphenylhydantoin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 5
- 239000003112 inhibitor Substances 0.000 title 1
- ZZPQSQFQHIGCRC-OOFFSTKBSA-N (2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-c Chemical compound [Zn].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ZZPQSQFQHIGCRC-OOFFSTKBSA-N 0.000 claims abstract 2
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims abstract 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 claims abstract 2
- 108010036949 Cyclosporine Proteins 0.000 claims abstract 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000005642 Oleic acid Substances 0.000 claims abstract 2
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims abstract 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract 2
- 229960001265 ciclosporin Drugs 0.000 claims abstract 2
- 229930182912 cyclosporin Natural products 0.000 claims abstract 2
- 239000003966 growth inhibitor Substances 0.000 claims abstract 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960001597 nifedipine Drugs 0.000 claims abstract 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract 2
- 229960002036 phenytoin Drugs 0.000 claims abstract 2
- 229940096998 ursolic acid Drugs 0.000 claims abstract 2
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000019155 vitamin A Nutrition 0.000 claims abstract 2
- 239000011719 vitamin A Substances 0.000 claims abstract 2
- 229940045997 vitamin a Drugs 0.000 claims abstract 2
- 230000035755 proliferation Effects 0.000 claims 1
- 210000004195 gingiva Anatomy 0.000 abstract 1
- 235000021156 lunch Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 235000011888 snacks Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 치은 중식 억제제 조성물을 제공한다.
본 발명의 치은 증식 억제제 조성물은 비타민 A, 감초산, 우르솔산 또는 올레산을 유효성분으로 함유함을 특징으로 한다. 본 발명의 조성물은 특히 디페닐히단토인, 니페디핀 또는 사이클로스포린의 사용에 의해 유발되는 치은 중식의 예방 또는 치료에 유용하다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 비타민 A, 감초산, 우르솔산 또는 올레산을 유효성분으로 함유함을 특징으로 하는 치은 증식 억제제 조성물.
- 제1항에 있어서, 치은 증식은 디페닐히단토인, 니페디핀 또는 사이클로스포린의 사용에 의해 유발되는 것임을 특징으로 하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019940000279A KR100360666B1 (ko) | 1994-01-10 | 1994-01-10 | 레티놀을함유하는치은증식억제제조성물 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019940000279A KR100360666B1 (ko) | 1994-01-10 | 1994-01-10 | 레티놀을함유하는치은증식억제제조성물 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020020015331A Division KR100360662B1 (ko) | 2002-03-21 | 2002-03-21 | 감초산을 함유하는 치은증식 억제제 조성물 |
| KR1020020015332A Division KR100360663B1 (ko) | 2002-03-21 | 2002-03-21 | 우르솔산을 함유하는 치은증식 억제제 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950023403A true KR950023403A (ko) | 1995-08-18 |
| KR100360666B1 KR100360666B1 (ko) | 2003-01-10 |
Family
ID=37490531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940000279A KR100360666B1 (ko) | 1994-01-10 | 1994-01-10 | 레티놀을함유하는치은증식억제제조성물 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR100360666B1 (ko) |
-
1994
- 1994-01-10 KR KR1019940000279A patent/KR100360666B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100360666B1 (ko) | 2003-01-10 |
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| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
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| E902 | Notification of reason for refusal | ||
| A107 | Divisional application of patent | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |